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Vaccines

The tangled history of mRNA vaccines.

15 Sep, 2021 | 09:06h | UTC

The tangled history of mRNA vaccines – Nature

Related:

mRNA vaccines for infectious diseases: principles, delivery and clinical translation.

After COVID-19 successes, researchers push to develop mRNA vaccines for other infectious diseases and cancer.

 

Commentary on Twitter

 

Report: Fully vaccinated people account for 1.2% of England’s Covid-19 deaths.

14 Sep, 2021 | 10:07h | UTC

Fully vaccinated people account for 1.2% of England’s Covid-19 deaths – The Guardian

Original Report: Deaths involving COVID-19 by vaccination status, England: deaths occurring between 2 January and 2 July 2021 – Office for National Statistics

 

COVID-19 vaccine efficacy does not support boosters for general population, review concludes.

14 Sep, 2021 | 10:08h | UTC

News release: COVID-19 vaccine efficacy does not support boosters for general population, review concludes – The Lancet

Original article: Considerations in boosting COVID-19 vaccine immune responses – The Lancet

Commentaries:

FDA experts among group opposing US booster shot plan – Associated Press

FDA vaccine regulators argue against Covid-19 vaccine boosters in new international review – STAT

Global experts pan wider use of COVID vaccine booster dose – CIDRAP

Expert reaction to viewpoint article on COVID-19 booster vaccines for general populations – Science Media Centre

Boosters Are ‘Not Appropriate’ – Reach Unvaccinated First – Health Policy Watch

Data Doesn’t Support Need for COVID-19 Vaccine Boosters: Experts – HealthDay

In a new review, some F.D.A. scientists and others say boosters aren’t needed for the general population. – The New York Times

 

Vaccines Will Not Produce Worse Variants.

14 Sep, 2021 | 09:53h | UTC

Vaccines Will Not Produce Worse Variants – Science

 

Four factors that increase the risk of vaccinated people getting COVID.

12 Sep, 2021 | 22:02h | UTC

Four factors that increase the risk of vaccinated people getting COVID – The Conversation

Original study: Risk factors and disease profile of post-vaccination SARS-CoV-2 infection in UK users of the COVID Symptom Study app: a prospective, community-based, nested, case-control study – The Lancet Infectious Diseases

 

What’s the evidence for COVID-19 booster shots?

12 Sep, 2021 | 22:05h | UTC

What’s the evidence for COVID-19 booster shots? – Canadian Medical Association Journal

 

Perspective | We’re Asking the Impossible of Vaccines – “Complete protection against infection has long been hailed as the holy grail of vaccination. It might simply be unachievable”.

12 Sep, 2021 | 21:59h | UTC

We’re Asking the Impossible of Vaccines – The Atlantic

 

Commentary on Twitter

 

Risk of severe breakthrough Covid-19 higher for seniors and people with underlying conditions.

12 Sep, 2021 | 22:03h | UTC

Risk of severe breakthrough Covid-19 higher for seniors and people with underlying conditions – CNN

Original study: Hospitalisation among vaccine breakthrough COVID-19 infections – The Lancet Infectious Diseases

News release: Study examines severe breakthrough cases of COVID-19 – YaleNews

 

Commentary on Twitter

 

India’s DNA COVID vaccine is a world first – more are coming.

10 Sep, 2021 | 05:30h | UTC

India’s DNA COVID vaccine is a world first – more are coming – Nature

 

Two observational studies suggest spontaneous abortion is not increased following COVID-19 mRNA vaccination during pregnancy.

9 Sep, 2021 | 10:04h | UTC

Study 1: Spontaneous Abortion Following COVID-19 Vaccination During Pregnancy – JAMA

Study 2: Receipt of mRNA Covid-19 Vaccines and Risk of Spontaneous Abortion – New England Journal of Medicine

 

Commentary on Twitter

 

[Preprint] RCT: Additional heterologous vs. homologous booster vaccination in immunosuppressed patients without SARS-CoV-2 antibody seroconversion after primary mRNA vaccination.

9 Sep, 2021 | 09:55h | UTC

Additional heterologous versus homologous booster vaccination in immunosuppressed patients without SARS-CoV-2 antibody seroconversion after primary mRNA vaccination: a randomized controlled trial – medRxiv

 

Commentary on Twitter (thread – click for more)

https://twitter.com/hildabast/status/1435720202147143680

 

AstraZeneca bosses warn against rush for boosters – “giving the most vulnerable, who may not have built up a full immune response from the first two, a third, top-up dose is “sensible”. But any decision to give a third, booster jab “to large swathes of the population”, to extend their protection from the first two, must be based on clinical data”.

9 Sep, 2021 | 09:59h | UTC

AstraZeneca bosses warn against rush for boosters – BBC

 

Commentary on Twitter (thread – click for more)

 

WHO appeals for countries to postpone COVID-19 vaccine boosters until 2022 to prioritize vaccinating the most at-risk people around the world who are yet to receive their first dose.

9 Sep, 2021 | 10:00h | UTC

WHO Appeals to Postpone COVID-19 Vaccine Boosters Until 2022; Tedros Lashes out at Pharma Association – Health Policy Watch

See also:

WHO chief urges halt to booster shots for rest of the year – Associated Press

WHO extends moratorium on booster COVID vaccine doses – CIDRAP

 

Balancing incentives and disincentives for vaccination in a pandemic.

