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Gastroenterology (all articles)

KDIGO 2022 Guideline for the prevention, diagnosis, evaluation, and treatment of Hepatitis C in chronic kidney disease.

23 Nov, 2022 | 14:11h | UTC

KDIGO 2022 Clinical Practice Guideline for the Prevention, Diagnosis, Evaluation, and Treatment of Hepatitis C in Chronic Kidney Disease – Kidney International

Executive Summary: KDIGO 2022 Clinical Practice Guideline for the Prevention, Diagnosis, Evaluation, and Treatment of Hepatitis C in Chronic Kidney Disease – Kidney International

News Release: KDIGO Announces Publication of 2022 Hepatitis C in Chronic Kidney Disease Guideline – Kidney Disease: Improving Global Outcomes (KDIGO)

 

RCT | New drug can improve constipation in patients with Parkinson Disease.

22 Nov, 2022 | 13:00h | UTC

Oral ENT-01 Targets Enteric Neurons to Treat Constipation in Parkinson Disease: A Randomized Controlled Trial – Annals of Internal Medicine (link to abstract – $ for full-text) 

Commentaries:  

New Drug Could Ease Parkinson’s-Related Constipation – HealthDay 

Oral ENT-01 safe, significantly improves constipation in persons with Parkinson disease – American College of Physicians 

 

Commentary on Twitter 

 

RCT | The effects of modifying amount and type of dietary carbohydrate on esophageal reflux symptoms.

21 Nov, 2022 | 14:42h | UTC

The Effects of Modifying Amount and Type of Dietary Carbohydrate on Esophageal Acid Exposure Time and Esophageal Reflux Symptoms: A Randomized Controlled Trial – The American Journal of Gastroenterology 

Commentary: Study finds that reducing intake of simple sugars improves GERD – Vanderbilt University 

 

Expert consensus on liver transplantation perioperative evaluation and rehabilitation for acute-on-chronic liver failure.

21 Nov, 2022 | 14:21h | UTC

Expert consensus on liver transplantation perioperative evaluation and rehabilitation for acute-on-chronic liver failure – Liver Research 

 

Portopulmonary hypertension: current developments and future perspectives.

21 Nov, 2022 | 14:20h | UTC

Portopulmonary hypertension: Current developments and future perspectives – Liver Research 

Related: Pulmonary complications in liver disease – Intensive Care Medicine (free) 

Related Reviews:  

Hepatopulmonary syndrome and portopulmonary hypertension: recent knowledge in pathogenesis and overview of clinical assessment – Liver International  

Pulmonary complications of hepatic diseases – World Journal of Gastroenterology  

Pulmonary Vascular Complications of Liver Disease – American Journal of Respiratory and Critical Care Medicine 

 

RCT | Helicobacter pylori eradication may prevent peptic ulcer bleeding in older patients prescribed aspirin in primary care.

11 Nov, 2022 | 14:00h | UTC

Helicobacter pylori eradication for primary prevention of peptic ulcer bleeding in older patients prescribed aspirin in primary care (HEAT): a randomised, double-blind, placebo-controlled trial – The Lancet

News Release: Cutting the risk of stomach bleeding, occasionally caused by regular aspirin use – University of Nottingham

 

Commentary on Twitter

 

Phase 2b RCT | Efficacy and safety of Bepirovirsen in chronic Hepatitis B infection.

11 Nov, 2022 | 13:44h | UTC

Efficacy and Safety of Bepirovirsen in Chronic Hepatitis B Infection – New England Journal of Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Retrospective Cohort Study | Perinatal outcomes associated with ICP in twin pregnancies were worse than singletons.

11 Nov, 2022 | 13:36h | UTC

Perinatal outcomes associated with ICP in twin pregnancies were worse than singletons: an almost 5-year retrospective cohort study – BMC Pregnancy and Childbirth

 

NICE Guideline Update | Colonoscopic surveillance in adults with inflammatory bowel disease or adenomas.

10 Nov, 2022 | 14:16h | UTC

Colorectal cancer prevention: colonoscopic surveillance in adults with ulcerative colitis, Crohn’s disease or adenomas – National Institute for Health and Care Excellence

Related:

British Society of Gastroenterology/Association of Coloproctology of Great Britain and Ireland/Public Health England post-polypectomy and post-colorectal cancer resection surveillance guidelines – Gut

Consensus Statement: U.S. Multi-Society Task Force on Colorectal Cancer now suggests average-risk CRC screening begins at age 45.

