A cluster randomized trial in a yaws-endemic area of Papua New Guinea showed a reduction in the community prevalence of yaws with three rounds of mass administration of azithromycin at 6-month intervals compared with one round of mass administration of azithromycin followed by two rounds of targeted treatment.

Trial of Three Rounds of Mass Azithromycin Administration for Yaws Eradication – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary on Twitter

Data from a community-based trial in Papua New Guinea suggest that more than one round of mass drug administration should be considered as part of the strategy for yaws eradication. https://t.co/7Cfuz16CUa pic.twitter.com/pVRyefOlTb

— NEJM (@NEJM) January 6, 2022