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Infectious Diseases (all articles)

Retrospective Cohort: Temporal Trends in Early Antibiotic Use Among Premature Infants

29 May, 2018 | 18:18h | UTC

Temporal Trends and Center Variation in Early Antibiotic Use Among Premature Infants – JAMA Network Open (free)

Commentaries: Avoiding Unnecessary Antibiotic Exposure in Premature Infants: Understanding When (Not) to Start and When to Stop – JAMA Network Open (free) AND Data show vast majority of preemies treated with antibiotics – CIDRAP (free) AND Most Preemies Get Early Antibiotic Tx in NICU – MedPage Today (free registration required)

 


IDSA & AASLD Hepatitis C Guidance Updates

28 May, 2018 | 12:56h | UTC

HCV Guidance: Recommendations for Testing, Managing, and Treating Hepatitis C – American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America (IDSA) (free)

News Release: HCV Guidance Updates Recommendations for Screening and Treating Key Populations (free)

Related Guideline: EASL Recommendations on Treatment of Hepatitis C 2018 – Journal of Hepatology (free)

 


Review: Principles of Fluid Management and Stewardship in Septic Shock

28 May, 2018 | 12:50h | UTC

Principles of fluid management and stewardship in septic shock: it is time to consider the four D’s and the four phases of fluid therapy – Annals of Intensive Care (free) (via @Fluid_Academy)

Related Review: Expert statement for the management of hypovolemia in sepsis – Intensive Care Medicine (free)

 


Latest Developments on the Ebola Outbreak in DRC

28 May, 2018 | 12:52h | UTC

Vaccinations set to begin in Ebola outbreak epicenter – STAT (free) AND Research during Ebola vaccine trial: It’s complicated – Science (free) AND New Ebola Tactics Raise Hope but May Sow Confusion – The New York Times (10 articles per month are free) AND Ebola outbreak in DRC on ‘epidemiological knife-edge,’ says WHO official – Devex (free) AND The success of the new Ebola vaccine will hinge on trust – VOX (free)

 


Pre-Post Intervention Study: Decreased Surgical Site Infection Rate in Hysterectomy

28 May, 2018 | 12:21h | UTC

Decreased Surgical Site Infection Rate in Hysterectomy: Effect of a Gynecology-Specific Bundle – Obstetrics & Gynecology (link to abstract – $ for full-text)

Commentaries: Surgical site infection rate can be reduced in hysterectomy – MedicalXpress (free) AND Prevention Bundle Halves Rate of Surgical Site Infections, Study Suggests – Medscape (free registration required)

 


WHO Disease Outbreak News: Ebola in Democratic Republic of the Congo

24 May, 2018 | 22:49h | UTC

Disease Outbreak News: Ebola virus disease – Democratic Republic of the Congo – World Health Organization (free)

Commentaries: WHO: 58 Ebola cases in DRC, 27 deaths – CIDRAP (free)

 


Research: Antibiotic Resistance Increases with Local Temperature

24 May, 2018 | 22:28h | UTC

Antibiotic resistance increases with local temperature – Nature Climate Change (free for a limited period)

Commentaries: A Warming Climate May Produce More Drug-Resistant Infections – Scientific American (free) AND Study finds antibiotic resistance rise tied to hotter temps – CIDRAP (free)

 


Disease Outbreak News: WHO Supports Ebola Vaccination of High Risk Populations in the DRC

23 May, 2018 | 12:44h | UTC

WHO supports Ebola vaccination of high risk populations in the Democratic Republic of the Congo – World Health Organization (free)

Commentaries: Experimental Ebola Vaccinations, Considered ‘Paradigm Shift,’ Begin In Congo – NPR (free) AND Ebola vaccine drive launches in DRC as cases rise to 49 – CIDRAP (free) AND Congo begins giving experimental Ebola vaccine to medics – Reuters (free)

See also: Frequently asked questions on Ebola virus disease vaccine – World Health Organization (free)

“Health workers operating in affected areas in the Democratic Republic of the Congo are being vaccinated today and community outreach has started to prepare for the ring vaccination” (via @WHO see Tweet)

 


Randomized Trial: Procalcitonin-Guided Therapy Did Not Reduce the Use of Antibiotics

23 May, 2018 | 12:43h | UTC

Procalcitonin-Guided Use of Antibiotics for Lower Respiratory Tract Infection – New England Journal of Medicine (free)

Commentaries: Procalcitonin-Guided Care Doesn’t Reduce Antibiotics for Lower Respiratory Tract Infection – NEJM Journal Watch (free) AND Infection blood test of limited value in reducing antibiotic use – MedicalXpress (free)

