Gastroenterology (all articles)
Study: Incidence of Early-Onset Colorectal Cancer Underestimated
5 Feb, 2020 | 08:14h | UTCCommentaries: Study shows advanced colorectal cancers at recommended screening age – Louisiana State University Health Sciences Center (free) AND Should Colon Cancer Screening Begin Before 50? – MedicalResearch.com (free)
Related: Another Study Points to Increased Colorectal Cancer Incidence in Young Adults (studies on the subject)
Study Commentary: PEPTIC
2 Feb, 2020 | 19:47h | UTCPEPTIC – The Bottom Line (free)
Original Study: Effect of Stress Ulcer Prophylaxis With Proton Pump Inhibitors vs Histamine-2 Receptor Blockers on In-Hospital Mortality Among ICU Patients Receiving Invasive Mechanical Ventilation: The PEPTIC Randomized Clinical Trial – JAMA (link to abstract, commentaries and study presentation)
FDA Safety Communication: Untreated Constipation caused by Clozapine Can Lead to Serious Bowel Problems
31 Jan, 2020 | 01:09h | UTCSource: FDA Strengthens Constipation Warning on Clozapine – NEJM Journal Watch (free)
Systematic Review: Oral Janus Kinase Inhibitors for Maintenance of Remission in Ulcerative Colitis
31 Jan, 2020 | 00:44h | UTCOral Janus kinase inhibitors for maintenance of remission in ulcerative colitis – Cochrane Library (free)
Summary: Oral Janus kinase inhibitors (tofacitinib) for maintenance of remission in ulcerative colitis – Cochrane Library (free)
[Abstract Only] Randomized Trial: Treatment of Helicobacter Pylori Reduces Gastric Cancer Among Patients with Positive Family History
30 Jan, 2020 | 07:39h | UTCFamily History of Gastric Cancer and Helicobacter pylori Treatment – New England Journal of Medicine (link to abstract – $ for full-text)
Visual Abstract: Family History of Gastric Cancer and Helicobacter pylori Treatment (free)
Commentary: Antibiotic therapy cuts stomach cancer rate by more than half in high-risk population – Reuters (free)
ACG Guideline: Small Intestinal Bacterial Overgrowth
29 Jan, 2020 | 08:25h | UTC
Viewpoint: Manipulating the Human Microbiome to Manage Disease
29 Jan, 2020 | 08:03h | UTCManipulating the Human Microbiome to Manage Disease – JAMA (free for a limited period)
Author Interview: The Potential of Manipulating the Human Microbiome to Manage Disease – JAMA (free)
Meta-Analysis: Induction Immunosuppression in Adults Undergoing Liver Transplantation
26 Jan, 2020 | 22:38h | UTCSummary: Medical interventions to prevent early graft rejection after liver transplantation – Cochrane Library (free)
Meta-Analysis: Antibiotic Prophylaxis to Prevent Spontaneous Bacterial Peritonitis in People with Liver Cirrhosis
26 Jan, 2020 | 22:37h | UTCAntibiotic prophylaxis to prevent spontaneous bacterial peritonitis in people with liver cirrhosis: a network meta-analysis – Cochrane Library (free)
Summary: Use of antibiotics to prevent spontaneous bacterial peritonitis in people with advanced liver disease – Cochrane Library (free)
Meta-Analysis: Treatment for Ascites in Adults with Decompensated Liver Cirrhosis
26 Jan, 2020 | 22:36h | UTCTreatment for ascites in adults with decompensated liver cirrhosis: a network meta‐analysis – Cochrane Library (free)
Summary: Treatments for ascites in people with advanced liver disease – Cochrane Library (free)
[Abstract Only] Randomized Trial: Primary Needle-Knife Fistulotomy vs. Conventional Cannulation in Patients at High-Risk of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis
26 Jan, 2020 | 22:32h | UTCPrimary Needle-Knife Fistulotomy Versus Conventional Cannulation Method in a High-Risk Cohort of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis – The American Journal of Gastroenterology (link to abstract – $ for full-text)
Source: EvidenceAlerts
Randomized Trial: Seven-day Vonoprazan and Low-dose Amoxicillin Dual Therapy as First-line Helicobacter Pylori Treatment
24 Jan, 2020 | 07:58h | UTCCommentary: Dual Therapy for 7 Days Effective for H. Pylori Eradication – Medscape (free registration required)
Update on the Diagnosis and Management of Exocrine Pancreatic Insufficiency
24 Jan, 2020 | 07:57h | UTCUpdate on the diagnosis and management of exocrine pancreatic insufficiency – F1000Research (free)
Randomized Trial: Early Surgery vs. Endoscopy-First Approach on Pain in Patients with Chronic Pancreatitis
23 Jan, 2020 | 09:43h | UTCEffect of Early Surgery vs Endoscopy-First Approach on Pain in Patients With Chronic Pancreatitis: The ESCAPE Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Tracing the Evidence to Address Painful Chronic Pancreatitis With Surgery (free)