USPSTF Statement: Start colorectal cancer screening at 45 years for most patients.

ACG Clinical Guidelines: Start colorectal cancer screening at 45

Evidence-based clinical practice guidelines for management of colorectal polyps – Journal of Gastroenterology

Meta-analysis: Risk of colorectal cancer and cancer related mortality after detection of low-risk or high-risk adenomas, compared with no adenoma, at index colonoscopy

Recommendations for Follow-Up After Colonoscopy and Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer – Gastroenterology

Endoscopic surveillance after surgical or endoscopic resection for colorectal cancer: European Society of Gastrointestinal Endoscopy (ESGE) and European Society of Digestive Oncology (ESDO) Guideline – Endoscopy

 

Guidelines | Managing functional dyspepsia overlapping with other gastrointestinal symptoms.

9 Nov, 2022 | 12:26h | UTC

Asia-Pacific Guidelines for Managing Functional Dyspepsia Overlapping with Other Gastrointestinal Symptoms – Journal of Gastroenterology and Hepatology

 

Defining the optimum strategy for identifying adults and children with celiac disease: systematic review and economic modeling.

9 Nov, 2022 | 12:16h | UTC

Defining the optimum strategy for identifying adults and children with coeliac disease: systematic review and economic modelling – Health Technology Assessment

 

Review | Intravenous fluid therapy in patients with severe acute pancreatitis admitted to the intensive care unit.

8 Nov, 2022 | 12:15h | UTC

Intravenous fluid therapy in patients with severe acute pancreatitis admitted to the intensive care unit: a narrative review – Intensive Care Medicine

Related:

Aggressive or Moderate Fluid Resuscitation in Acute Pancreatitis – New England Journal of Medicine (link to abstract – $ for full-text)

Acute Pancreatitis: Diagnosis and Treatment – Drugs

Revised Clinical Practice Guidelines of the Korean Pancreatobiliary Association for Acute Pancreatitis – Gut and Liver

Guidelines for the management of patients with severe acute pancreatitis, 2021 – Anaesthesia Critical Care & Pain Medicine

Evidence-Based Disposition of Acute Pancreatitis – emDocs

2019 WSES guidelines for the management of severe acute pancreatitis – World Journal of Emergency Surgery

American Gastroenterological Association Institute Guideline on Initial Management of Acute Pancreatitis

Pancreatitis – National Institute for Health and Care Excellence

 

M-A | Efficacy and safety of pharmacological interventions for pruritus in primary biliary cholangitis.

8 Nov, 2022 | 11:58h | UTC

Efficacy and safety of pharmacological interventions for pruritus in primary biliary cholangitis: A systematic review and meta-analysis – Frontiers in Pharmacology

 

RCT | Efficacy of prune juice containing sorbitol, pectin, and polyphenol in chronic constipation.

7 Nov, 2022 | 12:34h | UTC

Prune Juice Containing Sorbitol, Pectin, and Polyphenol Ameliorates Subjective Complaints and Hard Feces While Normalizing Stool in Chronic Constipation: A Randomized Placebo-Controlled Trial – American Journal of Gastroenterology (free for a limited period)

 

Commentary on Twitter

 

Review | Determining prognosis of alcoholic liver disease and alcoholic hepatitis.

4 Nov, 2022 | 13:17h | UTC

Determining Prognosis of ALD and Alcoholic Hepatitis – Journal of Clinical and Experimental Hepatology 

 

ERAS Guidelines for perioperative care for liver surgery.

1 Nov, 2022 | 12:16h | UTC

Guidelines for Perioperative Care for Liver Surgery: Enhanced Recovery After Surgery (ERAS) Society Recommendations 2022 – World Journal of Surgery

Related:

Complete List of Enhanced Recovery After Surgery (ERAS) Society Guidelines

Top 100 Most-Cited Articles on Enhanced Recovery After Surgery: A Bibliometric Analysis and Visualized Study – Frontiers in Surgery

 

RCT | Efficacy of RBX2660 for preventing recurrent Clostridioides difficile after antibiotic treatment.

1 Nov, 2022 | 12:07h | UTC

Efficacy and Safety of RBX2660 in PUNCH CD3, a Phase III, Randomized, Double-Blind, Placebo-Controlled Trial with a Bayesian Primary Analysis for the Prevention of Recurrent Clostridioides difficile Infection – Drugs

Commentary: RBX2660 shows promise in breaking the cycle of recurrent C. difficile – MDedge

 

M-A of RCT | Combination of ulinastatin and somatostatin evaluated in acute pancreatitis.

