Antibiotic Stewardship
M-A: Prevalence of respiratory viruses in community-acquired pneumonia in children.
1 Jun, 2022 | 10:57h | UTCPrevalence of respiratory viruses in community-acquired pneumonia in children: a systematic review and meta-analysis – The Lancet Child & Adolescent Health (link to abstract – $ for full-text)
Commentary on Twitter
#Respiratory viruses are frequently detected in community-acquired #pneumonia among #children of all ages and geographical regions. Most common viruses were #RSV (23%) and #rhinovirus (22%) in the pre-COVID years
New Research by @MejbahBhuiyan & team: https://t.co/4ph2Isotcu
— The Lancet Child & Adolescent Health (@LancetChildAdol) May 31, 2022
Long-term impact of Helicobacter pylori eradication therapy on gastric cancer incidence and mortality in healthy infected individuals: A meta-analysis beyond 10 years of follow-up.
31 May, 2022 | 11:47h | UTC
Commentary from the author on Twitter (thread – click for more)
https://twitter.com/alex_ford12399/status/1527601814765551616
Alcoholic chlorhexidine skin preparation or triclosan-coated sutures to reduce surgical site infection: a systematic review and meta-analysis of high-quality randomized controlled trials.
31 May, 2022 | 11:50h | UTCRelated Study: Reducing surgical site infections in low-income and middle-income countries (FALCON): a pragmatic, multicentre, stratified, randomised controlled trial – The Lancet AND Commentary: Expensive antiseptics and sutures do not reduce the risk of surgical infections – National Institute for Health and Care Research
Commentary from one of the authors on Twitter (thread – click for more)
1. Today: our @TheLancetInfDis meta-analysis based on @FalconRct – triclosan sutures and alcoholic skin prep to reduce surgical site infection.
Link to open access PDF:https://t.co/cj7yFdbNpB pic.twitter.com/VkKRaxCAtm
— Aneel Bhangu (@aneelbhangu) May 27, 2022
Most doctors still believe in prescribing unnecessary antibiotics to treat asymptomatic bacteriuria, study suggests.
31 May, 2022 | 11:31h | UTC
Commentary on Twitter
🆕💥💥@jamanetworkopen @dr_dmorgan et Al
In this survey study of 551 primary care clinicians, 392 (71%) reported that they would prescribe antibiotics for asymptomatic bacteriuria, shocking? #IDTwitter @BradSpellberg @DrToddLee @InfectiousDz @bwtrautnerhttps://t.co/tekcQVsfqk pic.twitter.com/1fRakHgjU7— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) May 27, 2022
RCT: Fast multiplex bacterial PCR of bronchoalveolar lavage for antibiotic stewardship in hospitalized patients with pneumonia at risk of Gram-negative bacterial infection.
31 May, 2022 | 10:55h | UTCFast multiplex bacterial PCR of bronchoalveolar lavage for antibiotic stewardship in hospitalised patients with pneumonia at risk of Gram-negative bacterial infection (Flagship II): a multicentre, randomised controlled trial – The Lancet Respiratory Medicine (link to abstract – $ for full-text)
Commentary on Twitter
NEW Research—Multiplex bacterial PCR examination of bronchoalveolar lavage decreases duration of inappropriate antibiotic therapy of pts admitted to hospital w/ pneumonia & at risk of Gram-negative rod infection
From @AndreiMDarie & colleagues https://t.co/jnBak5SkJo pic.twitter.com/Py28aFqMw9
— The Lancet Respiratory Medicine (@LancetRespirMed) May 25, 2022
[News release – not published yet] RCT: Doxycycline after unprotected sex significantly reduced STIs – study of men who have sex with men and transgender women stopped early for effectiveness.
30 May, 2022 | 11:57h | UTC
Brief Review: Catheter dressings.
