Internal Medicine
Consensus Paper | De-escalation or abbreviation of dual antiplatelet therapy in acute coronary syndromes and PCI
24 Jul, 2023 | 13:08h | UTCDe-escalation or abbreviation of dual antiplatelet therapy in acute coronary syndromes and percutaneous coronary intervention: a Consensus Statement from an international expert panel on coronary thrombosis – Nature Reviews Cardiology (if the link is paywalled, try this one)
Systematic Review | Dual therapy of Rifaximin and lactulose potentially reduces risk in hepatic encephalopathy
24 Jul, 2023 | 12:57h | UTC
Systematic Review | Insufficient evidence for ACEi/ARB’s impact on early non-diabetic CKD
24 Jul, 2023 | 12:56h | UTC
Review | Research on prescribing cascades
24 Jul, 2023 | 12:53h | UTCResearch on prescribing cascades: a scoping review – Frontiers in Pharmacology
RCT | Long-term Doxycycline for COPD does not reduce exacerbations, except possibly in severe cases or with low eosinophils
24 Jul, 2023 | 12:50h | UTCA Double-Blind, Randomised, Placebo-controlled Trial of Long-Term Doxycycline Therapy on Exacerbation Rate in Patients with Stable COPD – American Journal of Respiratory and Critical Care Medicine (link to abstract – $ for full-text)
2023 AHA/ACC Guideline for chronic coronary disease – B-blockers downgraded in patients without recent MI or low ejection fraction
21 Jul, 2023 | 13:52h | UTCKey Perspectives: 2023 Multisociety Guideline for Managing Chronic Coronary Disease – American College of Cardiology
Top things to know: 2023 AHA/ACC/ACCP/ASPC/NLA/PCNA Guideline for the Management of Patients With Chronic Coronary Disease – American Heart Association
News Releases:
Commentary: New Chronic Heart Disease Guidelines Update Roles of GDMT, Imaging, and Revascularization – TCTMD
Commentary on Twitter with key points (thread – click for more)
🆕2023 AHA/ACC/ACCP/ASPC/NLA/PCNA Guideline for the Management of Patients w/ Chronic Coronary Disease aims to provide recommendations for diagnostic evaluation, symptom relief, improvement in QoL & reduction of future #ASCVD-related events & #heartfailure in patients w/ CCD.
— American College of Cardiology (@ACCinTouch) July 20, 2023
Guideline | Laboratory analysis in the diagnosis and management of diabetes mellitus
21 Jul, 2023 | 13:50h | UTCExecutive Summary: Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus – Diabetes Care
Correspondence | Potential “healthy vaccinee bias” in a study of BNT162b2 vaccine against Covid-19
21 Jul, 2023 | 13:43h | UTC
Commentary from the author on Twitter (thread – click for more)
Our correspondence is out in @njem written w @VPrasadMDMPH & Ram Duriseti
We show v strong evidence of healthy vaccinee bias in an Israeli study of Pfizer booster vs covid death, which wasn't disclosed
Could explain ALL reported benefit of the booster🧵https://t.co/F3WeafvUnw pic.twitter.com/b29YQ0lblh
— Tracy Høeg, MD, PhD (@TracyBethHoeg) July 20, 2023
RCT | MIND diet, a hybrid of Mediterranean and DASH, shows no superiority in preventing cognitive decline
21 Jul, 2023 | 13:38h | UTCTrial of the MIND Diet for Prevention of Cognitive Decline in Older Persons – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries:
Commentary on Twitter
Original Article: Trial of the MIND Diet for Prevention of Cognitive Decline in Older Persons https://t.co/ED5Rd6oCTf #AAIC23
— NEJM (@NEJM) July 19, 2023
RCT | Half-dose Tenecteplase + later PCI if indicated seems to be viable option in older individuals when timely PCI is unavailable
21 Jul, 2023 | 13:36h | UTCHalf-Dose Tenecteplase or Primary Percutaneous Coronary Intervention in Older Patients With ST-Segment–Elevation Myocardial Infarction in STREAM-2: A Randomized, Open-Label Trial – Circulation (link to abstract – $ for full-text)
Commentary on Twitter
In the #STREAMI-2 trial of older adults w/ early-presenting STEMI, half-dose tenecteplase w/ PCI if indicated comparable to primary PCI for ECG/angio endpoints and 30d clinical efficacy but w/ higher risk of ICH @Cardio_KULeuven @CVC_UAlberta @BaineyKevin https://t.co/zFE6C1U98n pic.twitter.com/noWWhJ6y9h
— Circulation (@CircAHA) July 18, 2023
Cohort Study | Bipolar disorder associated with a 6-fold higher mortality risk from external causes
