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Internal Medicine

Review: Insulin therapy for the non-specialist physician.

27 Jul, 2021 | 03:18h | UTC

Insulin therapy for the non-specialist physician – Clinical Medicine Journal

 

Review: Diabetes and the kidney.

27 Jul, 2021 | 03:16h | UTC

Diabetes and the kidney – Clinical Medicine Journal

 

Review: Managing hyperglycemia in inpatients.

27 Jul, 2021 | 03:21h | UTC

Managing hyperglycaemia in inpatients – Clinical Medicine Journal

 

[Preprint] RCT: In patients with COVID-19 and severe hypoxia, dexamethasone 12 mg did NOT result in statistically significant improved outcomes compared to dexamethasone 6 mg – “Mortality at 28 days was 27.1% and 32.3% in patients assigned to 12 mg and 6 mg, respectively (adjusted relative risk 0.86, 99% CI, 0.68-1.08)”.

26 Jul, 2021 | 03:01h | UTC

Dexamethasone 12 mg versus 6 mg for patients with COVID-19 and severe hypoxia: an international, randomized, blinded trial – medRxiv

 

Review: Uncommon forms of diabetes.

27 Jul, 2021 | 03:14h | UTC

Uncommon forms of diabetes – Clinical Medicine Journal

 

Large cohort study finds one in two hospitalized COVID-19 patients develop a complication.

26 Jul, 2021 | 03:00h | UTC

Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study – The Lancet

Commentaries:

Landmark study finds one in two hospitalised COVID-19 patients develop a complication – National Institute for Health Research

In-hospital complications associated with COVID-19 – The Lancet

CV Complications Common in Hospitalized COVID-19 Patients – TCTMD

Almost Half of Patients Admitted With COVID-19 Have Complications – HealthDay

 

Commentary on Twitter (thread – click for more)

 

Study: Lateral flow antigen testing can rapidly and accurately detect early COVID-19 among patients presenting with flu-like illness and can be a plausible alternative to RT-PCR.

26 Jul, 2021 | 02:56h | UTC

Comparing the diagnostic accuracy of point-of-care lateral flow antigen testing for SARS-CoV-2 with RT-PCR in primary care (REAP-2) – EClinicalMedicine

News release: Lateral flow tests are 95% effective at detecting Covid-19 when used at the onset of symptoms – University of Oxford

Related:

Interactive Infographic | Interpreting a lateral flow SARS-CoV-2 antigen test – “This calculator demonstrates how interpreting a covid-19 lateral flow device (LFD) result varies according to the pre-test probability, and the sensitivity and specificity of the LFD used”.

Rapid point-of-care tests for diagnosing COVID-19 infection: the latest Cochrane evidence

 

Commentary on Twitter (thread – click for more)

 

M-A: Psychiatric patients at increased risk of COVID-19 hospitalization and mortality.

26 Jul, 2021 | 02:57h | UTC

News release: Psychiatric patients at increased risk of COVID-19 hospitalization and mortality – European College of Neuropsychopharmacology

Original article: Mental disorders and risk of COVID-19-related mortality, hospitalisation, and intensive care unit admission: a systematic review and meta-analysis – The Lancet Psychiatry

 

Study: Among kidney transplant recipients who did not respond after 2 doses, a third dose of an mRNA-1273 vaccine induced a serologic response in 49% of patients.

26 Jul, 2021 | 02:54h | UTC

Antibody Response After a Third Dose of the mRNA-1273 SARS-CoV-2 Vaccine in Kidney Transplant Recipients With Minimal Serologic Response to 2 Doses – JAMA

Commentary: Case Mounts for COVID Vaccine Boosters in Kidney Transplant Recipients – MedPage Today (free registration required)

Related:

Case series: Safety and immunogenicity of a third dose of SARS-CoV-2 vaccine in solid organ transplant recipients.

[Preprint] 3rd AstraZeneca shot gives strong immunity.