30 May, 2022 | 11:26h | UTCCatheter dressings – Intensive Care Medicine (if the link is paywalled, try this one)
Commentary on Twitter
🧫 Dressing short-term intravascular catheters in #ICU one of most important risk factors for intravascular catheter infections, impacting on extraluminal route (colonization & subsequent infection of from dermal surface). How to manage?#FOAMcc #FOANed
📎 https://t.co/dwdDMPM3Q1 pic.twitter.com/YqQPbgqA8g— Intensive Care Medicine (@yourICM) May 28, 2022
Combined bacterial meningitis and infective endocarditis: when should we search for the other when either one is diagnosed?
30 May, 2022 | 11:22h | UTC
Why we prescribe antibiotics for too long in the hospital setting: a systematic scoping review.
27 May, 2022 | 11:53h | UTC
Guideline on wound healing interventions to enhance healing of diabetic foot ulcers.
26 May, 2022 | 10:46h | UTC
Cohort Study: Pneumococcal urinary antigen testing for antimicrobial guidance in community-acquired pneumonia.
24 May, 2022 | 07:36h | UTC
Commentary on Twitter
🆕💥Large register-based cohort study
To evaluate the effect of pneumococcal urinary antigen test usage on broad-spectrum antibiotic treatment in CAP
Performing urinary antigen test has little effect on antibiotic therapy in pneumonia #IDTwitterhttps://t.co/Cxg9FDEUqk— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) May 23, 2022
Under a CC BY 4.0 license
Strategies to prevent ventilator-associated pneumonia, ventilator-associated events, and nonventilator hospital-acquired pneumonia in acute-care hospitals: 2022 Update.
23 May, 2022 | 01:58h | UTC
Commentary on Twitter
Just published 💥💥 @ICHEJournal @SHEA_Epi @IDSAInfo @APIC
Strategies to prevent ventilator-associated pneumonia, ventilator-associated events, and nonventilator hospital-acquired pneumonia in acute-care hospitals: 2022 Update #IDTwitter https://t.co/fipGfkyHi6 pic.twitter.com/c88X5GL0d6— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) May 20, 2022
Under a http://creativecommons.org/licenses/by/4.0/ license
M-A: Antibiotic duration for community acquired pneumonia in outpatient children in high-income countries – treatment duration of 3–5 days is equally effective and safe vs. 7–10 days.
20 May, 2022 | 11:10h | UTCRelated:
Antibiotics for Pediatric Pneumonia: Might Less Be Enough? – Annals of Emergency Medicine
Commentary on Twitter
Antibiotic treatment duration for community acquired pneumonia in outpatient children in high-income countries – a systematic review and meta-analysis https://t.co/HxKywgCiXS
A short AB treatment of 3–5 days was equally effective and safe compared to the longer – 7–10 days— Dr. Alex 💊🩺🎮 (@DrAlexxx78) May 17, 2022
Antibiotics given shortly before cesarean birth not linked to asthma and eczema in young children.
19 May, 2022 | 10:46h | UTCNews Release: Antibiotics given shortly before cesarean birth not linked to asthma and eczema in young children – University of Birmingham
Guideline of guidelines: management of recurrent urinary tract infections in women.
18 May, 2022 | 10:59h | UTC
RCT: Extended-course antibiotic prophylaxis in lower limb amputation.
17 May, 2022 | 10:50h | UTCExtended-course antibiotic prophylaxis in lower limb amputation: randomized clinical trial – British Journal of Surgery (link to abstract – $ for full-text)
Commentary on Twitter
In the May issue of BJS: Extended-course antibiotic prophylaxis in lower limb amputation: randomized clinical trial https://t.co/2H0TthufvZ @AmyLightnerMD @bplwijn @des_winter @ksoreide @MalinASund @evanscolorectal @nfmkok @robhinchliffe1 @young_bjs pic.twitter.com/taSa4Caibn
— BJS (@BJSurgery) April 30, 2022
Study Commentary | Antibiotics for pediatric pneumonia: might less be enough?
17 May, 2022 | 10:39h | UTCAntibiotics for Pediatric Pneumonia: Might Less Be Enough? – Annals of Emergency Medicine
Related:
Treatment of UTIs in Infants <2 Months: A Living Systematic Review – Hospital Pediatrics
RCT: Comparison of 8 versus 15 days of antibiotic therapy for Pseudomonas aeruginosa ventilator-associated pneumonia in adults.
