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Infectious Diseases (all articles)

Omicron-specific Sinopharm, Sinovac COVID vaccine candidates cleared for clinical trial.

19 Apr, 2022 | 02:25h | UTC

Omicron-specific Sinopharm, Sinovac COVID vaccine candidates cleared for clinical trial – Reuters

 

Commentary on Twitter

 

M-A: Global prevalence of post COVID-19 condition or long COVID.

19 Apr, 2022 | 02:18h | UTC

Global Prevalence of Post COVID-19 Condition or Long COVID: A Meta-Analysis and Systematic Review – The Journal of Infectious Diseases

Commentary: Global data reveal half may have long COVID 4 months on – CIDRAP

 

Commentary on Twitter (thread – click for more)

 

A systematic review of COVID-19 vaccine efficacy and effectiveness against SARS-CoV-2 infection and disease.

19 Apr, 2022 | 02:14h | UTC

A systematic review of COVID-19 vaccine efficacy and effectiveness against SARS-CoV-2 infection and disease – Open Forum Infectious Diseases

 

Commentary on Twitter

 

Acute hepatitis in ED setting: etiologies, evaluation, and management.

19 Apr, 2022 | 01:54h | UTC

Acute Hepatitis in ED Setting: Etiologies, Evaluation, and Management – emDocs

 

Public health doctors and scientists are investigating 74 cases of hepatitis in children living in the UK that were not caused by hepatitis A to E virus.

18 Apr, 2022 | 10:56h | UTC

Increase in hepatitis (liver inflammation) cases in children under investigation – UK Health Security Agency

Commentaries:

U.S., U.K. investigating unusual cases of hepatitis in young children – STAT

Acute hepatitis of unknown aetiology – the United Kingdom of Great Britain and Northern Ireland – World Health Organization

Increase in acute hepatitis of unknown origin among children – United Kingdom – European Centre for Disease Prevention and Control

Mysterious liver illness seen in kids in US, Europe – Associated Press

 

Commentary on Twitter (thread – click for more)

 

Review: Covid-19: virology, variants, and vaccines.

18 Apr, 2022 | 10:50h | UTC

Covid-19: virology, variants, and vaccines – BMJ Medicine

 

Commentary on Twitter

 

Household transmission of SARS-CoV-2 from unvaccinated asymptomatic and symptomatic household members with confirmed SARS-CoV-2 infection: an antibody-surveillance study.

18 Apr, 2022 | 10:52h | UTC

Household transmission of SARS-CoV-2 from unvaccinated asymptomatic and symptomatic household members with confirmed SARS-CoV-2 infection: an antibody-surveillance study – CMAJ Open

Commentary: COVID-19 household transmission is high, with children being a significant source of spread: study – CHEO

 

Commentary on Twitter (thread – click for more)

 

EBM Analysis: Factors influencing estimated effectiveness of COVID-19 vaccines in non-randomized studies.

18 Apr, 2022 | 10:48h | UTC

Factors influencing estimated effectiveness of COVID-19 vaccines in non-randomised studies – BMJ Evidence-Based Medicine

 

Commentary on Twitter

 

RCT: A 12-months oral itraconazole regimen is superior to 6-months of treatment to prevent relapses of chronic pulmonary aspergillosis.

18 Apr, 2022 | 10:36h | UTC

Efficacy of 12-months oral itraconazole versus 6-months oral itraconazole to prevent relapses of chronic pulmonary aspergillosis: an open-label, randomised controlled trial in India – The Lancet Infectious Diseases (link to abstract – $ for full-text)

 

Cohort Study: Changes in the incidence of retinal vascular occlusions after COVID-19 diagnosis.

18 Apr, 2022 | 10:34h | UTC

Changes in the Incidence of Retinal Vascular Occlusions After COVID-19 Diagnosis – JAMA Ophthalmology

Commentaries:

COVID-19 Diagnosis and Incidence of Retinal Thromboembolism – JAMA Ophthalmology

Threatening Eye Condition Rare After COVID Infection – HealthDay

 

M-A: Myopericarditis following COVID-19 vaccination and non-COVID-19 vaccination.

