Infectious Diseases (all articles)
Study: Rifampicin is Likely to be the Safest Latent Tuberculosis Infection Treatment Option
12 Jan, 2020 | 21:26h | UTCAdverse events in adults with latent tuberculosis infection receiving daily rifampicin or isoniazid: post-hoc safety analysis of two randomised controlled trials – The Lancet Infectious Diseases (free registration required)
Commentaries: What is the best regimen to treat latent tuberculosis infection? – The Lancet Infectious Diseases (free) AND Four Months of Rifampicin May Be Best Option for Latent TB – Medscape / Reuters (free registration required)
Related Commentary on Twitter
New study @McGill_TB: “In patients without a contraindication, rifampicin is likely to be the safest latent tuberculosis infection treatment option.” https://t.co/rg2wmcLcqo
— Madhu Pai, MD, PhD (@paimadhu) January 9, 2020
Special Issue: Uncommon Severe Infections in the Intensive Care Unit
12 Jan, 2020 | 21:20h | UTCHomepage: Uncommon Severe Infections in the Intensive Care Unit – Clinical Microbiology and Infection (free articles)
– Improving care for the ICU patient with suspected infection: a multidisciplinary perspective
– Necrotizing skin and soft-tissue infections in the intensive care unit
– Management of infected pancreatic necrosis in the intensive care unit: a narrative review
– Mediastinitis in the intensive care unit patient: a narrative review
– When not to start antibiotics: avoiding antibiotic overuse in the intensive care unit
WHO Statement Regarding Cluster of Pneumonia Cases in Wuhan, China
12 Jan, 2020 | 21:09h | UTCWHO Statement Regarding Cluster of Pneumonia Cases in Wuhan, China – World Health Organization (free)
Related: Mystery virus found in Wuhan resembles bat viruses but not SARS, Chinese scientist says – Science (free) AND China releases genetic data on new coronavirus, now deadly – CIDRAP (free) AND Man infected with mystery virus in China dies after outbreak – Reuters (free) AND Outbreak of Pneumonia of Unknown Etiology (PUE) in Wuhan, China – CDC (free) AND New virus identified as likely cause of mystery illness in China – Nature (free)
Global Burden of Cancer Attributable to Infections in 2018: A Worldwide Incidence Analysis
9 Jan, 2020 | 23:44h | UTC
Related Commentary on Twitter
New @IARCWHO data show that 2·2 million new cancer cases were attributable to infections in 2018, representing 13% of all cancer cases (excluding non-melanoma skin cancers). H pylori was responsible for most new cases, followed by #HPV, #HBV, and #HCV. https://t.co/X4oNNV7YXf pic.twitter.com/ZCue5yFMn3
— The Lancet Global Health (@LancetGH) December 19, 2019
Study Commentary: Herpes Zoster Vaccine Reduces Chances of Shingles after Stem Cell Transplants
9 Jan, 2020 | 23:22h | UTCHerpes zoster vaccine reduces chances of shingles after stem cell transplants – NIHR Signal (free)
Original Study: Effect of Recombinant Zoster Vaccine on Incidence of Herpes Zoster After Autologous Stem Cell Transplantation: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
AGA Clinical Practice Update: Management of Pancreatic Necrosis
9 Jan, 2020 | 01:27h | UTCRelated Reviews: Step-up approach for the management of pancreatic necrosis: a review of the literature – Trauma Surgery & Acute Care Open (free) AND Management of severe acute pancreatitis – The BMJ (free for a limited period)
Related Guidelines: 2019 WSES guidelines for the management of severe acute pancreatitis – World Journal of Emergency Surgery (free) AND American Gastroenterological Association Institute Guideline on Initial Management of Acute Pancreatitis (free) AND Pancreatitis – National Institute for Health and Care Excellence (free) AND American College of Gastroenterology Guideline: Management of Acute Pancreatitis (free)
[Abstract Only] Study: Hepatitis C–positive Donors are a Viable Option for Heart Transplant
9 Jan, 2020 | 01:18h | UTCExpanding Heart Transplant in the Era of Direct-Acting Antiviral Therapy for Hepatitis C – JAMA Cardiology (link to abstract – $ for full-text)
Commentaries: Hepatitis C-positive donors a viable option to expand heart donor pool – Vanderbilt University Medical Center (free) AND Expanding heart transplant in the era of direct-acting antiviral therapy for hepatitis C – 2 Minute Medicine (free)
