Covid-19
The COVID-19 Treatment Guidelines Panel’s Statement on Anticoagulation in Hospitalized Patients With COVID-19 – in the absence of contraindications, use therapeutic-dose anticoagulation with low molecular weight heparin for hospitalized patients not in the ICU who have a D-dimer above the upper limit of normal.
12 Jan, 2022 | 09:11h | UTC
Statement on therapies for high-risk, nonhospitalized patients with mild to moderate Covid-19.
12 Jan, 2022 | 09:14h | UTCSee also: What’s New in the Guidelines – NIH COVID-19 Treatment Guidelines
Recommendations on patient prioritization for outpatient Anti-SARS-CoV-2 therapies or preventive strategies when there are logistical or supply constraints.
12 Jan, 2022 | 09:06h | UTC
Commentary on Twitter
https://twitter.com/NIHCOVIDTxGuide/status/1475510894121697287
International study identifies predictors of severe outcomes in children with COVID-19.
12 Jan, 2022 | 09:05h | UTCNews Release: International study identifies predictors of severe outcomes in children with COVID-19 – University of Calgary
Original Study: Outcomes of SARS-CoV-2–Positive Youths Tested in Emergency Departments: The Global PERN–COVID-19 Study – JAMA Network Open
How do death rates from COVID-19 differ between people who are vaccinated and those who are not?
12 Jan, 2022 | 09:02h | UTC
Commentary from the author on Twitter
Updated: Now the ratio is 20.
The COVID death rate among unvaccinated people is 20-times higher than among vaccinated people.
This is the latest age-standardized data from Swizerland.
[From our post with @redouad on death rates by vaccination status: https://t.co/nNmfYAk0m1] pic.twitter.com/dRwkOWIRBa
— Max Roser (@MaxCRoser) December 26, 2021
Statement on potential drug-drug interactions between Ritonavir-boosted Nirmatrelvir (Paxlovid) and concomitant medications; antiarrhythmics, oral anticoagulants, immunosuppressants, anticonvulsants, antineoplastics, and neuropsychiatric drugs are among the drugs of concern.
12 Jan, 2022 | 09:09h | UTCCommentaries:
Pfizer antiviral pills may be risky with other medications – NBC News
See also: What’s New in the Guidelines – NIH COVID-19 Treatment Guidelines
Podcast: Long COVID Pearls.
12 Jan, 2022 | 09:04h | UTC#315 Long COVID with Dr. Monica Verduzco-Gutierrez – The Curbsiders
[Preprint] Saliva swabs may be the preferred sample for Omicron detection.
12 Jan, 2022 | 08:58h | UTCSaliva swabs are the preferred sample for Omicron detection – medRxiv
Commentary: Study suggests saliva swabs may be more suitable for omicron detection – News Medical
Perspective | Covid-19: Is it safe to reduce the self-isolation period?
12 Jan, 2022 | 09:00h | UTCCovid-19: Is it safe to reduce the self-isolation period? – The BMJ
Two years of coronavirus: how pandemic unfolded around the world.
12 Jan, 2022 | 09:02h | UTCTwo years of coronavirus: how pandemic unfolded around the world – The Guardian
Cohort study: Among health care workers previously vaccinated with 2 doses of the Pfizer-BioNTech vaccine, receiving a third dose was associated with reduced risk of SARS-CoV-2 infection.
11 Jan, 2022 | 01:35h | UTCEditorial: Booster Vaccination to Reduce SARS-CoV-2 Transmission and Infection – JAMA
Covid-19’s Devastating Effect on Tuberculosis Care — A Path to Recovery.
11 Jan, 2022 | 01:33h | UTC
Commentary on Twitter
In @NEJM today, @TerezaKasaeva @doctorsoumya and I write about
Covid-19’s devastating impact on tuberculosis care & offer suggestions for recoveryhttps://t.co/buOEOPVWwM pic.twitter.com/BfOK3X3MuU
— Madhu Pai, MD, PhD (@paimadhu) January 5, 2022
Review: Rapid diagnostic testing for SARS-CoV-2.
11 Jan, 2022 | 01:34h | UTCRapid Diagnostic Testing for SARS-CoV-2 – New England Journal of Medicine
[Preprint] Lab study shows Omicron infection enhances neutralizing immunity against the Delta variant.
11 Jan, 2022 | 01:29h | UTCOmicron infection enhances neutralizing immunity against the Delta variant – medRxiv
Study shows Covid-19 vaccination is associated with a smaller reduction in transmission of the delta variant compared with the alpha variant.
11 Jan, 2022 | 01:31h | UTC
Commentary on Twitter
Vaccination was associated with a smaller reduction in transmission of the SARS-CoV-2 delta variant than of the alpha variant, and the effects of vaccination decreased over time. #COVID19 #IDTwitter https://t.co/giGzWSx31k pic.twitter.com/HlwBqNGFO1
— NEJM (@NEJM) January 5, 2022
Clinical Practice Guideline Summary: Recommended Drugs and Biologics in Adult Patients with COVID-19.
11 Jan, 2022 | 01:26h | UTC
Commentary on Twitter
Fantastic outpatient treatment approach from Ontario #COVID19 Clinical Practice Guidelines
Risk level:high mod low
Eg:high:Sotrovimab is recommended if NA Remdesivir if NA Fluvoxamine or Budesonide
Paxlovid/Molnupiravir not added coz not yet approved CA https://t.co/dDhj6vA0uv pic.twitter.com/4ucrKIcMn8— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) January 8, 2022
M-A: Fatigue and cognitive impairment in Post-COVID-19 Syndrome.