 


Perspective: How PrEP to Prevent HIV May be Fueling a Rise in Other STDs

23 May, 2018 | 12:36h | UTC

How PrEP, the pill to prevent HIV, may be fueling a rise in other STDs – Vox (free)

Original Meta-Analysis: Effects of Pre-exposure Prophylaxis for the Prevention of Human Immunodeficiency Virus Infection on Sexual Risk Behavior in Men Who Have Sex With Men: A Systematic Review and Meta-analysis – Clinical Infectious Diseases (link to abstract – $ for full-text)

See also: Guidelines on HIV Pre-exposure Prophylaxis (all free)

 


Meta-Analysis: Corticosteroids for Patients with Septic Shock

23 May, 2018 | 12:28h | UTC

Low-dose corticosteroids for adult patients with septic shock: a systematic review with meta-analysis and trial sequential analysis – Critical Care Medicine (free for a limited period)

Source: Critical Care Reviews Newsletter

“In adults with septic shock treated with low dose corticosteroids, short- and longer-term mortality are unaffected, adverse events increase, but duration of shock, mechanical ventilation and ICU stay are reduced”.

 


Guideline: Use of Atraumatic Needles in All Patients Undergoing Lumbar Puncture

23 May, 2018 | 12:32h | UTC

Rapid Recommendations: Atraumatic (pencil-point) versus conventional needles for lumbar puncture: a clinical practice guideline – The BMJ (free)

“We issue a strong recommendation for use of atraumatic needles in all patients (adults and children) undergoing lumbar puncture because they decrease complications and are no less likely to work than conventional needles”

 


Research: Clinical Features of Guillain-Barré Syndrome With vs Without Zika Virus Infection

23 May, 2018 | 12:23h | UTC

Clinical Features of Guillain-Barré Syndrome With vs Without Zika Virus Infection, Puerto Rico, 2016 – JAMA Neurology (link to abstract – $ for full-text)

Commentary: Study: GBS symptoms more severe when caused by Zika – CIDRAP (free)

 


Pre-Post Intervention Study: Adverse Events Decline After Elimination of Contact Precautions

23 May, 2018 | 12:12h | UTC

Noninfectious Hospital Adverse Events Decline After Elimination of Contact Precautions for MRSA and VRE – Infection Control & Hospital Epidemiology (link to abstract – $ for full-text)

Commentary: Hospital adverse events decline after routine contact precautions removed – Healio (free registration required)

 


Disease Outbreak News: WHO Statement Regarding the Ebola Outbreak in 2018

21 May, 2018 | 13:13h | UTC

Statement on the 1st meeting of the IHR Emergency Committee regarding the Ebola outbreak in 2018 – World Health Organization (free)

Commentaries: WHO: Ebola in DRC not global emergency; ring vaccination starts in 2 days – CIDRAP (free) AND Ebola outbreak is concerning, but falls short of global emergency, WHO panel says – STAT (free)

 


CDC Report: Outbreaks Associated with Treated Recreational Water

21 May, 2018 | 13:10h | UTC

Outbreaks Associated with Treated Recreational Water — United States, 2000–2014 – MMWR, CDC (free)

Commentaries: Hotel pools a factor in water-related illness outbreaks – CIDRAP (free) AND Crypto, Pseudomonas and Legionella responsible for most outbreaks in swimming venues – Outbreak News Today (free) AND Sparkling Pool Water May Hold Disease-Causing Parasites – The New York Times (10 articles per month are free) AND CDC: How To Avoid Getting Sick From A Hotel Swimming Pool – Forbes (free)

 


Randomized Trial: Ibuprofen Alone For Uncomplicated UTI

18 May, 2018 | 02:41h | UTC

Ibuprofen versus pivmecillinam for uncomplicated urinary tract infection in women—A double-blind, randomized non-inferiority trial – PLOS Medicine (free)

Commentary: Ibuprofen alone not an option for simple UTIs, study finds – CIDRAP (free) AND Randomized trial finds ibuprofen not a safe alternative to antibiotics for UTIs – PLOS, via ScienceDaily (free)

Related Research: Symptomatic treatment of uncomplicated lower urinary tract infections in the ambulatory setting: randomised, double blind trial- The BMJ (free)

 


WHO Manual: Key Facts About Major Deadly Diseases

18 May, 2018 | 02:42h | UTC

Managing epidemics: Key facts about major deadly diseases – World Health Organization (free)

“Managing epidemics. This @WHO manual provides concise, up-to-date knowledge on 15 infectious diseases that have the potential to become international threats, and tips on how to respond to each of them”. (via @Onisillos and @claireekt see Tweet)

