Tropical Medicine
WHO guideline on control and elimination of human schistosomiasis.
16 Feb, 2022 | 10:11h | UTCWHO guideline on control and elimination of human schistosomiasis – World Health Organization
Community control strategies for scabies: A cluster randomized trial showed one dose of Ivermectin was noninferior to two doses (7 to 14 days apart) to reduce the prevalence of the disease at 12 months.
11 Feb, 2022 | 08:38h | UTCCommunity control strategies for scabies: A cluster randomised noninferiority trial – PLOS Medicine
News Release: One dose of anti-parasite drug just as effective as two at reducing scabies – Murdoch Children’s Research Institute
Cohort Study: In high-transmission settings, the use of malaria-preventing mosquito nets in early childhood was associated with increased survival decades later.
3 Feb, 2022 | 08:56h | UTCCommentaries:
Malaria-preventing bed nets save children’s lives—with impacts that can last for decades – Science
Mosquito nets in young children save lives into adulthood – University of Basel
5 years later, researchers assess how children exposed to Zika are developing.
14 Jan, 2022 | 07:53h | UTC5 years later, researchers assess how children exposed to Zika are developing – NPR
A cluster randomized trial in a yaws-endemic area of Papua New Guinea showed a reduction in the community prevalence of yaws with three rounds of mass administration of azithromycin at 6-month intervals compared with one round of mass administration of azithromycin followed by two rounds of targeted treatment.
12 Jan, 2022 | 08:44h | UTCTrial of Three Rounds of Mass Azithromycin Administration for Yaws Eradication – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Data from a community-based trial in Papua New Guinea suggest that more than one round of mass drug administration should be considered as part of the strategy for yaws eradication. https://t.co/7Cfuz16CUa pic.twitter.com/pVRyefOlTb
— NEJM (@NEJM) January 6, 2022
WHO Report: More malaria cases and deaths in 2020 linked to COVID-19 disruptions.
7 Dec, 2021 | 08:55h | UTCNews Release: More malaria cases and deaths in 2020 linked to COVID-19 disruptions – World Health Organization
Report: World Malaria Report 2021 – World Health Organization
Commentaries:
More people died of malaria in 2020 than in 2019. Here’s why – NPR
Malaria kills 180,000 more people annually than previously thought, says WHO – The Guardian
Commentary on Twitter (thread – click for more)
#COVID19 pandemic has disrupted #malaria services, leading to a marked increase in cases and deaths: 14 million more cases in 2020 compared to 2019, and 69,000 more deaths – new report.
➡️https://t.co/M9sNo2Pn4u #EndMalaria pic.twitter.com/g6MKFVpQKf— World Health Organization (WHO) (@WHO) December 6, 2021
Review: Prevention of emerging infections in children.
23 Nov, 2021 | 08:17h | UTCPrevention of Emerging Infections in Children – Pediatric Clinics of North America
#AHA21 – RCT: Among children and adolescents who had screening echocardiograms and were identified as having latent rheumatic heart disease, secondary antibiotic prophylaxis with penicillin G benzathine for 2 years was associated with reduced echocardiographic progression (0.8 vs. 8.2% in the control group).
14 Nov, 2021 | 20:03h | UTCSecondary Antibiotic Prophylaxis for Latent Rheumatic Heart Disease – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries:
Secondary Antibiotic Prophylaxis for Latent Rheumatic Heart Disease – American College of Cardiology
Commentaries on Twitter
One of most important studies ever Rheumatic Heart Disease @NEJM https://t.co/U8FuNHLqCJ RCT evidence 2ry prophylaxis reduces progression latent RhD pic.twitter.com/UycTElr7QM
— Michael Marks (@dr_michaelmarks) November 13, 2021
Penicillin slowed the devastating impact of rheumatic heart disease among children in Uganda. Findings of a large-scale, randomized controlled trial were completed in Uganda. Group A strep underlies rheumatic heart disease. New England Journal of Medicine https://t.co/1PKFJ12FvC
— delthia ricks ? (@DelthiaRicks) November 13, 2021
Systematic Review: Administration of antimalarial drugs to whole populations for reducing malaria.
