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Opinion | Medicinal cannabis for chronic pain: the Bermuda triangle of low-quality studies, countless meta-analyses and conflicting recommendations.

5 Apr, 2022 | 08:52h | UTC

Medicinal Cannabis for Chronic Pain: The Bermuda Triangle of Low Quality Studies, Countless Meta-analyses and Conflicting Recommendations – European Journal of Pain

Related:

RCT: Effect of medical marijuana card ownership on pain, insomnia, and affective disorder symptoms in adults.

Cohort Study: Long-term cannabis use is associated with cognitive deficits and smaller hippocampal volume in midlife.

AHA Scientific Statement | How does cannabis use affect brain health? Caution advised, more research needed.

M-A: Birth outcomes of neonates exposed to marijuana in utero.

Cannabis-related allergies: an international overview and consensus recommendations.

Review: Cannabis-based medicines and medical cannabis for chronic neuropathic pain.

Cannabinoid metabolites as inhibitors of major hepatic CYP450 enzymes, with implications for cannabis-drug interactions.

Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain.

The International Cannabis Toolkit (iCannToolkit): a multidisciplinary expert consensus on minimum standards for measuring cannabis use.

Cannabis products are being sold as sleep remedies – here’s the evidence about their effectiveness.

Guideline: Medical cannabis or cannabinoids for chronic pain.

Cannabis and Cannabinoid Analgesia position statement – “Due to the lack of high-quality clinical evidence, the IASP does not currently endorse general use of cannabis and cannabinoids for pain relief.”

NICE Guideline: Cannabis-Based Medicinal Products

Consensus recommendations for perioperative management of cannabis and cannabinoid-based medicine users

Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain – Agency for Healthcare Research and Quality

Short Review: Drug Interactions with Cannabinoids

Meta-Analysis: Cannabinoids Not Effective for Cancer-Related Pain

Review: Considerations for cannabinoids in perioperative care by anesthesiologists.

Review: Cannabis-based Medicines and the Perioperative Physician

Study: Cannabis Use Disorder May Increase the Risk of Cardiovascular Events in Major Elective Surgeries

Perspective: If You Smoke Pot, Your Anesthesiologist Needs To Know

Perioperative Care of Cannabis Users: A Comprehensive Review of Pharmacological and Anesthetic Considerations

 


Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge (deliberately infecting individuals in a controlled environment) in young adults.

4 Apr, 2022 | 01:27h | UTC

Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults – Nature Medicine

Commentaries:

Understanding COVID-19 through human challenge models – Nature Medicine

First human challenge study of Covid-19 yields valuable insights about how we get sick – CNN

First Human Challenge Trial Shows How COVID-19 Strikes – HealthDay

Related:

Scientists deliberately gave people COVID — here’s what they learnt.

[Preprint] Results from the first Covid-19 human challenge study (deliberately infecting individuals in a controlled environment).

Perspective | SARS-CoV-2 human challenge studies — establishing the model during an evolving pandemic.

World’s first coronavirus “Human Challenge” study receives ethics approval in the UK  (several texts on the subject)

Are SARS-CoV-2 Human Challenge Trials Ethical? – “A clinical trial is underway in the UK in which young, healthy participants are exposed deliberately to SARS-CoV-2 to assess the viral inoculum needed to produce an infection and to test vaccine efficacy”.

 

Commentary on Twitter

 


Researchers generate the first complete, gapless sequence of a human genome.

4 Apr, 2022 | 01:30h | UTC

News Release: Researchers generate the first complete, gapless sequence of a human genome – NIH News Releases

Original Study: The complete sequence of a human genome – Science

Commentaries:

Scientists sequence the complete human genome for the first time – CNN

First complete gap-free human genome sequence published – The Guardian

Scientists finally finish decoding entire human genome – Associated Press

 


Study finds no increased risk of brain tumors for mobile phone users.

1 Apr, 2022 | 10:04h | UTC

News Release: No increased risk of brain tumours for mobile phone users, new study finds – University of Oxford

Original Study: Cellular Telephone Use and the Risk of Brain Tumors: Update of the UK Million Women Study – JNCI: Journal of the National Cancer Institute

 


WHO recommendations on maternal and newborn care for a positive postnatal experience.

