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Infectious Diseases (all articles)

M-A | Prevalence of occult hepatitis B virus infection in adults.

15 Aug, 2022 | 11:59h | UTC

Prevalence of occult hepatitis B virus infection in adults: a systematic review and meta-analysis – The Lancet Gastroenterology & Hepatology

 

Commentary on Twitter

 


RCT | Safety and immunogenicity of a typhoid conjugate vaccine among children aged 9 months to 12 years in Malawi.

15 Aug, 2022 | 11:55h | UTC

Safety and immunogenicity of a typhoid conjugate vaccine among children aged 9 months to 12 years in Malawi: a nested substudy of a double-blind, randomised controlled trial – The Lancet Global Health

Commentaries:

Typhoid conjugate vaccine: are we heading towards the elimination of typhoid in endemic countries? – The Lancet Global Health

New TCV data from Malawi highlight longer-term immune response – Coalition Against Typhoid

Related:

Safety and Efficacy of a Typhoid Conjugate Vaccine in Malawian Children – New England Journal of Medicine

Cluster RCT: Vaccination of children against typhoid fever with a Vi-tetanus toxoid conjugate vaccine in urban Bangladesh conferred 85% total protection.

Randomized Trial: Efficacy Analysis of a Typhoid Conjugate Vaccine

 


M-A | Interventions to reduce infections in patients with hematological malignancies.

15 Aug, 2022 | 11:51h | UTC

Interventions to reduce infections in patients with hematological malignancies: a systematic review and meta-analysis – Blood Advances

Commentary: Prophylactic Immunoglobulin, Vaccinations May Reduce Infections in Hematologic Malignancies – AJMC

 


Review | The COVID-19 pandemic and its consequences for chronic pain.

12 Aug, 2022 | 15:02h | UTC

The COVID-19 pandemic and its consequences for chronic pain: a narrative review – Anaesthesia

 

Commentary on Twitter

 


Review | Cardiovascular complications of pregnancy-associated COVID-19 infections.

12 Aug, 2022 | 15:14h | UTC

Cardiovascular Complications of Pregnancy-Associated COVID-19 Infections – Journal of the American College of Cardiology

Commentaries:

Pregnant Women Are at Increased Risk of Severe Illness, Complications From COVID-19 – American College of Cardiology

Cardiovascular Complications of COVID-19 in Pregnancy Reviewed – HealthDay

 


Age–sex differences in the global burden of lower respiratory infections and risk factors, 1990–2019: results from the Global Burden of Disease Study 2019.

12 Aug, 2022 | 14:58h | UTC

Age–sex differences in the global burden of lower respiratory infections and risk factors, 1990–2019: results from the Global Burden of Disease Study 2019 – The Lancet Infectious Diseases

Invited Commentary: Trends in the global burden of lower respiratory infections: the knowns and the unknowns – The Lancet Infectious Diseases

 

Commentary on Twitter (thread – click for more)

 


M-A | Diagnostic accuracy of urinary antigen tests for pneumococcal pneumonia among patients with acute respiratory failure suspected pneumonia.

12 Aug, 2022 | 14:28h | UTC

Diagnostic accuracy of urinary antigen tests for pneumococcal pneumonia among patients with acute respiratory failure suspected pneumonia: a systematic review and meta-analysis – BMJ Open

 


Podcast | Meningitis pearls.

12 Aug, 2022 | 14:25h | UTC

#346 Meningitis – The Curbsiders

 


RCT | Tobramycin inhalation solution is effective in adults with bronchiectasis with pseudomonas aeruginosa infection.

11 Aug, 2022 | 12:15h | UTC

A Double-blind Randomized Placebo-controlled Phase-3 Trial of Tobramycin Inhalation Solution in Adults with Bronchiectasis with Pseudomonas aeruginosa Infection – CHEST

Commentary: Tobramycin Tames Infection in Bronchiectasis – Medscape (free registration required)

Related Study: Testing the effects of combining azithromycin with inhaled tobramycin for P. aeruginosa in cystic fibrosis: a randomised, controlled clinical trial – Thorax

 


Retrospective cohort study | In patients with recurrent prosthetic joint infection after attempted surgical eradication, chronic antibiotic suppression may be a reasonable strategy in patients who lack or refuse further surgical treatment options.

