Vaccines
Vaccines Will Not Produce Worse Variants.
14 Sep, 2021 | 09:53h | UTCVaccines Will Not Produce Worse Variants – Science
Four factors that increase the risk of vaccinated people getting COVID.
12 Sep, 2021 | 22:02h | UTCFour factors that increase the risk of vaccinated people getting COVID – The Conversation
What’s the evidence for COVID-19 booster shots?
12 Sep, 2021 | 22:05h | UTCWhat’s the evidence for COVID-19 booster shots? – Canadian Medical Association Journal
Perspective | We’re Asking the Impossible of Vaccines – “Complete protection against infection has long been hailed as the holy grail of vaccination. It might simply be unachievable”.
12 Sep, 2021 | 21:59h | UTCWe’re Asking the Impossible of Vaccines – The Atlantic
Commentary on Twitter
A really great read from @KatherineJWu on why it may be too much to expect vaccines—#covid19 or otherwise—to prevent infection. Still the vaccines are great at what we need—preventing hospitalizations and deaths! https://t.co/ufVBVn4wd1
— Jennifer Nuzzo, DrPH (@JenniferNuzzo) September 11, 2021
Risk of severe breakthrough Covid-19 higher for seniors and people with underlying conditions.
12 Sep, 2021 | 22:03h | UTCRisk of severe breakthrough Covid-19 higher for seniors and people with underlying conditions – CNN
Original study: Hospitalisation among vaccine breakthrough COVID-19 infections – The Lancet Infectious Diseases
News release: Study examines severe breakthrough cases of COVID-19 – YaleNews
Commentary on Twitter
New Comment: Hospitalisation among vaccine breakthrough #COVID19 infections https://t.co/1MtOoO8HVV, by Prerak V Juthani, @hyungjchun, and colleagues pic.twitter.com/mYAAEzHLDL
— The Lancet Infectious Diseases (@TheLancetInfDis) September 8, 2021
India’s DNA COVID vaccine is a world first – more are coming.
10 Sep, 2021 | 05:30h | UTCIndia’s DNA COVID vaccine is a world first – more are coming – Nature
Two observational studies suggest spontaneous abortion is not increased following COVID-19 mRNA vaccination during pregnancy.
9 Sep, 2021 | 10:04h | UTCStudy 1: Spontaneous Abortion Following COVID-19 Vaccination During Pregnancy – JAMA
Study 2: Receipt of mRNA Covid-19 Vaccines and Risk of Spontaneous Abortion – New England Journal of Medicine
Commentary on Twitter
? NO LINK BETWEEN MISCARRIAGE & COVID VACCINATION
This @JAMA_current study examined 105446 pregnancies, including 13160 miscarriages
Women with pregnancies ending in miscarriage were NOT more likely to have had ? in prior 28 days than those that didnthttps://t.co/7cFELq1oPM
— Ilan Schwartz MD PhD (@GermHunterMD) September 8, 2021
[Preprint] RCT: Additional heterologous vs. homologous booster vaccination in immunosuppressed patients without SARS-CoV-2 antibody seroconversion after primary mRNA vaccination.
9 Sep, 2021 | 09:55h | UTC
Commentary on Twitter (thread – click for more)
Results of 60-person randomized trial of 3rd shot of mRNA or AZ vax in people on rituximab who didn't seroconvert after BNT-Pfizer (most) or Moderna vax. Found dose 3 reduced those with no humoral or cellular response from 31% to 6% …1/2 https://t.co/HIjeDaFy7w Preprint #IC
— Hilda Bastian, PhD (@hildabast) September 8, 2021
AstraZeneca bosses warn against rush for boosters – “giving the most vulnerable, who may not have built up a full immune response from the first two, a third, top-up dose is “sensible”. But any decision to give a third, booster jab “to large swathes of the population”, to extend their protection from the first two, must be based on clinical data”.
9 Sep, 2021 | 09:59h | UTCAstraZeneca bosses warn against rush for boosters – BBC
Commentary on Twitter (thread – click for more)
"Moving too quickly to boost across the entire adult population will deprive us of these insights, leaving this important decision to rest on limited data," Mr Soriot and Sir Mene write.https://t.co/xTAk7yyu5G
— The Sharing Scientist (@ScienceShared) September 8, 2021
WHO appeals for countries to postpone COVID-19 vaccine boosters until 2022 to prioritize vaccinating the most at-risk people around the world who are yet to receive their first dose.
9 Sep, 2021 | 10:00h | UTCSee also:
WHO chief urges halt to booster shots for rest of the year – Associated Press
WHO extends moratorium on booster COVID vaccine doses – CIDRAP
Balancing incentives and disincentives for vaccination in a pandemic.
