Vaccines
Vaccines given in last 20 years could prevent 50 million deaths in LMICs.
12 Aug, 2021 | 08:43h | UTCVaccines given in last 20 years could prevent 50 million deaths in LMICs – Imperial College London
Original study: Lives saved with vaccination for 10 pathogens across 112 countries in a pre-COVID-19 world – eLife
CDC Report: COVID-19 morbidity and mortality far exceed the potential risks of rare side effects caused by vaccines.
11 Aug, 2021 | 08:45h | UTC
Review: Clinical characteristics and pharmacological management of COVID-19 vaccine–induced immune thrombotic thrombocytopenia with cerebral venous sinus thrombosis.
11 Aug, 2021 | 08:44h | UTCRelated:
NICE COVID-19 rapid guideline: vaccine-induced immune thrombocytopenia and thrombosis.
Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know.
Very rare cases of thrombosis with thrombocytopenia syndrome (TTS) after AstraZeneca vaccine: a global safety database analysis – the estimated rate of TTS after the first dose was 8.1 per million vaccinees; after the second dose, the estimated rate was 2.3 per million vaccinees. (several articles and resources on the subject)
Commentary on Twitter
https://twitter.com/JohnGRizk/status/1425126093288353800
Cluster RCT: Vaccination of children against typhoid fever with a Vi-tetanus toxoid conjugate vaccine in urban Bangladesh conferred 85% total protection.
11 Aug, 2021 | 08:28h | UTCInvited commentary: Salmonella Typhi Vi polysaccharide conjugate vaccine protects infants and children against typhoid fever – The Lancet
[Preprint] Phase 1/2 RCT: A booster dose is immunogenic and will be needed for older adults who have completed two doses vaccination with CoronaVac.
10 Aug, 2021 | 09:58h | UTC
Commentary on Twitter
https://twitter.com/hildabast/status/1424644994120372224
A WHO expert explains why she believes the rush for Covid-19 boosters is premature.
10 Aug, 2021 | 09:56h | UTCA WHO expert explains why she believes the rush for Covid-19 boosters is premature – STAT
Commentary on Twitter
Must read interview on rich nations rushing into booster doses
Dr @Kate_L_OBrien by @HelenBranswell @statnews
"We really have huge inequity right now in just getting primary doses to people. Does a third dose need to be given?"https://t.co/pRhYwINuKf pic.twitter.com/YQS6Nj0Hyi
— Madhu Pai, MD, PhD (@paimadhu) August 9, 2021
Covid-19: How effective are vaccines against the delta variant?
10 Aug, 2021 | 10:00h | UTCCovid-19: How effective are vaccines against the delta variant? – The BMJ
Study ties COVID vaccines to lower transmission rates.
10 Aug, 2021 | 09:51h | UTCStudy ties COVID vaccines to lower transmission rates – CIDRAP
Interactive infographic: Data shows how rare severe breakthrough Covid infections are.
9 Aug, 2021 | 00:01h | UTCData shows how rare severe breakthrough Covid infections are – NBC News
Commentary on Twitter
Very good interactive infographic for impact of vaccination in 2021 by state https://t.co/HAfYYPX9FI by @NBCNews @seenigel @ChicagoEl @pdrbarquinha @jiachuanwu @NBCNewsGraphics
Here for California: Hospitalizations, deaths and infections pic.twitter.com/83Hxl2x2gm— Eric Topol (@EricTopol) August 7, 2021
RCT: Safety and immunogenicity of heterologous vs. homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine.
9 Aug, 2021 | 00:06h | UTCInvited commentary: Optimising SARS-CoV-2 vaccination schedules – The Lancet
Related: Another study shows increased immune response with heterologous Oxford-AstraZeneca/mRNA vaccination (several articles on the subject)
Commentary on Twitter
Just published @TheLancet
A randomized mix and match trial of AZ and Pfizer vaccination in >800 people shows that mixing is safe and can engender at least as good, if not better, immune response https://t.co/V40Dy59Ia8 by @XinxueLiu and colleagues pic.twitter.com/tKl59LFz4i— Eric Topol (@EricTopol) August 6, 2021
COVID: WHO calls for moratorium on booster shots – is it justifiable?
8 Aug, 2021 | 23:54h | UTCCOVID: WHO calls for moratorium on booster shots – is it justifiable? – The Conversation
Related: Covid: WHO calls for booster pause to vaccinate poorer nations.
Commentary on Twitter
The authors put it well: Even if affluent countries prioritize boosters for the vulnerable, 'the degree of additional benefit…is uncertain.' Yet we know 'vaccines could do a huge amount of good for the large number of vulnerable ppl who've not yet received a single dose.' https://t.co/6qNV6pzDDk
— Tedros Adhanom Ghebreyesus (@DrTedros) August 7, 2021
CDC study showed a reduced risk of reinfection with SARS-CoV-2 after covid-19 vaccination.
9 Aug, 2021 | 00:03h | UTC
Commentaries on Twitter
This is non randomized. The two biases are:
1. Behavior among those who got vaccinated likely different than those who don't
2. Likely those who didn't tested more aggressively
I would not cite this as many are doinghttps://t.co/rSkBC37uq0
— Vinay Prasad MD MPH (@VPrasadMDMPH) August 7, 2021
Study shows that full #COVIDVaccination ⬇️ likelihood of being re-infected with #COVID19 compared to those who were previously had COVID but were not vaccinated (risk ⬆️ 2.3 fold)#GetVaccinated even if you have had COVID previouslyhttps://t.co/3dF3XPxwYp
@fascinatorfun pic.twitter.com/ip6zTvNN86
— Prof Kamlesh Khunti (@kamleshkhunti) August 7, 2021
Covid: WHO calls for booster pause to vaccinate poorer nations.