10 Aug, 2022 | 12:17h | UTC

Predictors of Success with Chronic Antibiotic Suppression for Prosthetic Joint Infections – The Journal of Arthroplasty (link to abstract – $ for full-text)

Commentary: Chronic antibiotic suppression may successfully treat periprosthetic joint infections – Healio (free registration required)

 


Guideline Synopsis | Treatment of Clostridioides difficile infection.

9 Aug, 2022 | 12:54h | UTC

Treatment of Clostridioides difficile Infection – JAMA (free for a limited period)

Original Guideline: ACG Clinical Guidelines: Prevention, Diagnosis, and Treatment of Clostridioides difficile Infections – American Journal of Gastroenterology

Related Guidelines:

Clinical Practice Guideline by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA): 2021 Focused Update Guidelines on Management of Clostridioides difficile Infection in Adults – Clinical Infectious Diseases

Prevention of Clostridioides difficile in hospitals: A position paper of the International Society for Infectious Diseases – International Journal of Infectious Diseases

Clostridioides difficile infection: antimicrobial prescribing – National Institute for Health and Care Excellence

Japanese Clinical Practice Guidelines for Management of Clostridioides (Clostridium) difficile infection – Journal of Infection and Chemotherapy

 

Commentary on Twitter

 


M-A | Immunogenicity, safety, and efficacy of the HPV vaccines among people living with HIV.

9 Aug, 2022 | 12:41h | UTC

Immunogenicity, safety, and efficacy of the HPV vaccines among people living with HIV: A systematic review and meta-analysis – eClinicalMedicine

 


Inhaled antibiotics in critical care: state of the art and future perspectives.

9 Aug, 2022 | 12:30h | UTC

Inhaled antibiotics in critical care: State of the art and future perspectives – Infectious Diseases Now

 


Review | Role of imaging in CNS infections.

9 Aug, 2022 | 12:26h | UTC

Role of imaging in CNS infections – Indian Journal of Pathology & Microbiology

 


Antimicrobial dosing recommendations in pediatric continuous renal replacement therapy: a critical appraisal of current evidence.

5 Aug, 2022 | 13:58h | UTC

Antimicrobial Dosing Recommendations in Pediatric Continuous Renal Replacement Therapy: A Critical Appraisal of Current Evidence – Frontiers in Pediatrics

 


Phase 1 Study | Low-dose subcutaneous or intravenous monoclonal antibody can prevent malaria in a human challenge model.

4 Aug, 2022 | 14:45h | UTC

Low-Dose Subcutaneous or Intravenous Monoclonal Antibody to Prevent Malaria – New England Journal of Medicine

Editorial: Monoclonal Antibodies for Malaria – New England Journal of Medicine

 


Case-Control Study | Outpatient oral macrolide use is associated with increased risk of sensorineural hearing loss in children, adolescents, and young adults.

4 Aug, 2022 | 14:29h | UTC

Association of Outpatient Oral Macrolide Use With Sensorineural Hearing Loss in Children, Adolescents, and Young Adults – JAMA Otolaryngology-Head & Neck Surgery (link to abstract – $ for full-text)

Commentary: Kids’ Hearing Loss Associated With Common Antibiotics — Children and teens with sensorineural hearing loss more often macrolide users – MedPage Today (free registration required)

 


RCT | 72 weeks post-partum follow-up of dolutegravir versus efavirenz initiated in late pregnancy.

4 Aug, 2022 | 14:33h | UTC

72 weeks post-partum follow-up of dolutegravir versus efavirenz initiated in late pregnancy (DolPHIN-2): an open-label, randomised controlled study – The Lancet HIV

Related:

WHO Recommends Dolutegravir as Preferred HIV Treatment Option in All Populations

Week 96 results from a RCT: Efficacy and safety of dolutegravir or darunavir combined with lamivudine plus either zidovudine or tenofovir for second-line treatment of HIV infection.

RCT: Efficacy and safety of switching to the 2-drug regimen Dolutegravir/Lamivudine vs. continuing a 3- or 4-Drug regimen for maintaining virologic suppression in adults living with HIV-1.

