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Internal Medicine

CDC Report: Unvaccinated 5 times more likely to get COVID-19 and 29 times more likely to be hospitalized than vaccinated individuals.

25 Aug, 2021 | 09:56h | UTC

SARS-CoV-2 Infections and Hospitalizations Among Persons Aged ≥16 Years, by Vaccination Status — Los Angeles County, California, May 1–July 25, 2021 – CDC Morbidity and Mortality Weekly Report

Commentary: CDC: Unvaccinated 5 times more likely to get COVID-19 – CIDRAP

 

Commentary on Twitter

 

What we actually know about the vaccines and the delta variant – “Covid-19 vaccines still are effective in preventing hospitalization. But vaccinated people are more likely to get sick than before”.

25 Aug, 2021 | 09:09h | UTC

What we actually know about the vaccines and the delta variant – Vox

 

CDC Report: Vaccine effectiveness dropped from 91% to 66% since the SARS-CoV-2 Delta variant became predominant.

25 Aug, 2021 | 09:11h | UTC

Effectiveness of COVID-19 Vaccines in Preventing SARS-CoV-2 Infection Among Frontline Workers Before and During B.1.617.2 (Delta) Variant Predominance — Eight U.S. Locations, December 2020–August 2021 – CDC Morbidity and Mortality Weekly Report

Commentaries:

Vaccines are less protective against Delta infection but still reduce risk by two-thirds, US CDC study shows – CNN

Messenger RNA COVID vaccines 66% effective against Delta: US study – Associated Press

 

Perspective | Delta has changed the pandemic risk calculus – “If you’re confused about what you can do right now, you should be”.

25 Aug, 2021 | 09:05h | UTC

Delta Has Changed the Pandemic Risk Calculus – The Atlantic

 

Axillary lymphadenopathy at the time of COVID-19 vaccination: ten recommendations from the European Society of Breast Imaging.

25 Aug, 2021 | 08:59h | UTC

Axillary lymphadenopathy at the time of COVID-19 vaccination: ten recommendations from the European Society of Breast Imaging (EUSOBI) – Insights into Imaging

Related:

Covid-19: Schedule breast screening before vaccine or 4 to 6 weeks after to avoid false positives, says guidance

2 Case Series and Guidance| Lymphadenopathy in COVID-19 Vaccine Recipients

COVID-19 vaccine-linked adenopathies could mimic breast malignancies

 

Third Pfizer dose 86% effective in over 60s, Israeli HMO says.

25 Aug, 2021 | 09:01h | UTC

Third Pfizer dose 86% effective in over 60s, Israeli HMO says – Reuters

 

Commentary on Twitter

 

Perspective | That ‘damn machine’: the dark side of mechanical ventilators in the ICU.

25 Aug, 2021 | 09:04h | UTC

That ‘damn machine’: the dark side of mechanical ventilators in the ICU – STAT

 

Review: Acute and chronic hyponatremia.

25 Aug, 2021 | 08:50h | UTC

Acute and Chronic Hyponatremia – Frontiers in Medicine

Related:

Randomized trial suggests rapid intermittent bolus of hypertonic saline is the best approach for the treatment of symptomatic hyponatremia

Podcast: Hyponatremia deconstructed

Diagnosis and Management of Disorders of Body Tonicity—Hyponatremia and Hypernatremia: Core Curriculum 2020 – American Journal of Kidney Diseases

Guidelines for the Management of Exercise-Associated Hyponatremia

 

Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants.

25 Aug, 2021 | 08:56h | UTC

Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants – The Lancet

Commentary: Global and national high blood pressure burden and control – The Lancet (free registration required)

 

Commentary on Twitter

 

New USPSTF statement recommends overweight and obese individuals should undergo screening for Prediabetes and Type 2 Diabetes at age 35 instead of 40.

25 Aug, 2021 | 08:54h | UTC

Final Recommendation Statement: Screening for Prediabetes and Type 2 Diabetes – U.S. Preventive Services Task Force

Editorials:

New USPSTF Recommendations for Screening for Prediabetes and Type 2 Diabetes: An Opportunity to Create National Momentum – JAMA

Updated USPSTF Screening Recommendations for Diabetes: Identification of Abnormal Glucose Metabolism in Younger Adults – JAMA Internal Medicine

Author interview: USPSTF Recommendation: Screening for Prediabetes and Type 2 Diabetes – JAMA

Evidence report: Screening for Prediabetes and Type 2 Diabetes: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA

JAMA Patient Page: Screening for Prediabetes and Type 2 Diabetes

 

RCT: Catheter-based adrenal ablation remits primary aldosteronism.

25 Aug, 2021 | 08:52h | UTC

Catheter-Based Adrenal Ablation Remits Primary Aldosteronism: A Randomized Medication-Controlled Trial – Circulation (free for a limited period)

 

Commentary on Twitter

 

Point-counterpoint: Are routine daily physical exams in hospitalized patients a waste of time?

25 Aug, 2021 | 08:45h | UTC

Point: Routine Daily Physical Exams in Hospitalized Patients Are a Waste of Time – Journal of Hospital Medicine

Counterpoint: Routine Daily Physical Exams Add Value for the Hospitalist and Patient – Journal of Hospital Medicine

Rebuttal: Routine Daily Physical Exam – Journal of Hospital Medicine

 

Commentary on Twitter

 

RCT: No effect of Vitamin D supplementation on kidney function in adults with prediabetes.

