Infectious Diseases (all articles)
[Abstract Only] Randomized Trial: Prevention of Early Ventilator-Associated Pneumonia after Cardiac Arrest
7 Nov, 2019 | 08:24h | UTCPrevention of Early Ventilator-Associated Pneumonia after Cardiac Arrest – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Routine Antibiotics Help Ventilated Patients After Cardiac Arrest – MedPage Today (free registration required)
[Abstract Only] Randomized Trial: Efficacy of a Tetravalent Dengue Vaccine in Healthy Children and Adolescents
7 Nov, 2019 | 08:28h | UTCEfficacy of a Tetravalent Dengue Vaccine in Healthy Children and Adolescents – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: A Takeda vaccine for dengue appears effective, but the story is nuanced – STAT (free) AND A new dengue vaccine shows promise — at least for now – ScienceNews (free) AND New dengue vaccine performs well in large trial, but safety remains key concern – Science (a few articles per month are free) AND Takeda’s dengue vaccine effective overall in study but with major limitation – Reuters (free)
Guidelines for Water Disinfection for Wilderness, International Travel, and Austere Situations
6 Nov, 2019 | 08:38h | UTC
[Abstract Only] Cohort Study: Fecal Microbiota Transplantation Associated with Improved Outcomes in Patients with Clostridium Difficile Infection
6 Nov, 2019 | 08:33h | UTCIncidence of Bloodstream Infections, Length of Hospital Stay, and Survival in Patients With Recurrent Clostridioides difficile Infection Treated With Fecal Microbiota Transplantation or Antibiotics: A Prospective Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Study: Fecal Transplants Cut Sepsis Risk in Patients With C. Diff – MedPage Today (free registration required)
Related: Clostridioides Difficile: Diagnosis and Treatments (free guidelines and reviews)
Systematic Review: Intra‐pleural Fibrinolytic Therapy for the Treatment of Parapneumonic Effusions and Empyema
31 Oct, 2019 | 08:18h | UTCIntra‐pleural fibrinolytic therapy versus placebo, or a different fibrinolytic agent, in the treatment of adult parapneumonic effusions and empyema – Cochrane Library (free)
Summary: Clot-busting drugs for infections of the lining of the lung – Cochrane Library (free)
Review: Vaccines for International Travel
4 Nov, 2019 | 00:28h | UTCVaccines for International Travel – Mayo Clinic Proceedings (free)
See also: Just Released. 2020 Edition of CDC Traveler’s Health Yellow Book (free resources)
Observational Study: Perioperative Disposable Jackets Not Associated with Reductions in Surgical Site Infections
3 Nov, 2019 | 20:03h | UTCAssociation of Disposable Perioperative Jackets With Surgical Site Infections in a Large Multicenter Health Care Organization – JAMA Surgery (free for a limited period)
Related Commentary on Twitter
Disposable perioperative jackets do not decrease the incidence of SSIs https://t.co/aLTeOT3CWL #NorthwellHealth #PlainviewOrthopaedics #NorthwellOrthopaedicInstitute pic.twitter.com/S58u9TYs1G
— JAMA Surgery (@JAMASurgery) October 23, 2019
Research: Measles Virus Infection Diminishes Preexisting Antibodies that Offer Protection from Other Pathogens
1 Nov, 2019 | 08:45h | UTCMeasles virus infection diminishes preexisting antibodies that offer protection from other pathogens – Science (free for a limited period)
Related Research: Incomplete genetic reconstitution of B cell pools contributes to prolonged immunosuppression after measles – Science Immunology (free for a limited period)
Commentaries: How measles infections can wipe away immunity to other diseases – STAT (free) AND Measles wipe immune system’s memory of other illnesses, studies find – CNN (free) AND Measles Virus May Wipe Out Immune Protection For Other Diseases – NPR (free) AND Measles vaccines protect against more than just measles. Here’s how. – National Geographic (free) AND Measles Infection Could Leave Kids Vulnerable to Other Diseases – Scientific American (free)
