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Geriatrics

M-A: Effectiveness of telerehabilitation in physical therapist practice.

10 Jun, 2021 | 09:29h | UTC

Effectiveness of Telerehabilitation in Physical Therapist Practice: An Umbrella and Mapping Review With Meta–Meta-Analysis – Physical Therapy & Rehabilitation Journal

 

FDA approvement of Alzheimer’s drug sparks controversy among doctors.

9 Jun, 2021 | 08:18h | UTC

News release: FDA Grants Accelerated Approval for Alzheimer’s Drug – U.S. Food & Drug Administration

Commentaries: ICER Issues Statement on the FDA’s Approval of Aducanumab for Alzheimer’s Disease – Institute for Clinical and Economic Review AND Landmark Alzheimer’s Drug Approval Confounds Research Community – Nature AND FDA approves Alzheimer’s drug from Biogen, against experts’ advice – NBC News AND F.D.A. Approves Alzheimer’s Drug Despite Fierce Debate Over Whether It Works – The New York Times (a few articles per month are free) AND Alzheimer’s drug approved despite doubts about effectiveness – Science (a few articles per month are free) AND The FDA Has Approved A New Alzheimer’s Drug — Here’s Why That’s Controversial – NPR AND Opinion: Bad medicine: aducanumab is a lackluster drug with a high price tag – STAT

 

RCT: Early, intensive mobilization poststroke may harm patients.

6 Jun, 2021 | 23:45h | UTC

Fatal and Nonfatal Events Within 14 days After Early, Intensive Mobilization Poststroke – Neurology

 

M-A: The benefit of dysphagia screening in adult patients with stroke.

6 Jun, 2021 | 23:43h | UTC

The Benefit of Dysphagia Screening in Adult Patients With Stroke: A Meta‐Analysis – Journal of the American Heart Association

 

RCT: Prophylactic post-exposure prophylaxis with Bamlanivimab reduced the incidence of Covid-19 among residents and staff of skilled nursing and assisted living facilities.

4 Jun, 2021 | 10:40h | UTC

Effect of Bamlanivimab vs Placebo on Incidence of COVID-19 Among Residents and Staff of Skilled Nursing and Assisted Living Facilities: A Randomized Clinical Trial – JAMA

Editorial: Bamlanivimab for Prevention of COVID-19

 

Covid-19: Pfizer-BioNTech vaccine is “likely” responsible for deaths of some elderly patients, Norwegian review finds.

28 May, 2021 | 08:22h | UTC

Covid-19: Pfizer-BioNTech vaccine is “likely” responsible for deaths of some elderly patients, Norwegian review finds – The BMJ

 

Commentary on Twitter

 

Advance Care Planning for people with dementia: recognizing moral dilemmas faced by physicians.

28 May, 2021 | 08:14h | UTC

Advance Care Planning for people with dementia: recognising moral dilemmas faced by physicians – The Mental Elf

Original study: Which moral barriers and facilitators do physicians encounter in advance care planning conversations about the end of life of persons with dementia? A meta-review of systematic reviews and primary studies – BMJ Open

 

Pessaries for pelvic organ prolapse – looking at the Cochrane evidence.

24 May, 2021 | 08:17h | UTC

Pessaries for pelvic organ prolapse – looking at the Cochrane evidence – Evidently Cochrane

Original Review: Pessaries (mechanical devices) for managing pelvic organ prolapse in women – Cochrane Library

 

RCT: Reduced-intensity chemotherapy among older and frail patients with advanced gastroesophageal cancer provides an improved patient experience with no significant detriment in cancer control.

20 May, 2021 | 08:18h | UTC

Efficacy of Reduced-Intensity Chemotherapy With Oxaliplatin and Capecitabine on Quality of Life and Cancer Control Among Older and Frail Patients With Advanced Gastroesophageal Cancer: The GO2 Phase 3 Randomized Clinical Trial – JAMA Oncology

Commentary: Lowering Chemo Dose Achieved Happier Patients, Good Outcomes in Elderly GI Cancer Patients – Physician’s Weekly

 

Commentary on Twitter

 

#ACC21 – RCT: No significant differences in cardiovascular events or major bleeding between patients receiving 81 mg vs. 325 mg of aspirin daily.

