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Gastrointestinal Surgery (all articles)

M-A | Efficacy of elimination diets in eosinophilic esophagitis

24 Feb, 2023 | 13:47h | UTC

Summary: This systematic review and meta-analysis evaluated the effectiveness of various dietary treatment regimens for eosinophilic esophagitis (EoE). After analyzing 34 studies with 1762 patients, it was concluded that dietary therapy is a viable and efficacious option for individuals with EoE of all ages, with an overall histological remission rate of 53.8% and a clinical response rate of 80.8%. The study also found that highly restrictive dietary regimes, such as a six-food elimination diet, may not be superior to less restrictive dietary regimens, such as a four-food elimination diet or one-food elimination diet, in achieving histological remission, supporting less restrictive dietary regimens as a treatment option. The study has several limitations, such as the observational nature of most studies included.

Article: Efficacy of elimination diets in eosinophilic esophagitis: a systematic review and meta-analysis – Clinical Gastroenterology and Hepatology

Commentary: Elimination diets effective for patients with eosinophilic esophagitis – ACP Gastroenterology

 

Commentary on Twitter

Article under a Creative Commons Attribution (CC BY 4.0) license

 

Review | Management of gastrointestinal foreign bodies with brief review of the guidelines

24 Feb, 2023 | 13:36h | UTC

Management of Gastrointestinal Foreign Bodies with Brief Review of the Guidelines – Pediatric Gastroenterology, Hepatology & Nutrition

 

RCT | Laparoscopic proximal gastrectomy with double-tract reconstruction vs. total gastrectomy in upper-third early gastric cancer

23 Feb, 2023 | 13:29h | UTC

Summary: This randomized trial examined whether laparoscopic proximal gastrectomy with double-tract reconstruction (LPG-DTR) is a superior surgical treatment compared to laparoscopic total gastrectomy (LTG) for patients with early gastric cancer (GC) in the upper third of the stomach. The study found that LPG-DTR resulted in significantly decreased amounts of vitamin B12 supplementation, but no significant difference in hemoglobin change compared to LTG. The study also found no difference in complication rates or overall and disease-free survival rates between the two groups. The study suggests that LPG-DTR may be a function-preserving procedure for the treatment of patients with upper-third early GC.

Article: Effect of Laparoscopic Proximal Gastrectomy With Double-Tract Reconstruction vs Total Gastrectomy on Hemoglobin Level and Vitamin B12 Supplementation in Upper-Third Early Gastric Cancer: A Randomized Clinical Trial – JAMA Network Open

 

Commentary on Twitter

 

AGA Guideline | Role of biomarkers for the management of ulcerative colitis

22 Feb, 2023 | 12:38h | UTC

AGA Clinical Practice Guideline on the Role of Biomarkers for the Management of Ulcerative Colitis – Gastroenterology

News Release: New AGA guideline recommends blood and stool tests for monitoring ulcerative colitis – American Gastroenterological Association

 

RCT | Cold snare polypectomy reduces bleeding compared to hot snare polypectomy

22 Feb, 2023 | 12:34h | UTC

Cold Versus Hot Snare Polypectomy for Small Colorectal Polyps: A Pragmatic Randomized Controlled Trial – Annals of Internal Medicine (link to abstract – $ for full-text)

News Release: Cold snare polypectomy significantly reduces bleeding risk compared to hot snare polypectomy – Science News Net

 

M-A | Efficacy and safety of drugs for gastroparesis

17 Feb, 2023 | 13:05h | UTC

Efficacy and Safety of Drugs for Gastroparesis: Systematic Review and Network Meta-analysis – Gastroenterology

Commentaries:

Review finds only two efficacious medications to treat gastroparesis – ACP Gastroenterology

Two drug classes appear effective for gastroparesis treatment – MDedge

 

Commentary from the author on Twitter (thread – click for more)

 

Review | Perioperative optimization of Crohn’s disease

17 Feb, 2023 | 12:39h | UTC

Perioperative optimization of Crohn’s disease – Annals of Gastroenterological Surgery

 

Review | Integrating geriatric assessment and prehabilitation into surgical practice can improve outcomes for GI cancer patients with frailty

17 Feb, 2023 | 12:37h | UTC

Frailty and surgical outcomes in gastrointestinal cancer: Integration of geriatric assessment and prehabilitation into surgical practice for vulnerable patients – Annals of Gastroenterological Surgery

 

Rare, overlooked, or underappreciated causes of recurrent abdominal pain: a primer for gastroenterologists

16 Feb, 2023 | 15:12h | UTC

Rare, Overlooked, or Underappreciated Causes of Recurrent Abdominal Pain: A Primer for Gastroenterologists – Clinical Gastroenterology and Hepatology

 

Commentary from the author on Twitter

 

Single-arm study | Effects of SER-109 as an investigational microbiome therapeutic in recurrent C. difficile infection

14 Feb, 2023 | 10:47h | UTC

Summary: This was a phase 3, open-label, single-arm trial of 263 adults with recurrent Clostridioides difficile Infection (CDI). The trial aimed to evaluate the safety and rate of CDI recurrence after administration of the investigational microbiome therapeutic SER-109. The trial found that SER-109 was well tolerated and the overall rate of recurrent CDI was low, regardless of the number of prior recurrences, demographics, or diagnostic approach.

(By ChatGPT, reviewed and edited)

 

Article: Safety and Tolerability of SER-109 as an Investigational Microbiome Therapeutic in Adults With Recurrent Clostridioides difficile Infection: A Phase 3, Open-Label, Single-Arm Trial – JAMA Network Open

Commentary: Phase 3 trial provides more positive data for recurrent C diff microbiome drug – CIDRAP

Related:

RCT: Among patients with recurrent Clostridioides difficile infection, the use of SER-109, an oral microbiome therapy, reduced recurrence rate compared to placebo (12% vs. 40%).

Post-trial follow-up | Microbiome therapeutic SER-109 through 24 weeks for recurrent Clostridioides difficile infection.

 

Guideline | Barrett’s esophagus and stage 1 esophageal adenocarcinoma: monitoring and management

13 Feb, 2023 | 12:49h | UTC

Barrett’s oesophagus and stage 1 oesophageal adenocarcinoma: monitoring and management – National Institute for Health and Care Excellence

Related: Diagnosis and Management of Barrett’s Esophagus: An Updated ACG Guideline – American Journal of Gastroenterology

 

Brief Review | Surgical management of ulcerative colitis

13 Feb, 2023 | 12:30h | UTC

Surgical management of ulcerative colitis – British Journal of Surgery

 

Brief Review | Contemporary management of parastomal hernia

13 Feb, 2023 | 12:29h | UTC

Contemporary management of parastomal hernia – British Journal of Surgery

 

RCT | Hyaluronic acid spacer for hypofractionated prostate radiation therapy

13 Feb, 2023 | 12:25h | UTC

Hyaluronic Acid Spacer for Hypofractionated Prostate Radiation Therapy: A Randomized Clinical Trial – JAMA Oncology

 

Commentary on Twitter

 

Consensus Statement | Development of an Enhanced Recovery After Surgery (ERAS) surgical safety checklist

10 Feb, 2023 | 14:03h | UTC

Development of an Enhanced Recovery After Surgery Surgical Safety Checklist Through a Modified Delphi Process – JAMA Network Open

 

Commentary from the author on Twitter (thread – click for more)

 

SR | Mechanical plus oral antibiotic bowel preparation may prevent complications in elective colorectal surgery

10 Feb, 2023 | 13:53h | UTC

Preoperative combined mechanical and oral antibiotic bowel preparation for preventing complications in elective colorectal surgery – Cochrane Library

Summary: Can combined mechanical and oral antibiotic bowel preparation reduce the risk of complications after scheduled colon or rectal resections compared with purely mechanical, purely oral antibiotic or no bowel preparation? – Cochrane Library

Related:

M-A: Strategies for antibiotic administration for bowel preparation among patients undergoing elective colorectal surgery – “the addition of oral antibiotics to intravenous antibiotics was associated with a reduction in the incidence of incisional surgical site infection by more than 50%”.

