Infectious Diseases (all articles)
Cluster RCT: Vaccination of children against typhoid fever with a Vi-tetanus toxoid conjugate vaccine in urban Bangladesh conferred 85% total protection.
11 Aug, 2021 | 08:28h | UTCInvited commentary: Salmonella Typhi Vi polysaccharide conjugate vaccine protects infants and children against typhoid fever – The Lancet
M-A: Child and youth mental health problems have doubled during COVID-19.
10 Aug, 2021 | 10:03h | UTCCommentary: Child and youth mental health problems have doubled during COVID-19 – The Conversation
Original study: Global Prevalence of Depressive and Anxiety Symptoms in Children and Adolescents During COVID-19: A Meta-analysis – JAMA Pediatrics
Editorial: Addressing the Global Crisis of Child and Adolescent Mental Health – JAMA Pediatrics
Related:
More data on the harmful effects of the COVID-19 pandemic on the mental health of adolescents.
COVID has caused ‘mass trauma,’ worsening mental health globally.
COVID’s mental-health toll: how scientists are tracking a surge in depression
WHO: COVID-19 disrupting mental health services in most countries
Commentary on Twitter (thread – click for more)
Many are rightfully sounding the alarm to a youth #mentalhealth crisis. Our meta-analysis of 29 studies w >80,000 youth worldwide in @JAMAPediatrics, shows 1 in 4 youth had elevated depression or anxiety during #COVID19. A thread 🧵 https://t.co/etIdZTHnme
— Dr. Sheri Madigan (she/her) (@sherimadigan) August 9, 2021
[Preprint] Phase 1/2 RCT: A booster dose is immunogenic and will be needed for older adults who have completed two doses vaccination with CoronaVac.
10 Aug, 2021 | 09:58h | UTC
Commentary on Twitter
https://twitter.com/hildabast/status/1424644994120372224
Viral load of SARS-CoV-2 in respiratory aerosols emitted by COVID-19 patients while breathing, talking, and singing.
10 Aug, 2021 | 10:02h | UTC
Commentary on Twitter
Our peer-reviewed research is now published in Clinical Infectious Diseases! No matter how you slice it, COVID-19 is an airborne disease. Let's call it like it is and put the appropriate measures in place.https://t.co/R4MeIlwBY6
— Kristen K. Coleman (@drkristenkc) August 7, 2021
A WHO expert explains why she believes the rush for Covid-19 boosters is premature.
10 Aug, 2021 | 09:56h | UTCA WHO expert explains why she believes the rush for Covid-19 boosters is premature – STAT
Commentary on Twitter
Must read interview on rich nations rushing into booster doses
Dr @Kate_L_OBrien by @HelenBranswell @statnews
"We really have huge inequity right now in just getting primary doses to people. Does a third dose need to be given?"https://t.co/pRhYwINuKf pic.twitter.com/YQS6Nj0Hyi
— Madhu Pai, MD, PhD (@paimadhu) August 9, 2021
Covid-19: How effective are vaccines against the delta variant?
10 Aug, 2021 | 10:00h | UTCCovid-19: How effective are vaccines against the delta variant? – The BMJ
A giant trial of COVID-19 treatments organized by the WHO is restarting. Here are the drugs it’s betting on.
10 Aug, 2021 | 09:52h | UTCA giant trial of COVID-19 treatments is restarting. Here are the drugs it’s betting on – Science
Related: WHO Solidarity trial to restart with focus on drugs that act on immune responses caused by Covid-19.
Study ties COVID vaccines to lower transmission rates.
10 Aug, 2021 | 09:51h | UTCStudy ties COVID vaccines to lower transmission rates – CIDRAP
‘Breakthrough’ infections do not mean COVID vaccines are failing.
10 Aug, 2021 | 09:54h | UTC‘Breakthrough’ Infections Do Not Mean COVID Vaccines Are Failing – Scientific American
Commentary on Twitter
https://twitter.com/laurahelmuth/status/1422897892797337609
Interactive infographic: Data shows how rare severe breakthrough Covid infections are.
