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Covid-19

Hospital admissions from childhood common infections were largely reduced in England during the pandemic due to control measures for Covid-19.

17 Jan, 2022 | 00:37h | UTC

Indirect effects of the covid-19 pandemic on childhood infection in England: population based observational study – The BMJ

Editorial: Covid-19 control measures and common paediatric infections – The BMJ

News Release: Dramatic fall in hospital admissions for child infections during first year of covid-19 pandemic – BMJ

 

One in 10 people may still be infectious for COVID after 10 days, new research indicates.

17 Jan, 2022 | 00:34h | UTC

News Release: One in 10 people may still be infectious for COVID after 10 days, new research indicates – University of Exeter

Original article: Persistence of clinically relevant levels of SARS-CoV2 envelope gene subgenomic RNAs in non-immunocompromised individuals – International Journal of Infectious Diseases

Commentary: Expert reaction to study looking at clinically relevant levels of potentially active virus 10 days after a positive PCR test – Science Media Centre

 

The French health pass holds lessons for mandatory COVID-19 vaccination.

17 Jan, 2022 | 00:38h | UTC

The French health pass holds lessons for mandatory COVID-19 vaccination – Nature Medicine

 

Is Covax finally going to vaccinate the world?

17 Jan, 2022 | 00:29h | UTC

Is Covax finally going to vaccinate the world? – Vox

Related:

How Covax failed on its promise to vaccinate the world – “Covax, described as “naively ambitious” by one expert, has contributed just 5% of all vaccines administered globally”.

Perspective | A beautiful idea: how COVAX has fallen short.

WHO Launches Strategy to Achieve Global Covid-19 Vaccination by mid-2022.

WHO special envoys: To beat Covid, there’s a simple lesson – no one’s safe until everyone’s safe.

Joint COVAX Statement on the Equal Recognition of Vaccines – COVAX urges all government authorities to recognize as fully vaccinated all people who have received COVID-19 vaccines that have been deemed safe and effective by WHO.

WHO COVAX Joint Statement: Call to action to equip COVAX to deliver 2 billion doses in 2021.

Covax: How will Covid vaccines be shared around the world?

 

N95 respirators can be safely decontaminated up to 25 times, research shows.

17 Jan, 2022 | 00:26h | UTC

News Release: N95 Respirators Can Be Safely Decontaminated Up to 25 Times, Research Shows – Beth Israel Deaconess Medical Center

Original Study: Assessing changes to N95 respirator filtration efficiency, qualitative and quantitative fit, and seal check with repeated vaporized hydrogen peroxide (VHP) decontamination – American Journal of Infection Control (link to abstract – $ for full-text)

 

Opinion: Omicron represents a new kind of epidemic – we must keep up.

17 Jan, 2022 | 00:28h | UTC

Omicron represents a new kind of epidemic – we must keep up – The Guardian

 

New UK Guidance: Self-isolation for those with COVID-19 can end after 5 full days following 2 negative rapid lateral flow tests – “The default self-isolation period continues to be 10 days, and you may only leave self-isolation early if you have taken 2 rapid lateral flow tests and do not have a temperature in line with guidance”.

14 Jan, 2022 | 08:48h | UTC

Self-isolation for those with COVID-19 can end after 5 full days following 2 negative LFD tests – Department of Health and Social Care

 

Commentary on Twitter (thread – click for more)

 

Unvaccinated pregnant people are at higher risk for Covid complications and newborn deaths.

14 Jan, 2022 | 08:44h | UTC

Unvaccinated pregnant people are at higher risk for Covid complications and newborn deaths – STAT

Original Study: SARS-CoV-2 infection and COVID-19 vaccination rates in pregnant women in Scotland – Nature Medicine

 

COVID vaccines safely protect pregnant people: the data are in.

14 Jan, 2022 | 08:43h | UTC

COVID vaccines safely protect pregnant people: the data are in – Nature

Related:

COVID-19 vaccination in pregnancy—number needed to vaccinate to avoid harm.

