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Covid-19

Systematic review: Clinical characteristics of multisystem inflammatory syndrome in adults.

23 Sep, 2021 | 10:12h | UTC

Clinical Characteristics of Multisystem Inflammatory Syndrome in Adults: A Systematic Review – JAMA Network Open

 

Commentary on Twitter

 

The lesson of ivermectin: meta-analyses based on summary data alone are inherently unreliable.

23 Sep, 2021 | 10:08h | UTC

The lesson of ivermectin: meta-analyses based on summary data alone are inherently unreliable – Nature Medicine

 

Commentary on Twitter

 

Perspective | Sorry, a Coronavirus Infection Might Not Be Enough to Protect You – “Anyone who’d rather have COVID-19 than get vaccinated is taking two gambles: that immunity will stick around, and that symptoms won’t”.

22 Sep, 2021 | 10:23h | UTC

Sorry, a Coronavirus Infection Might Not Be Enough to Protect You – The Atlantic

 

[Press release – not published yet] J&J says booster shot at two months provided 75% protection against moderate to severe COVID-19 globally and 94% of such cases in the U.S.

22 Sep, 2021 | 10:26h | UTC

Press release: Johnson & Johnson Announces Real-World Evidence and Phase 3 Data Confirming Strong and Long-Lasting Protection of Single-Shot COVID-19 Vaccine in the U.S.

Commentaries:

Johnson & Johnson says additional dose boosts Covid vaccine efficacy – STAT

J&J booster 94% effective against severe COVID, company says – CIDRAP

Two dose version of Johnson & Johnson shot 94% effective against Covid-19, study finds – CNN

 

Commentaries on Twitter

(thread – click for more)

(thread – click for more)

https://twitter.com/hildabast/status/1440363761299124229

 

[Preprint] SARS-like viruses may jump from animals to people hundreds of thousands of times a year.

22 Sep, 2021 | 10:22h | UTC

SARS-like viruses may jump from animals to people hundreds of thousands of times a year – Science

Original study: A strategy to assess spillover risk of bat SARS-related coronaviruses in Southeast Asia – medRxiv

Related:

Did the coronavirus jump from animals to people twice? – Nature

The Origins of SARS-CoV-2: A Critical Review.

The animal origin of SARS-CoV-2 – “Trading of animals susceptible to bat coronaviruses is the likely cause of the COVID-19 pandemic”.

Fauci says natural origins theory of coronavirus is still the most likely.

 

Interpreting SARS-CoV-2 Test Results.

22 Sep, 2021 | 10:24h | UTC

Interpreting SARS-CoV-2 Test Results – JAMA

 

Long Covid – The illness narratives.

22 Sep, 2021 | 10:19h | UTC

Long Covid – The illness narratives – Social Science & Medicine

 

Commentary on Twitter

https://twitter.com/trishgreenhalgh/status/1439199576158883843

 

The fight to manufacture COVID vaccines in lower-income countries.

22 Sep, 2021 | 10:21h | UTC

The fight to manufacture COVID vaccines in lower-income countries – Nature

 

[Press release – not published yet] Pfizer announces COVID-19 vaccine in children 5 to 11 years produced strong neutralizing antibody responses.

21 Sep, 2021 | 09:57h | UTC

Pfizer and BioNTech Announce Positive Topline Results From Pivotal Trial of COVID-19 Vaccine in Children 5 to 11 Years – Pfizer and BioNTech

Commentaries:

Covid-19 vaccine for 5- to 11-year-olds is safe and shows ‘robust’ antibody response, Pfizer says – CNN

Pfizer says COVID-19 vaccine safe, effective in younger children – CIDRAP

Pfizer Covid-19 vaccine generates robust antibody response in children, without serious safety issues, company says – STAT

Expert reaction to press release giving topline results from Pfizer and BioNTech from their phase 2/3 trial looking at safety and antibody responses from their COVID-19 vaccine in children aged 5 to 11 – Science Media Centre

 

Commentaries on Twitter

(thread – click for more)

(thread – click for more)

https://twitter.com/hildabast/status/1439976038964940803

 

M-A: Safety and efficacy of different prophylactic anticoagulation dosing regimens in critically and non-critically ill patients with COVID-19 – According to this analysis, standard-dose prophylactic anticoagulation should be the standard of care for hospitalized patients with COVID-19 who do not have an indication for therapeutic anticoagulation, irrespective of disease severity.

