Antibiotic Stewardship
Practice update to optimize the performance and interpretation of blood cultures.
6 Sep, 2022 | 14:31h | UTC
RCT | Maintaining continuous endotracheal cuff pressure control through an automated electronic device did not reduce the incidence of ventilator-associated respiratory infection.
5 Sep, 2022 | 14:25h | UTC
Systematic Review | Antifungal therapies for allergic bronchopulmonary aspergillosis in people with cystic fibrosis.
5 Sep, 2022 | 14:15h | UTC
AHA Scientific Statement | Management of infective endocarditis in people who inject drugs.
1 Sep, 2022 | 12:00h | UTCNews Release: Addiction management is key to treating heart infection in people who inject drugs – American Heart Association
Top Things to Know: Infective Endocarditis in People Who Inject Drugs – American Heart Association
Video: Management of Infective Endocarditis in People who Inject Drugs – American Heart Association
Commentaries:
AHA Addresses Infective Endocarditis in Injection Drug Users – HealthDay
Related: Management of Infective Endocarditis in People Who Inject Drugs – American College of Cardiology (the original article is paywalled but has an informative infographic)
Study Commentary | Zinc for the prevention or treatment of respiratory tract infections: a new systematic review.
1 Sep, 2022 | 11:46h | UTC
Study shows dentists should give antibiotics to high-risk patients to help prevent infectious endocarditis.
1 Sep, 2022 | 11:43h | UTCOriginal Study: Antibiotic Prophylaxis Against Infective Endocarditis Before Invasive Dental Procedures – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentary: UK dentists should give antibiotics to patients at risk of heart infection – study – The Guardian
Meta-analysis of randomized trials | Antibiotic therapy vs. appendicectomy for uncomplicated acute appendicitis.
1 Sep, 2022 | 11:40h | UTCRelated:
Review: Diagnosis of uncomplicated and complicated appendicitis in adults.
A Randomized trial comparing antibiotics with appendectomy for appendicitis
Commentary on Twitter
👼 The reborn of surgery for uncomplicated acute appendicitis ?!
🧐 RCT comparing antibiotic 🤜🤛 appendicectomy: meta analysis of > 3000 patients
💊 No benefit on complications and LOS
🏥 Antibiotics 6X increase in hospital readmission!
🆓 full text https://t.co/VhL9u0Weua pic.twitter.com/SdyK0rKS3f
— Giovanni Marchegiani (@Gio_Marchegiani) August 17, 2022
Meta-analysis of randomized trials | Efficacy and safety of Plazomicin in the treatment of Enterobacterales infections.
31 Aug, 2022 | 11:39h | UTC
M-A | Adverse pregnancy and birth outcomes associated with Mycoplasma hominis, Ureaplasma urealyticum and Ureaplasma parvum.
29 Aug, 2022 | 12:06h | UTC
Cluster RCT | Effect of antiseptic bathing with chlorhexidine or octenidine on central line–associated bloodstream infections in intensive care patients.
24 Aug, 2022 | 14:02h | UTCEffect of antiseptic bathing with chlorhexidine or octenidine on central line–associated bloodstream infections in intensive care patients: a cluster-randomized controlled trial – Clinical Microbiology and Infection (link to abstract – $ for full-text)
Commentary on Twitter
Antiseptic bathing for CLABSI prevention:
SW-RCT incl 72 ICUs with 76,815 showed no significant differences between daily bathing with a) 2% chlorhexidine-impregnated cloths vs b) 0.08% octenidine vs c) water & soap in CLAPSI
Thanks to @CritCareReviews https://t.co/Ou3g3ptMLp— Peter Nydahl (@NydahlPeter) May 30, 2022
Study Commentary | Non-sterile gloves for suturing traumatic lacerations?