A case-controlled study showed Covid-19 vaccination during early pregnancy was not associated with increased risk of first-trimester miscarriage.

Editorial: Covid-19 treatments and vaccines must be evaluated in pregnancy.

AstraZeneca vaccination not linked to reduced fertility rates and adverse birth outcomes.

Cohort study: Vaccinated pregnant patients had 90% lower risk of severe or critical Covid-19 compared with unvaccinated pregnant patients.

Two observational studies suggest spontaneous abortion is not increased following COVID-19 mRNA vaccination during pregnancy.

Study shows high effectiveness of the Pfizer mRNA COVID-19 vaccine in pregnancy.

5 Crucial Things to Know About COVID-19 Vaccines and Pregnancy.

CDC Guidance: Pregnant people should be vaccinated against COVID-19.

ACOG and SMFM Recommend COVID-19 Vaccination for Pregnant Individuals – “ACOG encourages its members to enthusiastically recommend vaccination to their patients.”

Cohort study: Pfizer/BioNTech COVID vaccine associated with 78% lower risk of Covid-19 in pregnancy.

 

Fluvoxamine for Covid-19: What Prescribers and Pharmacists Need to Know.

14 Jan, 2022 | 08:37h | UTC

Fluvoxamine: What Prescribers and Pharmacists Need to Know – Covid-19 Advisory for Ontario

Related:

Fluvoxamine for the early treatment of SARS-CoV-2 Infection: a review of current evidence.

RCT: Early treatment with fluvoxamine reduced the risk of emergency care and hospitalization among patients with COVID-19.

[Preprint] RCT: Fluvoxamine reduced the risk for ER visits and hospitalization among patients with Covid-19.

Opinion | Could this be our first effective, inexpensive, widely available outpatient treatment for COVID-19? (It’s fluvoxamine).

Preliminary study shows fluvoxamine may reduce clinical deterioration in outpatients with symptomatic COVID-19

 

Commentary on Twitter

 

Cohort Study: Patients who achieved weight loss through bariatric surgery may have lower risk for severe Covid-19 compared to patients who did not have surgical intervention for their obesity.

14 Jan, 2022 | 08:32h | UTC

Association of Weight Loss Achieved Through Metabolic Surgery With Risk and Severity of COVID-19 Infection – JAMA Surgery

Commentaries:

Is COVID-19 the Newest Comorbidity of Obesity Mitigated by Bariatric Surgery? – JAMA Surgery

Can weight loss help protect against Covid-19? – CNN

 

Perspective: Omicron is forcing us to rethink mild COVID.

14 Jan, 2022 | 08:30h | UTC

Omicron Is Forcing Us to Rethink Mild COVID – The Atlantic

 

RCT: Colchicine did not significantly reduce the need for intubation or 28-day mortality in patients hospitalized with Covid-19.

14 Jan, 2022 | 08:35h | UTC

Effect of Colchicine vs Usual Care Alone on Intubation and 28-Day Mortality in Patients Hospitalized With COVID-19: A Randomized Clinical Trial – JAMA Network Open

Related:

M-A: Colchicine doesn’t lessen COVID-19 severity or stave off risk of death.

RECOVERY Trial: In patients admitted to hospital with COVID-19, Colchicine did not reduce 28-day mortality, duration of hospital stay, or risk of progressing to invasive mechanical ventilation or death.

[Preprint] PRINCIPLE RCT: Colchicine does not improve time to recovery in outpatients with Covid-19 at higher risk of complications.

COLCORONA RCT: Colchicine for community-treated patients with COVID-19 – findings suggest it may lower death and hospital admission rates, but further studies are required.

[Preprint] RECOVERY Trial: Colchicine does not improve outcomes in patients admitted to hospital with COVID-19.

 

Commentary on Twitter

 

Mapping the unvaccinated world – “If landmass reflected the number of unvaccinated people, this is what the world would look like”.

14 Jan, 2022 | 08:26h | UTC

Mapping the unvaccinated world – Pandemic

 

5 reasons you should not deliberately catch Omicron to ‘get it over with’.

