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Internal Medicine

M-A: Low vitamin D levels do not aggravate COVID-19 risk or death, and vitamin D supplementation does not improve outcomes in hospitalized patients with COVID-19.

11 Nov, 2021 | 08:53h | UTC

Low vitamin D levels do not aggravate COVID-19 risk or death, and vitamin D supplementation does not improve outcomes in hospitalized patients with COVID-19: a meta-analysis and GRADE assessment of cohort studies and RCTs – Nutritional Journal

 

Consensus Statement: Advancing the global public health agenda for non-alcoholic fatty liver disease.

11 Nov, 2021 | 08:48h | UTC

Advancing the global public health agenda for NAFLD: a consensus statement – Nature Reviews Gastroenterology & Hepatology

Related:

Clinical Care Pathway for the Risk Stratification and Management of Patients with Nonalcoholic Fatty Liver Disease.

Non-alcoholic fatty liver disease: A patient guideline.

State of the art review: Management of non-alcoholic fatty liver disease

M-A: Non-alcoholic fatty liver disease linked to increased risk of fatal and non-fatal cardiovascular events.

M-A: non-invasive tests for advanced fibrosis can reduce the need for biopsy in patients with non-alcoholic fatty liver disease.

Review: Dietary carbohydrates and fats in nonalcoholic fatty liver disease.

 

Commentary on Twitter

 

RCT: In patients with acute myocardial infarction complicated by a reduced left ventricular ejection fraction, pulmonary congestion, or both, Sacubitril–valsartan was not associated with improved outcomes compared to Ramipril.

11 Nov, 2021 | 08:44h | UTC

Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction – New England Journal of Medicine (link to abstract – $ for full-text)

 

Whole genome sequencing may improve the diagnosis of rare diseases and shorten diagnostic journeys for patients.

11 Nov, 2021 | 08:46h | UTC

News Release: Whole genome sequencing improves diagnosis of rare diseases and shortens diagnostic journeys for patients – Queen Mary University of London

Original Study: 100,000 Genomes Pilot on Rare-Disease Diagnosis in Health Care — Preliminary Report – New England Journal of Medicine

Related:

RCT: Effect of whole-genome sequencing on the clinical management of acutely ill infants with suspected genetic disease.

Review: Genome sequencing as a diagnostic test.

 

M-A: Offspring’s risk for suicidal behavior in relation to parental death by suicide – “the experience of losing a parent to suicide is a strong and independent risk factor for suicidal behavior in offspring”.

11 Nov, 2021 | 08:39h | UTC

Offspring’s risk for suicidal behaviour in relation to parental death by suicide: systematic review and meta-analysis and a model for familial transmission of suicide – The British Journal of Psychiatry

 

Commentary on Twitter

 

Systematic Review: Beta‐blockers in patients without heart failure after myocardial infarction.

11 Nov, 2021 | 08:25h | UTC

Summary: Benefits and harms of beta-blockers versus placebo or no intervention in the non-acute phase of a myocardial infarction – Cochrane Library

Original Study: Beta‐blockers in patients without heart failure after myocardial infarction – Cochrane Library

 

Systematic Review: Prevention of dementia and decline in cognition by using multi-domain interventions.

11 Nov, 2021 | 08:27h | UTC

Summary: Prevention of dementia and decline in cognition by using multi-domain interventions – Cochrane Library

Original Study: Multi‐domain interventions for the prevention of dementia and cognitive decline – Cochrane Library

 

[Preprint] RCT: In hypoxic but not critically ill patients with COVID-19, an intervention to increase prone positioning did not improve outcomes.

10 Nov, 2021 | 07:20h | UTC

RCT: Prone positioning of patients with moderate hypoxia due to COVID-19 – medRxiv

Related:

RCT: Awake prone positioning reduces the need for intubation in patients with COVID-19.

RCT: Awake prone positioning in patients with hypoxemic respiratory failure due to COVID-19 – no difference in intubation rates compared to standard care.

M-A: Prone positioning of nonintubated patients with Covid-19 improve oxygenation variables without any reported serious adverse events – randomized trials with patient-relevant outcomes such as the need for intubation or mortality rates are required

 

Commentary from the author on Twitter (thread – click for more)

 

Opinion | Protective immunity after recovery from SARS-CoV-2 infection.

10 Nov, 2021 | 07:15h | UTC

Protective immunity after recovery from SARS-CoV-2 infection – The Lancet Infectious Diseases

 

Commentary on Twitter

 

RCT: One-time flexible sigmoidoscopy screening is associated with long-term reduction in colorectal cancer incidence and mortality.