25 Aug, 2021 | 08:41h | UTC

Effect of Vitamin D Supplementation on Kidney Function in Adults with Prediabetes: A Secondary Analysis of a Randomized Trial – Clinical Journal of the American Society of Nephrology (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Things we do for no reason: routinely holding metformin in the hospital.

25 Aug, 2021 | 08:43h | UTC

Things We Do For No Reason™: Routinely Holding Metformin in the Hospital – Journal of Hospital Medicine

 

Things we do for no reason: tumor markers CA125, CA19-9, and CEA in the initial diagnosis of malignancy.

25 Aug, 2021 | 08:42h | UTC

Things We Do for No Reason™: Tumor Markers CA125, CA19-9, and CEA in the Initial Diagnosis of Malignancy – Journal of Hospital Medicine

 

Review: Cryoballoon ablation as initial treatment for atrial fibrillation.

25 Aug, 2021 | 08:36h | UTC

Cryoballoon Ablation as Initial Treatment for Atrial Fibrillation: JACC State-of-the-Art Review – Journal of the American College of Cardiology

Related:

Subgroup analysis of RCT suggests early rhythm control therapy is beneficial for patients with atrial fibrillation and heart failure.

Meta-Analysis: Catheter Ablation Improves Outcomes in Patients with Atrial Fibrillation Complicated with Heart Failure

Catheter Ablation for Atrial Fibrillation Improves Outcomes in Heart Failure with Reduced Ejection Fraction

M-A: In patients with atrial fibrillation, catheter ablation was associated with a 38% reduction in recurrence and a 68% reduction in hospitalizations. The rate of serious complications was 4.2% with ablation vs. 2.8% in the antiarrhythmic group, a difference that was not statistically significant.

CABANATrial: Catheter Ablation vs Antiarrhythmic Drug Therapy on Mortality, Stroke, Bleeding, and Cardiac Arrest Among Patients With Atrial Fibrillation

 

Commentary on Twitter (thread – click for more)

 

Covid-19 booster vaccines: What we know and who’s doing what.

24 Aug, 2021 | 10:04h | UTC

Covid-19 booster vaccines: What we know and who’s doing what – The BMJ

 

[Preprint] RCT: Fluvoxamine reduced the risk for ER visits and hospitalization among patients with Covid-19.

24 Aug, 2021 | 10:06h | UTC

RCT: Effect of Early Treatment with Fluvoxamine on Risk of Emergency Care and Hospitalization Among Patients with COVID-19 – Together Clinical Trials

Related:

Opinion | Could this be our first effective, inexpensive, widely available outpatient treatment for COVID-19? (It’s fluvoxamine).

Preliminary study shows fluvoxamine may reduce clinical deterioration in outpatients with symptomatic COVID-19

 

Commentary on Twitter

 

Opinion | The FDA really did have to take this long – “If vaccine approval feels maddeningly scrupulous, that’s because the alternative is worse”.

24 Aug, 2021 | 10:01h | UTC

The FDA Really Did Have to Take This Long – The Atlantic

 

How I Do It: Considering lung transplantation for patients with COVID-19.

24 Aug, 2021 | 09:55h | UTC

How I Do It: Considering lung transplantation for patients with COVID-19 – CHEST

 

Related:

Early outcomes after lung transplantation for severe COVID-19: a series of the first consecutive cases from four countries

Report: Lung transplantation for 3 patients with severe COVID-19

 

COVID vaccines protect against Delta, but their effectiveness wanes.

24 Aug, 2021 | 09:57h | UTC

COVID vaccines protect against Delta, but their effectiveness wanes – Nature

Original study: [Preprint] Pfizer vaccine effectiveness against Delta declines faster than AstraZeneca, both offering the same protection after 4 months.

 

Guideline for immunizations in patients with inflammatory bowel disease.

24 Aug, 2021 | 09:00h | UTC

Canadian Association of Gastroenterology Clinical Practice Guideline for Immunizations in Patients With Inflammatory Bowel Disease (IBD)—Part 1: Live Vaccines – Gastroenterology

Canadian Association of Gastroenterology Clinical Practice Guideline for Immunizations in Patients With Inflammatory Bowel Disease (IBD)—Part 2: Inactivated Vaccine – Gastroenterology

 

European guidelines on microscopic colitis.

24 Aug, 2021 | 08:58h | UTC

European guidelines on microscopic colitis: United European Gastroenterology and European Microscopic Colitis Group statements and recommendations – UEG Journal

 

RCT: SGLT2 inhibition reduces the risk of hyperkalemia in patients with diabetes and chronic kidney disease.

24 Aug, 2021 | 08:57h | UTC

Effects of canagliflozin on serum potassium in people with diabetes and chronic kidney disease: the CREDENCE trial – European Heart Journal (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Systematic review: Pain management after complex spine surgery.

24 Aug, 2021 | 08:50h | UTC

Pain management after complex spine surgery – European Journal of Anaesthesiology

 

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