31 Mar, 2022 | 08:47h | UTC

WHO recommendations on maternal and newborn care for a positive postnatal experience – World Health Organization

News Release: WHO urges quality care for women and newborns in critical first weeks after childbirth – World Health Organization

Commentary: Postnatal care: WHO highlights urgency of physical and mental support – The BMJ

 


Cohort Study: Prenatal occupational disinfectant exposure linked to increased risk of childhood allergies.

30 Mar, 2022 | 08:48h | UTC

Prenatal occupational disinfectant exposure and childhood allergies: the Japan Environment and Children’s study – Occupational & Environmental Medicine

Commentary: Disinfectant use by pregnant women may increase risk for asthma and eczema in children – BMJ/News Medical

 

Commentary on Twitter

 


Cumulative burden of psychiatric disorders and self-harm across 26 adult cancers.

29 Mar, 2022 | 09:58h | UTC

Cumulative burden of psychiatric disorders and self-harm across 26 adult cancers – Nature Medicine

See also: Suicide risk and mortality among patients with cancer – Nature Medicine (if the link is paywalled, try this one)

Invited Commentary: Shining a light on the psychological burden of cancer – Nature Medicine

 

Commentary on Twitter

 


Scientists find that the impact of social media on wellbeing varies across adolescence.

29 Mar, 2022 | 09:56h | UTC

News Release: Scientists find that the impact of social media on wellbeing varies across adolescence – University of Cambridge

Original Study: Windows of developmental sensitivity to social media – Nature Communications

Commentaries:

Negative impact of social media affects girls and boys at different ages – study – University of Oxford

Teenage social media use linked to less life-satisfaction for some – BBC

Social media may affect girls’ mental health earlier than boys’, study finds – The Guardian

Expert reaction to study on social media use and wellbeing over adolescence – Science Media Centre

 


Study challenges the theory that light alcohol consumption benefits heart health.

28 Mar, 2022 | 10:09h | UTC

News Release: Large study challenges the theory that light alcohol consumption benefits heart health – Massachusetts General Hospital

Original Study: Association of Habitual Alcohol Intake With Risk of Cardiovascular Disease – JAMA Network Open

Related: No amount of alcohol is good for the heart, says World Heart Federation.

 

Commentary on Twitter

 


Riding the Twitter wave: Enthusiasm for the social media platform changed science communication during the pandemic—but will it last?

28 Mar, 2022 | 09:56h | UTC

Riding the Twitter wave: Enthusiasm for the social media platform changed science communication during the pandemic—but will it last? – Science

Related:

Optimizing the use of Twitter for research dissemination: The “Three Facts and a Story” randomized-controlled trial.

Perspective: How Twitter is Changing Medical Research

Keeping Up With Cardiology: Old-School Learning Versus the Twittersphere – TCTMD

Scientists on Twitter: Preaching to the choir or singing from the rooftops? – Facets

Rise of the Tweetorial – Precious Bodily Fluids

Social Medicine: Twitter in Healthcare – Journal of Clinical Medicine

University of Twitter? Scientists give impromptu lecture critiquing nutrition research – CBC

Twitter-Based Medicine: How Social Media is Changing the Public’s View of Medicine – The Health Care Blog

What’s your doctor reading? How social media is disrupting medical education – National Post

 

Commentary on Twitter

https://twitter.com/onisillos/status/1507398283416768515

 


Opinion: How we got herd immunity wrong.

28 Mar, 2022 | 09:50h | UTC

How we got herd immunity wrong – STAT

 


Did the COVID lockdowns work? Here’s what we know two years on.

25 Mar, 2022 | 09:44h | UTC

Did the COVID lockdowns work? Here’s what we know two years on – The Conversation

Related:

M-A: Effectiveness of public health measures in reducing the incidence of covid-19, SARS-CoV-2 transmission, and covid-19 mortality.

Is the cure really worse than the disease? The health impacts of lockdowns during COVID-19 – “While there are certainly costs to be expected from intervening against COVID-19—every decision has a cost, after all—the counterfactual of an unmitigated epidemic makes these restrictions far less damaging than some have suggested”.

