General Interest
Randomized Trial: Antibiotic Therapy Alone Seems Reasonable for Uncomplicated Appendicitis
28 Sep, 2018 | 00:55h | UTCFive-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Podcast: Treating Appendicitis Without Surgery – 5-Year Follow-up from a Randomized Clinical Trial of Antibiotic Treatment (free)
Video Summary: Five-Year Follow-up of Patients Given Antibiotic Therapy for Uncomplicated Acute Appendicitis (free)
Commentaries: Pills for appendicitis? Surgery often not needed, study says – STAT (free) AND Antibiotics Alone Seem Reasonable for Uncomplicated Appendicitis in Adults – Physician’s First Watch (free) AND Appendicitis? Antibiotics May Be All You Need – The New York Times (10 articles per month are free)
Related: Randomized clinical trial of antibiotic therapy for uncomplicated appendicitis (link to abstract and commentaries) AND Antibiotics Versus Surgical Therapy for Uncomplicated Appendicitis (link to abstract and commentaries) AND Antibiotic Therapy versus Appendectomy for Acute Uncomplicated Appendicitis (free study and commentaries) AND New appendicitis guideline incorporates the possibility of non-operative treatment for uncomplicated disease (free guideline)
Meta-Analysis of Observational Studies: Healthy Diets May Help in Depression Prevention
28 Sep, 2018 | 00:56h | UTCHealthy dietary indices and risk of depressive outcomes: a systematic review and meta-analysis of observational studies – Molecular Psychiatry (link to abstract – $ for full-text)
Commentaries: Plant-rich diets may help prevent depression – new evidence – The Conversation (free) AND Eating a Mediterranean diet ‘may lower your risk of depression’ – NHS Choices (free) AND Expert reaction to observational studies on diet and depression – Science Media Centre (free) AND Mediterranean diet could prevent depression, new study finds – CNN (free)
“The current evidence is not sufficient to prove plant-rich diets can prevent depression as most of the evidence so far simply shows that those with poorer mental health eat worse, so it may be that those more prone to depression also choose less health” (from CNN)
Study: Recovery of Walking after Complete Spinal Cord Injury
27 Sep, 2018 | 23:06h | UTCCommentaries: Technology and therapy help individuals with chronic spinal cord injuries take steps – University of Louisville (free) AND Epidural Stimulation Helps Patients Walk After Total Paralysis – MedPage Today (free registration required) AND Paralyzed Patients Able to Walk Following Epidural Stimulation, Intense Rehab – Physician’s First Watch (free)
Congratulations. Your Study Went Nowhere
27 Sep, 2018 | 22:42h | UTCCongratulations. Your Study Went Nowhere – The New York Times (10 articles per month are free) (via @kennylinafp)
“Researchers should embrace negative results instead of accentuating the positive, which is one of several biases that can lead to bad science.”
WHO Global Status Report on Alcohol and Health 2018
27 Sep, 2018 | 22:40h | UTCGlobal status report on alcohol and health 2018 – World Health Organization (free PDF)
News Release: Harmful use of alcohol kills more than 3 million people each year, most of them men (free)
Commentaries: Alcohol abuse kills 3 million a year, most of them men: WHO – Reuters (free) AND 1 in 20 deaths globally is a result of alcohol use – CNN (free) AND Alcohol causes one in 20 deaths worldwide, says WHO – The Guardian (free)
Perspective: Amazing Ways Artificial Intelligence is Used in Healthcare
27 Sep, 2018 | 22:33h | UTCAmazing ways artificial intelligence is used in healthcare – World Economic Forum (free)
The Cost of Persuasive Design: Digital Media Use and ADHD
27 Sep, 2018 | 22:34h | UTCThe cost of persuasive design: digital media use and ADHD – The Mental Elf (free)
Original Study: Association of Digital Media Use with ADHD Among Adolescents (link to abstract and free commentaries)
Study: Alzheimer’s Disease and Related Dementias will Double by 2060
27 Sep, 2018 | 22:31h | UTCRacial and ethnic estimates of Alzheimer’s disease and related dementias in the United States (2015–2060) in adults aged ≥65 years – Alzheimer’s & Dementia (free for a limited period)
Commentaries: Alzheimer’s and dementia cases will double by 2060 -HealthExec (free) AND Alzheimer’s Burden Projected to Double by 2060 – Physician’s First Watch (free) AND Alzheimer’s Disease Burden to Double by 2060 – MedPage Today (free registration required)
Study: Genetic Analysis of Over 1 million People Identifies 535 Genes Associated with Blood Pressure Traits
21 Sep, 2018 | 02:05h | UTCGenetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits – Nature Genetics (link to abstract – $ for full-text)
Commentaries: World’s biggest study of blood pressure genetics – Queen Mary University of London (free) AND Researchers find 535 new gene regions that influence blood pressure – UPI (free) AND High blood pressure breakthrough: Over 500 genes uncovered – Medical News Today (free)
Perspective: The Case for Expensive Antibiotics
21 Sep, 2018 | 02:00h | UTCThe Case For Expensive Antibiotics – WIRED (a few articles per month are free) (via @CarlosdelRio7)
Opinion: Everything You Know About Obesity Is Wrong
21 Sep, 2018 | 01:59h | UTCEverything You Know About Obesity Is Wrong – HuffPost (free) (via @cardiobrief)
“For decades, the medical community has ignored mountains of evidence to wage a cruel and futile war on fat people, poisoning public perception and ruining millions of lives.”
Cohort Study: Are Noise and Air Pollution Related to the Incidence of Dementia?
21 Sep, 2018 | 01:47h | UTCCommentaries: Air pollution linked to dementia risk – NHS Choices (free) AND Expert reaction to air pollution and risk of dementia – Science Media Centre (free) AND Air pollution may be linked to heightened dementia risk – OnMedica (free) AND Is air pollution tied to higher dementia risk? – CNN (free)
Cohort Study: Nutritional Quality of Food and Cancer Risk
21 Sep, 2018 | 01:46h | UTCCommentaries: Expert reaction to study looking at nutritional quality of food and risk of cancer – Science Media Centre (free) AND Foods with low nutritional quality tied to higher cancer risk – Medical News Today (free)
Study: Can Artificial Intelligence Reliably Report Chest X-Rays?
21 Sep, 2018 | 01:42h | UTCNews Release: Qure.ai’s qXR Algorithm can ID Abnormal Chest X-rays With Unprecedented Accuracy (free)
Commentary: AI algorithm IDs abnormal chest x-rays with 90% accuracy – Health Imaging (free) AND AI startup trains algorithm with 1.2M chest x-rays, confirms its accuracy – Radiology Business (free)
Study: Artificial Intelligence Can Determine Lung Cancer Type
20 Sep, 2018 | 19:47h | UTCClassification and mutation prediction from non–small cell lung cancer histopathology images using deep learning – Nature Medicine (link to abstract – $ for full-text)
Commentaries: Artificial intelligence can determine lung cancer type – eCancer News (free) AND Google AI Tool Identifies a Tumor’s Mutations From An Image – WIRED (free)
Study: Daily Fasting Improves Health and Survival in Male Mice
20 Sep, 2018 | 19:44h | UTCDaily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories – Cell Metabolism (link to abstract and infographic – $ for full-text)
Commentaries: Fasting increases health and lifespan in male mice – NIH Research Matters (free) AND Study: Mice healthier, live longer with increased daily fasting times – UPI (free) AND Study: Daily Fasting Improves Health and Longevity in Male Mice – Sci News (free)
Study: Effects of Medicare’s Bundled Payment
20 Sep, 2018 | 19:42h | UTCAssociation of Hospital Participation in a Medicare Bundled Payment Program With Volume and Case Mix of Lower Extremity Joint Replacement Episodes – JAMA (link to abstract – $ for full-text)
Commentaries: Can Paying for a Health Problem as a Whole, Not Piece by Piece, Save Medicare Money? – The New York Times (10 articles per month are free) AND Medicare’s Bundled Payment Program–Does it Change Hospital Volume or Case Mix? – MedicalResearch.com (free) AND One of Obamacare’s big experiments to lower costs is working surprisingly well – VOX (free)