9 Sep, 2021 | 09:52h | UTCBalancing incentives and disincentives for vaccination in a pandemic – Nature Medicine
Chile authorizes Sinovac vaccine for kids of 6 and older.
7 Sep, 2021 | 21:45h | UTCChile authorizes Sinovac vaccine for kids of 6 and older – Associated Press
Study shows high effectiveness of the Pfizer mRNA COVID-19 vaccine in pregnancy.
7 Sep, 2021 | 21:48h | UTCEffectiveness of the BNT162b2 mRNA COVID-19 vaccine in pregnancy – Nature Medicine
Commentaries on Twitter
NEW: Estimated vaccine effectiveness in #pregnancy from 7 through to 56 d after second dose was 96% (95% CI; 89–100%) for any documented infection, 97% (91–100%) for infections with documented symptoms & 89% (43–100%) for #COVID19-related hospitalization. https://t.co/bm950wUWGL
— All Source Pregnancy (@PregnancyAll) September 7, 2021
The Pfizer-BioNTech mRNA COVID-19 vaccine was estimated to have high vaccine effectiveness in pregnant women, which is similar to the effectiveness estimated in the general population, according to a @NatureMedicine paper. https://t.co/oz5zn7zNdq pic.twitter.com/9IP5ocxzXs
— Nature Portfolio (@NaturePortfolio) September 7, 2021
AAP flu recommendations allow for coadministration with COVID-19 vaccine.
7 Sep, 2021 | 21:44h | UTCNews release: AAP flu recommendations allow for coadministration with COVID-19 vaccine – American Academy of Pediatrics
Technical report: Recommendations for Prevention and Control of Influenza in Children, 2021–2022 – American Academy of Pediatrics
Commentary on Twitter
The 2021-’22 @AmerAcadPeds flu policy emphasizes the importance of flu vaccination during the SARS-CoV-2 pandemic, allows for coadministration with COVID-19 vaccine. https://t.co/usLaO276Ku pic.twitter.com/EaL5vocxMm
— AAP News (@AAPNews) September 7, 2021
Extended intervals and extra doses of the AstraZeneca vaccine are associated with increased immunogenicity.
7 Sep, 2021 | 10:56h | UTCInvited commentary: Longer intervals and extra doses of ChAdOx1 nCoV-19 vaccine
Commentaries on Twitter
(thread – click for more)
Substudy suggests extended interval (up to 45 wks) before 2nd dose of ChAdOx1 nCoV-19 leads to increased antibody titres, offering more flexibility in vaccine schedules.
Extended interval before 3rd dose resulted in further increase in immune responses. https://t.co/J3xOwSSYMN pic.twitter.com/8GotDI4ctS
— The Lancet (@TheLancet) September 2, 2021
(thread – click for more)
New @TheLancet
The heightened immune response to longer spacing @AstraZeneca 1st -> 2nd vaccine doses and the response 3rd booster dose, with high neutralizing antibodies and T cellshttps://t.co/A2UcPVIFYP pic.twitter.com/zfYaW0T8Yf— Eric Topol (@EricTopol) September 1, 2021
[Preprint] Large cohort study in Brazil showed AstraZeneca vaccine had high overall effectiveness against severe disease to individuals up to 89 years of age. In comparison, CoronaVac had high overall effectiveness against severe disease in individuals up to 79 years.
7 Sep, 2021 | 10:54h | UTC
Case series: COVID-19 mRNA vaccination leading to CNS inflammation.
7 Sep, 2021 | 10:49h | UTCCOVID-19 mRNA vaccination leading to CNS inflammation: a case series – Journal of Neurology
CDC report: Hospitalization rates for Covid-19 were 10 times higher among unvaccinated than among fully vaccinated adolescents.
7 Sep, 2021 | 10:52h | UTCCommentaries:
More kids hospitalized with Covid-19 in states with lower vaccination rates, CDC report finds – CNN
Child COVID hospital cases up in low-vaccination states – CIDRAP
Commentary on Twitter
From late June to mid-August, there was a 10x increase in the rate of hospitalizations among children ages 0-4 with #COVID19 while the #DeltaVariant was widely circulating. It is critical for children to #maskup and get vaccinated if eligible. Learn more: https://t.co/aHC1vYdKVG. pic.twitter.com/uUeNPG6d5r
— CDC (@CDCgov) September 3, 2021
Large surveillance study finds severe adverse events after COVID-19 mRNA vaccination are rare.
