Infectious Diseases (all articles)
Guideline: Differential diagnosis of acute and chronic redness of the lower legs.
29 Jun, 2022 | 11:42h | UTC
WHO Updated Report: Severe acute hepatitis of unknown etiology in children.
28 Jun, 2022 | 11:23h | UTCSevere acute hepatitis of unknown aetiology in children – Multi-country – World Health Organization
Related:
Outbreak of hepatitis in children: clinical course of children with acute liver failure admitted to the intensive care unit – Intensive Care Medicine (if the link is paywalled, try this one)
Investigating Acute Hepatitis of Unknown Origin in Children – American Society for Microbiology
What’s sending kids to hospitals with hepatitis—coronavirus, adenovirus, or both? – Science
Puzzling pediatric hepatitis cases echo an earlier mysterious illness – STAT
Why COVID is a key suspect in severe hepatitis cases in kids worldwide – CBC
Hepatitis outbreak in children: What do we know so far? – Imperial College London
Explaining the unexplained hepatitis in children – The Lancet Infectious Diseases
Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Rheumatic heart disease is a neglected disease relative to its burden worldwide: findings from Global Burden of Disease 2019.
28 Jun, 2022 | 11:17h | UTC
RCT: Two-day vs. seven-day course of levofloxacin in acute COPD exacerbation.
28 Jun, 2022 | 11:19h | UTCCommentary: Antibiotics in COPD Exacerbations – 2 days vs 7 days – RebelEM
Long COVID symptoms in SARS-CoV-2-positive children aged 0–14 years and matched controls in Denmark: a national, cross-sectional study.
28 Jun, 2022 | 11:16h | UTCNews Release: Largest study reports long COVID symptoms in children up to age 14 – Lancet
Commentaries:
Difficult questions about long COVID in children – The Lancet Child & Adolescent Health
Kids do get long COVID, but it seems uncommon, data reveal – CIDRAP
Cardiovascular damage in COVID-19: What we know two years later.
28 Jun, 2022 | 11:11h | UTCCardiovascular Damage in COVID-19: What We Know Two Years Later – Current Cardiology Reports
Cohort Study: Association of receipt of the fourth BNT162b2 dose with omicron infection and COVID-19 hospitalizations among residents of long-term care facilities.
28 Jun, 2022 | 11:08h | UTCCommentary: Fourth Dose of BNT162b2 Prevents Severe COVID-19 in Nursing Home Residents – HealthDay
Commentary on Twitter
Cohort study found that vaccination with a fourth BNT162b2 dose vs 3 doses given 4 months or earlier, was associated with lower risk of hospitalizations by 64-67% and deaths by 72%, among residents of long-term care facilities during massive Omicron surge. https://t.co/LTZ4umgSDh
— JAMA Internal Medicine (@JAMAInternalMed) June 23, 2022
Systematic Review: Antibiotics for uncomplicated diverticulitis.
27 Jun, 2022 | 11:56h | UTCAntibiotics for uncomplicated diverticulitis – Cochrane Library
Summary: Antibiotics for uncomplicated diverticulitis – Cochrane Library
Related:
Efficacy and Safety of Non-Antibiotic Outpatient Treatment in Mild Acute Diverticulitis (DINAMO-study): A Multicentre, Randomised, Open-Label, Non-Inferiority Trial – Annals of Surgery (link to abstract – $ for full-text)
Elective surgical management of diverticulitis – Current Problems in Surgery
Management of Colonic Diverticulitis – Agency for Healthcare Research and Quality
Commentary on Twitter
The benefits of antibiotics in diverticulitis are uncertain with respect to complications, emergency✂️, recurrence, elective colonic resections&long‐term complications. This may be because diverticulitis is❌an infectious disorder, but an inflammatory onehttps://t.co/0HmAllw5Af
— John Damianos, M.D. (@john_damianosMD) June 26, 2022
2022 AHA/ACC key data elements and definitions for cardiovascular and noncardiovascular complications of COVID-19.
27 Jun, 2022 | 12:01h | UTCNews Release: New ACC/AHA Data Standards Address CV, Noncardiovascular Complications of COVID-19 – American College of Cardiology
Epidemiology of myocarditis and pericarditis following mRNA vaccination by vaccine product, schedule, and interdose interval among adolescents and adults in Ontario, Canada.
27 Jun, 2022 | 11:51h | UTCCommentary: Young Men’s Myocarditis Risk 5 Times Higher With Moderna vs Pfizer Vax — But Canadian study finds that 8-week interval before second dose attenuates some of the risk – MedPage Today (free registration required)
[Press Release – not published yet]: RCT: Sanofi-GSK report its vaccine targeted against ancestral and Beta strains had an overall efficacy of 72% against the Omicron variant.
27 Jun, 2022 | 11:52h | UTCPress Release: Sanofi-GSK first to report a successful efficacy study against Omicron with COVID-19 Beta-containing vaccine – Sanofi
Commentaries: Bivalent COVID Vax Gets Phase III Win Against Omicron, Companies Say — Sanofi, GSK boast of 72% efficacy against Omicron variant – MedPage Today (free registration required)
Use of pragmatic and explanatory trial designs in acute care research: lessons from COVID-19.
27 Jun, 2022 | 11:49h | UTC
Commentary on Twitter
NEW Personal View—Use of pragmatic and explanatory trial designs in acute care research: lessons from #COVID19
From Jonathan Casey & colleagues https://t.co/3vJs5j6Q1Q pic.twitter.com/hEUFYxNKRf
— The Lancet Respiratory Medicine (@LancetRespirMed) June 14, 2022
Perspective | What Omicron’s BA.4 and BA.5 variants mean for the pandemic.