16 May, 2022 | 02:30h | UTCComparison of 8 versus 15 days of antibiotic therapy for Pseudomonas aeruginosa ventilator-associated pneumonia in adults: a randomized, controlled, open-label trial – Intensive Care Medicine (free article here)
Commentary on Twitter
🧫 8 vs 15 days ABT for Pseudomonas aeruginosa VAP in adults, iDIAPASON RCT: no differences in composite or separate outcomes (90-day mortality/VAP recurrence) between short & long duration treatment.
📢 @yourICM ground-breaking release #LIVES40 #FOAMcc
🖇 https://t.co/LfoUWxCkkl pic.twitter.com/XaWkQ5R6wT— Intensive Care Medicine (@yourICM) May 13, 2022
Molecular diagnostics in severe pneumonia: a new dawn or false promise?
16 May, 2022 | 01:43h | UTCMolecular diagnostics in severe pneumonia: a new dawn or false promise? – Intensive Care Medicine
Commentary on Twitter
Pneumonia? no gold standard diagnosis available, likely resulting in overtreatment. Molecular diagnostics more widely available even if interpretation/use complex, requiring to take into account data/characteristics when making decisions based on these.
📎 https://t.co/mae0vxBfkF pic.twitter.com/bbkxGLEumN— Intensive Care Medicine (@yourICM) May 14, 2022
Skeletal infections: microbial pathogenesis, immunity, and clinical management.
13 May, 2022 | 11:03h | UTCSkeletal infections: microbial pathogenesis, immunity and clinical management – Nature Reviews Microbiology (if the link is paywalled, try this one)
Pharmacist-led review tied to better antimicrobial prescribing at discharge.
13 May, 2022 | 10:59h | UTCCommentary: Pharmacist-led review tied to better antimicrobial prescribing at discharge – CIDRAP
Original Study: Pharmacist-Driven Transitions of Care Practice Model for Prescribing Oral Antimicrobials at Hospital Discharge – JAMA Network Open
Systematic Review: Antibiotic prophylaxis for preventing bacterial endocarditis following dental procedures.
12 May, 2022 | 10:24h | UTC
Commentary on Twitter
Have a look at the evidence on antibiotics for preventing bacterial endocarditis in people undergoing dental treatment. Summary here: https://t.co/7uxnkbgt8t. Full review here: https://t.co/3Au3EsHZIU pic.twitter.com/RLsF3fHiZa
— Cochrane Oral Health (@CochraneOHG) May 11, 2022
Use of novel strategies to develop guidelines for management of pyogenic osteomyelitis in adults: a WikiGuidelines group consensus statement.
11 May, 2022 | 11:23h | UTCCommentary: A new approach to medical guidelines, taking inspiration from Wikipedia – University of Michigan
Commentary on Twitter
This consensus statement & systematic review uses a WikiGuidelines methodology for clinical guideline development (precluding recommendations based on low-quality data/opinion), addressing 7 questions regarding osteomyelitis management. @BradSpellberg https://t.co/MVjkzC5rdf
— JAMA Network Open (@JAMANetworkOpen) May 10, 2022
RCT: Doxycycline vs. azithromycin for treating anorectal Chlamydia trachomatis infection in women.
11 May, 2022 | 11:15h | UTCDoxycycline versus azithromycin for the treatment of anorectal Chlamydia trachomatis infection in women concurrent with vaginal infection (CHLAZIDOXY study): a multicentre, open-label, randomised, controlled, superiority trial – The Lancet Infectious Diseases (link to abstract – $ for full-text)
Commentary: Doxycycline Bests Azithromycin for Anogenital Chlamydia in Women — Open-label randomized trial set out to duplicate results from prior studies in men – MedPage Today (free registration required)
Related:
Cohort Study: Community-acquired bacterial meningitis in patients of 80 years and older.
11 May, 2022 | 10:51h | UTC