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Internal Medicine

RCT: Text-message reminders can increase COVID-19 vaccinations.

4 Aug, 2021 | 09:12h | UTC

Behavioral Nudges Increase COVID-19 Vaccinations – Nature

Commentaries:

Text-message ‘nudges’ can encourage holdouts to get COVID vaccination, study finds – UCLA

Text reminders boost vaccine appointments – Carnegie Mellon University

 

Commentary on Twitter

 

Cannabis and Cannabinoid Analgesia position statement – “Due to the lack of high-quality clinical evidence, the IASP does not currently endorse general use of cannabis and cannabinoids for pain relief.”

4 Aug, 2021 | 09:07h | UTC

International Association for the Study of Pain Presidential Task Force on Cannabis and Cannabinoid Analgesia position statement – Pain

See also:

Cannabinoids, cannabis, and cannabis-based medicine for pain management: a systematic review of randomised controlled trials – Pain

General risks of harm with cannabinoids, cannabis, and cannabis-based medicine possibly relevant to patients receiving these for pain management: an overview of systematic reviews – Pain

Commentary:

More evidence needed to back cannabis as pain treatment, says review – Imperial College London

Medicinal cannabis to manage chronic pain? We don’t have evidence it works – The Conversation

Related:

NICE Guideline: Cannabis-Based Medicinal Products

Consensus recommendations for perioperative management of cannabis and cannabinoid-based medicine users

Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain – Agency for Healthcare Research and Quality

Short Review: Drug Interactions with Cannabinoids

Meta-Analysis: Cannabinoids Not Effective for Cancer-Related Pain

 

NCCN Guidelines Insights: Palliative Care.

4 Aug, 2021 | 09:02h | UTC

NCCN Guidelines® Insights: Palliative Care, Version 2.2021 – Journal of the National Comprehensive Cancer Network

 

Spontaneous pneumomediastinum in patients diagnosed with covid-19: a case series with review of literature.

4 Aug, 2021 | 09:13h | UTC

Spontaneous Pneumomediastinum in Patients Diagnosed with COVID-19: a Case Series with Review of Literature – Academic Radiology

 

RCT: Routine treatment with fluoxetine does not reduce the incidence of depression after stroke.

4 Aug, 2021 | 08:56h | UTC

Depression Outcomes Among Patients Treated With Fluoxetine for Stroke Recovery: The AFFINITY Randomized Clinical Trial – JAMA Neurology (free for a limited period)

Editorial: Poststroke Selective Serotonin Reuptake Inhibitors—Do They Work for Anything? (free for a limited period)

Related:

[Abstract Only] Randomized trial: Fluoxetine does not improve functional recovery after acute stroke

Randomized Trial: Effects of Fluoxetine on Functional Outcomes After Acute Stroke

 

Ketogenic Diets and Chronic Disease: Weighing the Benefits Against the Risks – “Given often-temporary improvements, unfavorable effects on dietary intake, and inadequate data demonstrating long-term safety, for most individuals, the risks of ketogenic diets may outweigh the benefits.”

4 Aug, 2021 | 08:53h | UTC

Ketogenic Diets and Chronic Disease: Weighing the Benefits Against the Risks – Frontiers in Nutrition

Commentary: Keto diets review finds heart risks, cancer risk, dangers to pregnant women and kidney patients – Physicians Committee for Responsible Medicine

 

RCT: Midodrine can reduce the recurrence of vasovagal syncope.

4 Aug, 2021 | 08:54h | UTC

Midodrine for the Prevention of Vasovagal Syncope: A Randomized Clinical Trial – Annals of Internal Medicine

Commentary: Midodrine Cuts Recurrent Syncope in Young, Healthy Patients – HealthDay

Summary for patients: Summary for Patients: Midodrine to Prevent Fainting – Annals of Internal Medicine

 

Commentary on Twitter

 

M-A: Noninvasive respiratory support outside the intensive care unit for acute respiratory failure related to coronavirus-19 disease.

3 Aug, 2021 | 09:09h | UTC

Noninvasive respiratory support outside the intensive care unit for acute respiratory failure related to coronavirus-19 disease: a systematic review and meta-analysis – Critical Care

 

A blood marker predicts who gets ‘breakthrough’ COVID (neutralizing antibodies).

3 Aug, 2021 | 09:01h | UTC

A blood marker predicts who gets ‘breakthrough’ COVID – Nature

Related:

A correlate of protection for SARS-CoV-2 vaccines is urgently needed – “Recent studies suggest that neutralizing antibodies could serve as a correlate of protection for vaccines against SARS-CoV-2 in humans”.

Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection.

Covid-19 breakthrough infections in vaccinated health care workers.

 

Postacute Sequelae of COVID-19 Pneumonia: 6-month Chest CT Follow-up.

3 Aug, 2021 | 09:02h | UTC

Postacute Sequelae of COVID-19 Pneumonia: 6-month Chest CT Follow-up – Radiology

 

Covid: Pulse oxygen monitors work less well on darker skin, experts say.

3 Aug, 2021 | 09:00h | UTC

Covid: Pulse oxygen monitors work less well on darker skin, experts say – BBC

Related:

FDA issues alert on ‘limitations’ of pulse oximeters, without explicit mention of racial bias

“Racial Bias in Pulse Oximetry Measurement”. In two large cohorts, Black patients had nearly three times the frequency of occult hypoxemia that was not detected by pulse oximetry as White patients

 

WHO Advocacy Brief: Scale, impact, and harms of social isolation and loneliness among older people.

3 Aug, 2021 | 02:29h | UTC

Social Isolation and Loneliness – World Health Organization

 

Commentary on Twitter (thread – click for more)

 

Prevalence, costs, and consequences of low-value preprocedural urinalyses in the US.

3 Aug, 2021 | 02:13h | UTC

Prevalence, Costs, and Consequences of Low-Value Preprocedural Urinalyses in the US – JAMA Internal Medicine

Editorial: Moving Beyond Guidelines—Use of Value-Based Preoperative Testing (free for a limited period)

Commentary: Preoperative screening urinalysis is widely used—but usually unnecessary, study finds – MedicalXpress

 

M-A: Association between adiposity and cardiovascular outcomes.

3 Aug, 2021 | 02:11h | UTC

Association between adiposity and cardiovascular outcomes: an umbrella review and meta-analysis of observational and Mendelian randomization studies – European Heart Journal

 

Commentary on Twitter

 

2021 Update in the diagnosis and management of acute coronary syndromes for the perioperative clinician.

3 Aug, 2021 | 02:22h | UTC

2021 Update in the Diagnosis and Management of Acute Coronary Syndromes For the Perioperative Clinician – Journal of Cardiothoracic and Vascular Anesthesia

 

Commentary on Twitter

https://twitter.com/AlejandroLemor/status/1418925354870349826

 

Opinion | Should pregnant women have a COVID vaccine? The evidence says it’s safe and effective.

2 Aug, 2021 | 00:28h | UTC

Should pregnant women have a COVID vaccine? The evidence says it’s safe and effective – The Conversation

 

Subgroup analysis of RCT suggests early rhythm control therapy is beneficial for patients with atrial fibrillation and heart failure.

3 Aug, 2021 | 02:00h | UTC

Early Rhythm Control Therapy in Patients with Atrial Fibrillation and Heart Failure – Circulation

Original study: #ESCCongress – [Abstract Only] Randomized trial: Early rhythm-control therapy in patients with atrial fibrillation (study and commentaries)

Related:

Meta-Analysis: Catheter Ablation Improves Outcomes in Patients with Atrial Fibrillation Complicated with Heart Failure

Catheter Ablation for Atrial Fibrillation Improves Outcomes in Heart Failure with Reduced Ejection Fraction

M-A: In patients with atrial fibrillation, catheter ablation was associated with a 38% reduction in recurrence and a 68% reduction in hospitalizations. The rate of serious complications was 4.2% with ablation vs. 2.8% in the antiarrhythmic group, a difference that was not statistically significant.

CABANATrial: Catheter Ablation vs Antiarrhythmic Drug Therapy on Mortality, Stroke, Bleeding, and Cardiac Arrest Among Patients With Atrial Fibrillation

 

The study behind new CDC’s mask guidance found vaccinated people can spread delta variant.

2 Aug, 2021 | 00:33h | UTC

CDC Report: Outbreak of SARS-CoV-2 Infections, Including COVID-19 Vaccine Breakthrough Infections, Associated with Large Public Gatherings — Barnstable County, Massachusetts, July 2021 – Centers for Disease Control and Prevention

Commentaries:

The Study Behind CDC’s Mask Guidance Found Vaccinated People Can Spread Delta Variant – NPR

What Delta has changed in the Covid pandemic — and what it hasn’t – STAT

 

Commentary on Twitter (thread – click for more)

 

Guideline: Clinical management of adult patients with COVID-19 Outside Intensive Care Units.