 


RCT: Multivitamins not beneficial for the prevention of cancer.

24 Mar, 2022 | 08:49h | UTC

Multivitamins in the prevention of cancer and cardiovascular disease: The COSMOS randomized clinical trial – American Journal of Clinical Nutrition

Commentary: Daily Multivitamin Does Not Cut Cancer Incidence in Older Adults – HealthDay

Related: USPSTF Draft Statement: Insufficient evidence to recommend multivitamin supplements for the prevention of CVD or cancer. The statement also recommends against the use of beta-carotene (increases risk of CVD mortality and lung cancer) or vitamin E (clear evidence of no benefit)

 


Oxford Covid jab gears up for final act: saving the rest of the world.

23 Mar, 2022 | 10:35h | UTC

Oxford Covid jab gears up for final act: saving the rest of the world – The Guardian

 


Review | Psychological stress and heart disease: fact or folklore?

23 Mar, 2022 | 10:30h | UTC

Psychological Stress and Heart Disease: Fact or Folklore? – The American Journal of Medicine

 


Review: Broadening risk factor or disease definition as a driver for overdiagnosis.

23 Mar, 2022 | 10:28h | UTC

Broadening risk factor or disease definition as a driver for overdiagnosis: A narrative review – Journal of Internal Medicine

 


Prevalence of third-party tracking on medical journal websites.

23 Mar, 2022 | 09:56h | UTC

Prevalence of Third-party Tracking on Medical Journal Websites – JAMA Health Forum

 

Commentary on Twitter

https://twitter.com/cleebennett/status/1504902204959862784

 


Study shows whole-genome risk prediction of common diseases in human preimplantation embryos is feasible, leading to ethical concerns.

22 Mar, 2022 | 09:42h | UTC

Whole-genome risk prediction of common diseases in human preimplantation embryos – Nature Medicine

Invited Commentaries:

Polygenic embryo testing: understated ethics, unclear utility – Nature Medicine

The uncertain science of preimplantation and prenatal genetic testing – Nature Medicine

Commentary: As genetic testing of human embryos expand, researchers call for frank assessment of profound ethical implications – The Hastings Center

Related: Opinion | “The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice”.

 

Commentary on Twitter (thread – click for more)

 


Perspective | Teaching more about less: preparing clinicians for practice.

22 Mar, 2022 | 08:51h | UTC

Teaching More About Less: Preparing Clinicians for Practice – The American Journal of Medicine (free for a limited period)

 


Editorial: Pig-to-human transplants take a leap toward reality.

22 Mar, 2022 | 08:31h | UTC

Pig-to-human transplants take a leap toward reality – Nature Medicine

 


Opinion: Health-related artificial intelligence needs rigorous evaluation and guardrails.

21 Mar, 2022 | 08:29h | UTC

Health-related artificial intelligence needs rigorous evaluation and guardrails – STAT

 


More data suggests reduced risks of hospitalization and death due to SARS-CoV-2 Omicron compared to the Delta variant.

18 Mar, 2022 | 09:36h | UTC

Comparative analysis of the risks of hospitalisation and death associated with SARS-CoV-2 omicron (B.1.1.529) and delta (B.1.617.2) variants in England: a cohort study – The Lancet

Invited Commentary: Omicron: fewer adverse outcomes come with new dangers – The Lancet

 

Commentary on Twitter

 


Denmark proposes ban on selling cigarettes to people born after 2010.

17 Mar, 2022 | 09:04h | UTC

Denmark proposes ban on selling cigarettes to people born after 2010 – euronews

Related: New Zealand to ban smoking for next generation in bid to outlaw habit by 2025 – “New legislation means the legal smoking age will increase every year, to create a smoke-free generation of New Zealanders”.

 

Commentary on Twitter

 


Review | Resistance exercise as a treatment for sarcopenia: prescription and delivery.

15 Mar, 2022 | 09:55h | UTC

Resistance exercise as a treatment for sarcopenia: prescription and delivery – Age and Ageing

 


Two years later, coronavirus evolution still surprises experts. Here’s why.

15 Mar, 2022 | 08:52h | UTC

Two years later, coronavirus evolution still surprises experts. Here’s why. – National Geographic

 


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