Infectious Diseases (all articles)
(Press release – not published yet) Novavax COVID-19 vaccine demonstrates 90% overall efficacy and 100% protection against moderate and severe disease.
15 Jun, 2021 | 09:12h | UTCCommentaries: U.S. clinical trial results show Novavax vaccine is safe and prevents COVID-19 – NIH News Releases AND Novavax Covid-19 vaccine highly effective in late-stage trial, long-awaited results show – STAT AND Powerful new COVID-19 vaccine shows 90% efficacy, could boost world’s supply – Science AND Novavax COVID vaccine 90% effective in phase 3 trial – CIDRAP AND What the Novavax vaccine means for the global fight against Covid-19 – Vox
Commentary on Twitter (thread – click for more)
Good news—Novavax protein-subunit vaccine phase 3 trial shown to to be 90.4% effective overall, 100% against moderate to severe disease. This is different type from mRNA and from AZ/J&J adenovirus vaccines, and different from inactivated types. #COVID19 https://t.co/ajoGhaOUu9
— Eric Feigl-Ding (@DrEricDing) June 14, 2021
SARS-CoV-2 Delta variant in Scotland: demographics, risk of hospital admission, and vaccine effectiveness – “Risk of COVID-19 hospital admission was approximately doubled in those with the Delta VOC when compared to the Alpha VOC”.
15 Jun, 2021 | 09:10h | UTCCommentaries: Delta may raise hospitalisation but vaccine still protects – UK Research and Innovation AND Expert reaction to Lancet research letter analysing data from Scotland on the Delta variant, looking at demographics, risk of hospital admission and vaccine effectiveness – Science Media Centre
Commentary on Twitter (thread – click for more)
Just published @TheLancet
The #DeltaVariant experience in Scotlandhttps://t.co/IfjDJnCAMC
1. #VaccinesWork ("AZ appeared less effective than Pfizer")
2. Younger, unvaccinated got the delta infections
3. Doubling of hospital admissions compared with alpha (B.1.1.7) variant pic.twitter.com/cP8clu57Rd— Eric Topol (@EricTopol) June 14, 2021
Delta variant producing more severe illness, doctors in China say.
15 Jun, 2021 | 09:02h | UTCIn China’s latest outbreak, doctors say the infected get sicker, faster. – The New York Times (a few articles per month are free)
Delta variant causes more than 90% of new Covid cases in UK.
15 Jun, 2021 | 09:04h | UTCDelta variant causes more than 90% of new Covid cases in UK – The Guardian
Commentary on Twitter (thread – click for more)
⚠️90-96% of all #COVID19 in ?? caused by #DeltaVariant.?
?32% of all Delta cases visiting the hospital emergency room are at least 1 dose vaccinated
?33% who are then hospitalized vaccinated
?45% of all deaths got at least 1 shot—➡️ 29% got 2 shots.https://t.co/RViq5NiioQ pic.twitter.com/v2OYV2GM09
— Eric Feigl-Ding (@DrEricDing) June 14, 2021
A new coronavirus variant (Delta) is on the rise. Here’s why experts are concerned.
15 Jun, 2021 | 09:03h | UTCA new coronavirus variant is on the rise. Here’s why experts are concerned – CNN
Case series: Safety and immunogenicity of a third dose of SARS-CoV-2 vaccine in solid organ transplant recipients.
15 Jun, 2021 | 08:59h | UTCCommentaries: For Transplant Recipients, Third Time May Be the Charm for Better COVID Vaccine Protection – Hopkins Medicine AND Extra COVID Vaccine May Help Protect Transplant Patients – Associated Press
Commentary on Twitter
Our report about 3rd vaccine doses in transplant patients is published! "It is encouraging that antibody titers increased after the 3rd dose in 1/3 of patients who had negative antibody titers and in all patients who had low-positive antibody titers"https://t.co/6XElwyIdAa
— Dorry Segev (@Dorry_Segev) June 14, 2021
Impact of vaccination on new SARS-CoV-2 infections in the United Kingdom – “no evidence of a difference between the BNT162b2 (Pfizer-BioNTech) and ChAdOx1 (AstraZeneca) vaccines”.