21 Sep, 2021 | 09:54h | UTC

Safety and efficacy of different prophylactic anticoagulation dosing regimens in critically and non-critically ill patients with COVID-19: A systematic review and meta-analysis of randomized controlled trials – European Heart Journal – Cardiovascular Pharmacotherapy

 

Commentary on Twitter (thread – click for more)

 

Uncoupling vaccination from politics: a call to action.

21 Sep, 2021 | 09:56h | UTC

Uncoupling vaccination from politics: a call to action – The Lancet

 

COVID will likely shift from pandemic to endemic — but what does that mean?

21 Sep, 2021 | 09:49h | UTC

COVID will likely shift from pandemic to endemic — but what does that mean? – The Conversation

 

An Update on Coronavirus Disease 2019 (COVID-19) and Pregnancy.

21 Sep, 2021 | 09:51h | UTC

An Update on Coronavirus Disease 2019 (COVID-19) and Pregnancy – American Journal of Obstetrics and Gynecology

 

Six rules that will define our second pandemic winter

21 Sep, 2021 | 09:47h | UTC

Six Rules That Will Define Our Second Pandemic Winter – The Atlantic

 

CDC Report: Moderna’s vaccine associated with greater effectiveness (93%) against Covid-19 hospitalization compared to Pfizer (88%) and J&J (71%) vaccines.

19 Sep, 2021 | 23:48h | UTC

Comparative Effectiveness of Moderna, Pfizer-BioNTech, and Janssen (Johnson & Johnson) Vaccines in Preventing COVID-19 Hospitalizations Among Adults Without Immunocompromising Conditions — United States, March–August 2021 – CDC Morbidity and Mortality Weekly Report

Commentaries:

Moderna’s vaccine is the most effective, but Pfizer and J&J also protect well, CDC-led study says – CNN

CDC: Moderna COVID vaccine most protective against hospital cases – CIDRAP

CDC data: Moderna vaccine has edge in preventing COVID-19 hospitalizations – UPI

 

Commentary on Twitter

 

Does everybody need a booster shot? – “Why some people might need Covid-19 booster shots — and some might not”.

19 Sep, 2021 | 23:43h | UTC

Does everybody need a booster shot? – Vox

 

An FDA panel says only high-risk Americans and those 65+ should get covid boosters.

19 Sep, 2021 | 23:45h | UTC

An FDA Panel Says Only High-Risk Americans And Those 65+ Should Get COVID Boosters – NPR

See also:

FDA advisory panel recommends booster doses of Covid-19 vaccine only for older and high-risk Americans – STAT

5 reasons why FDA advisers did not recommend Covid-19 booster shots for everyone – CNN

Top doctors say not so fast to Biden’s boosters-for-all plan – Associated Press

Related:

An observational study in Israel suggests additional protection from a 3rd dose of the Pfizer vaccine in individuals 60 years of age or older.

Third shot: UK to offer COVID booster jabs to over 50s.

COVID-19 vaccine efficacy does not support boosters for general population, review concludes.

COVID vaccine effects wane over time but still prevent death and severe illness.

What’s the evidence for COVID-19 booster shots?

WHO appeals for countries to postpone COVID-19 vaccine boosters until 2022 to prioritize vaccinating the most at-risk people around the world who are yet to receive their first dose.

AstraZeneca bosses warn against rush for boosters – “giving the most vulnerable, who may not have built up a full immune response from the first two, a third, top-up dose is “sensible”. But any decision to give a third, booster jab “to large swathes of the population”, to extend their protection from the first two, must be based on clinical data”.

 

COVID vaccine immunity is waning — how much does that matter? – “As debates about booster shots heat up, what’s known about the duration of vaccine-based immunity is still evolving”.

19 Sep, 2021 | 23:40h | UTC

COVID vaccine immunity is waning — how much does that matter? – Nature

 

Opinion | Vaccinate the World before Starting COVID Booster Shots – “Fewer than 0.5 percent of vaccine doses have been distributed to people living in low-income countries”.

19 Sep, 2021 | 23:41h | UTC

Vaccinate the World before Starting COVID Booster Shots – Scientific American

Related: WHO appeals for countries to postpone COVID-19 vaccine boosters until 2022 to prioritize vaccinating the most at-risk people around the world who are yet to receive their first dose.