31 Oct, 2022 | 13:44h | UTC

The combination of ulinastatin and somatostatin reduces complication rates in acute pancreatitis: a systematic review and meta-analysis of randomized controlled trials – Scientific Reports

 

Cohort Study | Diverticular disease linked to increased risk of cancer outside the GI tract.

31 Oct, 2022 | 13:33h | UTC

Cancer risk in patients with diverticular disease: a nationwide cohort study – JNCI: Journal of the National Cancer Institute (link to abstract – $ for full-text)

News Release: Diverticular disease associated with cancer outside gastrointestinal tract – Karolinska Institutet

 

Review | Management of NAFLD in primary care settings.

27 Oct, 2022 | 12:24h | UTC

Management of NAFLD in primary care settings – Liver International

Related:

Updated S2k Clinical Practice Guideline on Non-alcoholic Fatty Liver Disease (NAFLD) issued by the German Society of Gastroenterology, Digestive and Metabolic Diseases (DGVS) – Zeitschrift für Gastroenterologie

AGA Clinical Practice Update | Diagnosis and management of nonalcoholic fatty liver disease in lean individuals.

Quality standards for the management of non-alcoholic fatty liver disease (NAFLD): consensus recommendations from the British Association for the Study of the Liver and British Society of Gastroenterology NAFLD Special Interest Group – The Lancet Gastroenterology & Hepatology (free registration required)

Nonalcoholic Fatty Liver Disease and Cardiovascular Risk: A Scientific Statement From the American Heart Association – Arteriosclerosis, Thrombosis, and Vascular Biology

Advancing the global public health agenda for NAFLD: a consensus statement – Nature Reviews Gastroenterology & Hepatology

Clinical Care Pathway for the Risk Stratification and Management of Patients With Nonalcoholic Fatty Liver Disease – Gastroenterology

Non-alcoholic fatty liver disease: A patient guideline – JHEP Reports

 

Commentary on Twitter

 

RCT | Transcutaneous Electrical Acustimulation (TEA) vs. sham-TEA for irritable bowel syndrome with constipation.

25 Oct, 2022 | 13:12h | UTC

Transcutaneous Electrical Acustimulation Improves Irritable Bowel Syndrome With Constipation by Accelerating Colon Transit and Reducing Rectal Sensation Using Autonomic Mechanisms – American Journal of Gastroenterology

 

Systematic Review | Mu‐opioid antagonists for opioid‐induced bowel dysfunction in palliative care and people with cancer.

25 Oct, 2022 | 13:13h | UTC

Mu‐opioid antagonists for opioid‐induced bowel dysfunction in people with cancer and people receiving palliative care – Cochrane Library

Summary: Mu-opioid antagonists for bowel dysfunction due to opioids in people with cancer and people receiving palliative care – Cochrane Library

 

Post-trial follow-up | Microbiome therapeutic SER-109 through 24 weeks for recurrent Clostridioides difficile infection.

24 Oct, 2022 | 14:15h | UTC

Extended Follow-up of Microbiome Therapeutic SER-109 Through 24 Weeks for Recurrent Clostridioides difficile Infection in a Randomized Clinical Trial – JAMA (free for a limited period)

Original Study: RCT: Among patients with recurrent Clostridioides difficile infection, the use of SER-109, an oral microbiome therapy, reduced recurrence rate compared to placebo (12% vs. 40%).

 

Commentary on Twitter

 

AHA Scientific Statement | Emerging evidence on coronary heart disease screening in kidney and liver transplantation candidates.

24 Oct, 2022 | 14:11h | UTC

Emerging Evidence on Coronary Heart Disease Screening in Kidney and Liver Transplantation Candidates: A Scientific Statement From the American Heart Association – Circulation (PDF)

Top Things to Know: Emerging Evidence on Coronary Heart Disease (CHD) Screening in Kidney and Liver Transplantation Candidates – American Heart Association

Commentary: Trials and Tribulations of Cardiac Screening Asymptomatic Kidney and Liver Transplant Candidates – American Heart Association

 

Case-control study | Post-paracentesis ascitic fluid leak in patients with cirrhosis of liver and its management.

21 Oct, 2022 | 12:57h | UTC

Post-Paracentesis Ascitic Fluid Leak in Patients with Cirrhosis of Liver and its Management: A Prospective Study – Journal of Clinical and Experimental Hepatology

 

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