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Covid-19

RCT | Metformin, Ivermectin, and Fluvoxamine are not beneficial for obese outpatients with Covid-19.

18 Aug, 2022 | 13:00h | UTC

Randomized Trial of Metformin, Ivermectin, and Fluvoxamine for Covid-19 – New England Journal of Medicine

Editorial: Time to Stop Using Ineffective Covid-19 Drugs – New England Journal of Medicine

 

Commentary on Twitter

 


Retrospective cohort study | Risk of preterm birth, small for gestational age at birth, and stillbirth after covid-19 vaccination during pregnancy.

18 Aug, 2022 | 12:51h | UTC

Risk of preterm birth, small for gestational age at birth, and stillbirth after covid-19 vaccination during pregnancy: population based retrospective cohort study – The BMJ

News Release: No link between COVID-19 vaccination in pregnancy and higher risk of preterm birth or stillbirth – British Medical Journal

Related:

SARS-CoV-2 infection and COVID-19 vaccination in pregnancy – Nature Reviews Immunology

Cohort Study: COVID-19 vaccination during early pregnancy was not associated with increased risk of congenital fetal anomalies.

Retrospective Cohort: A population-based study in Sweden and Norway did not find an increased risk of pregnancy complications after COVID-19 vaccination.

WHO Questions and Answers: COVID-19 vaccines and pregnancy.

COVID vaccines safely protect pregnant people: the data are in.

COVID-19 vaccination in pregnancy—number needed to vaccinate to avoid harm.

A case-controlled study showed Covid-19 vaccination during early pregnancy was not associated with increased risk of first-trimester miscarriage.

Editorial: Covid-19 treatments and vaccines must be evaluated in pregnancy.

AstraZeneca vaccination not linked to reduced fertility rates and adverse birth outcomes.

Cohort study: Vaccinated pregnant patients had 90% lower risk of severe or critical Covid-19 compared with unvaccinated pregnant patients.

Two observational studies suggest spontaneous abortion is not increased following COVID-19 mRNA vaccination during pregnancy.

Study shows high effectiveness of the Pfizer mRNA COVID-19 vaccine in pregnancy.

5 Crucial Things to Know About COVID-19 Vaccines and Pregnancy.

CDC Guidance: Pregnant people should be vaccinated against COVID-19.

ACOG and SMFM Recommend COVID-19 Vaccination for Pregnant Individuals – “ACOG encourages its members to enthusiastically recommend vaccination to their patients.”

Cohort study: Pfizer/BioNTech COVID vaccine associated with 78% lower risk of Covid-19 in pregnancy.

 

Commentary on Twitter

 


Neurological and psychiatric risk trajectories after SARS-CoV-2 infection: an analysis of 2-year retrospective cohort studies including 1 284 437 patients.

18 Aug, 2022 | 12:49h | UTC

Neurological and psychiatric risk trajectories after SARS-CoV-2 infection: an analysis of 2-year retrospective cohort studies including 1 284 437 patients – The Lancet Psychiatry

News Release: Increased risk of some neurological and psychiatric disorders remains two years after COVID-19 infection – University of Oxford

Commentary: Covid-19: Increased risk of some neurological and psychiatric disorders remains two years after infection, study finds – The BMJ

 

Commentary on Twitter

 


Guideline | Use of COVID-19 convalescent plasma.

17 Aug, 2022 | 14:28h | UTC

Clinical Practice Guidelines From the Association for the Advancement of Blood and Biotherapies (AABB): COVID-19 Convalescent Plasma – Annals of Internal Medicine

Editorial: The Fast and the Furious: Chasing a Clinical Niche for COVID-19 Convalescent Plasma – Annals of Internal Medicine

News Release: The AABB releases clinical practice guidelines for the appropriate use of COVID-19 convalescent plasma – American College of Physicians

 


Study suggests long covid symptoms affect 1 in 8 patients.

16 Aug, 2022 | 13:52h | UTC

Persistence of somatic symptoms after COVID-19 in the Netherlands: an observational cohort study – The Lancet

News Release: Most reliable estimates to date suggest one in eight COVID-19 patients develop long COVID symptoms – Lancet

Commentaries:

Long COVID symptoms affect 1 in 8 adults, some for 2 years – CIDRAP

Covid-19: One in eight adults develops long covid symptoms, study suggests – The BMJ

 


UK approves updated Moderna vaccine targeting Omicron variant.

16 Aug, 2022 | 13:49h | UTC

UK approves updated Moderna vaccine targeting Omicron variant – Associated Press/MedicalXpress

See also: Covid: UK first country to approve dual-strain vaccine – BBC

 


Living through the psychological consequences of COVID-19 pandemic: a systematic review of effective mitigating interventions.

16 Aug, 2022 | 13:43h | UTC

Living through the psychological consequences of COVID-19 pandemic: a systematic review of effective mitigating interventions – BMJ Open

 


M-A | Efficacy and safety of heparin full-dose anticoagulation in hospitalized non-critically ill COVID-19 patients.

15 Aug, 2022 | 12:27h | UTC

Efficacy and safety of heparin full-dose anticoagulation in hospitalized non-critically ill COVID-19 patients: a meta-analysis of multicenter randomized controlled trials – Journal of Thrombosis and Thrombolysis

Related:

Efficacy and safety of intensified versus standard prophylactic anticoagulation therapy in patients with Covid-19: a systematic review and meta-analysis – Open Forum Infectious Diseases

Anticoagulants for people hospitalised with COVID‐19 – Cochrane Library

Anticoagulation in Patients With COVID-19: JACC Review Topic of the Week – Journal of the American College of Cardiology

Point/Counterpoint: Should therapeutic heparin be administered to acutely ill hospitalized patients with COVID-19?

 


Review | Long COVID headache.

15 Aug, 2022 | 12:25h | UTC

Long COVID headache – The Journal of Headache and Pain

 

Commentary on Twitter

Under a http://creativecommons.org/licenses/by/4.0/ license

 


Review | The COVID-19 pandemic and its consequences for chronic pain.

12 Aug, 2022 | 15:02h | UTC

The COVID-19 pandemic and its consequences for chronic pain: a narrative review – Anaesthesia

 

Commentary on Twitter

 


Review | Cardiovascular complications of pregnancy-associated COVID-19 infections.

12 Aug, 2022 | 15:14h | UTC

Cardiovascular Complications of Pregnancy-Associated COVID-19 Infections – Journal of the American College of Cardiology

Commentaries:

Pregnant Women Are at Increased Risk of Severe Illness, Complications From COVID-19 – American College of Cardiology

Cardiovascular Complications of COVID-19 in Pregnancy Reviewed – HealthDay

 


RECOVERY Trial | Baricitinib in patients admitted to hospital with COVID-19.

3 Aug, 2022 | 14:34h | UTC

Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis – The Lancet

Invited Commentary: Baricitinib in COVID-19: a coming-of-age from artificial intelligence to reducing mortality – The Lancet

Related:

Tocilizumab versus baricitinib in hospitalized patients with severe COVID-19: an open label, randomized controlled trial – medRxiv

Baricitinib versus dexamethasone for adults hospitalised with COVID-19 (ACTT-4): a randomised, double-blind, double placebo-controlled trial – The Lancet Respiratory Medicine

Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis – medRxiv

WHO recommends two new drugs to treat COVID-19 – World Health Organization

Efficacy and safety of baricitinib for the treatment of hospitalised adults with COVID-19 (COV-BARRIER): a randomised, double-blind, parallel-group, placebo-controlled phase 3 trial – The Lancet Respiratory Medicine

Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19 – New England Journal of Medicine

 

Commentary on Twitter

Under a Creative Commons Attribution (CC BY 4.0) license

 


Systematic Review | Rapid, point‐of‐care antigen tests for diagnosis of SARS‐CoV‐2 infection.

29 Jul, 2022 | 12:39h | UTC

Rapid, point‐of‐care antigen tests for diagnosis of SARS‐CoV‐2 infection – Cochrane Library

Summary: How accurate are rapid antigen tests for diagnosing COVID-19? – Cochrane Library

 


M-A | Prognosis and persistence of smell and taste dysfunction in patients with covid-19.

28 Jul, 2022 | 13:28h | UTC

Prognosis and persistence of smell and taste dysfunction in patients with covid-19: meta-analysis with parametric cure modelling of recovery curves – The BMJ

Editorial: Smell and taste dysfunction after covid-19 – The BMJ

Commentary: The burden of prolonged smell and taste loss in covid-19 – The BMJ

News Release: Millions of covid patients may have long term smell and taste problems – BMJ Newsroom

 


M-A | Antiviral drug treatment for nonsevere COVID-19.

27 Jul, 2022 | 12:14h | UTC

Antiviral drug treatment for nonsevere COVID-19: a systematic review and network meta-analysis – Canadian Medical Association Journal

News Release: Some antivirals used in nonsevere COVID-19 may reduce hospitalizations and deaths – Canadian Medical Association Journal

Commentary: COVID-19 antivirals may cut risk of hospitalization, death – CIDRAP

 


M-A | Beneficial and harmful effects of monoclonal antibodies for the treatment and prophylaxis of COVID-19.