Cohort Study: Higher Whole-Grain Intake Is Associated with Lower Risk of Type 2 Diabetes
20 Sep, 2018 | 19:43h | UTCHigher Whole-Grain Intake Is Associated with Lower Risk of Type 2 Diabetes among Middle-Aged Men and Women: The Danish Diet, Cancer, and Health Cohort – The Journal of Nutrition (link to abstract – $ for full-text)
Commentary: What you need to know about claims that whole grains can prevent diabetes – Health News Review (free)
Systematic Review: Prevalence of Burnout Among Physicians
20 Sep, 2018 | 19:41h | UTCPrevalence of Burnout Among Physicians: A Systematic Review – JAMA (link to abstract – $ for full-text)
Commentaries: Doctors Today May Be Miserable, But Are They ‘Burnt Out’? – NPR (free) AND Physician burnout taking center stage – Reuters (free) AND Burnout Found to Be Common Among U.S. Resident Physicians – Psychiatric News Alert (free)
Related: Why Physician Burnout Is Endemic, and How Health Care Must Respond – NEJM Catalyst (free) AND Counting the costs: U.S. hospitals feeling the pain of physician burnout – Reuters (free) AND To Care Is Human — Collectively Confronting the Clinician-Burnout Crisis – New England Journal of Medicine (free) AND Beyond Burnout — Redesigning Care to Restore Meaning and Sanity for Physicians (free) AND The Burnout Crisis in American Medicine – The Atlantic (free) AND To Combat Physician Burnout and Improve Care, Fix the Electronic Health Record (free commentaries)
Review: Implementing Optimal Team-Based Care to Reduce Clinician Burnout
20 Sep, 2018 | 19:40h | UTCImplementing Optimal Team-Based Care to Reduce Clinician Burnout – National Academy of Medicine (free)
Commentaries: Optimal team-based health care is associated with improved patient outcomes and physician well-being – ACP Newsroom (free) AND New Review Shows Team-Based Care May Reduce Physician Burnout – Medscape (free registration required)
Opinion: Medicine’s Financial Contamination
20 Sep, 2018 | 19:37h | UTCMedicine’s Financial Contamination – The New York Times (10 articles per month are free)
Study: Infant Walker–Related Injuries Still Sending Children to the ED
20 Sep, 2018 | 19:29h | UTCInfant Walker–Related Injuries in the United States – Pediatrics (free)
News Release: Study: Infant walker injuries support AAP’s call for a ban (free)
Commentaries: As Injuries Continue, Doctors Renew Call For Ban On Infant Walkers – NPR (free) AND Injuries associated with infant walkers still sending children to the emergency department – Nationwide Children’s Hospital (free)
Let’s Stop the Burning and the Bleeding at Cochrane—There’s Too Much at Stake
20 Sep, 2018 | 19:27h | UTCRelated: Evidence-based medicine group in turmoil after expulsion of co-founder – Science (free) AND Trish Greenhalgh: The Cochrane Collaboration—what crisis? – The BMJ Opinion (free) AND Cochrane – A sinking ship? – BMJ EBM Spotlight (free) AND Turmoil erupts over expulsion of member from leading evidence-based medicine group – STAT (free)
See also: Statement from Cochrane’s Governing Board (free)
Randomized Trial: Effect of Aspirin on All-Cause Mortality in the Healthy Elderly
20 Sep, 2018 | 19:25h | UTCEffect of Aspirin on All-Cause Mortality in the Healthy Elderly – New England Journal of Medicine (free) (via @EricTopol)
Related Studies: Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly – New England Journal of Medicine (free) AND Effect of Aspirin on Disability-free Survival in the Healthy Elderly – New England Journal of Medicine (free)
Commentaries: Daily low-dose aspirin found to have no effect on healthy life span in older people- NIH News Releases (free) AND Low-Dose Aspirin Late in Life? Healthy People May Not Need It – The New York Times (10 articles per month are free)
Shared Decision-Making: Staying Focused on the Ultimate Goal
20 Sep, 2018 | 19:21h | UTCShared Decision-Making: Staying Focused on the Ultimate Goal – NEJM Catalyst (free)