9 Aug, 2021 | 00:01h | UTCData shows how rare severe breakthrough Covid infections are – NBC News
Commentary on Twitter
Very good interactive infographic for impact of vaccination in 2021 by state https://t.co/HAfYYPX9FI by @NBCNews @seenigel @ChicagoEl @pdrbarquinha @jiachuanwu @NBCNewsGraphics
Here for California: Hospitalizations, deaths and infections pic.twitter.com/83Hxl2x2gm— Eric Topol (@EricTopol) August 7, 2021
RCT: Safety and immunogenicity of heterologous vs. homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine.
9 Aug, 2021 | 00:06h | UTCInvited commentary: Optimising SARS-CoV-2 vaccination schedules – The Lancet
Related: Another study shows increased immune response with heterologous Oxford-AstraZeneca/mRNA vaccination (several articles on the subject)
Commentary on Twitter
Just published @TheLancet
A randomized mix and match trial of AZ and Pfizer vaccination in >800 people shows that mixing is safe and can engender at least as good, if not better, immune response https://t.co/V40Dy59Ia8 by @XinxueLiu and colleagues pic.twitter.com/tKl59LFz4i— Eric Topol (@EricTopol) August 6, 2021
COVID: WHO calls for moratorium on booster shots – is it justifiable?
8 Aug, 2021 | 23:54h | UTCCOVID: WHO calls for moratorium on booster shots – is it justifiable? – The Conversation
Related: Covid: WHO calls for booster pause to vaccinate poorer nations.
Commentary on Twitter
The authors put it well: Even if affluent countries prioritize boosters for the vulnerable, 'the degree of additional benefit…is uncertain.' Yet we know 'vaccines could do a huge amount of good for the large number of vulnerable ppl who've not yet received a single dose.' https://t.co/6qNV6pzDDk
— Tedros Adhanom Ghebreyesus (@DrTedros) August 7, 2021
CDC study showed a reduced risk of reinfection with SARS-CoV-2 after covid-19 vaccination.
9 Aug, 2021 | 00:03h | UTC
Commentaries on Twitter
This is non randomized. The two biases are:
1. Behavior among those who got vaccinated likely different than those who don't
2. Likely those who didn't tested more aggressively
I would not cite this as many are doinghttps://t.co/rSkBC37uq0
— Vinay Prasad MD MPH (@VPrasadMDMPH) August 7, 2021
Study shows that full #COVIDVaccination ⬇️ likelihood of being re-infected with #COVID19 compared to those who were previously had COVID but were not vaccinated (risk ⬆️ 2.3 fold)#GetVaccinated even if you have had COVID previouslyhttps://t.co/3dF3XPxwYp
@fascinatorfun pic.twitter.com/ip6zTvNN86
— Prof Kamlesh Khunti (@kamleshkhunti) August 7, 2021
M-A: SARS-CoV-2 Setting-specific transmission rates – “Households showed the highest transmission rates, with a pooled secondary attack rates of 21.1%”.
8 Aug, 2021 | 23:57h | UTC
Commentary on Twitter
SARS-CoV-2 setting-specific transmission rates: a systematic review and meta-analysis
Households highest transmission rates, pooled SAR~21.1%. Contacts at social events~5.9%. Workplaces~1.9%. Age gradient for transmission potential in h/hold context. https://t.co/m27kkDrTgy
— Andrew Lee is heading to @andrewleedr.bsky.social (@andrewleedr) March 10, 2021
COVID vaccine boosters: the most important questions.
8 Aug, 2021 | 23:52h | UTCCOVID vaccine boosters: the most important questions – Nature
Commentary on Twitter
I agree with @nataliexdean: “We just don’t have clear evidence of enough of a loss of efficacy to change our focus or distract from the main goal, which is trying to get as many people first doses” as possible." https://t.co/FEKB4vg0Dz
— Sanghyuk Shin (@sanghyuk_shin) August 6, 2021
Tokyo feared Games would spread COVID; numbers suggest that didn’t happen.
8 Aug, 2021 | 23:56h | UTCTokyo feared Games would spread COVID; numbers suggest that didn’t happen – Reuters
Commentary on Twitter
Before the #Olympics began, Japan feared that the Games might spread COVID-19, introduce new variants and overwhelm the medical system. The infection numbers from inside the Olympic 'bubble' tell a different story https://t.co/EsIxj3gsNx
— Reuters (@Reuters) August 7, 2021
More data showing one dose of Pfizer vaccine may be enough for individuals who’ve had COVID.
