Geriatrics
Opinion | Things we do for no reason: prescribing appetite stimulants to hospitalized older adults with unintentional weight loss.
26 Nov, 2021 | 09:44h | UTC
Safety analysis of RCTs showed Alzheimer’s drug Aducanumab caused brain swelling in 35% of patients, and 26.0% experienced associated symptoms (e.g., headache, confusion, dizziness, and nausea).
24 Nov, 2021 | 08:35h | UTCCommentary: Biogen Alzheimer’s drug shows brain swelling in 35% of patients – MedicalXpress
Commentary on Twitter
Amyloid-related imaging abnormalities occurred in ~ 40% of participants in the phase 3 studies of aducanumab. Approximately one-quarter of patients with amyloid-related imaging abnormalities experience symptoms https://t.co/TnUPXT686l
— JAMA Neurology (@JAMANeuro) November 22, 2021
Three Neurologic Societies, Including the AAN, Issue Strong Position Statement on Aducanumab.
24 Nov, 2021 | 08:36h | UTCRelated:
Editorial: Aducanumab for Alzheimer’s disease?
FDA approvement of Alzheimer’s drug sparks controversy among doctors.
Commentary on Twitter
Decisions With Patients and Families Regarding #Aducanumab in Alzheimer Disease, With Recommendations for Consent—Read the full AAN @AANMember Position Statement: https://t.co/ckoIVRi4DE #Neurology pic.twitter.com/q8TSU67zm9
— Neurology Journal (@GreenJournal) November 19, 2021
Review: Prevention and treatment of atrial fibrillation via risk factor modification.
24 Nov, 2021 | 08:25h | UTC
Systematic Review: Selective serotonin reuptake inhibitors (SSRIs) for stroke recovery.
24 Nov, 2021 | 08:22h | UTCSummary: Selective serotonin reuptake inhibitors for stroke recovery – Cochrane Library
Original Article: Selective serotonin reuptake inhibitors (SSRIs) for stroke recovery – Cochrane Library
Related:
RCT: Routine treatment with fluoxetine does not reduce the incidence of depression after stroke.
[Abstract Only] Randomized trial: Fluoxetine does not improve functional recovery after acute stroke
Randomized Trial: Effects of Fluoxetine on Functional Outcomes After Acute Stroke
Commentary on Twitter
Selective #serotonin reuptake inhibitors for #stroke recovery https://t.co/7R5bijz49e Updated @CochraneStroke systematic review: 'reduced risk of future depression by about a quarter, but led to a slight increase in the risk of seizures & increased the risk of bone fractures.'
— The Cochrane Library (@CochraneLibrary) November 19, 2021
M-A: Current evidence does not support intensive blood pressure reduction as a preventive strategy for cognitive decline and dementia.
23 Nov, 2021 | 08:26h | UTC
Commentary on Twitter
Meta-analysis found no associated reduction in the risk of cognitive decline with intensive as compared to standard blood pressure (BP) interventions. There is insufficient evidence to support intensive BP management to prevent cognitive impairment. https://t.co/2BEV1ywrCO
— JAMA Network Open (@JAMANetworkOpen) November 22, 2021
EuGMS Guidance: Management of post-acute COVID-19 patients in geriatric rehabilitation.
21 Nov, 2021 | 23:14h | UTCRelated:
Addressing Post-COVID Symptoms: A Guide for Primary Care Physicians.
Update to post-acute sequelae of SARS-CoV-2 infection: Caring for the ‘long-haulers’.
Systematic Review: Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection.
WHO Consensus: A clinical case definition of post COVID-19 condition (Long Covid).
Characterizing long COVID: a living systematic review.
Long Covid – The illness narratives.
New guidelines to help doctors manage long COVID patients published.
M-A: More than 50 long-term effects of COVID-19. (several articles on the subject)
Systematic Review | Prehabilitation and rehabilitation for major joint replacement.
21 Nov, 2021 | 22:41h | UTCSee also:
Systematic Review: Multidisciplinary rehabilitation for older people with hip fractures.
18 Nov, 2021 | 08:28h | UTCOriginal Study: Multidisciplinary rehabilitation for older people with hip fractures – Cochrane Library
Commentary on Twitter
JUST PUBLISHED – Multidisciplinary #rehabilitation for older people with hip fractures ➡️ https://t.co/kjhycTCjE8 Updated @CochraneBJMT systematic review looks at the evidence from 28 trials involving 5,351. @CochraneRehab @CCGlobalAgeing #rehab pic.twitter.com/ZamV4xHObh
— The Cochrane Library (@CochraneLibrary) November 12, 2021
AAN Guideline: Dopaminergic Therapy for Motor Symptoms in Early Parkinson Disease.
17 Nov, 2021 | 08:32h | UTCNews Release: AAN Issues Guideline for Treatment of Early Parkinson’s Disease – American Academy of Neurology
Addressing Post-COVID Symptoms: A Guide for Primary Care Physicians.
17 Nov, 2021 | 08:42h | UTCRelated:
Update to post-acute sequelae of SARS-CoV-2 infection: Caring for the ‘long-haulers’.
Systematic Review: Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection.
WHO Consensus: A clinical case definition of post COVID-19 condition (Long Covid).
Characterizing long COVID: a living systematic review.
Long Covid – The illness narratives.
New guidelines to help doctors manage long COVID patients published.
M-A: More than 50 long-term effects of COVID-19. (several articles on the subject)
Position Statement: Preoperative Care for Cataract Surgery – “In spite of evidence debunking the utility of testing before cataract surgery, studies suggest that medical testing and the use of medical consultations before cataract surgery continue to increase”.
