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Covid-19

Vaccine induced immune thrombocytopenia and thrombosis: summary of NICE guidance.

3 Oct, 2021 | 22:59h | UTC

Vaccine induced immune thrombocytopenia and thrombosis: summary of NICE guidance – The BMJ

Original Guidance: NICE COVID-19 rapid guideline: vaccine-induced immune thrombocytopenia and thrombosis.

Related:

Clinical features of vaccine-induced immune thrombocytopenia and thrombosis.

Review: Clinical characteristics and pharmacological management of COVID-19 vaccine–induced immune thrombotic thrombocytopenia with cerebral venous sinus thrombosis.

Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know.

Very rare cases of thrombosis with thrombocytopenia syndrome (TTS) after AstraZeneca vaccine: a global safety database analysis – the estimated rate of TTS after the first dose was 8.1 per million vaccinees; after the second dose, the estimated rate was 2.3 per million vaccinees. (several articles and resources on the subject)

 


[Preprint] Assessing the Burden of COVID-19 in Developing Countries: Systematic Review, Meta-Analysis, and Public Policy Implications.

3 Oct, 2021 | 22:56h | UTC

Assessing the Burden of COVID-19 in Developing Countries: Systematic Review, Meta-Analysis, and Public Policy Implications – medRxiv

 

Commentary on Twitter

https://twitter.com/GidMK/status/1444125087553114113

 


Will the pandemic fade into an ordinary disease like the flu? The world is watching Denmark for clues.

3 Oct, 2021 | 22:58h | UTC

Will the pandemic fade into an ordinary disease like the flu? The world is watching Denmark for clues – Science

 


New analysis shows benefits of offering two doses of COVID-19 vaccine to children aged 12-17 clearly outweigh risks.

3 Oct, 2021 | 22:52h | UTC

News release: New analysis shows benefits of offering two doses of COVID-19 vaccine to children aged 12-17 clearly outweigh risks – The Royal Society of Medicine

Original report: Vaccinating adolescents against SARS-CoV-2 in England: a risk-benefit analysis

Related: Covid: Single jab recommended for 12 to 15-year-olds by UK’s top doctors.

 


Editorial | Clinical ethics: consent for vaccination in children.

3 Oct, 2021 | 22:53h | UTC

Clinical ethics: consent for vaccination in children – Archives of Disease in Childhood

 


Editorial | Covid-19 vaccination: evidence of waning immunity is overstated.

3 Oct, 2021 | 22:49h | UTC

Covid-19 vaccination: evidence of waning immunity is overstated – The BMJ

Related:

COVID vaccine immunity is waning — how much does that matter? – “As debates about booster shots heat up, what’s known about the duration of vaccine-based immunity is still evolving”.

COVID vaccine effects wane over time but still prevent death and severe illness.

Perspective | What we actually know about waning immunity.

Another study shows Pfizer mRNA vaccine immunity is reduced over time.

[Press release – not published yet] Study shows vaccine protection wanes over time, but vaccines still offer good protection against severe disease.

Studies: COVID vaccine protection waning against infection but not hospitalization.

Pfizer says it’s time for a Covid booster; FDA and CDC say not so fast.

 


Impact of COVID-19 on Pediatric Immunocompromised Patients.

1 Oct, 2021 | 10:36h | UTC

Impact of COVID-19 on Pediatric Immunocompromised Patients – Pediatric Clinics of North America

 


Efficient and targeted COVID-19 border testing via reinforcement learning.

1 Oct, 2021 | 10:33h | UTC

Efficient and targeted COVID-19 border testing via reinforcement learning – Nature

Editorial: Greece used AI to curb COVID: what other nations can learn – Nature

Commentary: An algorithm may have helped slow the spread of COVID-19 in Greece – University of Southern California

 

Commentary on Twitter

https://twitter.com/NaturePortfolio/status/1440810407334080519

 


Neurological Effects of COVID-19 in Children.

1 Oct, 2021 | 10:40h | UTC

Neurological Effects of COVID-19 in Children – Pediatric Clinics of North America

 


Transition to endemicity: Understanding COVID-19.

1 Oct, 2021 | 10:30h | UTC

Transition to endemicity: Understanding COVID-19 – Cell

Related:

COVID will likely shift from pandemic to endemic — but what does that mean?

Perspective | How Endemic COVID Becomes a Manageable Risk – “Businesses and schools must adapt, because the dual threat from the coronavirus and the flu will be too severe”.

 


Another meta-analysis suggests standard-dose prophylactic anticoagulation is the best option for patients hospitalized with Covid-19.

1 Oct, 2021 | 10:35h | UTC

A Systematic Review and a Meta-Analysis Comparing Prophylactic and Therapeutic Low Molecular Weight Heparins for Mortality Reduction in 32,688 COVID-19 Patients – Frontiers in Pharmacology

Related: M-A: Safety and efficacy of different prophylactic anticoagulation dosing regimens in critically and non-critically ill patients with COVID-19 – According to this analysis, standard-dose prophylactic anticoagulation should be the standard of care for hospitalized patients with COVID-19 who do not have an indication for therapeutic anticoagulation, irrespective of disease severity.

 


Review: COVID-19 in older adults.

