Antibiotic Stewardship
M-A: Intravenous iron is associated with increased risk of infection when compared with oral iron or no iron, which must be balanced with the potential benefits of reducing blood transfusion requirements.
19 Nov, 2021 | 10:31h | UTCInvited Commentary: Intravenous Iron and Infection Risk—Still an Unanswered Question – JAMA Network Open
Commentary on Twitter
In this systematic review and meta-analysis, administration of intravenous iron was associated with an increased risk of infection. This risk must be balanced with the potential benefits of treating anemia and reducing blood transfusion requirements. https://t.co/XkNJKCk7M7
— JAMA Network Open (@JAMANetworkOpen) November 12, 2021
Infection control in the intensive care unit: expert consensus statements for SARS-CoV-2 using a Delphi method.
12 Nov, 2021 | 10:41h | UTC
Commentary from the author on Twitter (thread – click for more)
Honoured to lead this Delphi on Infection Control in ICU for SARS-CoV-2 with global experts https://t.co/39NTHgfyZR @Drnasap @ElieAzoulay5 @jigidivatia @AlhazzaniW @NaomiHammond @criticcaredoc @YaseenarabiYa @Laura_Evans_206 @FlaviaSepsis @AndersPerner @jlvincen @TheLancetInfDis pic.twitter.com/RWw6vXcHb0
— Sheila Myatra (@SheilaMyatra) November 11, 2021
Estimating daily antibiotic harms: an umbrella review with individual study meta-analysis – “Each day of antibiotic therapy was associated with 4% increased odds of experiencing an adverse event”.
12 Nov, 2021 | 09:47h | UTC
Commentary on Twitter
Each additional day of antibiotic therapy is associated with measurable antibiotic harm, particularly adverse events
🆕💥💥 @CMIJournal @BRxAD et Al
Estimating daily antibiotic harms: an umbrella review with individual study meta-analysis #IDTwitter https://t.co/ERlUZ1ict6 pic.twitter.com/KOWU4PhSzK— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) November 11, 2021
RCT: Among children with community-acquired pneumonia discharged within 48 hours from the ED or hospital, lower-dose outpatient oral amoxicillin was noninferior to a higher dose, and a 3-day duration course was noninferior to 7 days.
3 Nov, 2021 | 09:56h | UTCEffect of Amoxicillin Dose and Treatment Duration on the Need for Antibiotic Re-treatment in Children With Community-Acquired Pneumonia: The CAP-IT Randomized Clinical Trial – JAMA (free for a limited period)
Related:
ACP Guidance: Appropriate Use of Short-Course Antibiotics in Common Infections
RCT: 7 days of antibiotic therapy as good as 14 days for afebrile men with urinary tract infection.
Commentary on Twitter
🔥Just published🔥
CAP-IT RCT
Children w CAP discharged from ED or hospital (w/in48 hrs)
lower-dose outpatient oral amoxicillin was noninferior to higher dose& 3d was noninferior to 7 d, w regard to need for Abx re-treatment @BradSpellberg table update 🤔 https://t.co/VkxBmJaEeW pic.twitter.com/fKzpGp1XM7— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) November 2, 2021
A comprehensive review of vascular complications in COVID-19.
2 Nov, 2021 | 03:01h | UTC
Short Review: Metronidazole-induced neurotoxicity.
2 Nov, 2021 | 02:41h | UTCMetronidazole-induced neurotoxicity – Canadian medical Association Journal
Commentary on Twitter
The ability of metronidazole to cause neurotoxicity is not widely appreciated. Here's our quick overview led by @DanicaQuickfall, just out in @CMAJ.
https://t.co/7sggYzCzGN pic.twitter.com/miW0trFuYv— David Juurlink (@DavidJuurlink) October 25, 2021
Review: How I manage a patient with MRSA bacteremia.
31 Oct, 2021 | 19:54h | UTCHow I manage a patient with MRSA bacteraemia – Clinical Microbiology and Infection
Systematic Review: Prophylactic antibiotics for preventing gram‐positive infections associated with long‐term central venous catheters in adults and children receiving treatment for cancer.
28 Oct, 2021 | 09:58h | UTC
Does procalcitonin have clinical utility in the management of pediatric community-acquired pneumonia? A PRO/CON debate.
28 Oct, 2021 | 09:54h | UTCPRO: Procalcitonin has clinical utility in children with community-acquired pneumonia
CON: Procalcitonin does not have clinical utility in children with community-acquired pneumonia
Systematic Review: Antibiotics for the treatment of COVID‐19 – “We are certain that risk of death in hospitalized COVID‐19 patients is not reduced by treatment with azithromycin after 28 days”.
26 Oct, 2021 | 02:07h | UTCAntibiotics for the treatment of COVID‐19 – Cochrane Library
Commentary on Twitter
JUST PUBLISHED – Are #antibiotics an effective treatment for #COVID19 & do they cause unwanted effects? https://t.co/EVHduxmtdD New Cochrane Review looked at evidence from 11 studies: ❌ antibiotic azithromycin is not an effective treatment, 🤔not enough research on other types.
— The Cochrane Library (@CochraneLibrary) October 22, 2021
Pragmatic randomized trial found similar rates of surgical site infectious with 2% alcoholic chlorhexidine skin preparation compared with povidone–iodine, or with triclosan-coated sutures compared with non-coated sutures.
