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Geriatrics

AAN Guideline: Oral and topical treatment of painful diabetic polyneuropathy.

8 Jan, 2022 | 23:18h | UTC

Oral and Topical Treatment of Painful Diabetic Polyneuropathy: Practice Guideline Update Summary: Report of the AAN Guideline Subcommittee – Neurology

News Release: AAN Issues Guideline for Treatment of Painful Diabetic Neuropathy – American Academy of Neurology

 

RCT: In older patients undergoing hip fracture surgery, regional anesthesia did not reduce the incidence of postoperative delirium compared to general anesthesia.

8 Jan, 2022 | 23:09h | UTC

Effect of Regional vs General Anesthesia on Incidence of Postoperative Delirium in Older Patients Undergoing Hip Fracture Surgery: The RAGA Randomized Trial – JAMA (link to abstract – $ for full-text)

Commentary: China-wide study will boost understanding of fatal surgical complication – University of Birmingham

Related:

RCT: Spinal Anesthesia not Superior to General Anesthesia for Hip Surgery in Older Adults.

RCT: Similar long-term survival after combined epidural–general anesthesia vs. general anesthesia alone.

Delirium in Older Patients after Combined Epidural–General Anesthesia or General Anesthesia for Major Surgery: A Randomized Trial – Anesthesiology

 

In a large retrospective cohort study of patients with atrial fibrillation 65 years or older, treatment with rivaroxaban compared with apixaban was associated with increased risk of major ischemic or hemorrhagic events.

8 Jan, 2022 | 22:37h | UTC

Association of Rivaroxaban vs Apixaban With Major Ischemic or Hemorrhagic Events in Patients With Atrial Fibrillation – JAMA

Commentary: Apixaban Appears Safer, More Effective Than Rivaroxaban in Medicare Study – TCTMD

Related:

Meta-Analysis Comparing Apixaban Versus Rivaroxaban for Management of Patients With Nonvalvular Atrial Fibrillation – American Journal of Medicine

Observational Study Suggests Apixaban May Be a Better Choice than Rivaroxaban for Patients with Atrial Fibrillation

 

Retrospective cohort study: In patients with venous thromboembolism (VTE), treatment with apixaban was associated with lower rates for recurrent VTE and bleeding compared to rivaroxaban.

8 Jan, 2022 | 22:36h | UTC

Risk for Recurrent Venous Thromboembolism and Bleeding With Apixaban Compared With Rivaroxaban: An Analysis of Real-World Data – Annals of Internal Medicine

Commentaries:

Apixaban shows superior effectiveness, safety compared to rivaroxaban – ACP Internist

Recurrent VTE and Bleeding With Apixaban vs. Rivaroxaban – American College of Cardiology

 

Prevention of Chemotherapy-induced nausea and vomiting in the older patient: optimizing outcomes.

17 Dec, 2021 | 08:32h | UTC

Prevention of Chemotherapy-Induced Nausea and Vomiting in the Older Patient: Optimizing Outcomes – Drugs & Aging (if the link is paywalled, try this one)

 

Management of Hip Fractures in Older Adults: Evidence-Based Clinical Practice Guideline.

16 Dec, 2021 | 09:42h | UTC

Management of Hip Fractures in Older Adults Evidence-Based Clinical Practice Guideline – American Academy of Orthopaedic Surgeons

Summary: Management of Hip Fractures in Older Adults – American Academy of Orthopaedic Surgeons

News Release: AAOS Updates Clinical Practice Guideline for Management of Hip Fractures in Older Adults

 

Expert consensus and practical guidance: A global perspective on improving patient care in uncomplicated urinary tract infection.

15 Dec, 2021 | 08:33h | UTC

A global perspective on improving patient care in uncomplicated urinary tract infection: Expert consensus and practical guidance – Journal of Global Antimicrobial Resistance

 

Proposed subtypes of long-Covid and their respective potential therapies.

14 Dec, 2021 | 09:49h | UTC

Proposed subtypes of post-COVID-19 syndrome (or long-COVID) and their respective potential therapies – Reviews in Medical Virology

Related:

EuGMS Guidance: Management of post-acute COVID-19 patients in geriatric rehabilitation.

