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Infectious Diseases (all articles)

Critical appraisal of the new CDC article on the effectiveness of masks for the prevention of Covid-19.

7 Feb, 2022 | 08:52h | UTC

Mask studies reach a new scientific low point – Vinay Prasad’s Observations and Thoughts

Original Study: Effectiveness of Face Mask or Respirator Use in Indoor Public Settings for Prevention of SARS-CoV-2 Infection — California, February–December 2021 – CDC Morbidity and Mortality Weekly Report

Related Studies:

Time to upgrade from cloth and surgical masks to respirators? Your questions answered.

CDC urges Americans to wear most-protective mask or respirator that fits well and that they’ll wear consistently.

Modeling COVID-19 mortality across 44 Countries: Face covering may reduce deaths.

What can masks do? Part 2: What makes for a good mask study — and why most fail.

Opinion | Why Are Americans Still—Still!—Wearing Cloth Masks?

Evidence shows that, yes, masks prevent COVID-19 – and surgical masks are the way to go.

Face masks for COVID pass their largest test yet – “A rigorous study finds that surgical masks are highly protective, but cloth masks fall short”.

[Preprint] Largest study of masks yet details their importance in fighting Covid-19.

 

Commentary on Twitter

 

How Denmark Decided COVID Isn’t a Critical Threat to Society – “The country became the first in the EU to lift all COVID restrictions despite leading the world in per capita infections”.

7 Feb, 2022 | 08:48h | UTC

How Denmark Decided COVID Isn’t a Critical Threat to Society – The Atlantic

Related:

Covid: Europe set for ‘long period of tranquillity’ in pandemic, says WHO.

As Denmark scraps COVID restrictions, WHO urges caution.

Despite the ongoing spread of Omicron, some European countries have decided to lift Covid-19 restrictions.

 

Scientists admit their Covid mistakes – “Being proved wrong lies at the heart of scientific progress. Here, experts reveal what they got wrong during the pandemic”.

7 Feb, 2022 | 08:46h | UTC

‘The case for masks became hugely stronger’: scientists admit their Covid mistakes – The Guardian

 

The costs and benefits of primary prevention of zoonotic pandemics.

7 Feb, 2022 | 08:45h | UTC

The costs and benefits of primary prevention of zoonotic pandemics – Science Advances

Commentary: Preventing pandemics costs far less than controlling them – Duke University

 

A highly virulent variant of HIV-1 circulating in the Netherlands.

7 Feb, 2022 | 08:42h | UTC

A highly virulent variant of HIV-1 circulating in the Netherlands – Science

Commentaries:

New highly virulent and damaging HIV variant discovered in the Netherlands – University of Oxford

Highly virulent HIV variant found circulating in Europe – Nature

 

Summary: 2021 CDC guidelines on sexually transmitted infections.

7 Feb, 2022 | 08:33h | UTC

2021 CDC guidelines on sexually transmitted infections – Family Medicine

Original Guideline: CDC releases new guidelines for the treatment of sexually transmitted infections.

Related: WHO Guidelines for the management of symptomatic sexually transmitted infections.

 

A cohort study including 11 US hospitals and 232 patients with Vancomycin-resistant enterococci (VRE) showed an 18% mortality rate; failure of early eradication of VRE from the bloodstream was the strongest predictor of in-hospital mortality.

7 Feb, 2022 | 08:12h | UTC

Contemporary Clinical and Molecular Epidemiology of Vancomycin-Resistant Enterococcal Bacteremia: A Prospective Multicenter Cohort Study (VENOUS I) – Open Forum Infectious Diseases

 

Commentary on Twitter

 

Expert reaction to a preprint looking at the impact of lockdowns, as posted on the John Hopkins Krieger School of Arts and Sciences website.

4 Feb, 2022 | 10:03h | UTC

Expert reaction to a preprint looking at the impact of lockdowns, as posted on the John Hopkins Krieger School of Arts and Sciences website – Science Media Centre

Original Article: a Literature Review And Meta-Analysis Of The Effects Of Lockdowns On Covid-19 Mortality – John Hopkins Krieger School of Arts and Sciences

Related:

M-A: Effectiveness of public health measures in reducing the incidence of covid-19, SARS-CoV-2 transmission, and covid-19 mortality.

Is the cure really worse than the disease? The health impacts of lockdowns during COVID-19 – “While there are certainly costs to be expected from intervening against COVID-19—every decision has a cost, after all—the counterfactual of an unmitigated epidemic makes these restrictions far less damaging than some have suggested”.

 

What the Omicron wave is revealing about human immunity.

4 Feb, 2022 | 10:01h | UTC

What the Omicron wave is revealing about human immunity – Nature

 

Covid: Europe set for ‘long period of tranquillity’ in pandemic, says WHO.

4 Feb, 2022 | 09:54h | UTC

Covid: Europe set for ‘long period of tranquillity’ in pandemic, says WHO – The Guardian

See also: In Europe, leaders are starting to turn the page on the pandemic. It’s a different story in the US – CNN

 

Experts question unusual authorization plan for Covid vaccine for kids under 5.

4 Feb, 2022 | 09:57h | UTC

Experts question unusual authorization plan for Covid vaccine for kids under 5 – STAT

Related:

Pfizer and BioNTech seeking emergency use authorization from FDA for Covid-19 vaccine for children younger than 5 – CNN

Pfizer asks FDA to allow COVID-19 vaccine for kids under 5 – Associated Press

Pfizer Asks FDA to Approve Its Vaccine for the Youngest Children – HealthDay

 

Podcast: Infective Endocarditis Pearls.

