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Infectious Diseases (all articles)

Long COVID: the physical and mental health of children and non-hospitalized young people after SARS-CoV-2 infection – one in seven children may still have symptoms 15 weeks after infection.

2 Sep, 2021 | 10:10h | UTC

Long COVID – the physical and mental health of children and non-hospitalised young people 3 months after SARS-CoV-2 infection; a national matched cohort study (The CLoCk) Study.

Commentaries:

Long Covid in children ‘nowhere near scale feared’ – BBC

Long covid: One in seven children may still have symptoms 15 weeks after infection, data show – The BMJ

Related:

Do kids get long COVID? And how often? A pediatrician looks at the data – Children also get Long Covid, but much less often than adults.

Illness duration and symptom profile in symptomatic school-aged children tested for SARS-CoV-2 – “Only 25 (1.8%) of 1379 children experienced symptoms for at least 56 days.”

Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – “This study found a low prevalence of symptoms compatible with long COVID in a randomly selected cohort of children assessed 6 months after serologic testing”.

Study shows low incidence of post-acute COVID-19 symptoms (“Long Covid”) in children after mild disease

Cohort study: Risk factors for long covid in previously hospitalized children.

M-A: More than 50 long-term effects of COVID-19.

 

Commentary on Twitter (thread – click for more)

 

Another study shows Pfizer mRNA vaccine immunity is reduced over time.

2 Sep, 2021 | 10:05h | UTC

Waning of BNT162b2 vaccine protection against SARS-CoV-2 infection in Qatar – medRxiv

Related:

[Press release – not published yet] Study shows vaccine protection wanes over time, but vaccines still offer good protection against severe disease.

Studies: COVID vaccine protection waning against infection but not hospitalization.

Pfizer says it’s time for a Covid booster; FDA and CDC say not so fast.

 

Commentary on Twitter (thread – click for more)

 

Scientific Statement: Coronavirus Disease-2019 and Heart Failure.

2 Sep, 2021 | 10:08h | UTC

Coronavirus Disease-2019 and Heart Failure: A Scientific Statement From the Heart Failure Society of America – Journal of Cardiac Failure

 

Commentary on Twitter

 

Recommendations for ventilation of indoor spaces to reduce COVID-19 transmission.

2 Sep, 2021 | 10:02h | UTC

Recommendations for ventilation of indoor spaces to reduce COVID-19 transmission – Journal of the Formosan Medical Association

Related:

We studied how to reduce airborne COVID spread in hospitals. Here’s what we learnt.

Report: Improved ventilation essential to safe use of buildings and public spaces, say leading engineers.

WHO: Roadmap to improve and ensure good indoor ventilation in the context of COVID-19

CDC releases new ventilation guidelines for indoor environments to reduce Covid-19 risk

Guidance: Using Ventilation and filtration to reduce aerosol transmission of COVID-19 in long-term care homes

 

Treatment of urinary tract infections in infants <2 Months: A Living Systematic Review - short and long duration of parenteral antibiotics were associated with a similar risk of UTI recurrence.

2 Sep, 2021 | 08:19h | UTC

Treatment of UTIs in Infants <2 Months: A Living Systematic Review – Hospital Pediatrics

 

World leaders and experts call for significant reduction in the use of antimicrobial drugs in global food systems.

2 Sep, 2021 | 08:13h | UTC

World leaders and experts call for significant reduction in the use of antimicrobial drugs in global food systems – World Health Organization

Commentary: Global group urges limits on antimicrobials in food production – CIDRAP

 

[Preprint] Randomized trials on non-pharmaceutical interventions for COVID-19 as of August 2021: a meta-epidemiological analysis – “Worldwide, 41 randomized trials assessing NPIs have been initiated with published results available to inform policy decisions for only 7 of them”.

1 Sep, 2021 | 10:01h | UTC

Randomized trials on non-pharmaceutical interventions for COVID-19 as of August 2021: a meta-epidemiological analysis – medRxiv

 

Commentary on Twitter

 

[Preprint] Pfizer vaccine booster dose protection: A nationwide study from Israel – “Twelve days or more after the booster dose we found an 11.4-fold decrease in the relative risk of confirmed infection, and a >10-fold decrease in the relative risk of severe illness”.

1 Sep, 2021 | 09:59h | UTC

BNT162b2 vaccine booster dose protection: A nationwide study from Israel – medRxiv

 

Perspective | COVID-19 boosters in rich nations will delay vaccines for all.

