Antibiotic Stewardship
Consensus Recommendations | Minimizing the risk of monkeypox virus transmission during fecal microbiota transplantation.
12 Oct, 2022 | 13:54h | UTC
Guideline Summary | Diagnostic stewardship for urinary tract infection.
11 Oct, 2022 | 13:37h | UTCOriginal Guideline: Optimal Urine Culture Diagnostic Stewardship Practice—Results from an Expert Modified-Delphi Procedure – Clinical Infectious Diseases
RCT | Cefepime/Enmetazobactam vs. Piperacillin/Tazobactam in patients with complicated urinary tract infections.
6 Oct, 2022 | 13:49h | UTCEffect of Cefepime/Enmetazobactam vs Piperacillin/Tazobactam on Clinical Cure and Microbiological Eradication in Patients With Complicated Urinary Tract Infection or Acute Pyelonephritis: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Cefepime/Enmetazobactam for Complicated Urinary Tract Infections – JAMA (free for a limited period)
Commentary on Twitter
https://twitter.com/JAMA_current/status/1577372986188906522
Review | Antimicrobial stewardship programs focused on de-escalation.
6 Oct, 2022 | 13:36h | UTC
RCT | Topical antibiotics reduce the time to clinical cure in children with infective conjunctivitis.
5 Oct, 2022 | 13:55h | UTCCommentaries:
Topical Antibiotics Shorten Duration of Conjunctival Symptoms – HealthDay
Commentary on Twitter
In this RCT and meta-analysis with 3 prior RCTs, children who received antibiotic eye drops had shorter duration of conjunctivitis vs. placebo. #OAResearch https://t.co/3mq5Fr8NDS
— JAMA Network Open (@JAMANetworkOpen) October 4, 2022
RCT | Antibiotic prophylaxis vs. no prophylaxis in breast cancer surgery.
3 Oct, 2022 | 13:47h | UTCAntibiotic prophylaxis in breast cancer surgery (PAUS trial): randomised clinical double-blind parallel-group multicentre superiority trial – British Journal of Surgery (link to abstract – $ for full-text)
Perspective/review | Bronchoscopy for diagnosis of ventilator-associated pneumonia.
30 Sep, 2022 | 12:40h | UTCBronchoscopy for diagnosis of ventilator-associated pneumonia – Intensive Care Medicine
WGO Guideline—Endoscope disinfection update.
29 Sep, 2022 | 13:31h | UTCWGO Guideline—Endoscope Disinfection Update – Journal of Clinical Gastroenterology
How applicable is the single-dose AMBITION regimen for HIV-associated cryptococcal meningitis to high-income settings?
29 Sep, 2022 | 13:26h | UTC
Commentary on Twitter
How applicable is the single-dose liposomal amphotericin B (AMBITION regimen) for HIV-associated cryptococcal meningitis to high-income settings?
Very, argue leaders of the @ambitioncm2020 trial in @CIDJournal https://t.co/eUlWG0t1Xv pic.twitter.com/8JGBU1oWeO
— Ilan Schwartz is on🦋 (@GermHunterMD) September 27, 2022
Under a https://creativecommons.org/licenses/by/4.0/ license
RCT | Fecal microbiota transplantation better than standard of care for first or second Clostridioides difficile infection.
26 Sep, 2022 | 12:08h | UTCFaecal microbiota transplantation for first or second Clostridioides difficile infection (EarlyFMT): a randomised, double-blind, placebo-controlled trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)
Commentary: New FMT Trial Halted Due to Effectiveness – HCP Live
Commentary from the author on Twitter (thread – click for more)
Happy (and proud) to share EarlyFMT is now published in @Lancetgashep!#FMT after vancomycin outperforms vancomycin alone for 1st or 2nd #Cdiff infection!
90% FMT vs 33% vancomycin alone.Our thoughts behind the trial journey that started 5 years ago?https://t.co/91nS2TRY6Y pic.twitter.com/sFy6G3io39
— Simon MD Baunwall (@SMDBaunwall) September 22, 2022
M-A | Antibiotics vs. no treatment for asymptomatic bacteriuria in residents of aged care facilities.
26 Sep, 2022 | 12:06h | UTCRelated:
USPSTF Recommendation Statement: Screening for Asymptomatic Bacteriuria in Adults
Brief Review | Source control in the management of sepsis and septic shock.
20 Sep, 2022 | 13:32h | UTCSource control in the management of sepsis and septic shock – Intensive Care Medicine (if the link is paywalled, try this one)
Commentary on Twitter
Source control to eliminate origin of infection, control contamination, restore premorbid anatomy/function in #sepsis & septic shock
🧫 think outside (abdominal) box
🧫 have multidisciplinary approach
🧫 first do NO (additional) harm#FOAMcc on @yourICM
🖇 https://t.co/GrA0oR5lf0 pic.twitter.com/ZyPaFF3qFH— Intensive Care Medicine (@yourICM) September 15, 2022
RCT | Multiple doses of prophylactic intravenous antibiotics are no better than a single dose in implant-based breast reconstruction.
19 Sep, 2022 | 12:48h | UTC
Commentary on Twitter
Multiple-dose antibiotic prophylaxis was not superior to a single-dose regimen in preventing surgical site infection and implant removal after implant-based breast reconstruction in this RCT. https://t.co/p7GbNRMPfW #OAResarch
— JAMA Network Open (@JAMANetworkOpen) September 16, 2022
RCT | Among neonates with probable bacterial infection, switching from intravenous to oral antibiotics (amoxicillin–clavulanic acid) was noninferior to a full course of intravenous antibiotics and resulted in shorter hospitalization (median duration of 3.4 vs. 6.8 days).
16 Sep, 2022 | 12:59h | UTCEfficacy and safety of switching from intravenous to oral antibiotics (amoxicillin–clavulanic acid) versus a full course of intravenous antibiotics in neonates with probable bacterial infection (RAIN): a multicentre, randomised, open-label, non-inferiority trial – The Lancet Child & Adolescent Health (link to abstract – $ for full-text)
Commentary: Dutch team devise less painful ‘drip and drink’ antibiotics treatment for babies – Dutch News
Commentaries on Twitter
*New trial*—early switch to #OralAntibiotics is not inferior to full-course IV antibiotics in #neonates with probable bacterial infection; & adverse events were not increased with use of oral antibiotics
By @IKMReiss @karelallegaert & colleagues
https://t.co/2yzeh3ptuc pic.twitter.com/BgBosxfECC
— The Lancet Child & Adolescent Health (@LancetChildAdol) September 12, 2022
In term and near-term infants <28 days with probable bacterial infection, how safe is it to switch to oral Amox-Clav as opposed to completing a course of intravenous antibiotics? A new RCT in @Lancet tries to answer this question.https://t.co/M2Za54cfxF#EBNeoAlerts#NeoEBM pic.twitter.com/zKpIiW1Whx
— Evidence-Based Neo (@EBNEO) September 12, 2022
(Thread – click for more)
Efficacy & safety of switching from intravenous to oral antibiotics (amoxicillin–clavulanic acid) vs full course of IV antibiotics in neonates with probable bacterial infection (RAIN):multicentre, randomised,open-label,non-inferiority trial -The Lancet https://t.co/mcyr9bILRq
— Prof. Dr. Sanjeev Bagai (@BagaiDr) September 13, 2022
RCT | Effect of different itraconazole dosing regimens on cure rates, treatment duration, safety, and relapse rates in adult patients with tinea corporis/cruris.
15 Sep, 2022 | 13:10h | UTCEffect of Different Itraconazole Dosing Regimens on Cure Rates, Treatment Duration, Safety, and Relapse Rates in Adult Patients With Tinea Corporis/Cruris: A Randomized Clinical Trial – JAMA Dermatology (free for a limited period)
Commentary on Twitter
Itraconazole is highly efficacious at all 3 doses but requires prolonged treatment, and a substantial number of patients relapsed after successful treatment. https://t.co/oOMkvp1WIp #Research pic.twitter.com/PoNYu50Cxr
— JAMA Dermatology (@JAMADerm) September 14, 2022
Study reveals the risk factors associated with infection following operative vaginal birth.