Related Commentary on Twitter
The measles infection can cripple long-term immunity against viruses and bacteria, creating a kind of “immune amnesia” that leaves individuals more vulnerable to future infections by other pathogens, according to two studies:
▶ https://t.co/te7kr7N7Ju
▶ https://t.co/tiSTrvyQob pic.twitter.com/taaN3KIMPk— Science Magazine (@ScienceMagazine) October 31, 2019
[Abstract Only] New Details Emerge in Case of First Death from Fecal Transplant
31 Oct, 2019 | 08:30h | UTCOriginal Article: Drug-Resistant E. coli Bacteremia Transmitted by Fecal Microbiota Transplant – New England Journal of Medicine ($)
Related FDA Safety Alert: Fecal Transplant May Have Caused a Patient’s Death Due to Transmission of a Multi-Drug Resistant Organism (free)
Study: Long-term Survival and Cause-specific Mortality of Patients Newly Diagnosed with Tuberculosis
31 Oct, 2019 | 08:27h | UTCLong-term survival and cause-specific mortality of patients newly diagnosed with tuberculosis in São Paulo state, Brazil, 2010–15: a population-based, longitudinal study – The Lancet Infectious Diseases (free) (via @otavio_ranzani see Tweet)
Invited Commentary: Tuberculosis: an instrument of early mortality in life course (free)
Related Commentary on Twitter
Important study from Brazil! Post-tuberculosis sequelae and vulnerability are associated with excess mortality and must be addressed to mitigate the tuberculosis burden worldwide. Via @TheLancetInfDis @otavio_ranzani https://t.co/xHtEmBc4Sr
— Madhu Pai, MD, PhD (@paimadhu) October 31, 2019
[Abstract Only] Randomized Trial: Experimental Vaccine Partially Effective at Preventing Latent Tuberculosis from Turning into Active Disease
30 Oct, 2019 | 08:20h | UTCFinal Analysis of a Trial of M72/AS01E Vaccine to Prevent Tuberculosis – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Vaccine shows promise for preventing active TB disease – Associated Press (free) AND Researchers move closer to new vaccine for killer TB – MedicalXpress (free)
Randomized Trial: Levofloxacin Prophylaxis Reduces Early Deaths in Patients with Newly Diagnosed Myeloma
30 Oct, 2019 | 08:17h | UTCCommentaries: Reducing infection-related morbidity and mortality in patients with myeloma – The Lancet Oncology (free) AND Abx Prophylaxis Cuts Early Death in Newly Diagnosed Myeloma – MedPage Today (free)
Congenital Chagas Disease: Updated Recommendations
30 Oct, 2019 | 07:44h | UTC
Analysis: Is Mycobacterium Tuberculosis Infection Life Long?
27 Oct, 2019 | 23:44h | UTCIs Mycobacterium tuberculosis infection life long? – The BMJ (free)
Commentaries: Tuberculous infection is not life-long in most people – University of Pennsylvania School of Medicine (free) AND In the absence of a true test for latent TB we need shorter, safer preventive treatments – The BMJ Opinion (free)
Related Commentary on Twitter
People with immunoreactivity to tuberculosis are thought to have lifelong asymptomatic infection and remain at risk for active tuberculosis. Is this assumption valid? Marcel A Behr and colleagues argue that most of these people are no longer infected https://t.co/LlRcMNlriJ
— The BMJ (@bmj_latest) October 27, 2019
Opinion – “Sepsis Hysteria: Excess Hype and Unrealistic Expectations”
27 Oct, 2019 | 23:49h | UTCSepsis hysteria: excess hype and unrealistic expectations – The Lancet (free)
Commentary: Sepsis myths create ‘unhealthy climate of fear’, say experts – The Guardian (free)
Source: Grupo UTIclínica – HCFMUSP
Related Commentary on Twitter
"It is crucial to expose the fictions surrounding #sepsis…to create realistic expectations about outcomes"
Sepsis hysteria: NEW Correspondence from M Singer, M Inada-Kim & M Shankar-Hari https://t.co/3oVYkE1BQS pic.twitter.com/gMvdVyCicc