21 Jul, 2023 | 13:29h | UTCNews Release: Bipolar disorder linked to 6-fold heightened risk of early death from external causes – BMJ Newsroom
Systematic Review | Medical treatment of eosinophilic esophagitis
21 Jul, 2023 | 13:27h | UTCMedical treatment of eosinophilic esophagitis – Cochrane Library
Summary: Medical treatments for eosinophilic esophagitis – Cochrane Library
Related:
M-A | Efficacy of elimination diets in eosinophilic esophagitis
RCT | Dupilumab in adults and adolescents with eosinophilic esophagitis
IDSA 2023 Guidance on the treatment of antimicrobial resistant gram-negative infections
20 Jul, 2023 | 11:15h | UTC
RCT | Hearing intervention fails to impact 3-year cognitive decline in older adults
20 Jul, 2023 | 11:09h | UTCHearing intervention versus health education control to reduce cognitive decline in older adults with hearing loss in the USA (ACHIEVE): a multicentre, randomised controlled trial – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter
#AAIC23 While hearing aids did not have an impact on cognitive decline over 3 years in a general population, treating hearing loss protected against cognitive decline in older adults at greater risk of dementia, finds a new trial: https://t.co/1UjGgDf5m5 pic.twitter.com/kuujeekCWW
— The Lancet (@TheLancet) July 18, 2023
M-A | Hepatic, extra-hepatic outcomes and causes of mortality in NAFLD
20 Jul, 2023 | 10:59h | UTC
RCT | Ischemic stroke patients benefit from Panax notoginseng saponins therapy
20 Jul, 2023 | 10:57h | UTCSee also: Visual Abstract
Systematic Review | Outcomes in deprescribing implementation trials and compliance with expert recommendations
20 Jul, 2023 | 10:55h | UTCRelated:
RCT | Opioids not more effective than placebo for acute low back and neck pain
RCT | A deprescribing intervention reduced medication burden among older adults in post-acute care
Deprescribing proton pump inhibitors – Australian Journal of General Practice
Antihypertensive Deprescribing in Older Adults: a Practical Guide – Current Hypertension Reports
Deprescribing in Palliative Cancer Care – Life
Less is More: Deprescribing Medications in Older Adults with Kidney Disease: A Review – Kidney360
Polypharmacy Management in Older Patients – Mayo Clinic Proceedings
Eliminating Medication Overload: A National Action Plan – Lown Institute
Common ED Medication Errors: Polypharmacy – emDocs
Current and future perspectives on the management of polypharmacy – BMC Family Practice
Polypharmacy—an Upward Trend with Unpredictable Effects – Deutsches Ärzteblatt international
Clinical Consequences of Polypharmacy in Elderly – Expert Opinion on Drug Safety
Review | Painful diabetic peripheral neuropathy
20 Jul, 2023 | 10:53h | UTC
Self-measured blood pressure telemonitoring programs: a pragmatic how-to guide
19 Jul, 2023 | 14:33h | UTC
ASCO Guideline | Practical assessment and management of vulnerabilities in older patients receiving systemic cancer therapy
19 Jul, 2023 | 14:31h | UTC
Systematic Review | An evidence-base for the implementation of hospital-based palliative care programs in routine cancer practice
19 Jul, 2023 | 14:23h | UTC
Podcast | Hematuria pearls
19 Jul, 2023 | 14:19h | UTC#404 Hematuria with Dr. Derek Fine – The Curbsiders
Large bowel obstruction | ED presentation, evaluation, and management
19 Jul, 2023 | 14:17h | UTCLarge bowel obstruction: ED presentation, evaluation, and management – emDocs
IARC, WHO agency, identifies aspartame as potentially carcinogenic but probably safe within established acceptable daily intake
18 Jul, 2023 | 13:58h | UTCNews Release: Aspartame hazard and risk assessment results released – World Health Organization
Commentaries:
Expert reaction to IARC and JEFCA summary on aspartame – Science Media Centre
Aspartame Hazard and Risk Assessment Results Released by IARC and JECFA – The ASCO Post
AHA Scientific Statement | Cardiopulmonary impact of electronic cigarettes and vaping products
18 Jul, 2023 | 13:56h | UTCNews Releases:
Top Things to Know: Cardiopulmonary Impact of Electronic Cigarettes and Vaping Products – American Heart Association
Commentary: Vaping’s Risks to CV Health Not Yet Fully Known: AHA – CIDRAP