Meta-Analysis: Effects of Mechanical Bowel Preparation and Oral Antibiotics Before Elective Colorectal Surgery

 

Opinion | Interpreting the results from the first randomized controlled trial of colonoscopy: does it save lives?

10 Feb, 2023 | 13:54h | UTC

Interpreting the results from the first randomised controlled trial of colonoscopy: does it save lives? – BMJ Evidence Based Medicine

Original Study: RCT | Effect of colonoscopy screening on risks of colorectal cancer and related death.

 

Cohort Study | Fecal hemoglobin concentrations are associated with all-cause mortality in colorectal cancer screening

10 Feb, 2023 | 13:41h | UTC

Faecal haemoglobin concentrations are associated with all-cause mortality and cause of death in colorectal cancer screening – BMC Medicine

Commentary: Faecal haemoglobin concentrations associated with mortality and cause of death in colorectal cancer screening – Physician’s Weekly

 

RCT | Effects of the interval between neoadjuvant chemoradiotherapy and surgery in rectal cancer

9 Feb, 2023 | 13:45h | UTC

Effect of interval between neoadjuvant chemoradiotherapy and surgery on disease recurrence and survival in rectal cancer: long-term results of a randomized clinical trial – BJS Open

 

Commentary on Twitter

 

RCT | Effect of the use of reinforced stapling on the occurrence of pancreatic fistula after distal pancreatectomy

9 Feb, 2023 | 13:34h | UTC

Effect of the Use of Reinforced Stapling on the Occurrence of Pancreatic Fistula After Distal Pancreatectomy: Results of the REPLAY (Reinforcement of the Pancreas in distaL pAncreatectomY) Multicenter Randomized Clinical Trial – Annals of Surgery (link to abstract – $ for full-text)

 

Complications of diagnostic upper gastrointestinal endoscopy: recognition, assessment and management

7 Feb, 2023 | 13:41h | UTC

Complications of diagnostic upper Gastrointestinal endoscopy: common and rare – recognition, assessment and management – BMJ Open Gastroenterology

 

Review | Prevention and management of minor complications in percutaneous endoscopic gastrostomy

7 Feb, 2023 | 13:39h | UTC

Prevention and management of minor complications in percutaneous endoscopic gastrostomy – BMJ Open Gastroenterology

 

ACG Guideline | Management of patients with acute lower gastrointestinal bleeding

6 Feb, 2023 | 13:43h | UTC

Management of Patients With Acute Lower Gastrointestinal Bleeding: An Updated ACG Guideline

Related:

Diagnosis and management of acute lower gastrointestinal bleeding: European Society of Gastrointestinal Endoscopy (ESGE) Guideline – Endoscopy

Randomized Trial: Efficacy and Safety of Early vs. Elective Colonoscopy for Acute Lower Gastrointestinal Bleeding

[Abstract Only] Systematic Review: Early Colonoscopy Does Not Improve Outcomes of Patients with Lower Gastrointestinal Bleeding

Diagnosis and management of acute lower gastrointestinal bleeding: guidelines from the British Society of Gastroenterology – Gut

 

Rates of antimicrobial resistance in Helicobacter pylori isolates across the US and Europe

6 Feb, 2023 | 13:12h | UTC

Rates of Antimicrobial Resistance in Helicobacter pylori Isolates From Clinical Trial Patients Across the US and Europe – The American Journal of Gastroenterology

Commentary: Time to ditch clarithromycin for H. pylori? – MDedge

 

Commentary on Twitter

 

Post-transplant biliary complications: advances in pathophysiology, diagnosis, and treatment

3 Feb, 2023 | 14:01h | UTC

Post-transplant biliary complications: advances in pathophysiology, diagnosis, and treatment – BMJ Open Gastroenterology

 

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