Infectious Diseases (all articles)
Another study showed neutralizing monoclonal antibody therapies are not effective when given after the patient is already hospitalized.
13 Jan, 2022 | 08:48h | UTCInvited Commentary: Time to knock monoclonal antibodies off the platform for patients hospitalised with COVID-19
‘Killer’ immune cells still recognize Omicron variant.
13 Jan, 2022 | 08:51h | UTC‘Killer’ immune cells still recognize Omicron variant – Nature
See also: T-cells: the superheroes in the battle against omicron – The Conversation
RCT: A single dose of a novel adenovirus type 5 vectored SARS-CoV-2 vaccine was safe and had 57.5% efficacy against symptomatic Covid-19 and 91.7% efficacy against severe disease in adults.
13 Jan, 2022 | 08:44h | UTCCommentaries:
Efficacy of an adenovirus type 5 vectored SARS-CoV-2 vaccine – The Lancet
A clinical case definition of post-COVID-19 condition by a Delphi consensus.
13 Jan, 2022 | 08:45h | UTC
Commentary on Twitter
New Review: A clinical case definition of post-#COVID19 condition by a Delphi consensus https://t.co/AoWBgCeMq5 pic.twitter.com/kAW1YY6kgr
— The Lancet Infectious Diseases (@TheLancetInfDis) December 22, 2021
Review: Diagnosis and treatment of sexually transmitted infections.
13 Jan, 2022 | 08:38h | UTCDiagnosis and Treatment of Sexually Transmitted Infections: A Review – JAMA (free for a limited period)
Cohort Study: Patient factors associated with appendectomy within 30 days of initiating antibiotic treatment for appendicitis – the presence of an appendicolith was associated with a nearly 2-fold increased risk of undergoing appendectomy within 30 days.
13 Jan, 2022 | 08:39h | UTCPatient Factors Associated With Appendectomy Within 30 Days of Initiating Antibiotic Treatment for Appendicitis – JAMA Surgery (free for a limited period)
Invited commentary: Appendicoliths, Antibiotic Treatment Failure, and Appendectomy—Is the Glass Half Full or Half Empty? – JAMA Surgery
The Antifungal Pipeline: Fosmanogepix, Ibrexafungerp, Olorofim, Opelconazole, and Rezafungin.
13 Jan, 2022 | 08:17h | UTCThe Antifungal Pipeline: Fosmanogepix, Ibrexafungerp, Olorofim, Opelconazole, and Rezafungin – Drugs
The COVID-19 Treatment Guidelines Panel’s Statement on Anticoagulation in Hospitalized Patients With COVID-19 – in the absence of contraindications, use therapeutic-dose anticoagulation with low molecular weight heparin for hospitalized patients not in the ICU who have a D-dimer above the upper limit of normal.
12 Jan, 2022 | 09:11h | UTC
Statement on therapies for high-risk, nonhospitalized patients with mild to moderate Covid-19.
12 Jan, 2022 | 09:14h | UTCSee also: What’s New in the Guidelines – NIH COVID-19 Treatment Guidelines
Cohort Study: In preterm premature rupture of membranes at 24-31 weeks, antibiotic prophylaxis based on third-generation cephalosporin may be associated with improved perinatal outcomes compared to amoxicillin.
13 Jan, 2022 | 08:10h | UTCAntibiotic prophylaxis in preterm premature rupture of membranes at 24-31 weeks’ gestation: perinatal and 2-year outcomes in the EPIPAGE-2 cohort – BJOG (link to abstract – $ for full-text)
Recommendations on patient prioritization for outpatient Anti-SARS-CoV-2 therapies or preventive strategies when there are logistical or supply constraints.
12 Jan, 2022 | 09:06h | UTC
Commentary on Twitter
https://twitter.com/NIHCOVIDTxGuide/status/1475510894121697287
International study identifies predictors of severe outcomes in children with COVID-19.
12 Jan, 2022 | 09:05h | UTCNews Release: International study identifies predictors of severe outcomes in children with COVID-19 – University of Calgary
Original Study: Outcomes of SARS-CoV-2–Positive Youths Tested in Emergency Departments: The Global PERN–COVID-19 Study – JAMA Network Open
How do death rates from COVID-19 differ between people who are vaccinated and those who are not?
12 Jan, 2022 | 09:02h | UTC
Commentary from the author on Twitter
Updated: Now the ratio is 20.