1 Sep, 2021 | 09:56h | UTC

COVID-19 boosters in rich nations will delay vaccines for all – Nature

 

Commentaries on Twitter

 

M-A mostly of observational studies found that in patients with Methicillin-Resistant Staphylococcus aureus Bloodstream Infection Daptomycin was associated with a lower risk of clinical failure than Vancomycin, without differences in mortality.

2 Sep, 2021 | 08:10h | UTC

Daptomycin versus Vancomycin for the Treatment of Methicillin-Resistant Staphylococcus aureus Bloodstream Infection with or without Endocarditis: A Systematic Review and Meta-Analysis – Antibiotics

 

Why is a third COVID-19 vaccine dose important for people who are immunocompromised?

1 Sep, 2021 | 09:57h | UTC

Why is a third COVID-19 vaccine dose important for people who are immunocompromised? – The Conversation

Related:

FDA authorizes additional Covid-19 vaccine dose for certain immunocompromised individuals – Other fully vaccinated individuals do not need an additional vaccine dose right now.

RCT: third dose of Moderna mRNA vaccine increases immunity in transplant recipients.

Study: Among kidney transplant recipients who did not respond after 2 doses, a third dose of an mRNA-1273 vaccine induced a serologic response in 49% of patients.

Case series: Safety and immunogenicity of a third dose of SARS-CoV-2 vaccine in solid organ transplant recipients.

 

COVID-19 patients at higher risk of blood clots after surgery, study shows.

1 Sep, 2021 | 09:54h | UTC

COVID-19 patients at higher risk of blood clots after surgery, study shows – CIDRAP

Original study: SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study – Anaesthesia

Related:

ASA Guidance: Preoperative testing for COVID-19 is essential, regardless of vaccination.

Position statement: Perioperative management of post-COVID-19 surgical patients.

Guideline: SARS‐CoV‐2 infection, COVID‐19 and timing of elective surgery

Study from 116 countries suggests surgery should be delayed for at least seven weeks following a COVID-19 diagnosis to reduce mortality risk

Cohort study: Postoperative in-hospital mortality of patients with COVID-19 infection was more than double that in patients without COVID-19

WSES Position Paper: The management of surgical patients in the emergency setting during COVID-19 pandemic

Preparing previously COVID-19-positive patients for elective surgery: A framework for preoperative evaluation

 

COVID may be most infectious 2 or 3 days around symptom onset.

1 Sep, 2021 | 09:51h | UTC

COVID may be most infectious 2 or 3 days around symptom onset – CIDRAP

Original article: COVID-19 Transmission Dynamics Among Close Contacts of Index Patients With COVID-19: A Population-Based Cohort Study in Zhejiang Province, China – JAMA Internal Medicine

 

Study: Patients, not staff, source of most hospital COVID spread.

1 Sep, 2021 | 09:52h | UTC

Study: Patients, not staff, source of most hospital COVID spread – CIDRAP

Original article: Superspreaders drive the largest outbreaks of hospital onset COVID-19 infections – eLife

 

Review: Initial antimicrobial management of sepsis – immediate, empiric, broad-spectrum therapy is key, but it must be accompanied by a commitment to de-escalation and antimicrobial stewardship.

1 Sep, 2021 | 08:59h | UTC

Initial antimicrobial management of sepsis – Critical Care

 

RCT: Severe malaria among young African children dramatically reduced through seasonal vaccination and preventative drug combination.

1 Sep, 2021 | 09:02h | UTC

News release: Severe malaria among young African children dramatically reduced through seasonal vaccination and preventative drug combination – London School of Hygiene & Tropical Medicine

Original article: Seasonal Malaria Vaccination with or without Seasonal Malaria Chemoprevention – New England Journal of Medicine

Commentary: Malaria trial shows ‘striking’ 70% reduction in severe illness in children – The Guardian

Related: Malaria vaccine becomes first to achieve WHO-specified 75% efficacy goal

 

Cohort study: A strategy combining a rapid antigen test and chest CT was effective in ruling out COVID-19 in the emergency department.

31 Aug, 2021 | 09:00h | UTC

Rapid Antigen Test Combined with Chest Computed Tomography to Rule Out COVID-19 in Patients Admitted to the Emergency Department – Journal of Clinical Medicine

 

WHO Issues COVID-19 Digital ‘Vaccine Pass’ Guidelines – But Stresses These Should Not be Requirements for Travel.