27 Jun, 2022 | 11:48h | UTCWhat Omicron’s BA.4 and BA.5 variants mean for the pandemic – Nature
Vaccinations may have prevented almost 20 million COVID-19 deaths worldwide.
27 Jun, 2022 | 11:46h | UTCNews Release: Vaccinations may have prevented almost 20 million COVID-19 deaths worldwide – Imperial College London
Original Study: Global impact of the first year of COVID-19 vaccination: a mathematical modelling study – The Lancet Infectious Diseases
Commentaries:
Covid-19 vaccines prevented nearly 20 million deaths in a year, study estimates – STAT
COVID-19 vaccines saved an estimated 20 million lives in 1 year – CIDRAP
Commentary on Twitter (thread – click for more)
🆕 @TheLancetInfDis
In the 1st year of Covid vaccinations, ~20 million deaths were prevented worldwide (data from 185 countries)
Another ~600,000 lives would have been saved if the @WHO 40% target been achievedhttps://t.co/BWig83xlnN @azraghani @imperialcollege @MRC_Outbreak pic.twitter.com/lF8biBJIlK— Eric Topol (@EricTopol) June 23, 2022
Phase 2a RCT: Vaccine efficacy in adults in a respiratory syncytial virus challenge study.
27 Jun, 2022 | 11:21h | UTCVaccine Efficacy in Adults in a Respiratory Syncytial Virus Challenge Study -New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Challenge Study Shows Efficacy of RSV Vaccine in Healthy Adults – HealthDay
Commentary on Twitter
A human challenge model was used to assess the safety and immunogenicity of an RSV prefusion F protein-based vaccine against RSV infection. The vaccine construct has advanced to further clinical testing.https://t.co/KKfqzCyyGF pic.twitter.com/H7i7F8KLmv
— NEJM (@NEJM) June 22, 2022
Global, regional, and national burden of hepatitis B, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019.
27 Jun, 2022 | 11:17h | UTCCommentary: Chronic Hepatitis B Infections Decreasing in Recent Years – HCP Live
Commentary on Twitter
New research from #GBDStudy – Global, regional, and national burden of hepatitis B, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019https://t.co/e0oxlT2gKd#hepB #HBV #nohep #livertwitter @IHME_UW pic.twitter.com/V8h1LrCoUQ
— The Lancet Gastroenterology & Hepatology (@LancetGastroHep) June 21, 2022
Cluster RCT: Effect of automated telephone infectious disease consultations to nonacademic hospitals on 30-day mortality among patients with Staphylococcus aureus bacteremia.
27 Jun, 2022 | 11:03h | UTC
Commentary on Twitter
In this cluster randomized clinical trial, unsolicited telephone infectious disease consultations did not improve 30-day all-cause mortality in patients with Staphylococcus aureus bacteremia, but may enhance quality of care. https://t.co/YvCy28oSVx
— JAMA Network Open (@JAMANetworkOpen) June 24, 2022
Systematic Review: Parenteral Vitamin C in patients with severe infection.
24 Jun, 2022 | 11:49h | UTCParenteral Vitamin C in Patients with Severe Infection: A Systematic Review – NEJM Evidence
Related:
New COVID drugs face delays as trials grow more difficult.
24 Jun, 2022 | 11:47h | UTCNew COVID drugs face delays as trials grow more difficult – Nature
Perspective | Four areas of health innovation boosted by the pandemic.
24 Jun, 2022 | 11:36h | UTCFour areas of health innovation boosted by the pandemic – Nature Medicine
Commentary on Twitter
Leading researchers speak with @NatureMedicine about how the COVID-19 pandemic has spurred research on wearables, genomic surveillance, behavioral interventions and drug discovery. https://t.co/k3Svb0xBVB
— Nature Portfolio (@NaturePortfolio) June 17, 2022
Is shorter always better? The pros and cons of treating Gram-negative bloodstream infections with 7 days of antibiotics.
24 Jun, 2022 | 11:38h | UTC
EULAR/PRES recommendations for vaccination of pediatric patients with autoimmune inflammatory rheumatic diseases.
24 Jun, 2022 | 11:17h | UTC
Cohort Study: COVID-19 trajectories among 57 million adults in England.
24 Jun, 2022 | 11:34h | UTCNews Release: Most comprehensive analysis of COVID-19 data reveals previously unattributed deaths – Health Data Research UK
Commentary from one of the authors on Twitter (thread – click for more)
📣 COVID-19 trajectories among 57 million adults in England: a cohort study using electronic health records
Proud to share this work with @johanhilge @SpirosDenaxas @BHFDataScience @HDR_UK + team in @LancetDigitalHhttps://t.co/DY96ClN0c3
🧵
— Chris Tomlinson (@tomlincr) June 9, 2022
Hemorrhagic fever with renal syndrome: literature review, epidemiology, clinical picture and pathogenesis.
24 Jun, 2022 | 11:02h | UTC
Retrospective Cohort Study: Prevalence and predictors of Pseudomonas aeruginosa among hospitalized patients with diabetic foot infections.
24 Jun, 2022 | 10:43h | UTC
Commentary on Twitter
Should Empiric DFI treatment include coverage for Pseudomonas aeruginosa?
🆕⚡Multicenter, retrospective cohort @OFIDJournal
257(88%) patients received empiric antibiotics active against PsA, but only 27 (9%) patients had PsA DFI #IDTwitter @BradSpellberg https://t.co/Ef5vD50LOD— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) June 17, 2022