10 Nov, 2021 | 07:04h | UTC

Long-Term Follow-up of the Italian Flexible Sigmoidoscopy Screening Trial – Annals of Internal Medicine

Commentaries:

Flexible sigmoidoscopy associated with long-term reduction in colorectal cancer incidence, mortality – ACP Internist

Flexible sigmoidoscopy screening associated with long-term reduction in colorectal cancer incidence and mortality – American College of Physicians

 

Review: Cardiogenic shock after acute myocardial infarction.

10 Nov, 2021 | 07:03h | UTC

Cardiogenic Shock After Acute Myocardial Infarction: A Review – JAMA (free for a limited period)

 

Review: Uremic Encephalopathy.

10 Nov, 2021 | 06:49h | UTC

Uremic Encephalopathy – Kidney International

 

Practice Review: COVID-19 rapid diagnostics.

9 Nov, 2021 | 01:52h | UTC

COVID-19 rapid diagnostics: practice review – Emergency Medicine Journal

 

Provocative study suggests that persistent physical symptoms after COVID-19 infection may be associated more with the belief in having been infected with SARS-CoV-2 than with having laboratory-confirmed COVID-19 infection.

9 Nov, 2021 | 01:46h | UTC

Association of Self-reported COVID-19 Infection and SARS-CoV-2 Serology Test Results With Persistent Physical Symptoms Among French Adults During the COVID-19 Pandemic – JAMA Internal Medicine

Author Interview: Association of Self-reported COVID-19 Infection and SARS-CoV-2 Serology Results With Persistent Physical Symptoms – JAMA Internal Medicine

Commentaries: Expert reaction to study looking at the association of self-reported COVID-19 infection and SARS-CoV-2 serology test results with persistent physical symptoms – Science Media Centre

Related:

Update to post-acute sequelae of SARS-CoV-2 infection: Caring for the ‘long-haulers’.

Systematic Review: Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection.

WHO Consensus: A clinical case definition of post COVID-19 condition (Long Covid).

Characterizing long COVID: a living systematic review.

Long Covid – The illness narratives.

New guidelines to help doctors manage long COVID patients published.

M-A: More than 50 long-term effects of COVID-19. (several articles on the subject)

 

Commentary on Twitter

 

Review: Antineutrophil cytoplasmic antibody-associated interstitial lung disease.

10 Nov, 2021 | 06:46h | UTC

Antineutrophil cytoplasmic antibody-associated interstitial lung disease: a review – European Respiratory Review

 

Systematic Review: Exercise‐based cardiac rehabilitation for coronary heart disease.

9 Nov, 2021 | 01:21h | UTC

Summary: Exercise-based rehabilitation for coronary heart disease – Cochrane Library

Original Study: Exercise‐based cardiac rehabilitation for coronary heart disease – Cochrane Library

 

Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain.

9 Nov, 2021 | 01:17h | UTC

Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain – Agency for Healthcare Research and Quality

See also:

Evidence Summary

Final Report

Related:

The International Cannabis Toolkit (iCannToolkit): a multidisciplinary expert consensus on minimum standards for measuring cannabis use.

Cannabis products are being sold as sleep remedies – here’s the evidence about their effectiveness.

Guideline: Medical cannabis or cannabinoids for chronic pain.

Cannabis and Cannabinoid Analgesia position statement – “Due to the lack of high-quality clinical evidence, the IASP does not currently endorse general use of cannabis and cannabinoids for pain relief.”

NICE Guideline: Cannabis-Based Medicinal Products

Consensus recommendations for perioperative management of cannabis and cannabinoid-based medicine users

Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain – Agency for Healthcare Research and Quality

Short Review: Drug Interactions with Cannabinoids

Meta-Analysis: Cannabinoids Not Effective for Cancer-Related Pain

 

Systematic Review | Management of High-Need, High-Cost Patients.

9 Nov, 2021 | 01:20h | UTC

Management of High-Need, High-Cost Patients: A “Best Fit” Framework Synthesis, Realist Review, and Systematic Review – Agency for Healthcare Research and Quality

See also:

Evidence Summary

Final Report

Related:

Designing a High-Performing Health Care System for Patients with Complex Needs: Ten Recommendations for Policymakers – The Commonwealth fund

Effective Care for High-Need Patients: Opportunities for Improving Outcomes, Value, and Health – National Academy of Medicine

Systematic review of high-cost patients’ characteristics and healthcare utilization – BMJ Open

Effectiveness of interventions for managing multiple high-burden chronic diseases in older adults: a systematic review and meta-analysis – Canadian Medical Association Journal

Multimorbidity: a priority for global health research – The Academy of Medical Sciences

The global burden of multiple chronic conditions: A narrative review – Preventive Medicine Reports

Redesigning Care for High-Cost, High-Risk Patients – Harvard Business Review

Multimorbidity: clinical assessment and management – NICE Guideline

Multimorbidity in Older Adults with Cardiovascular Disease – American College of Cardiology, Latest in Cardiology

Richard Smith: The challenge of high need, high cost patients – The BMJ Blogs

Better Care for People with Complex Needs – Institute for Healthcare Improvement

 

Choosing Wisely for Thyroid Conditions: Ten things clinicians and patients should question – “Do not order thyroid ultrasound for nodule detection in patients without thyroid anatomic anomalies on clinical examination”.