11 Jan, 2022 | 01:28h | UTC
Covid-19: An urgent call for global “vaccines-plus” action.
11 Jan, 2022 | 01:22h | UTCCovid-19: An urgent call for global “vaccines-plus” action – The BMJ
CDC Report: COVID-19 vaccine safety in children aged 5–11 Years.
9 Jan, 2022 | 01:09h | UTCCommentary: COVID-19 vaccine appears safe in children aged 5–11 Years – News Medical
Commentary on Twitter
Early vaccine safety data for children ages 5–11 years old found that reactions such as fatigue and headaches were commonly reported following Pfizer-BioNTech #COVID19 vaccine. Everyone ages 5 years & older should get vaccinated as soon as possible. https://t.co/D66QgLRWni pic.twitter.com/8I48L5GmcG
— MMWR (@CDCMMWR) December 30, 2021
New CDC Guidance shortens isolation and quarantine period for Covid-19; patients that tested positive should isolate for 5 days and, if asymptomatic after this period, can leave isolation if they can continue to mask for 5 days to minimize the risk of infecting others.
9 Jan, 2022 | 01:13h | UTCSee also: Quarantine and Isolation – Centers for Disease Control and Prevention
Commentaries:
Facing criticism, CDC updates Covid-19 isolation recommendations with guidance on testing – CNN
CDC posts rationale for shorter isolation, quarantine – Associated Press
Covid-19: CDC shortens isolation period as US cases hit record high – The BMJ
Shortened CDC COVID isolation guide draws sharply mixed reviews – CIDRAP
New CDC isolation guidelines raise concerns among health experts – NPR
CDC Reduces Recommended Isolation Time for People With COVID-19 – HealthDay
COVID isolation and quarantine period for general population shortened by CDC – News Medical
CDC shortens recommended Covid-19 isolation and quarantine time – CNN
CDC cuts the recommended isolation and quarantine periods for coronavirus infections – NPR
US officials recommend shorter COVID isolation, quarantine – Associated Press
See new recommendations from other countries:
Covid: Self-isolation cut from 10 days to seven with negative tests – BBC
Omicron’s feeble attack on the lungs could make it less dangerous.
11 Jan, 2022 | 01:23h | UTCOmicron’s feeble attack on the lungs could make it less dangerous – Nature
CDC Study: A test to stay strategy (allowing close contacts with masked COVID-19 exposures to remain in school) was very efficacious in preventing further school spread and allowed children to stay in the classroom as an alternative to home quarantine.
9 Jan, 2022 | 01:07h | UTCRelated CDC Guidance:
What You Should Know About COVID-19 Testing in Schools – Centers for Disease Control and Prevention
Commentary: ‘Test-to-stay’ works to keep students in school safely, CDC director says – CNN
Related:
Instead of quarantine for Covid-exposed students, some schools are trying test-to-stay.
Opinion | Data from routine Covid testing can help schools stay open this year.
Commentary on Twitter
Although vaccination is the best way to protect against #COVID19 for those aged 5 and up, schools might consider Test to Stay strategy for allowing close contacts who are not fully vaccinated to remain in the classroom. Learn more in a new @CDCMMWR: https://t.co/3m64vomRDh. pic.twitter.com/AAENAdxJ1y
— CDC (@CDCgov) December 17, 2021
Diagnostics for COVID-19: moving from pandemic response to control.
8 Jan, 2022 | 23:33h | UTCDiagnostics for COVID-19: moving from pandemic response to control – The Lancet
Commentary on Twitter
Diagnostics—crucial during the #COVID19 pandemic.
A new Review discusses the 3 major methods for detection of SARS-CoV-2 infection & their evolution over time: moving from pandemic response to control.
Learn more 👉 https://t.co/6Him1H3VG7 pic.twitter.com/jt7yHkolCK
— The Lancet (@TheLancet) December 21, 2021
[Preprint] Among individuals with prior SARS-CoV-2 infection in Brazil, vaccine effectiveness against hospitalization or death after vaccine series completion was 81.3% for CoronaVac, 89.9% for AstraZeneca, 57.7% for J&J, and 89.7% for Pfizer.
8 Jan, 2022 | 23:26h | UTCEffectiveness of CoronaVac, ChAdOx1, BNT162b2 and Ad26.COV2.S among – medRxiv
[In Portuguese] Commentary from one of the authors on Twitter (thread – click for more)
Já tive COVID, devo me vacinar?
Sim, sem dúvida. Como já dizíamos, agora com dados. Mostramos (preprint) que o ganho em proteção é muito grande. Para hospitalizações/óbito, após 2a dose:
➡️ 89.7% Pfizer
➡️ 89.9% AstraZeneca
➡️ 81.3% CoronaVacVacine-sehttps://t.co/Gzcb3cjirX pic.twitter.com/TRET1VQqQE
— Otavio Ranzani (@otavio_ranzani) December 29, 2021
[Preprint] Risk of myocarditis following sequential COVID-19 vaccinations by age and sex.
9 Jan, 2022 | 01:05h | UTCRisk of myocarditis following sequential COVID-19 vaccinations by age and sex – medRxiv
Note: this study is an updated analysis of a recent study published in Nature Medicine; see below: