Hematology (all articles)
Cancer drugs are getting better and dearer
1 Jun, 2017 | 18:27h | UTCCancer drugs are getting better and dearer – The Economist (a few articles per month are free) (RT @pash22 see Tweet)
See more articles and commentaries about “financial toxicity” of cancer treatments in our April 27 issue, see #8.
Maternal and Fetal Outcomes of Anticoagulation in Pregnant Women With Mechanical Heart Valves
1 Jun, 2017 | 18:25h | UTCCommentaries: Warfarin OK in Expectant Moms with Mechanical Heart Valve – MedPage Today (free registration required) AND Anticoagulation in Pregnant Women With Mechanical Valves – American College of Cardiology, Latest in Cardiology (free) (RT @keaglemd see Tweet)
In this meta-analysis, warfarin was associated with lower risk of adverse maternal outcomes, whereas LMWH was associated with lower risk of adverse fetal outcomes.
Exercise and other non-pharmaceutical interventions for cancer-related fatigue in patients during or after cancer treatment
29 May, 2017 | 15:21h | UTCCommentary: Several non-drug options help with fatigue during, after cancer treatment – Reuters Health News (free)
Thrombocytosis and cancer
29 May, 2017 | 15:18h | UTCClinical relevance of thrombocytosis in primary care: a prospective cohort study of cancer incidence using English electronic medical records and cancer registry data – British Journal of General Practice (link to abstract – $ for full-text)
Commentaries: Cautions and caveats help buoy Guardian story on using high platelet count for cancer detection – HealthNewsReview (free) High blood platelet count ‘as good a cancer predictor as a lump in the breast’ – The Guardian (free)
Thrombocytosis seems to be a risk marker of cancer in adults, but questions remain about the clinical usefulness of these findings.
Multiple Myeloma Guidelines
24 May, 2017 | 14:41h | UTCRelated: Multiple myeloma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up – Annals of Oncology (free)
Perioperative management of patients on direct oral anticoagulants
24 May, 2017 | 14:42h | UTCReview: Perioperative management of patients on direct oral anticoagulants – Thrombosis Journal (free)
Hodgkin Lymphoma – NCCN Clinical Practice Guidelines
12 May, 2017 | 19:31h | UTCHodgkin Lymphoma Version 1.2017, NCCN Clinical Practice Guidelines in Oncology (free)
Guideline for the Management of Fever and Neutropenia in Children
10 May, 2017 | 18:24h | UTC
Management of severe perioperative bleeding
6 May, 2017 | 20:31h | UTCManagement of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology (free)
Source: Critical Care Reviews Newsletter
Donor Age and Sex Do Not Affect of Patients Receiving Transfusions
5 May, 2017 | 20:21h | UTCAssociation of Donor Age and Sex With Survival of Patients Receiving Transfusions – JAMA Internal Medicine (link to abstract – $ required for full-text)
Source: Blood Donor Age, Sex Do Not Affect Outcomes After All – Medscape (free registration required)
“After reviewing almost 1 million transfusions, the researchers concluded all donations are about the same” (RT @theheartorg see Tweet)
Management of Inherited Bleeding Disorders in Pregnancy
1 May, 2017 | 16:47h | UTC
Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage
27 Apr, 2017 | 16:33h | UTCEditorial: WOMAN: reducing maternal deaths with tranexamic acid (free)
Commentary: Overlooked Drug Could Save Thousands Of Moms After Childbirth – NPR Goats and Soda (free)
“Tranexamic acid reduced deaths of mothers caused by bleeding after childbirth by 1/3” (RT @LSHTMpress see Tweet)
Standardized Criteria for Palliative Care Consultation
24 Apr, 2017 | 15:25h | UTCProspective, before-after cohort study: Standardized Criteria for Palliative Care Consultation on a Solid Tumor Oncology Service Reduces Downstream Health Care Use – Journal of Oncology Practice (free)
Editorial: Making the Right Thing Easier to Do: Standardized Integration of Oncology and Palliative Care – Journal of Oncology Practice (free)
Related Guideline: Integration of Palliative Care Into Standard Oncology Care: American Society of Clinical Oncology Clinical Practice Guideline Update (free)
Commentaries on the study: Standardized Palliative Care Consults Cut Cancer Readmissions – Also, less chemotherapy after discharge – MedPage Today (free registration required) AND Standardized Cancer Palliative Care Consults Linked to Stronger Home-Based Support – AJMC (free)
Patients with at least one of the following 4 criteria: 1) advanced solid tumor; 2) prior hospitalization within 30 days; 3) hospitalization > 7 days; or 4) active symptoms – received automatic palliative care consultation. The rates of 30-day readmissions dropped from 35% to 18% and chemotherapy after discharge dropped from 44% to 18%.
New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management
18 Apr, 2017 | 14:05h | UTCSource: Critical Care Reviews Newsletter
European Association of Urology releases its 1st thromboprophylaxis guideline
14 Apr, 2017 | 16:10h | UTCEuropean Association of Urology releases its 1st thromboprophylaxis guideline (free)
“Extended thromboprophylaxis is warranted in some procedures (eg, open and robotic cystectomy) but not others (eg, robotic prostatectomy without pelvic lymph node dissection in low-risk patients)”
“Extended prophylaxis is warranted for some procedures (eg, kidney transplantation procedures in high-risk patients) but not others (transurethral resection of the prostate and reconstructive female pelvic surgery in low-risk patients)”
Emergencies in Hematology and Oncology
11 Apr, 2017 | 15:45h | UTCEmergencies in Hematology and Oncology – Mayo Clinic Proceedings (free)
Comprehensive review covering the most common oncological emergencies.
Cancer patients have 55% greater risk of suicide
6 Apr, 2017 | 15:05h | UTCCancer patients have 55% greater risk of suicide, study finds – The Guardian (free) (RT @ghn_news)
American College of Radiology (ACR) Appropriateness Criteria Adds Topics
4 Apr, 2017 | 21:19h | UTCACR Appropriateness Criteria Adds Topics, Covers More Clinical Variants Than Ever Before (free)
Browse Appropriateness Criteria Topics (free)
Source: Newswise
This comprehensive guide from American College of Radiology (ACR) covers 230 topics with more than 1,100 clinical indications and has just been updated. It is a very useful resource for doctors in all specialties to guide which exam is most appropriate in each clinical situation.
Eosinophilia in Primary Care
4 Apr, 2017 | 19:30h | UTCEosinophilia – Primary Care: Clinics in Office Practice (free)
Anemia and blood transfusion in the critically ill patient with cardiovascular disease
3 Apr, 2017 | 19:14h | UTC
Non–Vitamin K Antagonist Oral Anticoagulants in Patients With Atrial Fibrillation and Valvular Heart Disease
30 Mar, 2017 | 17:27h | UTCSource: SciCombinator
Except for patients with moderate/severe mitral stenosis or mechanical heart valves, who were excluded in most trials, high-dose NOACs was as effective and safe for patients with valvular heart disease as for patients without valvular disorders.
HERDOO2 rule to guide treatment duration for women with unprovoked venous thrombosis
29 Mar, 2017 | 17:07h | UTCSource: Richard Lehman’s weekly review
HERDOO2 rule stands for Hyperpigmentation, Edema, or Redness in either leg; D-dimer level ≥250 μg/L; Obesity with body mass index ≥30; or Older age, ≥65 years. The authors concluded that women with a first unprovoked VTE event and none or one of the HERDOO2 criteria have a low risk (3.0% per patient year) of recurrent VTE and can safely discontinue anticoagulants after completing short term treatment.