1 Oct, 2021 | 10:27h | UTC

COVID-19 in older adults – Cleveland Clinic Journal of Medicine

 


RCT: REGEN-COV antibody combination reduces hospitalizations in outpatients with Covid-19.

30 Sep, 2021 | 10:33h | UTC

REGEN-COV Antibody Combination and Outcomes in Outpatients with Covid-19 – New England Journal of Medicine

 


[Press release – Not published yet] Clover’s COVID-19 vaccine candidate demonstrates 79% efficacy against Delta.

30 Sep, 2021 | 10:30h | UTC

Clover’s COVID-19 Vaccine Candidate Demonstrates 79% Efficacy Against Delta in Global Phase 2/3 SPECTRA Trial Dominated by Variants of Concern and Interest – Clover Biopharmaceutical

Commentary: New Chinese vaccine could bolster global arsenal – Science

 


A pandemic recap: lessons we have learned.

30 Sep, 2021 | 10:29h | UTC

A pandemic recap: lessons we have learned – World Journal of Emergency Surgery

 


Randomized trial with over 30.000 patients showed AstraZeneca vaccine was safe and resulted in 74% efficacy against symptomatic SARS-CoV-2 infection.

30 Sep, 2021 | 10:32h | UTC

Phase 3 Safety and Efficacy of AZD1222 (ChAdOx1 nCoV-19) Covid-19 Vaccine – New England Journal of Medicine

 

Commentaries on Twitter

https://twitter.com/NEJM/status/1443331005050355715

https://twitter.com/EricTopol/status/1443336261897392133

 


Review: Clinical features, laboratory, and radiological findings of patients with acute inflammatory myelopathy after COVID-19 infection.

30 Sep, 2021 | 10:27h | UTC

Clinical Features, Laboratory, and Radiological Findings of Patients With Acute Inflammatory Myelopathy After COVID-19 Infection: A Narrative Review – American Journal of Physical Medicine & Rehabilitation

 


Over a third of COVID-19 patients diagnosed with at least one long-COVID symptom.

30 Sep, 2021 | 10:25h | UTC

News release: Over a third of COVID-19 patients diagnosed with at least one long-COVID symptom – University of Oxford

Original study: Incidence, co-occurrence, and evolution of long-COVID features: A 6-month retrospective cohort study of 273,618 survivors of COVID-19 – PLOS Medicine

Commentaries:

Two studies tie long COVID-19 to severe initial illness – CIDRAP

Covid: 37% of people have symptoms six months after infection – The Guardian

Long Covid is a bigger problem than we thought – CNN

Expert reaction to study looking at incidence and co-occurrence of long COVID symptoms following COVID-19 infection and also after influenza – Science Media Centre

 


CDC Study: Side effect rates from a third Covid-19 vaccine dose similar to those after second shot.

29 Sep, 2021 | 10:26h | UTC

Side effect rates from a third Covid-19 vaccine dose similar to those after second shot, early data indicate – STAT

Original study: Safety Monitoring of an Additional Dose of COVID-19 Vaccine — United States, August 12–September 19, 2021 – CDC Morbidity and Mortality Weekly Report

 


M-A: Efficacy and secondary infection risk of tocilizumab, sarilumab and anakinra in COVID-19 patients.

29 Sep, 2021 | 10:24h | UTC

Efficacy and secondary infection risk of tocilizumab, sarilumab and anakinra in COVID-19 patients: A systematic review and meta-analysis – Reviews in Medical Virology

 


Never Waste a Pandemic: Strategies to Increase Advance Care Planning Now.

29 Sep, 2021 | 10:22h | UTC

Never Waste a Pandemic: Strategies to Increase Advance Care Planning Now – Mayo Clinic Proceedings

 


Opinion | Data from routine Covid testing can help schools stay open this year.

29 Sep, 2021 | 10:14h | UTC

Data from routine Covid testing can help schools stay open this year – STAT

Related: Cluster RCT: Daily contact testing of school-based contacts was non-inferior to self-isolation for control of COVID-19 transmission.

 


Routine COVID testing doubles detection at 3 public schools.

29 Sep, 2021 | 10:16h | UTC

Routine COVID testing doubles detection at 3 public schools – CIDRAP

Original study: Assessment of a Program for SARS-CoV-2 Screening and Environmental Monitoring in an Urban Public School District – JAMA Network Open

Related: Cluster RCT: Daily contact testing of school-based contacts was non-inferior to self-isolation for control of COVID-19 transmission.

 


Characterizing long COVID: a living systematic review.

29 Sep, 2021 | 10:29h | UTC

Characterising long COVID: a living systematic review – BMJ Global Health

Related:

Long Covid – The illness narratives.

New guidelines to help doctors manage long COVID patients published.

M-A: More than 50 long-term effects of COVID-19. (several articles on the subject)

 

Commentary on Twitter

https://twitter.com/CharitiniSt/status/1442528255718748164

 


Impact of the COVID-19 pandemic on transgender and gender diverse health care.

29 Sep, 2021 | 10:21h | UTC

Impact of the COVID-19 pandemic on transgender and gender diverse health care – The Lancet Diabetes & Endocrinology

 


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