Antibiotic Stewardship
RCT: Among adults with idiopathic pulmonary fibrosis, antimicrobial therapy with co-trimoxazole or doxycycline is not associated with improved outcomes.
12 May, 2021 | 08:37h | UTCEffect of Antimicrobial Therapy on Respiratory Hospitalization or Death in Adults With Idiopathic Pulmonary Fibrosis: The CleanUP-IPF Randomized Clinical Trial – JAMA (free for a limited period)
Commentary on Twitter
Among adults with idiopathic pulmonary fibrosis, addition of co-trimoxazole or doxycycline compared with usual care did not significantly improve the time to nonrespiratory hospitalization or death https://t.co/t6WQ2sifx0
— JAMA (@JAMA_current) May 11, 2021
RCT: Prophylactic closed incision negative pressure wound therapy reduces (difference close to statistical significance; P=0.06) the risk of surgical site infection in obese women undergoing cesarean section.
7 May, 2021 | 08:24h | UTC
ATS Guideline: Nucleic acid–based testing for noninfluenza viral pathogens in adults with suspected community-acquired pneumonia – Testing should be considered only in patients with severe CAP and in immunocompromised patients
5 May, 2021 | 08:28h | UTCNews Release: New clinical practice guideline on community acquired pneumonia – American Thoracic Society
Study: Most patients who develop a non-IgE-mediated hypersensitivity reaction to nafcillin can be safely treated with cefazolin
4 May, 2021 | 08:36h | UTC
Commentary on Twitter
New case series found 90% tolerated switching to cefazolin out of 80 patients who experienced non-IgE hypersensitivity reactions to nafcillin.https://t.co/YbFeWS4n4k
Our previous metas-analysis https://t.co/sJBjrx4a3r found higher odds of these reactions with nafcillin. pic.twitter.com/SIWcSuPcct— Antibiotic Tweets (@khalideljaaly) April 28, 2021
Study: Patients with heart failure have a much higher incidence of pneumonia than matched individuals in the population. The development of pneumonia in these patients is associated with a 3- to 4-fold higher risk of cardiovascular and all-cause death.
3 May, 2021 | 05:18h | UTCCommentaries: Pneumonia in HF Patients Is Common, Lethal, and Preventable – TCTMD AND Outcomes of Pneumonia in Patients With Heart Failure – American College of Cardiology
ACG Clinical Guideline: Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury – antimicrobials, herbal and dietary supplements, and anticancer therapeutics are the most common classes of agents
3 May, 2021 | 05:22h | UTC
M-A: Delayed antibiotic prescribing for respiratory tract infections is a safe and effective strategy for most patients
30 Apr, 2021 | 08:33h | UTCCommentaries: Delayed Antibiotic Prescribing Safe for Respiratory Tract Infection – HealthDay
AHA Statement: Prevention of Viridans Group Streptococcal Infective Endocarditis – Antibiotic prophylaxis for invasive dental procedures is suggested only for high-risk patients with the following conditions: 1) cardiac prosthetic valve; 2) previous infective endocarditis; 3) congenital heart disease; or 4) previous heart transplant
30 Apr, 2021 | 08:35h | UTCNews release: Good dental health may help prevent heart infection from mouth bacteria – American Heart Association
Top Things to Know: Prevention of Viridans Group Streptococcal Infective Endocarditis – American Heart Association
Slide set: Prevention of Viridans Group Streptococcal Infective Endocarditis
Commentaries: Commentary for Prevention of Viridans Group Streptococcal Infective Endocarditis – American Heart Association
Commentary on Twitter (thread – click for more)
In 2007, antibiotic prophylaxis to prevent VGS IE was scaled back.
“There was no convincing evidence that VGS IE frequency, morbidity, or mortality has increased since 2007.”