5 Aug, 2021 | 08:59h | UTCCovid: WHO calls for booster pause to vaccinate poorer nations – BBC
See also:
Why WHO Is Calling For A Moratorium On COVID Vaccine Boosters – NPR
WHO calls for moratorium on COVID-19 boosters – CIDRAP
WHO asks wealthy nations to hold off on Covid vaccine boosters at least through September – CNBC
WHO calls for a temporary moratorium on administering booster shots of Covid-19 vaccines – STAT
Commentary on Twitter (thread – click for more)
NEW—The World Health Organization called for a moratorium on coronavirus booster vaccinations until the end of September, so that vaccine supplies can be focused on helping less wealthy countries to vaccinate at least ten percent of their populations,https://t.co/fwBl28fjWn
— Eric Feigl-Ding (@DrEricDing) August 4, 2021
Myocarditis and pericarditis after vaccination for COVID-19.
5 Aug, 2021 | 08:57h | UTCMyocarditis and Pericarditis After Vaccination for COVID-19 – JAMA
Related:
Analysis finds benefits of COVID-19 vaccination outweigh risks of rare cases of myocarditis.
Case Series: Myocarditis following immunization with mRNA COVID-19 vaccines.
RCT: Text-message reminders can increase COVID-19 vaccinations.
4 Aug, 2021 | 09:12h | UTCBehavioral Nudges Increase COVID-19 Vaccinations – Nature
Commentaries:
Text-message ‘nudges’ can encourage holdouts to get COVID vaccination, study finds – UCLA
Text reminders boost vaccine appointments – Carnegie Mellon University
Commentary on Twitter
Sometimes the tools that actually work in public health are profoundly boring. Here, a text message reminder system is shown in a randomized trial to increase vaccine uptake. Years of HIV adherence research has shown the value of simple nudges like this.https://t.co/1ndpnQ6Ha6 https://t.co/Gltll8DTJ4
— Natalie E. Dean, PhD (@nataliexdean) August 3, 2021
Opinion | Should pregnant women have a COVID vaccine? The evidence says it’s safe and effective.
2 Aug, 2021 | 00:28h | UTC
ACOG and SMFM Recommend COVID-19 Vaccination for Pregnant Individuals – “ACOG encourages its members to enthusiastically recommend vaccination to their patients.”
2 Aug, 2021 | 00:31h | UTCAdditional reading:
Practice Advisory: COVID-19 Vaccination Considerations for Obstetric-Gynecologic Care
COVID-19 Vaccines and Pregnancy: Conversation Guide for Clinicians
Commentaries:
Obstetrician groups recommend COVID vaccine during pregnancy – Associated Press
Statements By Obstetrics Societies Strongly Advise Covid-19 Vaccinations For Pregnant Women – Forbes
Commentary on Twitter
Pregnant? ACOG and @MySMFM now recommend #COVID19 vaccination of pregnant individuals and urge our members to recommend that pregnant patients #GetVaccinated. The #covidvaccine is the best tool we have to save lives and end the pandemic: https://t.co/pUbLqqkKym #VaccinesWork pic.twitter.com/Ef2MOPv27L
— ACOG (@acog) July 30, 2021
COVID boosters for wealthy nations spark outrage.
2 Aug, 2021 | 00:21h | UTCCOVID boosters for wealthy nations spark outrage – Nature
Scientists Grapple with Question of COVID-19 Vaccine Booster, as Some Countries Push Ahead.
2 Aug, 2021 | 00:19h | UTC
NICE COVID-19 rapid guideline: vaccine-induced immune thrombocytopenia and thrombosis.
30 Jul, 2021 | 12:14h | UTCNews release: NICE publishes new rapid guideline to diagnose and treat rare blood clotting condition associated with COVID-19 vaccination – National Institute for Health and Care Excellence
Related: Very rare cases of thrombosis with thrombocytopenia syndrome (TTS) after AstraZeneca vaccine: a global safety database analysis – the estimated rate of TTS after the first dose was 8.1 per million vaccinees; after the second dose, the estimated rate was 2.3 per million vaccinees. (several articles and resources on the subject)
Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know.
30 Jul, 2021 | 12:12h | UTCVaccine-induced immune thrombotic thrombocytopenia: what we know and do not know – Blood
Related: Very rare cases of thrombosis with thrombocytopenia syndrome (TTS) after AstraZeneca vaccine: a global safety database analysis – the estimated rate of TTS after the first dose was 8.1 per million vaccinees; after the second dose, the estimated rate was 2.3 per million vaccinees. (several articles and resources on the subject)
Israel to offer 3rd COVID booster shot to older citizens.
30 Jul, 2021 | 11:57h | UTCIsrael to offer 3rd COVID booster shot to older citizens – Associated Press
Updated WHO SAGE roadmap for prioritizing uses of COVID-19 vaccines in the context of limited supply.
29 Jul, 2021 | 11:34h | UTC
COVID vaccines slash viral spread, but Delta is an unknown – “Studies show that vaccines reduce the spread of SARS-CoV-2 by more than 80%, but the Delta variant is creating fresh uncertainty”.
29 Jul, 2021 | 11:21h | UTCCOVID vaccines slash viral spread – but Delta is an unknown – Nature
What is a breakthrough infection? 6 questions answered about catching COVID-19 after vaccination.
29 Jul, 2021 | 11:28h | UTC