23 Aug, 2022 | 13:29h | UTCNon-Sterile Gloves for Suturing Traumatic Lacerations? – RebelEM
Original Study: Non-sterile gloves and dressing versus sterile gloves, dressings and drapes for suturing of traumatic wounds in the emergency department: a non-inferiority multicentre randomised controlled trial – Emergency Medicine Journal (link to abstract – $ for full-text)
Review | The role of abdominal drain cultures in managing abdominal infections.
23 Aug, 2022 | 12:48h | UTCThe Role of Abdominal Drain Cultures in Managing Abdominal Infections – Antibiotics
Review | Drug regimens of novel antibiotics in critically ill patients with varying renal functions.
23 Aug, 2022 | 12:49h | UTC
RCT | Ceftolozane/Tazobactam plus Metronidazole vs. Meropenem in patients with complicated intra-abdominal infections.
18 Aug, 2022 | 12:37h | UTC
AAP Updated Clinical Report | The use of systemic and topical fluoroquinolones.
17 Aug, 2022 | 14:19h | UTCThe Use of Systemic and Topical Fluoroquinolones – Pediatrics
NICE Guideline | Urinary tract infection in under 16s: diagnosis and management.
15 Aug, 2022 | 12:34h | UTC
M-A | Interventions to reduce infections in patients with hematological malignancies.
15 Aug, 2022 | 11:51h | UTCCommentary: Prophylactic Immunoglobulin, Vaccinations May Reduce Infections in Hematologic Malignancies – AJMC
Age–sex differences in the global burden of lower respiratory infections and risk factors, 1990–2019: results from the Global Burden of Disease Study 2019.
12 Aug, 2022 | 14:58h | UTCInvited Commentary: Trends in the global burden of lower respiratory infections: the knowns and the unknowns – The Lancet Infectious Diseases
Commentary on Twitter (thread – click for more)
New Research: Age–sex differences in the global burden of lower respiratory infections and risk factors, 1990–2019: results from the Global Burden of Disease Study 2019 https://t.co/rhV7lRaZvc (1/2) pic.twitter.com/I0INjaMh4I
— The Lancet Infectious Diseases (@TheLancetInfDis) August 12, 2022
M-A | Diagnostic accuracy of urinary antigen tests for pneumococcal pneumonia among patients with acute respiratory failure suspected pneumonia.
12 Aug, 2022 | 14:28h | UTC
Podcast | Meningitis pearls.
12 Aug, 2022 | 14:25h | UTC#346 Meningitis – The Curbsiders
RCT | Tobramycin inhalation solution is effective in adults with bronchiectasis with pseudomonas aeruginosa infection.
11 Aug, 2022 | 12:15h | UTCCommentary: Tobramycin Tames Infection in Bronchiectasis – Medscape (free registration required)
Retrospective cohort study | In patients with recurrent prosthetic joint infection after attempted surgical eradication, chronic antibiotic suppression may be a reasonable strategy in patients who lack or refuse further surgical treatment options.
10 Aug, 2022 | 12:17h | UTCPredictors of Success with Chronic Antibiotic Suppression for Prosthetic Joint Infections – The Journal of Arthroplasty (link to abstract – $ for full-text)
Commentary: Chronic antibiotic suppression may successfully treat periprosthetic joint infections – Healio (free registration required)
Guideline Synopsis | Treatment of Clostridioides difficile infection.
9 Aug, 2022 | 12:54h | UTCTreatment of Clostridioides difficile Infection – JAMA (free for a limited period)
Original Guideline: ACG Clinical Guidelines: Prevention, Diagnosis, and Treatment of Clostridioides difficile Infections – American Journal of Gastroenterology
Related Guidelines:
Commentary on Twitter
A summary of @AmCollegeGastro’s 2021 guidelines on treatment of Clostridioides difficile infection. https://t.co/QzrMa71ttu
— JAMA (@JAMA_current) August 8, 2022
Inhaled antibiotics in critical care: state of the art and future perspectives.
9 Aug, 2022 | 12:30h | UTC
Antimicrobial dosing recommendations in pediatric continuous renal replacement therapy: a critical appraisal of current evidence.
5 Aug, 2022 | 13:58h | UTC