Addressing Post-COVID Symptoms: A Guide for Primary Care Physicians.

Global surveillance, research, and collaboration needed to improve understanding and management of long COVID.

Provocative study suggests that persistent physical symptoms after COVID-19 infection may be associated more with the belief in having been infected with SARS-CoV-2 than with having laboratory-confirmed COVID-19 infection.

Update to post-acute sequelae of SARS-CoV-2 infection: Caring for the ‘long-haulers’.

Systematic Review: Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection.

WHO Consensus: A clinical case definition of post COVID-19 condition (Long Covid).

Characterizing long COVID: a living systematic review.

Long Covid – The illness narratives.

New guidelines to help doctors manage long COVID patients published.

M-A: More than 50 long-term effects of COVID-19. (several articles on the subject)

 

Large observational study in Israel showed a third dose (booster) of the Pfizer–BioNTech vaccine had 90% effectiveness at preventing death due to Covid-19 compared to a two-dose regimen.

9 Dec, 2021 | 10:35h | UTC

BNT162b2 Vaccine Booster and Mortality Due to Covid-19 – New England Journal of Medicine

Editorial: Booster Doses and Prioritizing Lives Saved

 

Review: Neuropsychiatric assessment and management of the ICU survivor.

10 Dec, 2021 | 10:01h | UTC

Neuropsychiatric assessment and management of the ICU survivor – Cleveland Clinic Journal of Medicine

 

Review: Current issues in the use of opioids for the management of postoperative pain.

9 Dec, 2021 | 10:18h | UTC

Current Issues in the Use of Opioids for the Management of Postoperative Pain: A Review – JAMA Surgery (free for a limited period)

 

Review: Perioperative pain management issues unique to older adults undergoing surgery.

8 Dec, 2021 | 09:52h | UTC

Perioperative Pain Management Issues Unique to Older Adults Undergoing Surgery: A Narrative Review – Annals of Surgery Open

 

Raising awareness for time-limited trial discussion upon ICU triage and admission.

8 Dec, 2021 | 09:57h | UTC

Raising awareness for time-limited trial discussion upon ICU triage and admission – Intensive Care Medicine (if the link is paywalled, try this one)

 

Commentary on Twitter

 

Evaluation and management of pelvic organ prolapse.

8 Dec, 2021 | 09:50h | UTC

Evaluation and Management of Pelvic Organ Prolapse – Mayo Clinic Proceedings

 

Care of older people and people requiring palliative care with COVID-19: guidance from the Australian National COVID-19 Clinical Evidence Taskforce.

7 Dec, 2021 | 10:12h | UTC

Care of older people and people requiring palliative care with COVID-19: guidance from the Australian National COVID-19 Clinical Evidence Taskforce – Medical Journal of Australia

 

Cohort Study: Timing of dialysis initiation to reduce mortality and cardiovascular events in advanced chronic kidney disease.

2 Dec, 2021 | 09:47h | UTC

Timing of dialysis initiation to reduce mortality and cardiovascular events in advanced chronic kidney disease: nationwide cohort study – The BMJ

 

Commentary from the author on Twitter (thread – click for more)

 

WHO advice for international traffic in relation to the SARS-CoV-2 Omicron variant (B.1.1.529).

1 Dec, 2021 | 10:02h | UTC

WHO advice for international traffic in relation to the SARS-CoV-2 Omicron variant (B.1.1.529) – World Health Organization

Commentary: Over-60s, vulnerable should postpone travel due to Omicron: WHO – MedicalXpress

See also the latest articles on the subject:

Will omicron – the new coronavirus variant of concern – be more contagious than delta? A virus evolution expert explains what researchers know and what they don’t – The Conversation

WHO pleads for ‘rational’ Omicron response – MedicalXpress

Omicron: WHO warns of ‘high infection risk’ around globe – BBC

Video: Why Omicron is the most worrying Covid variant yet – video explainer – The Guardian

Doctors hope Omicron causes milder cases of Covid — but it’s still too early to say – STAT

Doctor: Many South Africans ill in surge have mild symptoms – Associated Press

New Findings Show the Omicron Variant Spread Widely At a Faster Pace Than Initially Thought – TIME