17 May, 2021 | 08:31h | UTC

Comparative Effectiveness of Aspirin Dosing in Cardiovascular Disease – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: High- and Low-Dose Aspirin Equivalent in ASCVD: ADAPTABLE – TCTMD AND Aspirin Dosing: A Patient-Centric Trial Assessing Benefits and Long-Term Effectiveness – ADAPTABLE – American College of Cardiology

Video: Aspirin Dosing: A Patient-centric Trial Assessing Benefits And Long-term Effectiveness Trial

 

#ACC21 – RCT: Tailored, earlier heart failure rehabilitation program has physical and emotional benefits for older patients.

17 May, 2021 | 08:23h | UTC

Physical Rehabilitation for Older Patients Hospitalized for Heart Failure – New England Journal of Medicine

Commentaries: Tailored, earlier heart failure rehab has physical, emotional benefits for patients – National institutes of Health AND REHAB-HF: Tailored Cardiac Rehab Program Improved Function and Quality of Life in Older HF Patients – American College of Cardiology AND Rehabilitation Therapy in Older Acute Heart Failure Patients – REHAB-HF – American College of Cardiology

Video: A Novel Physical Rehabilitation Intervention For Older Patients With Acute Decompensated Heart Failure: The REHAB-HF Trial

 

Commentaries on Twitter

 

2 recent meta-analysis highlight the benefits of short term (30 days) dual antiplatelet therapy with aspirin + clopidogrel in patients within 24 hours of high-risk transient ischemic attack or mild-moderate ischemic stroke.

17 May, 2021 | 08:16h | UTC

Meta-analysis 1: Dual Antiplatelet Therapy Versus Aspirin in Patients With Stroke or Transient Ischemic Attack: Meta-Analysis of Randomized Controlled Trials – Stroke

Meta-analysis 2: Efficacy and Safety of Using Dual Versus Monotherapy Antiplatelet Agents in Secondary Stroke Prevention: Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials – Circulation (link to abstract – $ for full-text)

Commentary: Dual vs. Monotherapy Antiplatelet Agents in Secondary Stroke Prevention – American College of Cardiology

Related Guideline: Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke – The BMJ

 

Unnecessary care? 1 in 3 patients with advanced dementia and atrial fibrillation still given anticoagulants.

17 May, 2021 | 08:13h | UTC

Unnecessary care? 1 in 3 patients with advanced dementia and AFib still given anticoagulants – Cardiovascular Business

Original study: Anticoagulant Use for Atrial Fibrillation Among Persons With Advanced Dementia at the End of Life – JAMA Internal Medicine (free for a limited period)

Editorial: Anticoagulation at the End of Life: Time for a Rational Framework (free for a limited period)

 

Opinion | Reconceptualizing how to support surrogates making medical decisions for critically ill patients.

17 May, 2021 | 08:08h | UTC

Reconceptualizing How to Support Surrogates Making Medical Decisions for Critically Ill Patients – JAMA (free for a limited period)

 

Polypharmacy, inappropriate prescribing, and deprescribing in older people: through a sex and gender lens.

14 May, 2021 | 08:30h | UTC

Polypharmacy, inappropriate prescribing, and deprescribing in older people: through a sex and gender lens – The Lancet Health Longevity

Podcast with the author: Dr Paula Rochon talks with The Lancet Healthy Longevity about polypharmacy in older people through a sex and gender lens

Related: Reducing Inappropriate Medication Use & Polypharmacy (several articles and commentaries on the subject) AND Polypharmacy Management in Older Patients – Mayo Clinic Proceedings AND Psychopharmacological Treatment in Older People: Avoiding Drug Interactions and Polypharmacy – Deutsches Ärzteblatt internationa AND Eliminating Medication Overload: A National Action Plan AND Deprescribing in Older Adults With Cardiovascular Disease – Journal of the American College of Cardiology

 

Commentary on Twitter

 

M-A: Omega-3 fatty acids supplementation increases the risk of atrial fibrillation in patients with lipid disorders.

10 May, 2021 | 01:00h | UTC

Omega-3 fatty acids supplementation and risk of atrial fibrillation: an updated meta-analysis of randomized controlled trials – European Heart Journal – Cardiovascular Pharmacotherapy

Commentaries: Fish oil supplements linked with heart rhythm disorder – European Society of Cardiology AND Could High-Dose Fish Oil Raise Odds for A-Fib in Heart Patients? – HealthDay

 

Commentary on Twitter

 

Guideline: Diagnosis and treatment of neurogenic dysphagia.