— The Lancet (@TheLancet) October 25, 2019
Cohort Study: Transmissibility and Potential for Disease Progression of Drug Resistant Mycobacterium Tuberculosis
27 Oct, 2019 | 19:15h | UTCCommentary: Peruvian study finds MDR-TB just as transmissible as drug-sensitive TB – CIDRAP (free – 2nd commentary)
WHO: Two out of Three Wild Poliovirus Strains Eradicated
25 Oct, 2019 | 08:47h | UTCTwo out of three wild poliovirus strains eradicated – World Health Organization (free)
Commentaries: World Polio Day: Wild poliovirus type 3 declared eradicated – CIDRAP (free) AND WHO just declared another polio virus strain eradicated. There’s one more to go. – VOX (free) AND Two Strains of Polio Are Gone, but the End of the Disease Is Still Far Off – The New York Times (10 articles per month are free) AND Two Strains of Polio Down, One to Go – Scientific American (3 articles per month are free)
Study Suggests Methicillin-Resistant Staphylococcus Aureus (MRSA) Acquisition and Infections are Not Impacted by use of Active Surveillance and Contact Precautions
24 Oct, 2019 | 08:14h | UTCThe effectiveness of Contact Precautions on methicillin-resistant Staphylococcus aureus (MRSA) in long-term care across the United States – Clinical Infectious Diseases (free for a limited period)
Commentary: VA study finds contact precautions don’t affect MRSA in long-term care – CIDRAP (free)
Study: Stress Related Disorders Linked to Subsequent Risk of Life-Threatening Infections
24 Oct, 2019 | 07:33h | UTCEditorial: Stress related disorders and physical health (free)
Commentary: Stress-related disorders linked to subsequent risk of severe infections – British Medical Journal (free)
[Abstract Only] Study: Pan-viral Serology Implicates Enteroviruses in Acute Flaccid Myelitis
22 Oct, 2019 | 08:08h | UTCPan-viral serology implicates enteroviruses in acute flaccid myelitis – Nature (link to abstract – $ for full-text)
Commentaries: ‘Missing’ Virus Detected in Dozens of Children Paralyzed by Polio-Like Illness – UC San Francisco (free) AND What Causes a Mysterious Paralysis in Children? Researchers Find Viral Clues – The New York Times (10 articles per month are free) AND Virus could be the cause of mysterious polio-like illness AFM, study says – CNN (free)
Podcast: Tuberculosis Updates
22 Oct, 2019 | 08:05h | UTC#178 Tuberculosis Updates with Laila Woc-Colburn MD – The Curbsiders Internal Medicine Podcast (free audio)
Systematic Review: Pharmacologic and Nonpharmacologic Therapies in Adult Patients with Exacerbation of COPD
20 Oct, 2019 | 23:11h | UTCSee also: Full Report (free PDF)
Related: NICE Guideline: Acute Exacerbation of COPD (free)
Meta-Analysis: Interleukin Inhibitors Increase the Risk of Infections and Cancer in Patients with Rheumatologic Diseases
22 Oct, 2019 | 07:38h | UTCCommentary: Interleukin Targeted Biologics Increase Risks of Infection – RheumNow (free)
Commentary on the New Pneumonia Guidelines Using GIFs & Some Mini-rants
20 Oct, 2019 | 23:03h | UTCPulmCrit- Commentary on the new pneumonia guidelines using GIFs & some mini-rants (free)
Original Article: ATS/IDSA Guideline: Diagnosis and Treatment of Adults with Community-acquired Pneumonia (free resources)
WHO Global Tuberculosis Report 2019
18 Oct, 2019 | 08:29h | UTCGlobal tuberculosis report 2019 – World Health Organization (free)
New Release: 7 million people receive record levels of lifesaving TB treatment but 3 million still miss out – World Health Organization (free)
Commentaries: WHO TB 2019 report: Unprecedented political commitment leads to unprecedented progress – Science Speaks: Global ID News (free) AND World Falling Short Of 2020 Targets For ‘End TB’ Strategy – Health Policy Watch (free) AND Fighting TB: Slow Progress Should Ignite Action – Forbes (free)