Why some researchers think the omicron variant could be the most infectious one yet – NPR

Omicron Covid variant ‘present in Europe at least 10 days ago’ – The Guardian

Netherlands says Omicron variant was already in country earlier than previously thought – CNN

Netherlands detections hint at earlier Omicron spread – CIDRAP

Epidemiologist awaits clearer picture on omicron – Harvard University

Pfizer research head envisions a sprint to develop Omicron vaccine, if it’s needed – STAT

Omicron COVID variant was in Europe before South African scientists detected and flagged it to the world – CBS News

Moderna boss predicts current vaccines may be less effective against Omicron – The Guardian

Wealthy nations starved the developing world of vaccines. Omicron shows the cost of this greed – The Conversation

Travel restrictions by country following the Omicron variant outbreak – CNN

 

Guideline Interventions for the management of acute and chronic low back pain.

30 Nov, 2021 | 10:15h | UTC

Interventions for the Management of Acute and Chronic Low Back Pain: Revision 2021 – Journal of Orthopaedic & Sports Physical Therapy

 

Commentary on Twitter

 

Systematic Review: Quantifying anticholinergic burden and sedative load in older adults with polypharmacy.

26 Nov, 2021 | 09:58h | UTC

Quantifying Anticholinergic Burden and Sedative Load in Older Adults with Polypharmacy: A Systematic Review of Risk Scales and Models – Drugs & Aging

 

Commentary on Twitter

 

Opinion | Things we do for no reason: prescribing appetite stimulants to hospitalized older adults with unintentional weight loss.

26 Nov, 2021 | 09:44h | UTC

Things We Do for No Reason: Prescribing Appetite Stimulants to Hospitalized Older Adults With Unintentional Weight Loss – Journal of Hospital Medicine

 

Safety analysis of RCTs showed Alzheimer’s drug Aducanumab caused brain swelling in 35% of patients, and 26.0% experienced associated symptoms (e.g., headache, confusion, dizziness, and nausea).

24 Nov, 2021 | 08:35h | UTC

Amyloid-Related Imaging Abnormalities in 2 Phase 3 Studies Evaluating Aducanumab in Patients With Early Alzheimer Disease – JAMA Neurology

Commentary: Biogen Alzheimer’s drug shows brain swelling in 35% of patients – MedicalXpress

 

Commentary on Twitter

 

Three Neurologic Societies, Including the AAN, Issue Strong Position Statement on Aducanumab.

24 Nov, 2021 | 08:36h | UTC

Three Neurologic Societies, Including the AAN, Issue Strong Position Statement on Aducanumab – Neurology Today

See statement: Decisions With Patients and Families Regarding Aducanumab in Alzheimer Disease, With Recommendations for Consent: AAN Position Statement – Neurology

Related:

Editorial: Aducanumab for Alzheimer’s disease?

FDA approvement of Alzheimer’s drug sparks controversy among doctors.

 

Commentary on Twitter

 

Review: Prevention and treatment of atrial fibrillation via risk factor modification.

24 Nov, 2021 | 08:25h | UTC

Prevention and Treatment of Atrial Fibrillation via Risk Factor Modification – American Journal of Cardiology

 

Systematic Review: Selective serotonin reuptake inhibitors (SSRIs) for stroke recovery.

24 Nov, 2021 | 08:22h | UTC

Summary: Selective serotonin reuptake inhibitors for stroke recovery – Cochrane Library

Original Article: Selective serotonin reuptake inhibitors (SSRIs) for stroke recovery – Cochrane Library

Related:

RCT: Routine treatment with fluoxetine does not reduce the incidence of depression after stroke.

[Abstract Only] Randomized trial: Fluoxetine does not improve functional recovery after acute stroke

Randomized Trial: Effects of Fluoxetine on Functional Outcomes After Acute Stroke

 

Commentary on Twitter

 

M-A: Current evidence does not support intensive blood pressure reduction as a preventive strategy for cognitive decline and dementia.

23 Nov, 2021 | 08:26h | UTC

Evaluation of Intensive vs Standard Blood Pressure Reduction and Association With Cognitive Decline and Dementia: A Systematic Review and Meta-analysis – JAMA Network Open

 

Commentary on Twitter

 

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