2 Aug, 2021 | 00:26h | UTC

Clinical Management of Adult Patients with COVID-19 Outside Intensive Care Units: Guidelines from the Italian Society of Anti-Infective Therapy (SITA) and the Italian Society of Pulmonology (SIP) – Infectious Diseases and Therapy

 

ACOG and SMFM Recommend COVID-19 Vaccination for Pregnant Individuals – “ACOG encourages its members to enthusiastically recommend vaccination to their patients.”

2 Aug, 2021 | 00:31h | UTC

ACOG and SMFM Recommend COVID-19 Vaccination for Pregnant Individuals – American College of Obstetricians and Gynecologists (ACOG) and the Society for Maternal-Fetal Medicine (SMFM)

Additional reading:

Practice Advisory: COVID-19 Vaccination Considerations for Obstetric-Gynecologic Care

COVID-19 Vaccines and Pregnancy: Conversation Guide for Clinicians

Commentaries:

Obstetrician groups recommend COVID vaccine during pregnancy – Associated Press

Statements By Obstetrics Societies Strongly Advise Covid-19 Vaccinations For Pregnant Women – Forbes

 

Commentary on Twitter

 

Post-viral effects of COVID-19 in the olfactory system and their implications.

2 Aug, 2021 | 00:24h | UTC

Post-viral effects of COVID-19 in the olfactory system and their implications – The Lancet Neurology

Related:

Study finds 96.1% of patients objectively recovered from anosmia 1 year after COVID-19 diagnosis.

Eight out of ten people hospitalized with COVID-19 develop neurological problems – the most common self-reported symptoms included headache (37%) and anosmia or ageusia (26%).

Loss of smell in mild Covid-19 cases occurs 86% of the time, study says

Management of anosmia and loss of smell in the era of Covid-19

 

What every intensivist should know about Tocilizumab.

2 Aug, 2021 | 00:25h | UTC

What every intensivist should know about Tocilizumab – Critical Care

Related:

Tocilizumab in COVID-19 therapy: who benefits, and how?

A living WHO guideline on drugs for covid-19 – interleukin-6 receptor blockers are now recommended for patients with severe or critical covid-19.

M-A: Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19 – “The 4% absolute risk reduction in mortality from 25% to 21% with IL-6 inhibition added to glucocorticoids may not translate to patients with a lower baseline mortality risk and likely do not justify the additional expense and risk for toxicities for patients hospitalized with modest oxygen requirements and a stable clinical course (from editorial)”.

RECOVERY trial: In hospitalized COVID-19 patients with hypoxia and systemic inflammation (C-reactive protein ≥75 mg/L), tocilizumab improved survival and other clinical outcomes

Secondary analysis of RCT finds Tocilizumab was beneficial to patients hospitalized with Covid-19 if CRP levels were greater than 15.0 mg/dL, but not if CRP levels were 15.0 mg/dL or less.

M-A: Tocilizumab in COVID-19 – “For hospitalized COVID-19 patients, there is some evidence that tocilizumab use may be associated with a short-term mortality benefit, but further high-quality data are required”.

 

Clinical practice guidelines for the management of colonic volvulus and acute colonic pseudo-obstruction.

2 Aug, 2021 | 00:13h | UTC

The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Colonic Volvulus and Acute Colonic Pseudo-Obstruction – Diseases of the Colon & Rectum

News release: American Society of Colon & Rectal Surgeons Publishes New Guidelines for Colonic Volvulus and Acute Colonic Pseudo-Obstruction

 

Ten things to know about ten imaging studies: A preventive cardiology perspective.

2 Aug, 2021 | 00:12h | UTC

Ten things to know about ten imaging studies: A preventive cardiology perspective (“ASPC top ten imaging”) – American Journal of Preventive Cardiology

 

AHA Scientific Statement: Lower extremity peripheral artery disease: contemporary epidemiology, management gaps, and future directions.

2 Aug, 2021 | 00:17h | UTC

Lower Extremity Peripheral Artery Disease: Contemporary Epidemiology, Management Gaps, and Future Directions: A Scientific Statement From the American Heart Association – Circulation

Top Things to Know: Lower Extremity Peripheral Artery Disease: Contemporary Epidemiology, Management Gaps, and Future Directions – American Heart Association

Commentary: The Need for Improved Identification and Treatment of Peripheral Arterial Disease – American Heart Association

 

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