6 May, 2021 | 08:51h | UTC

Diagnosis and treatment of neurogenic dysphagia – S1 guideline of the German Society of Neurology – Neurological Research and Practice

 

Study: Patients with heart failure have a much higher incidence of pneumonia than matched individuals in the population. The development of pneumonia in these patients is associated with a 3- to 4-fold higher risk of cardiovascular and all-cause death.

3 May, 2021 | 05:18h | UTC

Incidence and Outcomes of Pneumonia in Patients With Heart Failure – Journal of the American College of Cardiology

Commentaries: Pneumonia in HF Patients Is Common, Lethal, and Preventable – TCTMD AND Outcomes of Pneumonia in Patients With Heart Failure – American College of Cardiology

 

Randomized trial: Admission Avoidance Hospital at Home + Geriatric Assessment led to similar outcomes compared to hospital admission for older persons

3 May, 2021 | 05:13h | UTC

Is Comprehensive Geriatric Assessment Admission Avoidance Hospital at Home an Alternative to Hospital Admission for Older Persons? A Randomized Trial – Annals of Internal Medicine (link to abstract – $ for full-text)

Related: Pandemic Boosts an Old Idea—Bringing Acute Care to the Patient

 

Cohort Study: The risk of overdose with concomitant use of Z-Drugs (zolpidem, zopiclone, zaleplon) and prescription opioids is significantly increased

30 Apr, 2021 | 08:32h | UTC

The Risk of Overdose With Concomitant Use of Z-Drugs and Prescription Opioids: A Population-Based Cohort Study – American Journal of Psychiatry (link to abstract – $ for full-text)

Commentary: Co-prescribing Opioids, Z-Drugs May Increase Risk of Overdose – Psychiatric News Alert

 

CDC Study: Pfizer-BioNTech and Moderna vaccines reduce Covid-19 hospitalization risk by 64% after the first dose and 94% after the second dose among adults aged ≥65 years

29 Apr, 2021 | 08:42h | UTC

Effectiveness of Pfizer-BioNTech and Moderna Vaccines Against COVID-19 Among Hospitalized Adults Aged ≥65 Years — United States, January–March 2021 – CDC Morbidity and Mortality Weekly Report

Commentaries: Pfizer/Moderna Vaccine Protection: 64% at First Dose, 94% at Second – HealthDay AND Pfizer and Moderna vaccines reduce Covid-19 hospitalization risk by 94% among older adults, CDC study says – CNN

 

Commentary on Twitter

 

Ethics Commission Position Statement: Admission criteria and management of critical care patients in a pandemic context – “Age cannot be used as the sole criterion for admission nor denial of access to ICU settings”

29 Apr, 2021 | 08:36h | UTC

Admission criteria and management of critical care patients in a pandemic context: position of the Ethics Commission of the French Intensive Care Society, update of April 2021 – Annals of Intensive Care

 

Study in nursing homes shows rapid antigen testing could be a useful tool to identify contagious people at risk for transmitting SARS-CoV-2

27 Apr, 2021 | 08:35h | UTC

Performance Evaluation of Serial SARS-CoV-2 Rapid Antigen Testing During a Nursing Home Outbreak – Annals of Internal Medicine

Editorial: Utility of Rapid Antigen Tests in Nursing Homes

 

Commentary on Twitter

 

RCT: Promising results with vagus nerve stimulation paired with rehabilitation for upper limb motor function after ischemic stroke

25 Apr, 2021 | 21:10h | UTC

Vagus nerve stimulation paired with rehabilitation for upper limb motor function after ischaemic stroke (VNS-REHAB): a randomised, blinded, pivotal, device trial – The Lancet

Commentary: Vagus nerve stimulation: a potential new treatment for ischaemic stroke – The Lancet

 

Commentary on Twitter

 

Long Covid: Largest post-acute COVID-19 study to date examined the health outcomes in more than 73,000 people who’d had COVID-19 and were not hospitalized

23 Apr, 2021 | 08:48h | UTC

High-dimensional characterization of post-acute sequalae of COVID-19 – Nature

Commentary: Among COVID-19 survivors, an increased risk of death, serious illness – Washington University School of Medicine

 

Commentary on Twitter (thread – click for more)

 

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