 

Review: Long COVID symptoms in children rarely persist beyond three months.

19 Sep, 2021 | 23:47h | UTC

News release: Long COVID symptoms in children rarely persist beyond three months –  Murdoch Children’s Research Institute

Original study: How Common Is Long COVID in Children and Adolescents? – The Pediatric Infectious Disease Journal

Commentary: Long Covid in children and adolescents is less common than previously feared – The Guardian

Related:

Cohort study: long term follow-up showed most patients with post–COVID-19 Multisystem Inflammatory Syndrome in Children had good outcomes with no significant medium- or long-term sequelae.

Long COVID: the physical and mental health of children and non-hospitalized young people after SARS-CoV-2 infection – one in seven children may still have symptoms 15 weeks after infection.

Do kids get long COVID? And how often? A pediatrician looks at the data – Children also get Long Covid, but much less often than adults.

Illness duration and symptom profile in symptomatic school-aged children tested for SARS-CoV-2 – “Only 25 (1.8%) of 1379 children experienced symptoms for at least 56 days.”

Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – “This study found a low prevalence of symptoms compatible with long COVID in a randomly selected cohort of children assessed 6 months after serologic testing”.

Study shows low incidence of post-acute COVID-19 symptoms (“Long Covid”) in children after mild disease

Cohort study: Risk factors for long covid in previously hospitalized children.

M-A: More than 50 long-term effects of COVID-19.

 

Commentary on Twitter (thread – click for more)

 

CDC Report: SARS-CoV-2 transmission to masked and unmasked close contacts of university students with COVID-19.

17 Sep, 2021 | 10:17h | UTC

SARS-CoV-2 Transmission to Masked and Unmasked Close Contacts of University Students with COVID-19 — St. Louis, Missouri, January–May 2021 – CDC Morbidity and Mortality Weekly Report

 

Commentary on Twitter

https://twitter.com/eliowa/status/1436017429927370758

 

CDC Report: Using Wastewater Surveillance Data to Support the COVID-19 Response — United States, 2020–2021.

17 Sep, 2021 | 10:15h | UTC

Using Wastewater Surveillance Data to Support the COVID-19 Response — United States, 2020–2021 – CDC Morbidity and Mortality Weekly Report

Related:

Rapid, large-scale wastewater surveillance and automated reporting system enabled early detection of nearly 85% of COVID-19 cases on a University campus.

[Preprint] Wastewater genomic testing can effectively track COVID-19 variants of concern.

Human Waste Could Be The Next Big Weapon in Controlling COVID-19 – TIME

Next steps for wastewater testing to help end this pandemic — and prevent the next one – STAT

Sewage sleuths helped an Arizona town beat back Covid-19. For wastewater epidemiology, that’s just the start – STAT

The myriad ways sewage surveillance is helping fight COVID around the world – Nature

Testing sewage can give school districts, campuses and businesses a heads-up on the spread of COVID-19 – The Conversation

It’s time to begin a national wastewater testing program for Covid-19 – STAT

Coronavirus: Testing sewage an ‘easy win’ – BBC

Development of wastewater pooled surveillance of SARS-CoV-2 from congregate living settings – high sensitivity, but unable to distinguish new infectious cases from persistent convalescent shedding.

 

Commentary on Twitter

 

RCT: Rivaroxaban does not have an impact on disease progression and symptoms resolution in high-risk adults with mild COVID-19.

17 Sep, 2021 | 10:19h | UTC

Randomized study of rivaroxaban vs. placebo on disease progression and symptoms resolution in high-risk adults with mild COVID-19 – Clinical Infectious Diseases

 

Vaccine passports are coming. But are they ethical?

17 Sep, 2021 | 10:10h | UTC

Vaccine passports are coming. But are they ethical? – The Conversation

Related:

Infographic: Vaccine passports around the world.

WHO panel comes out against requiring vaccination proof for travel

Opinion | How to lose friends and alienate people? On the problems of vaccine passports (several texts on the subject)

 

How the Delta variant’s remarkable ability to replicate threw new twists into the Covid-19 pandemic.

17 Sep, 2021 | 10:09h | UTC

How the Delta variant’s remarkable ability to replicate threw new twists into the Covid-19 pandemic – STAT

 

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