14 Jun, 2021 | 08:52h | UTCImpact of vaccination on new SARS-CoV-2 infections in the United Kingdom – Nature Medicine
Commentaries on Twitter
The ChAdOx1 nCoV-19 and BNT162b2 #COVID19 #vaccines reduce incidence of new #SARSCoV2 infections by up to 65% with a single dose and up to 80% after two doses in the United Kingdom @kb_pouwels @ONS @Oxford_NDPH @UniofOxford https://t.co/K1f68MMYyO
— Nature Medicine (@NatureMedicine) June 9, 2021
First-dose vaccination with the Oxford–AstraZeneca or Pfizer–BioNTech vaccine against SARS-CoV-2 reduced the incidence of new infections in the UK by 61% and 66%, respectively, according to a study in @NatureMedicine. https://t.co/2TUFE1DeII pic.twitter.com/KuMtc1cD7l
— Nature Portfolio (@NaturePortfolio) June 9, 2021
Lab study shows sera from persons fully vaccinated with the Pfizer–BioNTech vaccine can effectively neutralize B.1.617 (Delta) and other SARS-CoV-2 variants.
14 Jun, 2021 | 08:53h | UTCBNT162b2-elicited neutralization of B.1.617 and other SARS-CoV-2 variants – Nature
Commentary on Twitter
An in-vitro study of sera from persons fully vaccinated with the Pfizer-BioNTech vaccine found that all samples neutralized SARS-CoV-2 virus variants B.1.617.1 (Kappa), B.1.617.2 (Delta), B.1.618 and B.1.525. https://t.co/7lXCVe7sPY
— Carlos del Rio (@CarlosdelRio7) June 12, 2021
Cohort study showed that the incidence of Multisystem Inflammatory Syndrome in Children (MIS-C) was 316 persons per 1 000 000 SARS-CoV-2 infections in persons younger than 21 years. The incidence was higher among Black, Hispanic or Latino, and Asian or Pacific Islander persons.
14 Jun, 2021 | 08:48h | UTCCommentary: MIS-C Incidence 316 Persons Per 1 Million SARS-CoV-2 Infections – HealthDay
Commentary on Twitter
About 1 in every 3,000 children who got COVID ended up with MIS-C. MIS-C incidence among Black persons and Hispanic or Latino persons was approximately 9x higher, and incidence among Asian or Pacific Islander persons was approximately 3x higher https://t.co/JTEsvgvFcz
— Daniel Griffin MD PhD (@DanielGriffinMD) June 12, 2021
Children with symptomatic SARS-CoV-2 infection have similar viral loads and may be as contagious as symptomatic adults.
14 Jun, 2021 | 08:49h | UTCEditorial: Implications of SARS-CoV-2 Viral Load in Children: Getting Back to School and Normal
Commentary on Twitter (thread – click for more)
In a new study in @JAMAPediatrics, we compared symptoms and viral load in children and adults with SARS-CoV-2. Those with symptoms had higher virus loads than those without. Importantly, within these groups – viral load was the same in children and adults. https://t.co/UgaFzvMNlg pic.twitter.com/cjpt2yqQ3R
— Helen Chu (@HelenChuMD) June 11, 2021
Opinion | I Run the W.H.O., and I Know That Rich Countries Must Make a Choice.
14 Jun, 2021 | 08:44h | UTCI Run the W.H.O., and I Know That Rich Countries Must Make a Choice – The New York Times
RCT: No difference in 30-day mortality with discontinuation vs. continuation of renin-angiotensin-system inhibitors in patients with COVID-19, but secondary and explorative analysis showed discontinuation of RAS-inhibition may lead to a faster and better recovery.
14 Jun, 2021 | 08:47h | UTCEditorial: RAS inhibition and COVID-19: more questions than answers?
Related randomized trials showing no benefit from discontinuation: Randomized trial: No benefit from discontinuing ACE Inhibitors and ARBs in patients admitted with COVID-19 AND Randomized trial: Renin–angiotensin system inhibitors can be safely continued in patients admitted to hospital with COVID-19
Video | Evaluation and care of patients with persistent symptoms following acute SARS-CoV-2 infection.
14 Jun, 2021 | 08:45h | UTC
Perspective | More transmissible, wilier variant makes Covid-19 vaccinations even more crucial, experts say.