31 Aug, 2021 | 09:02h | UTC

WHO Issues COVID-19 Digital ‘Vaccine Pass’ Guidelines – But Stresses These Should Not be Requirements for Travel – Health Policy Watch

See guidance: Digital documentation of COVID-19 certificates: vaccination status: technical specifications and implementation guidance, 27 August 2021 – World Health Organization

 

Study shows young children gained weight during the pandemic.

31 Aug, 2021 | 08:59h | UTC

News release: Young children gained weight during the pandemic – Kaiser Permanente

Original study: Changes in Body Mass Index Among Children and Adolescents During the COVID-19 Pandemic – JAMA

 

Commentary on Twitter

 

Study demonstrates a significantly higher humoral immunogenicity induced by the SARS-CoV-2 Moderna vaccine compared with the Pfizer- BioNTech vaccine.

31 Aug, 2021 | 09:04h | UTC

Comparison of SARS-CoV-2 Antibody Response Following Vaccination With BNT162b2 and mRNA-1273 – JAMA

Related:

Moderna may be superior to Pfizer against Delta variant — breakthrough odds rise with time.

[Preprint] Pfizer vs. Moderna COVID-19 vaccine effectiveness against the Delta variant in Qatar – Effectiveness against symptomatic disease due to Delta was 53.5% for Pfizer and 84.8% for Moderna; effectiveness against severe disease due to Delta was 89.7% for Pfizer and 100.0% for Moderna.

 

Do kids get long COVID? And how often? A pediatrician looks at the data – Children also get Long Covid, but much less often than adults.

31 Aug, 2021 | 08:57h | UTC

Do kids get long COVID? And how often? A paediatrician looks at the data – The Conversation

Related:

Illness duration and symptom profile in symptomatic school-aged children tested for SARS-CoV-2 – “Only 25 (1.8%) of 1379 children experienced symptoms for at least 56 days.”

Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – “This study found a low prevalence of symptoms compatible with long COVID in a randomly selected cohort of children assessed 6 months after serologic testing”.

Study shows low incidence of post-acute COVID-19 symptoms (“Long Covid”) in children after mild disease

Cohort study: Risk factors for long covid in previously hospitalized children.

M-A: More than 50 long-term effects of COVID-19.

 

Opinion | COVID vaccines: we need to find out which incentives actually work – the author argues that policies to promote vaccine uptake should be tested in randomized clinical trials.

31 Aug, 2021 | 08:56h | UTC

COVID vaccines: we need to find out which incentives actually work – The Conversation

 

#ESCCongress – RCT: Influenza vaccination early after a myocardial infarction (MI) or in high-risk coronary heart disease resulted in a lower risk of a composite of all-cause death, MI, or stent thrombosis compared with placebo.

31 Aug, 2021 | 08:52h | UTC

Influenza Vaccination after Myocardial Infarction: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial – Circulation

Commentaries:

IAMI: Influenza Vaccine Beneficial for Post-MI Patients – TCTMD

Influenza Vaccination After Myocardial Infarction – IAMI – American College of Cardiology

Flu vaccine after heart attack reduces risk of death – Cardiovascular Business

 

Commentary on Twitter

 

Study with over 29 million people in England shows Covid-19, not vaccination, presents biggest blood clot risks.

29 Aug, 2021 | 18:57h | UTC

Press release: Covid-19, not vaccination, presents biggest blood clot risks – University of Oxford

Original study: Risk of thrombocytopenia and thromboembolism after covid-19 vaccination and SARS-CoV-2 positive testing: self-controlled case series study – The BMJ

Editorial: Strengthening international surveillance of vaccine safety – The BMJ

Commentaries:

Expert reaction to study looking at risk of thrombocytopenia and thromboembolism after COVID-19 vaccination and SARS-CoV-2 infection – Science Media Centre

Covid: Vaccine complications dwarfed by virus risks – BBC

 

Commentary on Twitter

 

Cohort study: Patients with Covid-19 infected with the Delta variant are twice as likely to need hospital admission or emergency care attendance.

29 Aug, 2021 | 19:02h | UTC

Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B.1.617.2) compared with alpha (B.1.1.7) variants of concern: a cohort study – The Lancet Infectious Diseases

Commentaries:

Importance of epidemiological factors in the evaluation of transmissibility and clinical severity of SARS-CoV-2 variants – The Lancet Infectious Diseases

Covid: Delta variant patients twice as likely to need hospital care – BBC

Covid-19 hospitalization risk doubles with Delta variant, UK study suggests – CNN

Expert reaction to study looking at risk of hospitalisation from the delta variant compared with alpha – Science Media Centre

 

Commentary on Twitter

 

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