9 Nov, 2021 | 01:11h | UTC

Choosing Wisely for Thyroid Conditions: Recommendations of the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism

See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada

 

[Press release – not published yet] RCT: Pfizer’s novel Covid-19 oral antiviral treatment candidate reduced risk of hospitalization or death by 89% in interim analysis of phase 2/3 EPIC-HR study.

7 Nov, 2021 | 20:35h | UTC

Pfizer’s novel Covid-19 oral antiviral treatment candidate reduced risk of hospitalization or death by 89% in interim analysis of phase 2/3 EPIC-HR Study

Commentaries:

Expert reaction to press release from Pfizer giving interim analysis of their Phase 2/3 EPIC-HR study of PAXLOVID™ in non-hospitalized high-risk adults with COVID-19 – Science Media Centre

Pfizer’s Good News Is the World’s Good News – Science

Experimental Pfizer pill prevents Covid hospitalizations and deaths – STAT

Pfizer Says New Anti-Viral Drug Combination Cuts Risks Of Serious COVID-19 By 89% – Health Policy Watch

Pfizer reports good results against severe COVID-19 for its antiviral pill – CIDRAP

Covid: Pfizer says antiviral pill 89% effective in high-risk cases – BBC

Pfizer says COVID-19 pill cut hospital, death risk by 90% – Associated Press

Pfizer’s COVID-19 pill treatment reduces risk of being hospitalized or dying by 89%, company says – ABC News

 

Commentary on Twitter (thread – click for more)

 

Myocarditis Following COVID-19 mRNA Vaccine: A Case Series and Incidence Rate Determination.

7 Nov, 2021 | 20:29h | UTC

Myocarditis Following COVID-19 mRNA Vaccine: A Case Series and Incidence Rate Determination – Clinical Infectious Diseases

Related:

Heart-inflammation risk from Pfizer COVID vaccine is very low.

Large cohort study with over 2.5 million individuals showed the incidence of myocarditis after the Pfizer vaccine was 2.13 cases per 100,000 persons.

Study with over 5.1 million vaccinated individuals showed the incidence of myocarditis after the receipt of the Pfizer vaccine was low and more common after the second dose in young male recipients.

Large Observational study shows Pfizer Covid vaccine is mostly safe but is associated with increased risk of myocarditis, adenopathy, appendicitis, and herpes zoster.

 

COVID-19 vaccination in pregnancy, pediatrics, immunocompromised patients, and persons with history of allergy or prior SARS-CoV-2 infection: overview of current recommendations and pre- and post-marketing evidence for vaccine efficacy and safety.

7 Nov, 2021 | 20:27h | UTC

COVID-19 Vaccination in Pregnancy, Paediatrics, Immunocompromised Patients, and Persons with History of Allergy or Prior SARS-CoV-2 Infection: Overview of Current Recommendations and Pre- and Post-Marketing Evidence for Vaccine Efficacy and Safety – Drug Safety

 

RCT: In patients with chronic kidney diseases and anemia undergoing dialysis, Daprodustat (oral drug) was noninferior to darbepoetin alfa to increase hemoglobin levels and regarding cardiovascular outcomes.

7 Nov, 2021 | 20:18h | UTC

Daprodustat for the Treatment of Anemia in Patients Undergoing Dialysis – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Oral pill as safe, efficacious as conventional treatment for anemia in patients with kidney disease – Brigham and Women’s Hospital

 

Commentary on Twitter

 

RCT: In patients with chronic kidney diseases and anemia not undergoing dialysis, Daprodustat (oral drug) was noninferior to darbepoetin alfa in increasing hemoglobin levels and regarding cardiovascular outcomes.

7 Nov, 2021 | 20:17h | UTC

Daprodustat for the Treatment of Anemia in Patients Not Undergoing Dialysis – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Oral pill as safe, efficacious as conventional treatment for anemia in patients with kidney disease – Brigham and Women’s Hospital

 

Commentary on Twitter

 

RCT: In patients with advanced chronic kidney disease and poorly controlled hypertension, Chlortalidone had a significant impact in blood-pressure control (−11.0 mm Hg vs. −0.5 mm Hg in the placebo group).

7 Nov, 2021 | 20:20h | UTC

Chlorthalidone for Hypertension in Advanced Chronic Kidney Disease – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Cheap Diuretic, Chlorthalidone, Drops BP in Advanced Kidney Disease – Medscape (free registration required)

 

Commentary on Twitter

 

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