14 Jun, 2021 | 08:42h | UTCMore transmissible, wilier variant makes Covid-19 vaccinations even more crucial, experts say – STAT
9 Steps to End COVID-19 and Prevent the Next Pandemic: Essential Outcomes From the World Health Assembly.
14 Jun, 2021 | 08:39h | UTC
Covid: Is there a limit to how much worse variants can get?
14 Jun, 2021 | 08:43h | UTCCovid: Is there a limit to how much worse variants can get? – BBC
Perspective | Does vaccinating adults stop kids from spreading COVID too?
11 Jun, 2021 | 08:32h | UTCDoes vaccinating adults stop kids from spreading COVID too? – Nature
High COVID vaccine uptake may protect the unvaccinated.
11 Jun, 2021 | 08:34h | UTCHigh COVID vaccine uptake may protect the unvaccinated – CIDRAP
Original Study: Community-level evidence for SARS-CoV-2 vaccine protection of unvaccinated individuals – Nature Medicine
Commentaries on Twitter
Just published @NatureMedicine
Evidence that "vaccination not only protects individuals who have been vaccinated but also provides cross-protection to unvaccinated individuals in the community" as seen in kids benefiting from high % of adults vaxxedhttps://t.co/IPQo6WTFZX pic.twitter.com/jtfD93onnn— Eric Topol (@EricTopol) June 10, 2021
Nature Medicine: "On average, for each 20% increase in the number of vaccinated people in a given population, the number of positive SARS-CoV-2 tests in the unvaccinated population in the same community decreased approximately two fold." https://t.co/QhMqSbZDtc
— Niklas Fagerström (@niklasf) June 10, 2021
US donation of 500 million Pfizer vaccines could help ‘turn tide’ as Africa runs out of doses, says WHO.
11 Jun, 2021 | 08:31h | UTC
Naturally acquired SARS-CoV-2 immunity persists for up to 11 months following infection.
11 Jun, 2021 | 08:24h | UTC
CDC says heart inflammation cases were higher than expected in 16- to 24-year-olds after second Covid vaccine shot, but still rare.
11 Jun, 2021 | 08:28h | UTCSee also: CDC plans “emergency meeting” on rare heart inflammation following COVID-19 vaccines – CBC News
Related: Israel reports link between rare cases of heart inflammation and COVID-19 vaccination in young men.
Opinion | The Covid-19 Delta variant poses a threat to our return to ‘normal’.
11 Jun, 2021 | 08:23h | UTCThe Covid-19 Delta variant poses a threat to our return to ‘normal’ – CNN
Commentary on Twitter
In @CNNOpinion I offer thoughts on how the COVID Delta variant should cause the US to rethink national SARS-CoV-2 goal setting…as well as adjust other policy and communications strategies in response to the unique challenges posed by Delta. https://t.co/N4j5HdREnY @ASPPHtweets
— David R Holtgrave (@HoltgraveHealth) June 10, 2021
WHO Report: Global antimicrobial resistance and use surveillance system.
11 Jun, 2021 | 08:22h | UTCNews Release: Record response to WHO’s call for antimicrobial resistance surveillance reports in 2020 – World Health Organization
Commentary: WHO reveals new global antibiotic resistance data, more concerns – CIDRAP
Commentary on Twitter (thread – click for more)
WHO received over 3⃣ million reports for the Global #AntimicrobialResistance and Use Surveillance System (GLASS)
The more information we have the better placed the ?
is to tackle this increasingly serious health threat.? https://t.co/ccZCzdyZUc
pic.twitter.com/DMuLwVu4rC— World Health Organization (WHO) (@WHO) June 9, 2021
Editorial: Embrace the WHO’s new naming system for coronavirus variants.
10 Jun, 2021 | 09:48h | UTCEmbrace the WHO’s new naming system for coronavirus variants – Nature
Opinion | Epidemiology, not geopolitics, should guide COVID-19 vaccine donations.
10 Jun, 2021 | 09:51h | UTCEpidemiology, not geopolitics, should guide COVID-19 vaccine donations – The Lancet
Commentary on Twitter (thread – click for more)
Maximizing potential benefit of vaccine donations depends on doses going where they can do the"most good" but there's no consensus on where that would be
Murray @IHME_UW @RCReinerJr & I propose an approach that prioritizes epidemiology over geopolitics 1/https://t.co/OxOXLr5L55
— Tom Bollyky (@TomBollyky) June 9, 2021