26 Oct, 2021 | 01:52h | UTCCommentaries:
Prevention of surgical site infection in low-resource settings – The Lancet
Commentary on Twitter
2% alcoholic chlorhexidine skin preparation and triclosan-coated sutures – no benefit in preventing surgical site infection in clean-contaminated or contaminated or dirty surgical woundshttps://t.co/QVkdYYmDvP pic.twitter.com/8hAO5lqFTV
— K Pavithran (@drkpavithran) October 25, 2021
Cohort Study: Bacterial Superinfection Pneumonia in Patients Mechanically Ventilated for COVID-19 Pneumonia – “Bacterial superinfection within 48 hours of intubation was detected in 21 percent of patients”.
26 Oct, 2021 | 01:59h | UTC
Commentary on Twitter
Bacterial Superinfection Pneumonia in Patients Mechanically Ventilated for COVID-19 Pneumonia
🔓 Open Access
🔗 https://t.co/MaCZkKrQdQ pic.twitter.com/sscICvqYjS— ATS Blue Journal (@ATSBlueEditor) October 19, 2021
M-A: Strategies for antibiotic administration for bowel preparation among patients undergoing elective colorectal surgery – “the addition of oral antibiotics to intravenous antibiotics was associated with a reduction in the incidence of incisional surgical site infection by more than 50%”.
26 Oct, 2021 | 01:42h | UTCStrategies for Antibiotic Administration for Bowel Preparation Among Patients Undergoing Elective Colorectal Surgery: A Network Meta-analysis – JAMA Surgery (free for a limited period)
Commentaries:
Bowel Preparation for Colorectal Surgery: Have All Questions Been Answered? – JAMA Surgery (free for a limited period)
Oral Abx Cut Surgical Site Infections in Colorectal Surgeries — Network meta-analysis finds over 50% SSI reduction with addition of oral to IV antibiotics – MedPage Today (free registration required)
Commentary on Twitter
Network meta-analysis demonstrates that use of oral antibiotics in addition to IV antibiotics greatly reduce the incidence of incisional SSI in elective colorectal surgery https://t.co/pUoWzsmm56
— JAMA Surgery (@JAMASurgery) October 22, 2021
The cost-effectiveness of cefazolin compared to anti-staphylococcal penicillins for the treatment of methicillin-sensitive Staphylococcus aureus bacteremia.
24 Oct, 2021 | 23:41h | UTCRelated:
Meta-Analysis: Cefazolin vs. Antistaphylococcal Penicillins for MSSA Bacteremia
Commentaries on Twitter
While Cefazolin and anti-staphylococcal penicillins (ASPs), such as nafcillin, are the preferred treatments for MSSA bacteremia it looks more and more like Cefazolin is really the preferred approach. https://t.co/6FVVEWMxBY
— Daniel Griffin MD PhD (@DanielGriffinMD) October 8, 2021
New in OFID: The use of cefazolin is a cost-effective strategy for the treatment of methicillin-sensitive S. aureus bacteremia and, when clinically appropriate, results in health care cost-savings.
📄: https://t.co/lRfsZdMjLJ#IDSAJournals @PaulSaxMD @DrJLi @ElMylonakis pic.twitter.com/hhzik4ppUW
— IDSA (@IDSAInfo) October 8, 2021
M-A: In patients with Staphylococcus aureus bacteremia, combination therapy does not reduce mortality and is associated with increased risks of adverse events.
24 Oct, 2021 | 23:42h | UTC
M-A: Risk factors for invasive candida infection in critically ill patients – The risk factors associated with the highest risk for ICI were broad spectrum antibiotics (OR 5.6), blood transfusion (OR 4.9), Candida colonization (OR 4.7), central venous catheter (OR 4.7) and total parenteral nutrition (OR 4.6).
19 Oct, 2021 | 08:47h | UTC
Review: Management of infectious emergencies for the inpatient dermatologist.
17 Oct, 2021 | 21:06h | UTCManagement of Infectious Emergencies for the Inpatient Dermatologist – Current Dermatology Reports (if this link is paywalled, try this one)
Review: Timing of antibiotic therapy in the ICU.
17 Oct, 2021 | 21:05h | UTCTiming of antibiotic therapy in the ICU – Critical Care
Cluster RCT: An antimicrobial stewardship intervention safely reduced the use of broad-spectrum antibiotics among patients hospitalized with moderately severe community-acquired pneumonia.
11 Oct, 2021 | 23:55h | UTCNarrow-spectrum antibiotics for community-acquired pneumonia in Dutch adults (CAP-PACT): a cross-sectional, stepped-wedge, cluster-randomised, non-inferiority, antimicrobial stewardship intervention trial – The Lancet Infectious Diseases (link to abstract – $ for full-text)
U.S. Data: Drug-resistant Infections led to $1.9 billion in health care costs, more than 10,000 deaths among older adults in one year.
8 Oct, 2021 | 10:11h | UTCCommentaries:
Study highlights impact of antibiotic resistance on older Americans – CIDRAP
RCT: Immediate drainage did not improve outcomes compared to postponed intervention in patients with infected necrotizing pancreatitis.
7 Oct, 2021 | 10:35h | UTC
Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.
3 Oct, 2021 | 22:41h | UTC
WSES/GAIS/SIS-E/WSIS/AAST global clinical pathways for patients with intra-abdominal infections.
1 Oct, 2021 | 10:24h | UTCRelated:
RCT: Doxycycline better than Azithromycin for the treatment of rectal Chlamydia in men who have sex with men.
1 Oct, 2021 | 10:09h | UTC
Optimizing antimicrobial use in humans – review of current evidence and an interdisciplinary consensus on key priorities for research.
30 Sep, 2021 | 10:05h | UTC