Thanks Drs. @LBaddour1, Daniel DeSimone and Walter Wilsonhttps://t.co/r9It8c3IwA pic.twitter.com/EO3gcKZAzG
— Mayo Clinic Infectious Diseases (@MayoClinicINFD) April 18, 2021
Guideline: Vulvovaginal Candidosis (Excluding Mucocutaneous Candidosis)
25 Apr, 2021 | 20:47h | UTC
New-Generation Antibiotics for Treatment of Gram-Positive Infections: A Review with Focus on Endocarditis and Osteomyelitis
23 Apr, 2021 | 08:06h | UTC
An Update on Eight “New” Antibiotics against Multidrug-Resistant Gram-Negative Bacteria
23 Apr, 2021 | 08:05h | UTC
NICE Guideline | Neonatal infection: antibiotics for prevention and treatment
21 Apr, 2021 | 06:46h | UTC
RCT: Effect of infusion set replacement intervals on catheter-related bloodstream infections – “Infusion set use can be safely extended to 7 days with resultant cost and workload reductions”
20 Apr, 2021 | 05:37h | UTCEffect of infusion set replacement intervals on catheter-related bloodstream infections (RSVP): a randomised, controlled, equivalence (central venous access device)–non-inferiority (peripheral arterial catheter) trial – The Lancet (link to abstract – $ for full-text)
Commentaries on Twitter
If you're an #RN👩⚕️or #infection preventer & it makes you crazy🤯that different hospitals🏥use infusion sets for different durations⏰- READ this massive #RCT in @TheLancet from @AVATAR_grp @UQHealth @UQMedicine @MetroNorthHHS @MenziesHealth & large team https://t.co/lpz1C6ceM2
— Prof Claire Rickard (@Claire_AVATAR) April 18, 2021
Use for 7 vs. 4 days = similar outcomes. Effect of infusion set replacement intervals on catheter-related bloodstream infections (RSVP): a randomised, controlled, equivalence (CV access device)–non-inferiority (peripheral arterial catheter) trial https://t.co/6qaJczu1Cr
— Skeptical Scalpel (@Skepticscalpel) April 16, 2021
Catheter-related bloodstream infections (CRBSIs) account for around 70% of all health care associated bloodstream infections. New trial indicates that 7-day replacement of infusion sets is safe, with resultant cost and workload reductions. https://t.co/ua633FkA3K pic.twitter.com/LfaC6lZYMv
— The Lancet (@TheLancet) April 19, 2021
WHO: Global shortage of innovative antibiotics fuels emergence and spread of drug-resistance
16 Apr, 2021 | 06:20h | UTCNews release: Global shortage of innovative antibiotics fuels emergence and spread of drug-resistance – World Health Organization
Commentary: WHO report highlights shortage of new antibiotics – CIDRAP
IDSA Guidance on the Treatment of ESBL Enterobacterales, Carbapenem-Resistant Enterobacterales, and Pseudomonas
13 Apr, 2021 | 05:11h | UTC
Cohort Study: Effects of fluoroquinolones on outcomes of patients with aortic dissection or aneurysm
13 Apr, 2021 | 05:05h | UTCRelated: Another study suggests fluoroquinolone use may increase the risk of development of aortic aneurysms (study and commentaries) AND Link between fluoroquinolones, aorta problems may not be as strong as thought AND Study: Oral Fluoroquinolones and Risk of Mitral and Aortic Regurgitation AND FDA Warns About Increased Risk of Aortic Dissection and Ruptures of Aortic Aneurism with Fluoroquinolones AND Meta-analysis: Fluoroquinolones and the Risk of Aortopathy AND Study: Oral Fluoroquinolone and the Risk of Aortic Dissection AND Research: Fluoroquinolone use and risk of aortic aneurysm and dissection
Consensus Document: Management of the complications of long term indwelling catheters
7 Apr, 2021 | 01:20h | UTC
ACP Guidance: Appropriate Use of Short-Course Antibiotics in Common Infections
6 Apr, 2021 | 01:12h | UTCSummary for Patients: Appropriate Use of Short-Course Antibiotics in Common Infections: Best Practice Advice From the American College of Physicians
Many hospitalized Covid-19 patients are given antibiotics. That’s a problem
5 Apr, 2021 | 01:33h | UTCMany hospitalized Covid-19 patients are given antibiotics. That’s a problem – STAT
Consensus Document: Management of superficial and deep surgical site infection
1 Apr, 2021 | 03:33h | UTCRelated Guidelines: Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017 – JAMA Surgery AND Global guidelines on the prevention of surgical site infection – World Health Organization AND Surgical site infections: prevention and treatment – National Institute for Health and Care Excellence AND APSIC guidelines for the prevention of surgical site infections – Antimicrobial Resistance & Infection Control
Antimicrobial resistance in ICUs: an update in the light of the COVID-19 pandemic
30 Mar, 2021 | 03:21h | UTC
RCT: Discontinuing betalactam treatment after 3 days as good as 8 days of treatment for stable patients with community-acquired pneumonia in non-critical care wards
28 Mar, 2021 | 22:25h | UTC
Commentary on Twitter
Less can be more for pneumonia. In 50% CAP patients was possible stop Abx at 3 days and outcomes were the same @TheLancet https://t.co/Hc1AxyndWS pic.twitter.com/Ypk2uXeDQV
— Michael Marks (@dr_michaelmarks) March 26, 2021
State of the Art Review | Management of colonic diverticulitis
25 Mar, 2021 | 08:14h | UTCManagement of colonic diverticulitis – The BMJ
Commentary on Twitter
NEW 🔥💥State of the Art Clinical Review @bmj_latest
Management of colonic diverticulitis #IDTwitter https://t.co/aUOGYZ8I4n pic.twitter.com/vYjzQ50LY1— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) March 24, 2021
Review: Management of Staphylococcus aureus Bloodstream Infections
23 Mar, 2021 | 02:13h | UTCManagement of Staphylococcus aureus Bloodstream Infections – Frontiers in Medicine
Nephrotoxicity from Vancomycin Combined with Piperacillin-Tazobactam: A Comprehensive Review
23 Mar, 2021 | 02:01h | UTC