17 Nov, 2021 | 08:33h | UTC
Commentary on Twitter
Nicely written position paper on preop care for cataract surgery. Addresses the most frequent questions (although actual study data is limited). Basically no tests, continue meds, and proceed in most cases unless recent MI,PCI,VTE,CVA,DKA, or HTN urgency. https://t.co/PLHm1LjhZg
— Steven Cohn, MD (@preopconsult) November 16, 2021
Randomized, crossover clinical trial: In patients with heart failure with preserved ejection fraction and chronotropic incompetence, betablocker withdrawal improved maximal functional capacity.
17 Nov, 2021 | 08:27h | UTCCommentary: Peak VO2 Improved After Beta-Blocker Withdrawal in Some HFpEF Patients: Beta-blockers may not benefit HFpEF patients with chronotropic incompetence – MedPage Today (free registration required)
Real-world ethics in palliative care: A systematic review of the ethical challenges reported by specialist palliative care practitioners in their clinical practice.
17 Nov, 2021 | 08:18h | UTC
Commentary on Twitter
The range of ethical challenges faced by specialist palliative care practitioners exceeds the breadth of those detailed in palliative care textbooks and ethics resources. #hpm #hapc https://t.co/pvwkYrJmIo pic.twitter.com/qb5803oQg1
— Palliative Medicine (@PalliativeMedJ) March 3, 2021
Drug-induced orthostatic hypotension: A systematic review and meta-analysis of randomized controlled trials.
17 Nov, 2021 | 08:12h | UTC
#AHA21 – [News release – not published yet] RCT: Long-term, low-dose aspirin did not affect risk of dementia in adults with type 2 diabetes.
16 Nov, 2021 | 08:30h | UTCOriginal Study: Randomized Trial: Effects of Aspirin for Primary Prevention in Persons with Diabetes
Global surveillance, research, and collaboration needed to improve understanding and management of long COVID.
12 Nov, 2021 | 10:32h | UTCRelated:
Update to post-acute sequelae of SARS-CoV-2 infection: Caring for the ‘long-haulers’.
Systematic Review: Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection.
WHO Consensus: A clinical case definition of post COVID-19 condition (Long Covid).
Characterizing long COVID: a living systematic review.
Long Covid – The illness narratives.
New guidelines to help doctors manage long COVID patients published.
M-A: More than 50 long-term effects of COVID-19. (several articles on the subject)
Cohort study: Among older adults with diabetes who were hospitalized for common medical conditions, intensification of diabetes medications at hospital discharge was associated with an increased short-term risk of severe hypoglycemia events but was not associated with improved glycemic control.
12 Nov, 2021 | 09:51h | UTC
Cohort study: After an episode of severe hypoglycemia in older adults with diabetes, sulfonylurea or insulin treatment deintensification occurred in fewer than 50% of episodes.
12 Nov, 2021 | 09:53h | UTC
Commentary on Twitter
Less than half of older adults with diabetes seen in the ED or hospitalized for hypoglycemia had high-risk medications (sulfonylureas or insulin) deintensified in the following 100 days, although deintensification rates may be increasing over time. https://t.co/X0TAbUxcIh
— JAMA Network Open (@JAMANetworkOpen) November 2, 2021
A New Dementia Test Raises More Questions Than Answers – “A 5-minute assessment on an iPad could transform how we screen for dementia—or overwhelm the health care system with worried test-takers”.
11 Nov, 2021 | 08:29h | UTCA New Dementia Test Raises More Questions Than Answers – Wired
Systematic Review: Prevention of dementia and decline in cognition by using multi-domain interventions.
11 Nov, 2021 | 08:27h | UTCOriginal Study: Multi‐domain interventions for the prevention of dementia and cognitive decline – Cochrane Library
Systematic Review | Management of High-Need, High-Cost Patients.
9 Nov, 2021 | 01:20h | UTCSee also:
Related:
Systematic review of high-cost patients’ characteristics and healthcare utilization – BMJ Open
Multimorbidity: a priority for global health research – The Academy of Medical Sciences
The global burden of multiple chronic conditions: A narrative review – Preventive Medicine Reports
Redesigning Care for High-Cost, High-Risk Patients – Harvard Business Review
Multimorbidity: clinical assessment and management – NICE Guideline
Richard Smith: The challenge of high need, high cost patients – The BMJ Blogs
Better Care for People with Complex Needs – Institute for Healthcare Improvement
Cluster RCT: In older adults with advanced cancer, a geriatric assessment program reduced the toxic effects of cancer treatment.
5 Nov, 2021 | 09:48h | UTCRelated:
Perspective: A Cancer Care Approach Tailored to The Elderly May Have Better Results
Commentary from the author on Twitter (thread – click for more)
I’m proud of this @mycarg @WilmotCancer effort published online @TheLancet on the eve of @SIOGorg meeting—GA w/management lowers tox in #gerionc pts (RR 0.74, CI 0.64-0.84; p=0.0001). https://t.co/tr6zVXe6Jd
— Supriya Mohile (@rochgerionc) November 3, 2021
Things We Do for No Reason: Prescribing Tramadol for Inpatients in Pain.
5 Nov, 2021 | 09:44h | UTCRelated:
Cohort Study: Chronic Use of Tramadol After Acute Pain Episode
Update to post-acute sequelae of SARS-CoV-2 infection: Caring for the ‘long-haulers’.
29 Oct, 2021 | 10:20h | UTCRelated:
Systematic Review: Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection.
WHO Consensus: A clinical case definition of post COVID-19 condition (Long Covid).
Characterizing long COVID: a living systematic review.
Long Covid – The illness narratives.
New guidelines to help doctors manage long COVID patients published.
M-A: More than 50 long-term effects of COVID-19. (several articles on the subject)