Related Studies: Transplant of Hepatitis C–Infected Kidneys Into Uninfected Recipients (link to abstract and commentaries) AND Heart and Lung Transplants from HCV-Infected Donors to Uninfected Recipients (link to abstract and commentaries) AND Direct-Acting Antiviral Prophylaxis in Kidney Transplantation From Hepatitis C Virus–Infected Donors to Noninfected Recipients (link to abstract and commentaries) AND Favorable 1-Year Outcomes with Transplantation of HCV-Viremic Kidneys (link to abstract and commentaries)
Diagnosing Fracture-Related Infection: Current Concepts and Recommendations
8 Jan, 2020 | 21:55h | UTC
Update on Management of Pleural Disease
8 Jan, 2020 | 21:52h | UTCUpdate on Management of Pleural Disease – Current Pulmonology Reports (free)
Related: Pleural Effusion in Adults—Etiology, Diagnosis, and Treatment (free guideline and reviews)
The Decade’s Top 10 Biggest Changes to ID Clinical Practice
8 Jan, 2020 | 08:45h | UTCThe Decade’s Top 10 Biggest Changes to ID Clinical Practice – HIV and ID Observations (free)
Randomized Trial: Switching to Dolutegravir/Lamivudine Two-Drug Regimen Noninferior to Continuing a Tenofovir Alafenamide–Based Three- or Four-Drug Regimen for Maintenance of Virologic Suppression in Adults With HIV-1
8 Jan, 2020 | 08:37h | UTC
Study: Neurodevelopmental Abnormalities in Children with in Utero Zika Virus Exposure Without Congenital Zika Syndrome
8 Jan, 2020 | 08:40h | UTCNeurodevelopmental Abnormalities in Children With In Utero Zika Virus Exposure Without Congenital Zika Syndrome – JAMA Pediatrics (free for a limited period)
Editorial: Neurodevelopmental Abnormalities Associated With In Utero Zika Virus Infection in Infants and Children—The Unfolding Story (free for a limited period)
Commentaries: Study underscores the importance of long-term follow-up for Zika-exposed infants – Children’s National Hospital (free) AND New study shows Zika’s long arm in children – CIDRAP (free) AND Healthy babies exposed to Zika in the womb may suffer developmental delays – ScienceNews (free)
Related: Study: Nearly A Third of Children Exposed to Zika In-utero Develop Neurological Problems by Age 3 (link to abstract and commentary) AND Study: Neurodevelopment in Infants Exposed to Zika Virus In Utero (free study and commentaries)
Clinical Guideline Highlights for the Hospitalist: Diagnosis and Management of Measles
8 Jan, 2020 | 01:00h | UTCOriginal Guideline: Centers for Disease Control and Prevention. Measles (Rubeola): For Healthcare Professionals. 2019 (free)
CDC Recommendations for Providing Quality Sexually Transmitted Diseases Clinical Services
6 Jan, 2020 | 23:25h | UTCCommentary: Guidance developed for providing quality STD care – MedicalXpress (free)
[Abstract Only] Open-Label Randomized Trial: Oseltamivir vs. Usual Care for Influenza-like Illness in Primary Care
6 Jan, 2020 | 23:21h | UTCOseltamivir plus usual care versus usual care for influenza-like illness in primary care: an open-label, pragmatic, randomised controlled trial – The Lancet (link to abstract – $ for full-text)
Commentaries (with conflicting opinions): Tamiflu, Cure-All – Emergency Literature of Note (free) AND Flu antiviral has bigger benefits for sicker, older patients – University of Oxford (free)
Related Systematic Reviews: Neuraminidase inhibitors for preventing and treating influenza in adults and children – Cochrane Library (free) AND Oseltamivir for influenza in adults and children: systematic review of clinical study reports and summary of regulatory comments – The BMJ (free) AND Oseltamivir treatment for influenza in adults: a meta-analysis of randomised controlled trials – The Lancet (free registration required) AND Effectiveness of oseltamivir in adults: a meta-analysis of published and unpublished clinical trials – Family Practice (free)
Related Commentary on Twitter
New paper published in the Lancet found a moderate improvement in symptoms in pts treated with open label oseltamivir compared to usual care. Any one else find it curious it worked equally well in pts with and without confirmed influenza? https://t.co/KpBM1xMOTu pic.twitter.com/GcGi4yFBVO
