Internal Medicine
Top antimicrobial stewardship intervention publications in 2020.
17 Aug, 2021 | 08:51h | UTC
Accuracy of novel antigen rapid diagnostics for SARS-CoV-2: A living systematic review and meta-analysis.
17 Aug, 2021 | 09:02h | UTC
RCT: Once-weekly tirzepatide vs. once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes.
17 Aug, 2021 | 08:50h | UTCOnce-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, phase 3 trial – The Lancet (link to abstract – $ for full-text)
Related:
FDA authorizes additional Covid-19 vaccine dose for certain immunocompromised individuals – Other fully vaccinated individuals do not need an additional vaccine dose right now.
16 Aug, 2021 | 01:22h | UTCCommentaries:
CDC, FDA recommend COVID booster for immune-compromised – CIDRAP
FDA authorizes additional dose of Covid-19 vaccine for the immunocompromised – STAT
Covid booster: US approves third jab for the immunocompromised – BBC
CDC Panel Recommends 3rd Vaccine Dose For Immunocompromised People – NPR
6 Things To Know If You’re Immunocompromised And Considering A 3rd Shot – NPR
CDC recommends third Covid-19 vaccine dose for certain immunocompromised people – CNN
Commentary on Twitter
The Infectious Diseases Society of America (IDSA) supports the @FDA and @CDCgov's decision to authorize a supplemental vaccine dose for immunocompromised patients.
Read our statement: https://t.co/odzzSgIxnY pic.twitter.com/4PZfUwpjhM
— IDSA (@IDSAInfo) August 13, 2021
Perspective | Don’t panic, but breakthrough cases may be a bigger problem than you’ve been told.
16 Aug, 2021 | 01:17h | UTCDon’t Panic, But Breakthrough Cases May Be a Bigger Problem Than You’ve Been Told – Intelligencer
Commentary on Twitter (thread – click for more)
The vaccines are still performing quite well in preventing severe disease. But with Delta they are doing much worse in stopping transmission. Breakthroughs are probably now 10-20% of new infections, and perhaps as much as 5% of new deaths. A thread. (1/x) https://t.co/NvGends1ZP
— David Wallace-Wells (@dwallacewells) August 12, 2021
CDC Guidance: Pregnant people should be vaccinated against COVID-19.
16 Aug, 2021 | 01:19h | UTCCOVID-19 Vaccines While Pregnant or Breastfeeding – Centers for Disease Control and Prevention
Related:
Opinion | Should pregnant women have a COVID vaccine? The evidence says it’s safe and effective.
Antibody responses after a single dose of AstraZeneca Covid-19 vaccine in previously infected individuals were similar or higher compared to antibody responses in SARS-CoV-2 naïve participants who received two doses of Pfizer mRNA vaccine.
16 Aug, 2021 | 01:15h | UTCCommentary (on the preprint): Single dose of Oxford-AstraZeneca vaccine protective in previously infected recipients, suggests study – News Medical
Related: More data showing one dose of Pfizer vaccine may be enough for individuals who’ve had COVID. (studies on the subject)
Systematic review: Enteral tube feeding for people with severe dementia – “We found no evidence that tube feeding improves survival; improves quality of life; reduces pain; reduces mortality; decreases behavioural and psychological symptoms of dementia”.
16 Aug, 2021 | 00:54h | UTCEnteral tube feeding for people with severe dementia – Cochrane Library
Summary: Enteral tube feeding for people with severe dementia – Cochrane Library
Related: Viewpoint: Tube Feeding and Deteriorating Patients (resources on the subject)
Commentary on Twitter
🚨🚨So happy our @CochraneUK review on enteral tube feeding in #dementia is now published – no evidence tube feeding improves #survival; improves quality of life; reduces #pain; reduces #mortality. But was evidence of increase risk of pressure ulcers https://t.co/uUHJEboNCd
— Nathan Davies (@NathanDavies50) August 13, 2021
Guideline: Acute abdomen in the immunocompromised patient.
16 Aug, 2021 | 01:00h | UTC
Guideline: Diagnosis and management of cutaneous lupus erythematosus – Classification, diagnosis, prevention, activity scores.
16 Aug, 2021 | 00:57h | UTC
Guideline Synopsis: Management of patients with microhematuria.
16 Aug, 2021 | 00:45h | UTCManagement of Patients With Microhematuria – JAMA (free for a limited period)
Original guideline: Microhematuria: AUA/SUFU Guideline
Perspective: How the pandemic now ends.
13 Aug, 2021 | 10:03h | UTCHow the pandemic now ends – The Atlantic
Commentary on Twitter (thread – click for more)
🚨I wrote a big piece about how Delta affects the pandemic endgame.
Many folks are upset & confused by the last month. Here's an attempt to reset expectations, lay out our goals, map the near-term future, & show how the pandemic ends–which it will. 1/https://t.co/4Ukv7zs91X
— Ed Yong is not here (@edyong209) August 12, 2021
How do vaccinated people spread Delta? What the science says.
13 Aug, 2021 | 09:55h | UTCHow do vaccinated people spread Delta? What the science says – Nature
Opinion | Could this be our first effective, inexpensive, widely available outpatient treatment for COVID-19? (It’s fluvoxamine).
13 Aug, 2021 | 09:58h | UTC
Opinion: Time for a smart approach to boosters.