6 Sep, 2021 | 11:02h | UTCSurveillance for Adverse Events After COVID-19 mRNA Vaccination – JAMA
Editorial: Safety Surveillance of COVID-19 mRNA Vaccines Through the Vaccine Safety Datalink – JAMA
Commentaries:
mRNA COVID vaccines not tied to serious side effects – CIDRAP
Researchers find no serious health effects linked to mRNA COVID-19 vaccines – News Medical
Commentary on Twitter
Concerned about the safety of mRNA vaccines? This study of 6.2 million people who got 11.8 million doses is immensely reassuring. https://t.co/nUIqTacl0g pic.twitter.com/JBvenRVrRc
— David Juurlink (@DavidJuurlink) September 4, 2021
Double vaccination halves risk of Long COVID.
3 Sep, 2021 | 10:29h | UTCNews release: Double vaccination halves risk of Long COVID – King’s College London
Commentaries:
Largest study of its kind finds face masks reduce COVID-19 – University of California – Berkeley
Study: Vaccines slash long-haul COVID, hospital rates – CIDRAP
Vaccination reduces risk of long Covid, even when people are infected, U.K. study indicates – STAT
Being fully vaccinated reduces odds of long-term Covid-19 symptoms by half, UK study suggests – CNN
Coronavirus vaccines cut risk of long Covid, study finds – BBC
Related: M-A: More than 50 long-term effects of COVID-19.
Commentary on Twitter
NEW evidence on breakthrough infections indicates people who tested positive for #SARS-CoV-2 after 1 or 2 vaccine doses had significantly lower odds of severe disease, hospitalisation, or #LongCOVID than unvaccinated. https://t.co/MgHt7Ztqa0 @TheLancetInfDis pic.twitter.com/nt2b7jVrH9
— The Lancet (@TheLancet) September 1, 2021
EU agency says to focus on vaccines first not booster shots.
3 Sep, 2021 | 10:34h | UTCEU agency says to focus on vaccines first not booster shots – Associated Press
See also: European officials say COVID-19 booster isn’t urgent – CIDRAP
Another study shows Pfizer mRNA vaccine immunity is reduced over time.
2 Sep, 2021 | 10:05h | UTCWaning of BNT162b2 vaccine protection against SARS-CoV-2 infection in Qatar – medRxiv
Related:
Studies: COVID vaccine protection waning against infection but not hospitalization.
Pfizer says it’s time for a Covid booster; FDA and CDC say not so fast.
Commentary on Twitter (thread – click for more)
The evidence of mRNA vaccine effectiveness (VE) waning grows: large Qatar experience shows substantial 5 month attrition for symptomatic infection VE below 50% and, to a lesser extent, vs hospitalization and deathhttps://t.co/4lIG68Bxm0 pic.twitter.com/rnyo0Si3RP
— Eric Topol (@EricTopol) August 27, 2021
[Preprint] Pfizer vaccine booster dose protection: A nationwide study from Israel – “Twelve days or more after the booster dose we found an 11.4-fold decrease in the relative risk of confirmed infection, and a >10-fold decrease in the relative risk of severe illness”.
1 Sep, 2021 | 09:59h | UTCBNT162b2 vaccine booster dose protection: A nationwide study from Israel – medRxiv
Perspective | COVID-19 boosters in rich nations will delay vaccines for all.
1 Sep, 2021 | 09:56h | UTCCOVID-19 boosters in rich nations will delay vaccines for all – Nature
Commentaries on Twitter
In @NatureMedicine, @zchagla & I ask:
Are we as a species willing to protect all humankind, or do we mostly care about optimizing protection for people in wealthy nations?https://t.co/LCS5Dxf1II pic.twitter.com/vdn4oRiYyz
— Madhu Pai, MD, PhD (@paimadhu) August 31, 2021
"There remain 3.5 billion people on this earth, nearly half of the world’s population, who have not received even a first dose of vaccine. Only 2% of the African population has received even a single dose." #Equity #COVID19 Via @NatureMedicine https://t.co/k6cG6vyQ5d pic.twitter.com/DsbWVvQ9R7
— Muin J. Khoury (@MuinJKhoury) August 31, 2021
Prioritising COVID booster shots in high income countries is unethical – until health care workers and those at high risk in low and middle income countries have been vaccinated. @paimadhu and @zchagla wrote this much better than I could – thank you! https://t.co/F89o8y9V8P
— Ben Johnson ?? (@drbenjohnson) August 31, 2021
Why is a third COVID-19 vaccine dose important for people who are immunocompromised?
1 Sep, 2021 | 09:57h | UTCRelated:
RCT: third dose of Moderna mRNA vaccine increases immunity in transplant recipients.