18 Apr, 2022 | 10:32h | UTC

Myopericarditis following COVID-19 vaccination and non-COVID-19 vaccination: a systematic review and meta-analysis – The Lancet Respiratory Medicine

Commentaries:

Myopericarditis following COVID-19 vaccination is rare, finds international study – The Lancet

Myopericarditis after COVID-19 vaccination: unexpected but not unprecedented – The Lancet Respiratory Medicine

Study explores myopericarditis incidence and COVID-19 vaccination – News Medical

 

Commentary on Twitter

 

Diarrhea during critical illness: a multicenter cohort study.

18 Apr, 2022 | 10:20h | UTC

Diarrhea during critical illness: a multicenter cohort study – Intensive Care Medicine

 

Commentary on Twitter

 

Guidelines for therapeutic drug monitoring of vancomycin in the framework of model-informed precision dosing.

18 Apr, 2022 | 10:26h | UTC

Clinical Practice Guidelines for Therapeutic Drug Monitoring of Vancomycin in the Framework of Model-Informed Precision Dosing: A Consensus Review by the Japanese Society of Chemotherapy and the Japanese Society of Therapeutic Drug Monitoring – Pharmaceutics

Related Guideline:

Guideline: Therapeutic monitoring of vancomycin for serious methicillin-resistant Staphylococcus aureus infections: A revised consensus guideline and review by the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the Society of Infectious Diseases Pharmacists

Summary: Therapeutic Monitoring of Vancomycin for Serious Methicillin-resistant Staphylococcus aureus Infections: A Revised Consensus Guideline and Review by the American Society of Health-system Pharmacists, the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the Society of Infectious Diseases Pharmacists – Clinical Infectious Diseases

 

Commentary on Twitter

https://twitter.com/IDPharmacometrx/status/1514219239732912131

 

A preliminary study showed prolonged viral suppression is feasible with anti-HIV-1 antibody therapy.

18 Apr, 2022 | 10:06h | UTC

Prolonged viral suppression with anti-HIV-1 antibody therapy – Nature

 

Commentary on Twitter

 

Prospective validation of a rapid host gene expression test to discriminate bacterial from viral respiratory infection.

18 Apr, 2022 | 09:58h | UTC

Prospective Validation of a Rapid Host Gene Expression Test to Discriminate Bacterial From Viral Respiratory Infection – JAMA Network Open

 

Commentary on Twitter

 

Risk for asymptomatic household transmission of Clostridioides difficile infection associated with recently hospitalized family members.

18 Apr, 2022 | 09:41h | UTC

Risk for Asymptomatic Household Transmission of Clostridioides difficile Infection Associated with Recently Hospitalized Family Members – Emerging Infectious Diseases

Commentary: Recently Discharged Patients Pose Risk for Spreading C. Difficile Infection – HealthDay

 

Systematic Review: The effect of conditional cash transfers on the control of neglected tropical disease.

18 Apr, 2022 | 09:38h | UTC

The effect of conditional cash transfers on the control of neglected tropical disease: a systematic review – The Lancet Global Health

Invited Commentary: The potential of conditional cash transfers for the control of neglected tropical diseases – The Lancet Global Health

Related: Does giving money to people, in low- and middle-income countries, without conditions attached lead to better health and other life improvements? – Cochrane Library

 

Commentary from the author on Twitter (thread – click for more)

 

A nationwide observational analysis in Israel showed a fourth dose of the Pfizer vaccine may reduce the short-term risk of Covid-19–related outcomes.

14 Apr, 2022 | 08:51h | UTC

Fourth Dose of BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Setting – New England Journal of Medicine

Editorial: Covid-19 Boosters — Where from Here?

Related:

COVID-19: Joint statement from ECDC and EMA on the administration of a fourth dose of mRNA vaccines.

Observational study suggests a fourth dose of the Pfizer vaccine provided additional protection against severe disease in patients 60 years of age or older during the Omicron wave in Israel.

Perspective: The evidence on 4th doses of covid vaccines & the thorny question of age thresholds.