7 Oct, 2021 | 10:36h | UTCAdministration of antimalarial drugs to whole populations for reducing malaria – Cochrane Library
Original study: Mass drug administration for malaria – Cochrane Library
Commentary on Twitter
Administration of #antimalarial drugs to whole populations for reducing #malaria – https://t.co/4Q4vGKwmgU – Updated #OpenAccess @Cochrane_IDG review includes 13 studies and gives implications for practice & future research. pic.twitter.com/EMB2Tihs81
— Cochrane UK (@CochraneUK) October 3, 2021
WHO approves first ever malaria vaccine for children at risk.
7 Oct, 2021 | 10:40h | UTCWHO recommends groundbreaking malaria vaccine for children at risk – World Health Organization
Commentaries:
WHO Approves First Ever Malaria Vaccine – Health Policy Watch
In major decision, WHO recommends broad rollout of world’s first malaria vaccine – STAT
Why the WHO approval of the first malaria vaccine is a big deal – Vox
WHO greenlights the world’s first malaria vaccine — but it’s not a perfect shot – NPR
The World Health Organization Just Endorsed The World’s First Malaria Vaccine – TIME
WHO Backs Widespread Use Of First Malaria Vaccine – Forbes
World’s 1st malaria vaccine recommended by WHO – LiveScience
Commentaries on Twitter
I started my career as a #malaria researcher, and I longed for the day that we would have an effective vaccine against this ancient and terrible disease. Today is that day: @WHO is recommending the broad use of the world’s first malaria vaccine. #EndMalaria https://t.co/Oh1O155tYj
— Tedros Adhanom Ghebreyesus (@DrTedros) October 6, 2021
(thread – click for more)
A child dies from #malaria every two minutes.
One death is one too many.? Today, WHO recommends RTS,S, a groundbreaking malaria vaccine, to reduce child illness & deaths in areas with moderate and high malaria transmission https://t.co/xSk58nTIV1#VaccinesWork pic.twitter.com/mSECLtRhQs
— World Health Organization (WHO) (@WHO) October 6, 2021
Drug-resistant malaria is gaining a foothold in Africa – “Analyses of patient blood samples suggest artemisinin effectiveness is slipping”.
28 Sep, 2021 | 08:49h | UTCDrug-resistant malaria is gaining a foothold in Africa – Science
Commentary on Twitter
Drug-evading parasites appeared in Southeast Asia in the early 2000s, eventually leading to failures of key therapies.
But the stakes are higher for Africa, home to 94% of both malaria cases and deaths worldwide in 2019. https://t.co/ILamXKP3yh
— Global Health NOW (@ghn_news) September 27, 2021
How COVID is derailing the fight against HIV, TB and malaria.
15 Sep, 2021 | 09:01h | UTCHow COVID is derailing the fight against HIV, TB and malaria – Nature
Related:
How COVID hurt the fight against other dangerous diseases
World TB Day | Report: COVID-19 Eliminates Twelve Years of Progress Against Tuberculosis
An update on prevention of malaria in travelers.
15 Sep, 2021 | 08:39h | UTCAn update on prevention of malaria in travelers – Therapeutic Advances in Infectious Disease
Related: CDC Yellow Book
RCT: Severe malaria among young African children dramatically reduced through seasonal vaccination and preventative drug combination.
1 Sep, 2021 | 09:02h | UTCOriginal article: Seasonal Malaria Vaccination with or without Seasonal Malaria Chemoprevention – New England Journal of Medicine
Commentary: Malaria trial shows ‘striking’ 70% reduction in severe illness in children – The Guardian
Related: Malaria vaccine becomes first to achieve WHO-specified 75% efficacy goal
Cluster RCT: Vaccination of children against typhoid fever with a Vi-tetanus toxoid conjugate vaccine in urban Bangladesh conferred 85% total protection.