 


Disease Outbreak: Ebola Case Confirmed in Urban Area of DRC

18 May, 2018 | 02:30h | UTC

WHO concerned as one Ebola case confirmed in urban area of Democratic Republic of the Congo – World Health Organization (free)

Commentary: As Ebola hits major DRC city, WHO convenes emergency panel – CIDRAP (free) AND WHO to weigh declaration of international emergency over Ebola outbreak – STAT (free) AND Congo and WHO race to prevent runaway Ebola outbreak – Reuters (free) AND Fears of Larger Contagion as Ebola Spreads to Major Congo City  The New York Times (10 articles per month are free)

 


Report: The Characteristics of Pandemic Pathogens

16 May, 2018 | 01:23h | UTC

The Characteristics of Pandemic Pathogens: Improving Pandemic Preparedness by Identifying the Attributes of Microorganisms Most Likely to Cause a Global Catastrophic Biological Event – Johns Hopkins Bloomberg School of Public Health (free PDF)

News release: Study by center for health security identifies characteristics of microorganisms most likely to cause a global pandemic (free)

Commentaries: Is this the face of Disease X? The deadly pathogens which could cause the next global pandemic – The Telegraph (free) AND The Next Deadly Pandemic Could Be Unlike Any Threats We Know, Say Experts – Science Alert (free) AND The Next Pandemic: Forget Zika Or Ebola, Airborne Viruses Like The Flu And The Common Cold Are The Real Threat – Inquisitr (free) AND Report: Next Pandemic Will Likely Be Respiratory-Based Virus – MedPage Today (free)

Related: Are we prepared for the looming epidemic threat? (free commentaries and video)

 


News Story: Experimental Vaccine to be Used Against New Ebola Outbreak in the DRC

16 May, 2018 | 01:11h | UTC

Experimental vaccine to be used against Ebola outbreak in the DRC – STAT (free)

Related: WHO to send vaccines to fight new Ebola outbreak – NBC News (free) AND The New Ebola Outbreak Could Take ‘Three, Maybe Four’ Months to Control – The Atlantic (free)

See also: WHO News: Ebola Outbreak Declared in Democratic Republic of the Congo (free news release and commentaries)

 


Report: Anesthesia, Surgery and Life-Threatening Allergic Reactions

16 May, 2018 | 00:59h | UTC

NAP6 Report: Anaesthesia, Surgery and Life-Threatening Allergic Reactions: Report and findings of the Royal College of Anaesthetists’ 6th National Audit Project (free PDF)

News Release: RCoA undertakes largest ever study of anaphylaxis in anaesthesia and surgery (free)

Infographic: Anaesthesia, Surgery and Life-Threatening Allergic Reactions (free PDF)

“The study found teicoplanin is 17-fold more likely to cause anaphylaxis than penicillin and similar drugs. As 90 per cent of patients who report penicillin allergy are in fact not allergic, better identification of true allergy would reduce risk”. (from News Release)

 


Case Control Study: Oral Antibiotic Exposure and Kidney Stone Disease

16 May, 2018 | 00:56h | UTC

Oral Antibiotic Exposure and Kidney Stone Disease – Journal of the American Society of Nephrology (link to abstract – $ for full-text)

Commentaries: Study suggests oral antibiotics may increase kidney stone risk – CIDRAP (free) AND Antibiotics May Raise the Risk for Kidney Stones – The New York Times (free) AND Oral Antibiotics May Raise Risk of Kidney Stones – Children’s Hospital of Philadelphia, via NewsWise (free)

 


Study: Testing Blood Donations for Zika Virus is Costly and Finds Few Infections

15 May, 2018 | 09:36h | UTC

Investigational Testing for Zika Virus among U.S. Blood Donors – New England Journal of Medicine (free)

Quick Take Video Summary: Testing Blood Donations for Zika Virus (free)

Sounding Board: Revisiting Blood Safety Practices Given Emerging Data about Zika Virus (free)

Commentaries: Study: Zika blood donation screening costly, finds few cases – CIDRAP (free) AND Testing for Zika virus in blood donors finds few infections — at a cost of about $5.3 million each – STAT (free)

 


Perspective: The Catch-22 of Mass-Prescribing Antibiotics

11 May, 2018 | 02:57h | UTC

The Catch-22 of Mass-Prescribing Antibiotics – Wired (free)

Related Commentary: African study on pre-emptive antibiotics in kids spurs resistance debate – CIDRAP (free)

Related Study: Azithromycin to Reduce Childhood Mortality in Sub-Saharan Africa – New England Journal of Medicine (free)

 


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