15 Sep, 2022 | 13:02h | UTC
M-A of randomized trials | In patients hospitalized with community-acquired pneumonia, corticosteroids reduce the need for mechanical ventilation without significant effects on mortality, treatment failure, or adverse events.
14 Sep, 2022 | 13:16h | UTCEffect of corticosteroids on mortality and clinical cure in community-acquired pneumonia: A systematic review, meta-analysis, and meta-regression of randomized control trials – CHEST Journal (link to abstract – $ for full-text)
M-A | Antibiotic use in ambulatory care for acutely ill children in high-income countries.
14 Sep, 2022 | 13:10h | UTC
Retrospective Cohort Study | Outcomes of partial oral antibiotic treatment for complicated S. aureus bacteremia in people who inject drugs.
13 Sep, 2022 | 13:09h | UTCOutcomes of Partial Oral Antibiotic Treatment for Complicated S. aureus Bacteremia in People Who Inject Drugs – Clinical Infectious Diseases (free PDF for a limited period)
Commentaries on Twitter
Interesting cohort study from @WashUID led by @LauraMarks5: IV–>PO antibiotics for PWID with Staph bacteremia associated with comparable outcomes to "standard of care" all IV, esp after 10 days of IV. Don't d/c all abx at time of discharge! @CIDJournal https://t.co/0rOfYSTnkH pic.twitter.com/yqCjifWAEK
— Paul Sax (@PaulSaxMD) September 6, 2022
🆕⚡⚡#CID @LauraMarks5
PWID w comp SA bacteremia who received oral antibiotics after an incomplete IV antibiotic(~10d) were significantly less likely to experience microbiologic failure or death than pts discharged without oral antibiotics #IDTwitter https://t.co/5zXeNfx2YL pic.twitter.com/hVhFD4iJik— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) September 2, 2022
Review | Acute pancreatitis: diagnosis and treatment.
13 Sep, 2022 | 13:04h | UTCAcute Pancreatitis: Diagnosis and Treatment – Drugs
Commentaries:
Evidence-Based Disposition of Acute Pancreatitis – emDocs
Pancreatitis – National Institute for Health and Care Excellence
RCT | Sulopenem vs. Ciprofloxacin for the treatment of uncomplicated urinary tract infections in women.
13 Sep, 2022 | 13:00h | UTC
Guideline Summary | Management of patients with suspected or confirmed antibiotic allergy.
8 Sep, 2022 | 14:42h | UTCRelated:
M-A: Most patients with allergy to Penicillin can be given Cefazolin
Podcast: A Clinical Pharmacologist’s Perspective on Penicillin Allergy
Study: Development and Validation of a Penicillin Allergy Clinical Decision Rule
NICE: Double Check Patients with ‘Penicillin Allergy’ to Avoid Increased MRSA Risk
RCT | Sulopenem (it has both IV and oral formulations) did not meet the criteria for noninferiority compared to Ertapenen for treating complicated urinary tract infections, including pyelonephritis.
8 Sep, 2022 | 14:37h | UTC
Pediatric infective endocarditis: a literature review.
8 Sep, 2022 | 14:31h | UTCPediatric Infective Endocarditis: A Literature Review – Journal of Clinical Medicine
Systematic Review | Probiotics for preventing acute upper respiratory tract infections.
6 Sep, 2022 | 14:40h | UTCProbiotics for preventing acute upper respiratory tract infections – Cochrane Library
Commentary on Twitter
#probiotics for preventing colds? @CochraneARI looked at 24 studies w 6,950 people.
👍 may be beneficial in preventing at least 1 occurrence of acute upper respiratory tract infection #URTI & likely beneficial in preventing 3 occurrences of URTIs.https://t.co/A6XxrjKKcI pic.twitter.com/mDR3NYLLzQ— The Cochrane Library (@CochraneLibrary) August 24, 2022