14 Jan, 2022 | 08:29h | UTC

5 reasons you should not deliberately catch Omicron to ‘get it over with’ – CNN

 

Observational study in adolescents showed the Pfizer-BioNTech vaccine had an overall effectiveness of 94% against hospitalization and 98% against critical Covid-19.

13 Jan, 2022 | 09:00h | UTC

Effectiveness of BNT162b2 Vaccine against Critical Covid-19 in Adolescents – New England Journal of Medicine

Editorial: Sparing of Severe Covid-19 in Vaccinated Adolescents – New England Journal of Medicine

 

Study shows COVID-19 vaccines offer lasting protection against hospitalization and death.

13 Jan, 2022 | 09:01h | UTC

Duration of Protection against Mild and Severe Disease by Covid-19 Vaccines – New England Journal of Medicine

News Release: Study shows COVID-19 vaccines offer lasting protection – University of North Carolina at Chapel Hill

 

An observational study in South Africa estimates the Pfizer vaccine had an effectiveness of 70% against hospitalization for Covid-19 caused by the omicron variant.

13 Jan, 2022 | 08:56h | UTC

Effectiveness of BNT162b2 Vaccine against Omicron Variant in South Africa – New England Journal of Medicine

Commentary: BNT162b2 still effective, but less so, against Omicron – HealthDay

 

The COVID generation: how is the pandemic affecting kids’ brains?

13 Jan, 2022 | 08:53h | UTC

The COVID generation: how is the pandemic affecting kids’ brains? – Nature

 

Omicron Infection Curve ‘Staggering’ – 36 Countries Have Vaccinated Less than 10% of Citizens.

13 Jan, 2022 | 08:49h | UTC

Omicron Infection Curve ‘Staggering’ – 36 Countries Have Vaccinated Less than 10% of Citizens – Health Policy Watch

 

RCT: Early Remdesivir in outpatients can prevent progression to severe Covid-19.

13 Jan, 2022 | 08:54h | UTC

Early Remdesivir to Prevent Progression to Severe Covid-19 in Outpatients – New England Journal of Medicine

Editorial: The Goldilocks Time for Remdesivir — Is Any Indication Just Right?

Commentary: Three days of remdesivir cuts risk for severe COVID-19 in outpatients – MedicalXpress

 

Commentary on Twitter

 

Another study showed neutralizing monoclonal antibody therapies are not effective when given after the patient is already hospitalized.

13 Jan, 2022 | 08:48h | UTC

Efficacy and safety of two neutralising monoclonal antibody therapies, sotrovimab and BRII-196 plus BRII-198, for adults hospitalised with COVID-19 (TICO): a randomised controlled trial – The Lancet Infectious Diseases

Invited Commentary: Time to knock monoclonal antibodies off the platform for patients hospitalised with COVID-19

 

‘Killer’ immune cells still recognize Omicron variant.

13 Jan, 2022 | 08:51h | UTC

‘Killer’ immune cells still recognize Omicron variant – Nature

See also: T-cells: the superheroes in the battle against omicron – The Conversation

 

RCT: A single dose of a novel adenovirus type 5 vectored SARS-CoV-2 vaccine was safe and had 57.5% efficacy against symptomatic Covid-19 and 91.7% efficacy against severe disease in adults.

13 Jan, 2022 | 08:44h | UTC

Final efficacy analysis, interim safety analysis, and immunogenicity of a single dose of recombinant novel coronavirus vaccine in adults 18 years and older: an international, multicentre, randomised, double-blinded, placebo-controlled phase 3 trial – The Lancet

Commentaries:

Efficacy of an adenovirus type 5 vectored SARS-CoV-2 vaccine – The Lancet

Phase 3 trial reports one dose of Ad5-nCoV COVID-19 vaccine is safe and effective, including against severe disease – The Lancet

 

A clinical case definition of post-COVID-19 condition by a Delphi consensus.

13 Jan, 2022 | 08:45h | UTC

A clinical case definition of post-COVID-19 condition by a Delphi consensus – The Lancet Infectious Diseases

 

Commentary on Twitter

 

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