 

Commentary on Twitter

 

Case report: Kawasaki-like multisystem inflammatory syndrome associated with SARS-CoV-2 infection in an adult.

26 Jul, 2021 | 02:52h | UTC

Kawasaki-like multisystem inflammatory syndrome associated with SARS-CoV-2 infection in an adult – BMJ Case Reports

Related:

Case report: Multisystem inflammatory syndrome in an adult after SARS-CoV-2 infection.

Characteristics associated with Multisystem Inflammatory Syndrome among adults with SARS-CoV-2 infection

Case series of multisystem inflammatory syndrome in adults associated with SARS-CoV-2 infection

Case Reports: 2 Adults with Kawasaki-like Multisystem Inflammatory Syndrome Associated with COVID-19

 

Position paper: Advancing precision medicine for acute respiratory distress syndrome.

26 Jul, 2021 | 02:28h | UTC

Advancing precision medicine for acute respiratory distress syndrome – The Lancet Respiratory Medicine

Related:

Review: Personalized mechanical ventilation in acute respiratory distress syndrome.

Seminar | Acute respiratory distress syndrome.

M-A of randomized trials: In patients with acute respiratory distress syndrome, there was no difference in mortality between higher vs. lower positive end-expiratory pressure strategies.

M-A: High versus low PEEP levels for mechanically ventilated adult patients with acute lung injury and ARDS

M-A: Decreased mortality in acute respiratory distress syndrome patients treated with corticosteroids

ARDS: Contemporary management and novel approaches during COVID-19

Systematic review: Evidence-based practices for acute respiratory failure and Acute Respiratory Distress Syndrome

Current and evolving standards of care for patients with acute respiratory distress syndrome (ARDS). Definition, ventilatory support, fluid management, use of corticosteroids, indications of prone positioning and ECMO, and more.

 

Review: Dietary carbohydrates and fats in nonalcoholic fatty liver disease.

26 Jul, 2021 | 02:22h | UTC

Dietary carbohydrates and fats in nonalcoholic fatty liver disease – Nature Reviews Gastroenterology & Hepatology (free for a limited period)

 

Commentary on Twitter

 

Clinical practice guidelines for the medical management of Graves’ orbitopathy.

26 Jul, 2021 | 02:26h | UTC

The 2021 European Group on Graves’ Orbitopathy (EUGOGO) Clinical Practice Guidelines for The Medical Management of Graves’ Orbitopathy – European Journal of Endocrinology

 

Editorial | Antibiotic overuse: managing uncertainty and mitigating against overtreatment.

26 Jul, 2021 | 02:16h | UTC

Antibiotic overuse: managing uncertainty and mitigating against overtreatment – BMJ Quality & Safety

 

Commentary on Twitter

 

Cohort study: Higher intake of ultra-processed food linked to increased risk of inflammatory bowel disease.

26 Jul, 2021 | 02:13h | UTC

Association of ultra-processed food intake with risk of inflammatory bowel disease: prospective cohort study – The BMJ

Commentaries:

Ultra-processed food linked to higher risk of IBD – BMJ

International study links ultra-processed foods with IBD risk – Medical News Today

 

M-A of cohort studies: Meat consumption and risk of ischemic heart disease.

26 Jul, 2021 | 02:09h | UTC

Meat consumption and risk of ischemic heart disease: A systematic review and meta-analysis – Critical Reviews in Food Science and Nutrition

Commentary: Red and processed meat linked to increased risk of heart disease, Oxford study shows – Oxford University

 

Opinion | Tocilizumab in COVID-19 therapy: who benefits, and how? – the researchers suggest that maybe IL-6 inhibitors should be given only to patients with high IL-6.

23 Jul, 2021 | 10:51h | UTC

Tocilizumab in COVID-19 therapy: who benefits, and how? – The Lancet

Related: A living WHO guideline on drugs for covid-19 – interleukin-6 receptor blockers are now recommended for patients with severe or critical covid-19. AND M-A: Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19 – “The 4% absolute risk reduction in mortality from 25% to 21% with IL-6 inhibition added to glucocorticoids may not translate to patients with a lower baseline mortality risk and likely do not justify the additional expense and risk for toxicities for patients hospitalized with modest oxygen requirements and a stable clinical course (from editorial)”. AND RECOVERY trial: In hospitalized COVID-19 patients with hypoxia and systemic inflammation (C-reactive protein ≥75 mg/L), tocilizumab improved survival and other clinical outcomes AND Secondary analysis of RCT finds Tocilizumab was beneficial to patients hospitalized with Covid-19 if CRP levels were greater than 15.0 mg/dL, but not if CRP levels were 15.0 mg/dL or less. AND M-A: Tocilizumab in COVID-19 – “For hospitalized COVID-19 patients, there is some evidence that tocilizumab use may be associated with a short-term mortality benefit, but further high-quality data are required”.

 

What are the Delta, Gamma, Beta and Alpha Covid variants?

23 Jul, 2021 | 10:45h | UTC

What are the Delta, Gamma, Beta and Alpha Covid variants? – BBC

Related: Increased transmissibility and global spread of SARS-CoV-2 variants of concern – “Estimated transmissibility increases of alpha 29% (95% CI: 24–33), beta 25% (95% CI: 20–30), gamma 38% (95% CI: 29–48) & delta 97% (95% CI: 76–117)”. AND WHO renames COVID-19 variants with the Greek alphabet (i.e., Alpha, Beta, Gamma, etc), making them simple, easy to say and remember. The naming system aims to prevent calling COVID-19 variants by the places where they are detected, which is stigmatizing & discriminatory.

 

Secondary sclerosing cholangitis: an emerging complication in critically ill COVID-19 patients.

23 Jul, 2021 | 10:47h | UTC

Secondary sclerosing cholangitis: an emerging complication in critically ill COVID-19 patients – Intensive Care Medicine

 

New series from The Lancet: Physical Activity 2021.

23 Jul, 2021 | 10:37h | UTC

Homepage: Physical Activity 2021 – The Lancet (free registration required for all articles)

Summary and commentary: Experts call for immediate action to ensure physical activity is built into everyday lives – News Medical

 

Commentary on Twitter (thread – click for more)

 

How the Delta variant achieves its ultrafast spread – “Viral load is roughly 1,000 times higher in people infected with the Delta variant than those infected with the original coronavirus strain, according to a study in China”.

23 Jul, 2021 | 10:46h | UTC

How the Delta variant achieves its ultrafast spread – Nature

Original study: Study shows the viral loads in the Delta infections are ~1000 times higher than those in the earlier strain infections on the day when viruses are firstly detected.

 

CDC releases new guidelines for the treatment of sexually transmitted infections.

23 Jul, 2021 | 10:41h | UTC

Table of Contents: Sexually Transmitted Infections Treatment Guidelines, 2021

Guideline: Sexually Transmitted Infections Treatment Guidelines, 2021 – Centers for Disease Control and Prevention

Related (just released): WHO Guidelines for the management of symptomatic sexually transmitted infections.

 

Commentary on Twitter (thread – click for more)

 

Review: Treatment strategies for new onset atrial fibrillation in patients treated on an intensive care unit.

23 Jul, 2021 | 10:30h | UTC

Treatment strategies for new onset atrial fibrillation in patients treated on an intensive care unit: a systematic scoping review – Critical Care

 

Position Statement on Endomyocardial Biopsy.

23 Jul, 2021 | 10:33h | UTC

Heart Failure Association, Heart Failure Society of America, and Japanese Heart Failure Society Position Statement on Endomyocardial Biopsy

 

Commentary on Twitter

 

Review: Ethics in extracorporeal life support.

23 Jul, 2021 | 10:29h | UTC

Ethics in extracorporeal life support: a narrative review – Critical Care

 

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