8 Aug, 2021 | 23:50h | UTCCommentary: One Dose of Pfizer Vaccine May Be Enough for Folks Who’ve Had COVID – HealthDay
Related:
Perspective | Is one vaccine dose enough if you’ve had COVID? What the science says.
Another study shows a single dose of mRNA vaccine may be enough for patients with previous Covid-19
Spain to give just one vaccine dose to under 55-year olds who had COVID-19
Perspective: Is one vaccine dose enough after COVID-19 infection?
France’s health authority recommends single vaccine shot for people who have had COVID-19
Covid-19: People who have had infection might only need one dose of mRNA vaccine
Commentary on Twitter
SARS-CoV-2 Antibody Responses After 1 and 2 Doses of the BNT162b2 Vaccine https://t.co/ARMdH8Yboo via @JAMANetworkOpen part of @JAMANetwork Small study but one that confirms the policy of many European countries in which one dose of vaccine is sufficient after having COVID.
— Carlos del Rio (@CarlosdelRio7) August 7, 2021
Case report: Systemic capillary leak syndrome after ChAdOx1 nCOV-19 (Oxford–AstraZeneca) vaccination.
8 Aug, 2021 | 23:49h | UTC
[Preprint] RCT: non-invasive respiratory strategies in acute respiratory failure in patients with COVID-19 – CPAP reduced the composite outcome of intubation or death within 30 days; high-flow nasal oxygenation was not associated with better outcomes.
6 Aug, 2021 | 10:18h | UTCCommentary: Covid: Pressured oxygen reduces ventilator need – BBC
Commentary on Twitter (thread – click for more)
RECOVERY-RS results out, and confirm what most of us have been doing:
CPAP reduces intubation/mortality by 28% compared with no CPAP/HFNO (composite outcome, mostly intubation)
Nasal high flow not so successful1/https://t.co/bcB2sTdAsu pic.twitter.com/fvT8IbyxUr
— 𝚃𝚘𝚖 𝙻𝚊𝚠𝚝𝚘𝚗 💙 (@LawtonTri) August 5, 2021
Review: Transmission of infections during cardiopulmonary resuscitation.
8 Aug, 2021 | 23:16h | UTCTransmission of Infections during Cardiopulmonary Resuscitation – Clinical Microbiology Reviews
Systematic Review: “Remdesivir probably has little or no effect on all‐cause mortality at up to 28 days in hospitalized adults with SARS‐CoV‐2 infection. We are uncertain about the effects of remdesivir on clinical improvement and worsening”.
6 Aug, 2021 | 10:15h | UTCRemdesivir for the treatment of COVID‐19 – Cochrane Library
Summary: Remdesivir for the treatment of COVID-19 – Cochrane Library
Commentary on Twitter (thread – click for more)
JUST PUBLISHED – Is #remdesivir an effective treatment for #COVID19? https://t.co/ntgfDQjMqs This @CochraneHaem systematic review looked at this antiviral medicine to see if it's an effective treatment for people in hospital w #COVID & if it causes unwanted effects. 1/5 pic.twitter.com/UtIW83uTtn
— The Cochrane Library (@CochraneLibrary) August 5, 2021
Flawed ivermectin preprint highlights challenges of COVID drug studies.
6 Aug, 2021 | 10:07h | UTCFlawed ivermectin preprint highlights challenges of COVID drug studies – Nature
Related:
Systematic review: no evidence to support the use of Ivermectin for treating or preventing COVID-19.
Why was a major study on ivermectin for covid-19 just retracted?
Dexamethasone and tocilizumab treatment considerably reduces the value of C-reactive protein and procalcitonin to detect secondary bacterial infections in COVID-19 patients.
6 Aug, 2021 | 10:13h | UTC
Clinical Picture: Mucormycosis after COVID-19 in a patient with diabetes.
6 Aug, 2021 | 10:09h | UTCMucormycosis after COVID-19 in a patient with diabetes – The Lancet
Related:
COVID-19 and mucormycosis superinfection: the perfect storm.
What is mucormycosis, the fungal infection affecting COVID patients in India?
[Preprint] The Emergence of COVID-19 Associated Mucormycosis: Analysis of Cases From 18 Countries.
Mucormycosis: The ‘black fungus’ maiming Covid patients in India
Global Guideline for the Diagnosis and Management of Mucormycosis
M-A: Chest radiograph findings in COVID-19.
6 Aug, 2021 | 10:03h | UTC