RCT: Low-cost, easy to take antiretroviral treatment based on Dolutegravir as first- or second-Line therapy found to be non-inferior to standard care for treating HIV-1 infection in children.

RCT: Dolutegravir or Darunavir in combination with Zidovudine or Tenofovir to treat HIV.

Randomized controlled trial compared three antiretroviral regimens started in pregnant women with HIV

Randomized Trial: Switching to Dolutegravir/Lamivudine Two-Drug Regimen Noninferior to Continuing a Tenofovir Alafenamide–Based Three- or Four-Drug Regimen for Maintenance of Virologic Suppression in Adults With HIV-1

 


M-A | Efficacy of Doxycycline for mild-to-moderate community-acquired pneumonia in adults.

4 Aug, 2022 | 14:17h | UTC

Efficacy of Doxycycline for Mild-to-moderate Community-acquired Pneumonia in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials – Clinical Infectious Diseases (link to abstract – $ for full-text)

 

Commentary on Twitter

 


M-A | The global burden of sore throat and group A Streptococcus pharyngitis.

4 Aug, 2022 | 13:33h | UTC

The global burden of sore throat and group A Streptococcus pharyngitis: A systematic review and meta-analysis – eClinicalMedicine

 


Network M-A | Evidence synthesis evaluating body weight gain among people treating HIV with antiretroviral therapy.

4 Aug, 2022 | 13:30h | UTC

Evidence synthesis evaluating body weight gain among people treating HIV with antiretroviral therapy – a systematic literature review and network meta-analysis – eClinicalMedicine

 

Commentary on Twitter

 


RECOVERY Trial | Baricitinib in patients admitted to hospital with COVID-19.

3 Aug, 2022 | 14:34h | UTC

Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis – The Lancet

Invited Commentary: Baricitinib in COVID-19: a coming-of-age from artificial intelligence to reducing mortality – The Lancet

Related:

Tocilizumab versus baricitinib in hospitalized patients with severe COVID-19: an open label, randomized controlled trial – medRxiv

Baricitinib versus dexamethasone for adults hospitalised with COVID-19 (ACTT-4): a randomised, double-blind, double placebo-controlled trial – The Lancet Respiratory Medicine

Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis – medRxiv

WHO recommends two new drugs to treat COVID-19 – World Health Organization

Efficacy and safety of baricitinib for the treatment of hospitalised adults with COVID-19 (COV-BARRIER): a randomised, double-blind, parallel-group, placebo-controlled phase 3 trial – The Lancet Respiratory Medicine

Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19 – New England Journal of Medicine

 

Commentary on Twitter

Under a Creative Commons Attribution (CC BY 4.0) license

 


Antivirals with activity against Monkeypox: a clinically oriented review.

3 Aug, 2022 | 14:26h | UTC

Antivirals with Activity Against Monkeypox: A Clinically Oriented Review – Clinical Infectious Diseases

Related:

WHO chief advises men who have sex with men to reduce partners to limit exposure to monkeypox – CNN

Clinical features and novel presentations of human monkeypox in a central London centre during the 2022 outbreak: descriptive case series – The BMJ

WHO Declares Global Public Health Emergency Over Monkeypox Virus Outbreak – Health Policy Watch

Monkeypox Virus Infection in Humans across 16 Countries — April–June 2022 – New England Journal of Medicine

Monkeypox: A Contemporary Review for Healthcare Professionals – Open Forum Infectious Diseases

 


Review | Diagnosis, treatment, and prevention of Malaria in the US.

3 Aug, 2022 | 14:27h | UTC

Diagnosis, Treatment, and Prevention of Malaria in the US: A Review – JAMA (free for a limited period)

Audio Clinical Review: Diagnosis, Treatment, and Prevention of Malaria in the US – JAMA

 


Cohort Study | Association of higher-dose fluoroquinolone therapy with serious adverse events in older adults with advanced chronic kidney disease.

3 Aug, 2022 | 14:22h | UTC

Association of Higher-Dose Fluoroquinolone Therapy With Serious Adverse Events in Older Adults With Advanced Chronic Kidney Disease – JAMA Network Open

 


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