11 Aug, 2021 | 08:28h | UTCInvited commentary: Salmonella Typhi Vi polysaccharide conjugate vaccine protects infants and children against typhoid fever – The Lancet
Diagnosis and clinical management of hepatosplenic schistosomiasis: A scoping review of the literature.
15 Jul, 2021 | 09:02h | UTC
CDC advisory panel backs use of dengue vaccine in high-risk areas, despite delivery challenges.
25 Jun, 2021 | 10:13h | UTC
WHO issues new guidance for research on genetically modified mosquitoes to fight malaria and other vector-borne diseases.
10 Jun, 2021 | 09:38h | UTCGuideline: The guidance framework for testing genetically modified mosquitoes – World Health Organization
Cluster-randomized trial: Wolbachia-infected Aedes aegypti (less susceptible than wild-type A. aegypti to dengue virus infection) deployments reduced the incidence of symptomatic dengue and resulted in fewer hospitalizations.
10 Jun, 2021 | 09:40h | UTCCommentary: ‘Miraculous’ mosquito hack cuts dengue by 77% – BBC
Video Abstract: Efficacy of Wolbachia-infected Mosquito Deployments for the Control of Dengue
Malaria vaccine becomes first to achieve WHO-specified 75% efficacy goal
25 Apr, 2021 | 21:17h | UTCNews release: Malaria vaccine becomes first to achieve WHO-specified 75% efficacy goal – University of Oxford
Original study (preprint): High Efficacy of a Low Dose Candidate Malaria Vaccine, R21 in 1 Adjuvant Matrix-M™, with Seasonal Administration to Children in Burkina Faso – The Lancet
Commentaries: Malaria vaccine hailed as potential breakthrough – BBC AND Oxford Malaria vaccine proves highly effective in Burkina Faso trial – The Guardian
Commentary on Twitter (thread – click for more)
?AMAZING—First high >75% efficacy vaccine for a disease with 229 million cases & 409,000 deaths worldwide in 2019 —#Malaria!
Created by Oxford, produced by Serum Institute of India, & supporting adjuvant by Novavax, SII expects to make 200 mil doses a year!
Science! #vaccine pic.twitter.com/gnPMvXxww6
— Eric Feigl-Ding (@DrEricDing) April 23, 2021
Ahead of World Malaria Day, WHO launches effort to stamp out malaria in 25 more countries by 2025
22 Apr, 2021 | 08:23h | UTCReport: Zeroing in on malaria elimination: Final report of the E-2020 initiative – World Health Organization
How COVID hurt the fight against other dangerous diseases
22 Apr, 2021 | 08:35h | UTCHow COVID hurt the fight against other dangerous diseases – Nature
Related: World TB Day | Report: COVID-19 Eliminates Twelve Years of Progress Against Tuberculosis AND WHO: Benefits of continuing to provide life-saving HIV services outweigh the risk of COVID-19 transmission by 100 to 1
RCT: New shorter regimens of benznidazole monotherapy and in combination with fosravuconazole for treatment of Chagas disease
8 Apr, 2021 | 08:47h | UTC
Ebola Virus Transmission Initiated by Relapse of Systemic Ebola Virus Disease
5 Apr, 2021 | 01:05h | UTC
Commentary on Twitter
In this report from the Democratic Republic of Congo, Ebola virus disease developed in a young man, and he recovered after treatment with a monoclonal antibody.
6 months later, EVD recrudesced, and he transmitted the virus to others & died from EVD @NEJM https://t.co/kJSBNdN5bC pic.twitter.com/jDnnGMLmOG— Antibiotic Steward??Bassam Ghanem (@ABsteward) March 31, 2021
Diagnosis and clinical management of hepatosplenic schistosomiasis: A scoping review of the literature
31 Mar, 2021 | 03:01h | UTC