13 Aug, 2021 | 09:51h | UTCTime for a Smart Approach to Boosters – Think Global Health
How COVID-19 will change the management of other respiratory viral infections.
13 Aug, 2021 | 09:52h | UTC
Commentary on Twitter
Still in the midst of #SARSCoV2 #pandemic, still so much to learn… but #COVID19 experience should transform approach to research on RVIs
🦠antiviral therapy
🦠corticosteroids
🦠specific immune modulation
🦠anticoagulation
🦠respiratory support#COVIDFOAM https://t.co/WVKRSJARvl pic.twitter.com/qMkB4tkz06— Intensive Care Medicine (@yourICM) August 11, 2021
M-A: Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients.
13 Aug, 2021 | 09:01h | UTC
Commentary on Twitter
Preventing #delirium in #ICU SR/NMA
💉dexmedetomidine likely ⬇️ occurrence vs placebo & BDZs (moderate certainty)
💉sedation-minimization strategies vs BDZs may ⬇️ (uncertain)
💉DEX likely ⬇️ICU LoS vs placebo (moderate certainty) & vs antipsychotics (low)https://t.co/PWqKiyqLJz pic.twitter.com/QlANSH8icr— Intensive Care Medicine (@yourICM) August 13, 2021
Study shows clinicians significantly overestimate the benefits of treatment to individual patients.
13 Aug, 2021 | 08:58h | UTC
Commentary on Twitter
All clinicians & trainees should read this study by @dr_dmorgan et al: in this survey N=542 “Clinicians consistently overestimated the chance that treatments would benefit an individual patient.”
Not by a few %age points, but overestimations of >10-20x!https://t.co/o5SSTnztgi
— Awais Aftab (@awaisaftab) August 10, 2021
Cohort study: Long-term night shift work is associated with the risk of atrial fibrillation and coronary heart disease.
13 Aug, 2021 | 08:56h | UTC
Commentary on Twitter
Long-term night shift work is associated with the risk of atrial fibrillation and coronary heart disease.#EHJ #AF https://t.co/fd13eaDfmO pic.twitter.com/e1XmcTYcK5
— EHJ Editor-in-Chief (@ehj_ed) August 12, 2021
M-A of randomized trials: proton pump inhibitors for gastro-esophageal reflux disease does not improve outcomes in patients with asthma.
13 Aug, 2021 | 08:53h | UTC
Review: Preoperative laboratory testing in elderly patients.
13 Aug, 2021 | 08:50h | UTCPreoperative laboratory testing in elderly patients – Current Opinion in Anesthesiology
RCT: third dose of Moderna mRNA vaccine increases immunity in transplant recipients.
12 Aug, 2021 | 09:56h | UTCEditorial: Third Time’s a Charm — Covid-19 Vaccine Hope for Solid-Organ Transplant Recipients
Related:
[Preprint] 3rd AstraZeneca shot gives strong immunity.
Commentaries on Twitter
https://twitter.com/hildabast/status/1425576801850433537
The authors conclude that a third-dose booster of mRNA-1273 vaccine should be considered for transplant recipients. https://t.co/Q3gakSaNjd pic.twitter.com/CMN8f7cq29
— NEJM (@NEJM) August 11, 2021
RCT: Evaluation of Moderna mRNA vaccine in adolescents.
12 Aug, 2021 | 09:58h | UTCEvaluation of mRNA-1273 SARS-CoV-2 Vaccine in Adolescents – New England Journal of Medicine
Related:
Commentaries on Twitter
The mRNA-1273 vaccine was effective in preventing #COVID19 in 12-to-17-year-olds. Immune response was similar to young adults. https://t.co/aC3Dmjqe2T pic.twitter.com/9RxgHApW29
— NEJM (@NEJM) August 11, 2021
The @moderna_tx covid vaccine trial in 3,732 teens, placebo-controlled, published today @NEJM with both excellent safety profile and efficacy vs covid, and immune response as least as good as young adults https://t.co/PVmhjwgwsU pic.twitter.com/3uCmteaWNx
— Eric Topol (@EricTopol) August 11, 2021
Moderna may be superior to Pfizer against Delta variant — breakthrough odds rise with time.
12 Aug, 2021 | 09:54h | UTCModerna may be superior to Pfizer against delta variant — breakthrough odds rise with time – CNBC
Original Study 1 (preprint): Comparison of two highly-effective mRNA vaccines for COVID-19 during periods of Alpha and Delta variant prevalence – medRxiv
Original Study 2 (preprint): Neutralizing antibody responses to SARS-CoV-2 variants in vaccinated Ontario long-term care home residents and workers – medRxiv
Related:
[Preprint] Pfizer vs. Moderna COVID-19 vaccine effectiveness against the Delta variant in Qatar – Effectiveness against symptomatic disease due to Delta was 53.5% for Pfizer and 84.8% for Moderna; effectiveness against severe disease due to Delta was 89.7% for Pfizer and 100.0% for Moderna.
12 Aug, 2021 | 09:53h | UTCRelated:
Commentary on Twitter
New and important data on Delta breakthrough infections, large Qatar experience and follow-up of > 1.2 million vaccinees https://t.co/2ye1Kz9OPV
2-doses vaccine effectiveness vs infections
Pfizer 53.5%
Moderna 84.8%
Either 57.2%
(replicates gap of recent Mayo Clinic study) pic.twitter.com/ghWuWbYPLH— Eric Topol (@EricTopol) August 11, 2021