4 Feb, 2022 | 08:27h | UTC

Infective Endocarditis Pearls – The Curbsiders

 

First patients vaccinated in clinical trial of HIV experimental vaccine that uses Moderna’s mRNA technology.

4 Feb, 2022 | 08:25h | UTC

First patients vaccinated in clinical trial of HIV experimental vaccine that uses Moderna’s mRNA technology – CNN

 

[Preprint] Results from the first Covid-19 human challenge study (deliberately infecting individuals in a controlled environment).

3 Feb, 2022 | 09:48h | UTC

Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge – Research Square

Commentaries:

Scientists deliberately gave people COVID — here’s what they learnt – Nature

Expert reaction to a preprint looking at the course of SARS-CoV-2 infection in a COVID-19 human challenge study – Science Media Centre

First COVID-19 human challenge study yields infection clues – CIDRAP

Exposure to one nasal droplet enough for Covid infection – study – The Guardian

Related:

Perspective | SARS-CoV-2 human challenge studies — establishing the model during an evolving pandemic.

World’s first coronavirus “Human Challenge” study receives ethics approval in the UK  (several texts on the subject) Are SARS-CoV-2 Human Challenge Trials Ethical? – “A clinical trial is underway in the UK in which young, healthy participants are exposed deliberately to SARS-CoV-2 to assess the viral inoculum needed to produce an infection and to test vaccine efficacy”.

 

Perspective: Challenges in inferring intrinsic severity of the SARS-CoV-2 Omicron variant.

3 Feb, 2022 | 09:58h | UTC

Challenges in Inferring Intrinsic Severity of the SARS-CoV-2 Omicron Variant – New England Journal of Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 

[Preprint] SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters.

3 Feb, 2022 | 09:50h | UTC

SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters – Nature

See also: [Preprint] Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron – Nature

Commentary: Omicron causes less severe illness in animal models than previous variants – University of Wisconsin–Madison

 

Commentary on Twitter

 

Cohort Study: In high-transmission settings, the use of malaria-preventing mosquito nets in early childhood was associated with increased survival decades later.

3 Feb, 2022 | 08:56h | UTC

Mosquito Net Use in Early Childhood and Survival to Adulthood in Tanzania – New England Journal of Medicine

Commentaries:

Malaria-preventing bed nets save children’s lives—with impacts that can last for decades – Science

Mosquito nets in young children save lives into adulthood – University of Basel

 

Omicron’s sister variant spreads faster. So why did the one we call Omicron hit first?

3 Feb, 2022 | 08:54h | UTC

Omicron’s sister variant spreads faster. So why did the one we call Omicron hit first? – STAT

Related:

[Preprint] Study suggests SARS-CoV-2 Omicron subvariants BA.2 is even more transmissible than the original variant.

BA.2 is like Omicron’s sister. Here’s what we know about it so far – The Conversation

 

Cluster randomized controlled trial: An innovative telemedical network to improve infectious disease management in critically ill patients and outpatients.

3 Feb, 2022 | 08:53h | UTC

An innovative telemedical network to improve infectious disease management in critically ill patients and outpatients: a stepped-wedge, cluster randomized controlled trial (TELnet@NRW) – Journal of Medical Internet Research

Related:

The “Choosing Wisely” initiative in infectious diseases – German Society of Infectious Diseases (link to abstract – $ for full-text)

Infectious Diseases Society of America: Five Things Physicians and Patients Should Question

 

Perspective: Trade-offs and policy options — using insights from economics to inform public health policy.

3 Feb, 2022 | 08:39h | UTC

Trade-offs and Policy Options — Using Insights from Economics to Inform Public Health Policy – New England Journal of Medicine

 

Review: Evaluation and management of vaginitis.

3 Feb, 2022 | 08:37h | UTC

Evaluation and Management of Vaginitis – Mayo Clinic Proceedings

 

Development and validation of BLOOMY prediction scores for 14-day and 6-month mortality in hospitalized adults with bloodstream infections: a multicenter, prospective, cohort study.

3 Feb, 2022 | 08:28h | UTC

Development and validation of BLOOMY prediction scores for 14-day and 6-month mortality in hospitalised adults with bloodstream infections: a multicentre, prospective, cohort study – The Lancet Infectious Diseases (link to abstract – $ for full-text)

 

In mechanically ventilated pediatric patients, an observational study showed hospitals varied widely in their use of endotracheal aspirates cultures, and higher rates were correlated with increased antibiotic use.

3 Feb, 2022 | 08:19h | UTC

Association of Endotracheal Aspirate Culture Variability and Antibiotic Use in Mechanically Ventilated Pediatric Patients – JAMA Network Open

 

Commentary from the author on Twitter (thread – click for more)

https://twitter.com/andreaprinzi/status/1476627285490864128

 

Outpatient Therapies for COVID-19: How do we choose?

2 Feb, 2022 | 08:53h | UTC

Outpatient Therapies for COVID-19: How do we choose? – Open Forum Infectious Diseases

 

WHO Report: Global analysis of health care waste in the context of COVID-19.

2 Feb, 2022 | 08:54h | UTC

Global analysis of health care waste in the context of COVID-19 – World Health Organization

News Release: Tonnes of COVID-19 health care waste expose urgent need to improve waste management systems – World Health Organization

Commentaries:

Covid-19: Pandemic waste threatens human and environmental health, says WHO – The BMJ

Amid Mountains of COVID Waste, WHO Urges Sustainable Solutions – Health Policy Watch

 

Commentary on Twitter (thread – click for more)

 

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