U.S. approves second Covid-19 booster for people 50 and older and immunocompromised individuals.

[Preprint] Retrospective cohort study: second booster vaccine and Covid-19 mortality in adults 60 to 100 years old.

Among health care workers, a fourth dose vaccine effectiveness against any SARS-CoV-2 Omicron variant infection was 30% for the Pfizer–BioNTech and 11% for the Moderna.

[Preprint] Fourth dose of COVID vaccine offers only slight boost against Omicron infection.

Covid-19: Fourth vaccine doses—who needs them and why?

[Not published yet] Study in Israel finds fourth COVID booster has limited efficacy.

 

Commentary on Twitter

 

Covid-19: What is the evidence for the antiviral molnupiravir?

14 Apr, 2022 | 08:47h | UTC

Covid-19: What is the evidence for the antiviral molnupiravir? – The BMJ

 

Study showed low rates of severe COVID-19 in children hospitalized with confirmed SARS-CoV-2 infection.

14 Apr, 2022 | 08:49h | UTC

Very low rates of severe COVID-19 in children hospitalised with confirmed SARS-CoV-2 infection in London, England – Journal of Infection

Commentary: Severe COVID-19 extremely rare among children – News Medical

Related:

[Preprint] Risk of Hospitalization, severe disease, and mortality due to COVID-19 in children with SARS-CoV-2 infection in Germany – “overall hospitalization rate associated with SARS-CoV-2 infection was 35.9 per 10,000 children, ICU admission rate was 1.7 per 10,000 and case fatality was 0.09 per 10,000”.

Deaths in children and young people in England after SARS-CoV-2 infection during the first pandemic year – “In total, 99.995% of children and young people with a positive SARS-CoV-2 test survived”.

Editorial: COVID-19 vaccines for children – “Although it is true that most children experience asymptomatic or mild disease, some will get quite sick, and a small number will die. It’s why children are vaccinated against influenza, meningitis, chickenpox, and hepatitis”.

COVID-19 disease severity in children infected with the Omicron variant.

Risk factors for PICU admission and death among children and young people hospitalized with COVID-19 and PIMS-TS in England during the first pandemic year.

Study identifies risk factors for severe CoviD-19 in children.

A nationwide cohort study in Denmark showed Long Covid in children is rare and mainly of short duration.

International study identifies predictors of severe outcomes in children with COVID-19.

 

RCT: Efficacy, safety, and immunogenicity of an inactivated, adjuvanted enterovirus 71 vaccine in infants and children.

14 Apr, 2022 | 08:43h | UTC

Efficacy, safety, and immunogenicity of an inactivated, adjuvanted enterovirus 71 vaccine in infants and children: a multiregion, double-blind, randomised, placebo-controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)

 

Review | Role of the radiologist in the diagnosis and management of the two forms of hepatic echinococcosis.

14 Apr, 2022 | 07:55h | UTC

Role of the radiologist in the diagnosis and management of the two forms of hepatic echinococcosis – Insights into Imaging

 

Perspective: The concept of classical herd immunity may not apply to COVID-19.

13 Apr, 2022 | 10:54h | UTC

The Concept of Classical Herd Immunity May Not Apply to COVID-19 – The Journal of Infectious Diseases

News Release: NIH experts discuss controlling COVID-19 in commentary on herd immunity – NIH News Releases

 

Commentary on Twitter

 

Cluster RCT: A shorter antimicrobial prophylaxis duration (less than 24 hours after surgery) is noninferior to a more extended regimen (24-48 hours) after clean orthopedic surgery.

13 Apr, 2022 | 10:56h | UTC

Effect of Antimicrobial Prophylaxis Duration on Health Care–Associated Infections After Clean Orthopedic Surgery: A Cluster Randomized Trial – JAMA Network Open

 

Commentary on Twitter

 

Cluster RCT: A multifaceted intervention did not reduce catheter related bloodstream infections in patients on hemodialysis.

13 Apr, 2022 | 10:29h | UTC

Multifaceted intervention to reduce haemodialysis catheter related bloodstream infections: REDUCCTION stepped wedge, cluster randomised trial – The BMJ

 

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