The COVID death rate among unvaccinated people is 20-times higher than among vaccinated people.
This is the latest age-standardized data from Swizerland.
[From our post with @redouad on death rates by vaccination status: https://t.co/nNmfYAk0m1] pic.twitter.com/dRwkOWIRBa
— Max Roser (@MaxCRoser) December 26, 2021
Statement on potential drug-drug interactions between Ritonavir-boosted Nirmatrelvir (Paxlovid) and concomitant medications; antiarrhythmics, oral anticoagulants, immunosuppressants, anticonvulsants, antineoplastics, and neuropsychiatric drugs are among the drugs of concern.
12 Jan, 2022 | 09:09h | UTCCommentaries:
Pfizer antiviral pills may be risky with other medications – NBC News
See also: What’s New in the Guidelines – NIH COVID-19 Treatment Guidelines
Podcast: Long COVID Pearls.
12 Jan, 2022 | 09:04h | UTC#315 Long COVID with Dr. Monica Verduzco-Gutierrez – The Curbsiders
[Preprint] Saliva swabs may be the preferred sample for Omicron detection.
12 Jan, 2022 | 08:58h | UTCSaliva swabs are the preferred sample for Omicron detection – medRxiv
Commentary: Study suggests saliva swabs may be more suitable for omicron detection – News Medical
Perspective | Covid-19: Is it safe to reduce the self-isolation period?
12 Jan, 2022 | 09:00h | UTCCovid-19: Is it safe to reduce the self-isolation period? – The BMJ
Two years of coronavirus: how pandemic unfolded around the world.
12 Jan, 2022 | 09:02h | UTCTwo years of coronavirus: how pandemic unfolded around the world – The Guardian
A cluster randomized trial in a yaws-endemic area of Papua New Guinea showed a reduction in the community prevalence of yaws with three rounds of mass administration of azithromycin at 6-month intervals compared with one round of mass administration of azithromycin followed by two rounds of targeted treatment.
12 Jan, 2022 | 08:44h | UTCTrial of Three Rounds of Mass Azithromycin Administration for Yaws Eradication – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Data from a community-based trial in Papua New Guinea suggest that more than one round of mass drug administration should be considered as part of the strategy for yaws eradication. https://t.co/7Cfuz16CUa pic.twitter.com/pVRyefOlTb
— NEJM (@NEJM) January 6, 2022
Systematic Review: First-generation cephalosporins for the treatment of complicated upper urinary tract infection in adults.
11 Jan, 2022 | 02:23h | UTC
Commentary on Twitter
Interesting! Why not?
🆕💥Systematic literature review First-generation cephalosporins mainly Cefazolin and one study Cefadroxil for the treatment of complicated upper urinary tract infection in adults
Comparators mainly 3d G
Old studies
No meta-analysis https://t.co/EHamKpfKZQ— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) January 10, 2022
Systematic Review: The effectiveness and safety of treatments for recurrent vulvovaginal candidiasis.
11 Jan, 2022 | 02:24h | UTCTreatment for recurrent vulvovaginal candidiasis (thrush) – Cochrane Library
Cohort Study: Ciprofloxacin exposure during pregnancy was not associated with miscarriage or major malformations in a nationwide study from Denmark.
11 Jan, 2022 | 02:08h | UTCCiprofloxacin exposure and adverse pregnancy outcomes: a Danish nationwide cohort study – BJOG (link to abstract – $ for full-text)
Cohort study: Among health care workers previously vaccinated with 2 doses of the Pfizer-BioNTech vaccine, receiving a third dose was associated with reduced risk of SARS-CoV-2 infection.
11 Jan, 2022 | 01:35h | UTCEditorial: Booster Vaccination to Reduce SARS-CoV-2 Transmission and Infection – JAMA
Covid-19’s Devastating Effect on Tuberculosis Care — A Path to Recovery.
11 Jan, 2022 | 01:33h | UTC
Commentary on Twitter
In @NEJM today, @TerezaKasaeva @doctorsoumya and I write about
Covid-19’s devastating impact on tuberculosis care & offer suggestions for recoveryhttps://t.co/buOEOPVWwM pic.twitter.com/BfOK3X3MuU
— Madhu Pai, MD, PhD (@paimadhu) January 5, 2022
Review: Rapid diagnostic testing for SARS-CoV-2.
11 Jan, 2022 | 01:34h | UTCRapid Diagnostic Testing for SARS-CoV-2 – New England Journal of Medicine