27 Jul, 2022 | 12:12h | UTC

Beneficial and harmful effects of monoclonal antibodies for the treatment and prophylaxis of COVID-19: a systematic review and meta-analysis of randomized controlled trials – American Journal of Medicine

 


Cohort Study | Cardiometabolic outcomes up to 12 months after COVID-19 infection.

26 Jul, 2022 | 13:30h | UTC

Cardiometabolic outcomes up to 12 months after COVID-19 infection. A matched cohort study in the UK – PLOS Medicine

News Release: COVID-19 patients more likely to develop cardiovascular diseases and diabetes soon after infection – PLOS

Commentaries:

COVID: risk of diabetes and heart disease is higher after infection – but maybe only temporarily – The Conversation

COVID-19 tied to new-onset, short-term heart disease, diabetes – CIDRAP

CVD, Diabetes Spike in Acute Phase of COVID-19 – TCTMD

Covid-19: Infection raises risk of diabetes and heart disease diagnoses in following weeks, study finds – The BMJ

 


[PREPRINT] RCT | Inhaled fluticasone not beneficial for outpatients with Covid-19.

25 Jul, 2022 | 13:01h | UTC

Inhaled Fluticasone for Outpatient Treatment of Covid-19: A Decentralized, Placebo-controlled, Randomized, Platform Clinical Trial – medRxiv

News Release: Study finds no benefit to taking fluticasone furoate for COVID-19 symptoms – Duke Clinical Research Institute

Commentary: Asthma Drug Fluticasone Fails as Potential COVID-19 Treatment – HealthDay

 


Retrospective Cohort Study | Effectiveness of a fourth dose of mRNA COVID-19 vaccine against all-cause mortality in long-term care facility residents and in the oldest old.

25 Jul, 2022 | 13:03h | UTC

Effectiveness of a fourth dose of mRNA COVID-19 vaccine against all-cause mortality in long-term care facility residents and in the oldest old: A nationwide, retrospective cohort study in Sweden – The Lancet Regional Health Europe

Related:

Effectiveness of a fourth dose of covid-19 mRNA vaccine against the omicron variant among long term care residents in Ontario, Canada: test negative design study – The BMJ

Association of Receipt of the Fourth BNT162b2 Dose With Omicron Infection and COVID-19 Hospitalizations Among Residents of Long-term Care Facilities – JAMA Internal Medicine

Short term, relative effectiveness of four doses versus three doses of BNT162b2 vaccine in people aged 60 years and older in Israel: retrospective, test negative, case-control study – The BMJ

Fourth Dose of BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Setting – New England Journal of Medicine

 


Cohort Study | Effectiveness of the Pfizer vaccine against Omicron in children 5 to 11 years of age.

21 Jul, 2022 | 13:28h | UTC

Effectiveness of BNT162b2 Vaccine against Omicron in Children 5 to 11 Years of Age – New England Journal of Medicine

 


Guideline | Neurological manifestations of post-COVID-19 syndrome.

20 Jul, 2022 | 12:18h | UTC

Neurological manifestations of post-COVID-19 syndrome S1-guideline of the German society of neurology – Neurological Research and Practice

 


A prospective study of the association between SARS-CoV-2 infection and COVID-19 vaccination with changes in usual menstrual cycle characteristics.

20 Jul, 2022 | 12:27h | UTC

A prospective study of the association between SARS-CoV-2 infection and COVID-19 vaccination with changes in usual menstrual cycle characteristics – American Journal of Obstetrics and Gynecology

Commentary: Study suggests COVID-19 vaccination may be associated with short-term changes in usual menstrual cycle length – News Medical

 


M-A | Colchicine does not improve outcomes in patients with COVID-19.

20 Jul, 2022 | 12:20h | UTC

Effect of colchicine on the outcomes of patients with COVID-19: a systematic review and meta-analysis of randomised controlled trials – Annals of Medicine

 


Who to vaccinate first? A peek at decision-making in a pandemic.

19 Jul, 2022 | 13:40h | UTC

Who to vaccinate first? A peek at decision-making in a pandemic – Nature

 


A pandemic treaty for equitable global access to medical countermeasures: seven recommendations for sharing intellectual property, know-how and technology.

19 Jul, 2022 | 13:38h | UTC

A pandemic treaty for equitable global access to medical countermeasures: seven recommendations for sharing intellectual property, know-how and technology – BMJ Global Health

 


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