— Rory Spiegel (@EMNerd_) January 3, 2020
Randomized Trial: Effect of Treating Parents Colonized with Staphylococcus aureus on Transmission to Neonates in the Intensive Care Unit
5 Jan, 2020 | 14:16h | UTCEffect of Treating Parents Colonized With Staphylococcus aureus on Transmission to Neonates in the Intensive Care Unit: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Decreasing Staphylococcus aureus in the Neonatal Intensive Care Unit by Decolonizing Parents – JAMA (free for a limited period)
Commentaries: Decolonizing parents could cut spread of Staph to newborns – CIDRAP (free) AND Trial suggests babies in intensive care can be better protected from parental bacteria – Johns Hopkins Medicine (free)
Intravenous BCG Immunization Greatly Improves its Efficacy in Animal Study
5 Jan, 2020 | 14:12h | UTCPrevention of tuberculosis in macaques after intravenous BCG immunization – Nature (free)
Commentaries: Tuberculosis vaccine finds an improved route – Nature (free) AND New Injection Method Makes an Old TB Vaccine Far More Powerful – New York Times (10 articles per month are free) AND Changed Route of Immunization Dramatically Improves Efficacy of TB Vaccine – NIH News Releases (free)
Another Observational Study Suggests One Dose of HPV Vaccine may be Enough
5 Jan, 2020 | 13:25h | UTCCommentaries: One dose of HPV vaccine may prevent infection from cancer-causing virus, study reveals – News Medical (free) AND Just 1 dose of the HPV vaccine may protect against infection, new study suggests – CNN (free)
Related: Systematic Review: Comparison of Different HPV Vaccine Types and Dose Schedules for Prevention of HPV‐related Disease in Females and Males – Cochrane Library (free) AND Large Observational Study Suggests One Dose of HPV Vaccine May Be as Effective as Three (free)
Schistosomiasis — Assessing Progress toward the 2020 and 2025 Global Goals
5 Jan, 2020 | 13:21h | UTC
Review: Vaccination of Adults in General Medical Practice
5 Jan, 2020 | 13:15h | UTCVaccination of Adults in General Medical Practice – Mayo Clinic Proceedings (free)
Related Immunization Tables: WHO recommendations for routine immunization – summary tables – World Health Organization (free) AND Recommended Adult Immunization Schedule for ages 19 years or older, United States, 2019 – Centers for Disease Control and Prevention (CDC) (free)
Review: Routine Childhood Vaccines Given in the First 11 Months After Birth
5 Jan, 2020 | 13:16h | UTCRoutine Childhood Vaccines Given in the First 11 Months After Birth – Mayo Clinic Proceedings (free)
Related Immunization Tables: WHO recommendations for routine immunization – summary tables – World Health Organization (free) AND Recommended Child and Adolescent Immunization Schedule for ages 18 years or younger, United States, 2019 – Centers for Disease Control and Prevention (CDC) (free)
Review: Selective Decontamination of the Digestive Tract in Critically Ill Patients
13 Dec, 2019 | 10:17h | UTC
Study Shows High Burden of STI Among Individuals Using Preexposure Prophylaxis for the Prevention of HIV Infection
13 Dec, 2019 | 10:15h | UTCCommentaries: The High Burden of Sexually Transmitted Infections in Persons Initiating Preexposure Prophylaxis—Challenge or Opportunity? – JAMA Network Open (free) AND High burden of STIs in people starting treatment to prevent HIV infection – World Health Organization (free) AND STD Infections Common Among Those Starting or Staying on Prep For HIV Prevention – MedicalResearch.com (free)
Systematic Review: Not Enough Evidence to Recommend Shorter Treatment Regimens for People with Pulmonary TB
13 Dec, 2019 | 10:16h | UTCShortened treatment regimens versus the standard regimen for drug‐sensitive pulmonary tuberculosis – Cochrane Library (free)
Summary: Shorter treatment regimens for people with pulmonary tuberculosis – Cochrane Library (free)
European Guidelines for the Treatment of HIV-positive Adults
12 Dec, 2019 | 08:29h | UTCEuropean Guidelines for the treatment of HIV-positive adults – European AIDS Clinical Society (free PDF)
Source: HIV Infection Clinical Practice Guidelines (2019): European AIDS Clinical Society (EACS) – Medscape (free summary – registration required)