See also: Visual Abstract
The Global, Regional, and National Burden of Cirrhosis by Cause in 195 Countries and Territories
23 Jan, 2020 | 09:38h | UTCInvited Commentary: Addressing the global cirrhosis epidemic: one size will not fit all – The Lancet Gastroenterology & Hepatology (free)
Related: Findings from the Global Burden of Disease Study 2017 – The Lancet / Institute for Health Metrics and Evaluation (free PDF)
Related Commentary on Twitter
Our latest study, "The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017," was just published in @LancetGastroHep. Read online: https://t.co/5shiB3DaYb pic.twitter.com/E6wKw1F4hT
— Institute for Health Metrics and Evaluation (IHME) (@IHME_UW) January 23, 2020
[Abstract Only] Randomized Trial: Polypectomy During the Insertion Phase vs. During Withdrawal Phase of Colonoscopy
23 Jan, 2020 | 02:03h | UTCClinical importance of cold polypectomy during the insertion phase in the left side of the colon and rectum: a multicenter randomized controlled trial (PRESECT STUDY) – Gastrointestinal Endoscopy (link to abstract – $ for full-text)
[Abstract Only] Meta-Analysis: Treatment of Uncomplicated Acute Diverticulitis Without Antibiotics May be Safe
22 Jan, 2020 | 09:31h | UTCTreatment of Uncomplicated Acute Diverticulitis Without Antibiotics: A Systematic Review and Meta-analysis – Diseases of the Colon & Rectum (link to abstract – $ for full-text)
Related: Randomized Trial: Antibiotic Avoidance Associated with Similar Long-term Outcomes in Uncomplicated Diverticulitis (randomized trials on the subject)
Randomized Trial: Efficacy of Glecaprevir and Pibrentasvir in Patients with Chronic HCV Genotype 1 Patients After Treatment Failure with NS5A Inhibitor Plus Sofosbuvir Therapy
22 Jan, 2020 | 09:11h | UTCEditorial: Retreatment Options for Patients Who Failed Direct-Acting Antiviral Regimens Containing NS5A Inhibitors: Is Glecaprevir/Pibrentasvir a Valid and Robust Option? (free)
Source: EvidenceAlerts
Related Commentary on Twitter
16 weeks treatment with G/P produced sustained virologic response 12 weeks after treatment in >90% of chronic #HCV genotype 1 patients https://t.co/YGM81urXpm pic.twitter.com/g1OtzeKQsL
— Gastroenterology (@AGA_Gastro) November 27, 2019
Screening for Colon Cancer in Older Adults: Risks, Benefits, and When to Stop
21 Jan, 2020 | 03:02h | UTC
Update on the Management of Inflammatory Bowel Disease During Pregnancy and Breastfeeding
21 Jan, 2020 | 01:17h | UTC
Meta-analysis: Stage-Specific Sensitivity of Fecal Immunochemical Tests for Detecting Colorectal Cancer
21 Jan, 2020 | 01:13h | UTCSource: EvidenceAlerts
AGA Clinical Practice Guidelines on the Management of Moderate to Severe Ulcerative Colitis
19 Jan, 2020 | 21:47h | UTCRelated: British Society of Gastroenterology Guidelines on the Management of Inflammatory Bowel Disease (guidelines on the subject)
The PEPTIC Randomized Clinical Trial: Similar Outcomes with Stress Ulcer Prophylaxis with Proton Pump Inhibitors vs. Histamine-2 Receptor Blockers Among ICU Patients Receiving Invasive Mechanical Ventilation
19 Jan, 2020 | 21:42h | UTCEditorial: Proton Pump Inhibitors vs Histamine-2 Receptor Blockers for Stress Ulcer Prophylaxis in Critically Ill Patients: Issues of Interpretability in Pragmatic Trials (free for a limited period)
Conference Presentation: Effect of Stress Ulcer Prophylaxis With PPIs vs H2RBs on Mortality in Ventilated ICU Patients (free)
Commentaries: JC: The PEPTIC study PPI vs H2RBs on the ICU – St Emlyn’s (free) AND Risks And Benefits Of Proton Pump Inhibitors To Prevent Gi Bleeds In Intensive Care Patients – MedicalResearch.com (free)
An Integrated Perfusion Machine Preserves Injured Human Livers for 1 Week
16 Jan, 2020 | 04:08h | UTCAn integrated perfusion machine preserves injured human livers for 1 week – Nature Biotechnology (free for a limited period)
Commentaries: Machine keeps human livers alive for one week outside of the body – University of Zurich (free) AND Machine Could Expand Pool of Livers for Donation – HealthDay News (free)
[Abstract Only] Cohort Study: Colorectal Cancer in Ulcerative Colitis
16 Jan, 2020 | 02:34h | UTCColorectal cancer in ulcerative colitis: a Scandinavian population-based cohort study – The Lancet (link to abstract – $ for full-text)
Commentary: Association Between Colorectal Cancer and Ulcerative Colitis – The ASCO Post (free)