9 Sep, 2021 | 09:52h | UTC

Balancing incentives and disincentives for vaccination in a pandemic – Nature Medicine

Related: Opinion | COVID vaccines: we need to find out which incentives actually work – the author argues that policies to promote vaccine uptake should be tested in randomized clinical trials.

 

Chile authorizes Sinovac vaccine for kids of 6 and older.

7 Sep, 2021 | 21:45h | UTC

Chile authorizes Sinovac vaccine for kids of 6 and older – Associated Press

 

Study shows high effectiveness of the Pfizer mRNA COVID-19 vaccine in pregnancy.

7 Sep, 2021 | 21:48h | UTC

Effectiveness of the BNT162b2 mRNA COVID-19 vaccine in pregnancy – Nature Medicine

 

Commentaries on Twitter

 

AAP flu recommendations allow for coadministration with COVID-19 vaccine.

7 Sep, 2021 | 21:44h | UTC

News release: AAP flu recommendations allow for coadministration with COVID-19 vaccine – American Academy of Pediatrics

Guidance: Recommendations for Prevention and Control of Influenza in Children, 2021–2022 – American Academy of Pediatrics

Technical report: Recommendations for Prevention and Control of Influenza in Children, 2021–2022 – American Academy of Pediatrics

Related: New CDC Guidance says influenza and Covid vaccines can be given together – “COVID-19 vaccines and other vaccines may now be administered without regard to timing”

 

Commentary on Twitter

 

Extended intervals and extra doses of the AstraZeneca vaccine are associated with increased immunogenicity.

7 Sep, 2021 | 10:56h | UTC

Reactogenicity and immunogenicity after a late second dose or a third dose of ChAdOx1 nCoV-19 in the UK: a substudy of two randomised controlled trials (COV001 and COV002) – The Lancet

Invited commentary: Longer intervals and extra doses of ChAdOx1 nCoV-19 vaccine

 

Commentaries on Twitter

(thread – click for more)

(thread – click for more)

 

[Preprint] Large cohort study in Brazil showed AstraZeneca vaccine had high overall effectiveness against severe disease to individuals up to 89 years of age. In comparison, CoronaVac had high overall effectiveness against severe disease in individuals up to 79 years.

7 Sep, 2021 | 10:54h | UTC

Influence of age on the effectiveness and duration of protection in Vaxzevria and CoronaVac vaccines – medRxiv

 

Case series: COVID-19 mRNA vaccination leading to CNS inflammation.

7 Sep, 2021 | 10:49h | UTC

COVID-19 mRNA vaccination leading to CNS inflammation: a case series – Journal of Neurology

 

CDC report: Hospitalization rates for Covid-19 were 10 times higher among unvaccinated than among fully vaccinated adolescents.

7 Sep, 2021 | 10:52h | UTC

Hospitalizations Associated with COVID-19 Among Children and Adolescents — COVID-NET, 14 States, March 1, 2020–August 14, 2021 – CDC Morbidity and Mortality Weekly Report

Commentaries:

More kids hospitalized with Covid-19 in states with lower vaccination rates, CDC report finds – CNN

The hospitalization rate among teens who are unvaccinated is 10 times higher than teens who are vaccinated, new CDC data shows – Insider

Child COVID hospital cases up in low-vaccination states – CIDRAP

 

Commentary on Twitter

 

Large surveillance study finds severe adverse events after COVID-19 mRNA vaccination are rare.

6 Sep, 2021 | 11:02h | UTC

Surveillance for Adverse Events After COVID-19 mRNA Vaccination – JAMA

Editorial: Safety Surveillance of COVID-19 mRNA Vaccines Through the Vaccine Safety Datalink – JAMA

Commentaries:

mRNA COVID vaccines not tied to serious side effects – CIDRAP

Researchers find no serious health effects linked to mRNA COVID-19 vaccines – News Medical

 

Commentary on Twitter

 

Double vaccination halves risk of Long COVID.

3 Sep, 2021 | 10:29h | UTC

News release: Double vaccination halves risk of Long COVID – King’s College London

Original study: Risk factors and disease profile of post-vaccination SARS-CoV-2 infection in UK users of the COVID Symptom Study app: a prospective, community-based, nested, case-control study – The Lancet Infectious Diseases

Commentaries:

Largest study of its kind finds face masks reduce COVID-19 – University of California – Berkeley

Study: Vaccines slash long-haul COVID, hospital rates – CIDRAP

Vaccination reduces risk of long Covid, even when people are infected, U.K. study indicates – STAT

Being fully vaccinated reduces odds of long-term Covid-19 symptoms by half, UK study suggests – CNN

Coronavirus vaccines cut risk of long Covid, study finds – BBC

Related: M-A: More than 50 long-term effects of COVID-19.

 

Commentary on Twitter

 

EU agency says to focus on vaccines first not booster shots.

3 Sep, 2021 | 10:34h | UTC

EU agency says to focus on vaccines first not booster shots – Associated Press

See also: European officials say COVID-19 booster isn’t urgent – CIDRAP

 

Another study shows Pfizer mRNA vaccine immunity is reduced over time.

2 Sep, 2021 | 10:05h | UTC

Waning of BNT162b2 vaccine protection against SARS-CoV-2 infection in Qatar – medRxiv

Related:

[Press release – not published yet] Study shows vaccine protection wanes over time, but vaccines still offer good protection against severe disease.

Studies: COVID vaccine protection waning against infection but not hospitalization.

Pfizer says it’s time for a Covid booster; FDA and CDC say not so fast.

 

Commentary on Twitter (thread – click for more)

 

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