Family Medicine
M-A: Dose-dependent effect of carbohydrate restriction for type 2 diabetes management.
17 May, 2022 | 10:30h | UTCDose-dependent effect of carbohydrate restriction for type 2 diabetes management: a systematic review and dose-response meta-analysis of randomized controlled trials – American Journal of Clinical Nutrition (link to abstract – $ for full-text)
Commentary on Twitter
#LowCarb: Carbohydrate restriction exerts a significant & important reduction on levels of cardiometabolic risk factors in patients with type 2 diabetes. Levels of most cardiometabolic outcomes decreased linearly with the decrease in carbohydrate intake. https://t.co/L8zwbsiTyn
— Nicolai Worm (@NicolaiWorm) May 15, 2022
Retrospective Cohort Study: Association of race and ethnicity with incidence of dementia among older adults.
17 May, 2022 | 10:29h | UTCAssociation of Race and Ethnicity With Incidence of Dementia Among Older Adults – JAMA (link to abstract – $ for full-text)
News Release: Cross-racial study of 1.87m vets shows wide disparities in dementia – University of California – San Francisco
Commentaries:
Significant Differences in Dementia Incidence Based on Race and Ethnicity – NeurologyToday
Strong evidence for differences in dementia risk by race and ethnicity – MedicalResearch
Dementia Incidence Varies by Race, Ethnicity – HealthDay
Commentary on Twitter
In this retrospective cohort study, among adults who received care at Veterans Health Administration medical centers, significant differences in #dementia incidence existed based on race and ethnicity. https://t.co/WguRziHyMa
— JAMA (@JAMA_current) April 25, 2022
Cohort Study: Antipsychotic use during pregnancy and risk for gestational diabetes.
17 May, 2022 | 10:24h | UTC
Commentary on Twitter
cohort study: Olanzapine, clozapine and quetiapine used during pregnancy were associated with increased risks for gestational diabetes (aRR=1.8; 1.3–2.4) and the infant being large for gestational age (aRR=1.6; 1.3–1.9) vs. untreated pregnant women https://t.co/VxmAxU9w4n
— P𝘧OL (@psychopharmacol) May 12, 2022
M-A: Prevalence and methods for assessment of oropharyngeal dysphagia in older adults.
17 May, 2022 | 10:21h | UTC
RCT: Albuterol–budesonide fixed-dose combination rescue inhaler for asthma.
16 May, 2022 | 02:33h | UTCAlbuterol–Budesonide Fixed-Dose Combination Rescue Inhaler for Asthma – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
The risk of severe asthma exacerbation was significantly lower with as-needed use of a fixed-dose combination of 180 μg of albuterol and 160 μg of budesonide than with albuterol alone. #ATS2022 https://t.co/MRGaUaGVwj pic.twitter.com/6BZX9Q6WxX
— NEJM (@NEJM) May 15, 2022
Test-negative, case-control study: Association of prior BNT162b2 COVID-19 vaccination with symptomatic SARS-CoV-2 infection in children and adolescents during Omicron predominance.
16 May, 2022 | 02:25h | UTCEditorial: Protecting Children Against Omicron – JAMA
Commentary on Twitter (thread – click for more)
This new JAMA study is worth discussing. It found that, this winter, vax effectiveness in 12-15 yos dropped to 0% after 3-5 months & vaccinated were MORE likely to test+ at month 7. May be confounded (see🧵)
But I don't see this as good reason for boostershttps://t.co/zpkIDdZhnn pic.twitter.com/bxAIDmiR8s— Tracy Høeg, MD, PhD (@TracyBethHoeg) May 14, 2022
Hypotheses | Severe acute hepatitis in children: investigate SARS-CoV-2 superantigens.
16 May, 2022 | 02:22h | UTCRelated:
Why COVID is a key suspect in severe hepatitis cases in kids worldwide – CBC
Hepatitis outbreak in children: What do we know so far? – Imperial College London
Explaining the unexplained hepatitis in children – The Lancet Infectious Diseases
Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Commentary on Twitter
A solid hypothesis for the basis of the mysterious, severe acute hepatitis in children: superantigen formation from prior Covid viral reservoir in the GI tract with superimposed adenovirus infection https://t.co/1eehyQmlhi @LancetGastroHep pic.twitter.com/UqCAh3igMH
— Eric Topol (@EricTopol) May 14, 2022
Clinical Report: Health supervision for children and adolescents with Down Syndrome.
16 May, 2022 | 02:15h | UTCHealth Supervision for Children and Adolescents With Down Syndrome – Pediatrics
European Guidelines on the management of female non-neurogenic lower urinary tract symptoms.
16 May, 2022 | 02:13h | UTC
2022 EULAR points to consider for remote care in rheumatic and musculoskeletal diseases.
16 May, 2022 | 02:11h | UTC
Commentary on Twitter
2022 #EULAR points to consider for remote care in #rheumatic and #musculoskeletal diseaseshttps://t.co/oB0Fo0wzoM pic.twitter.com/LS95rSvCmh
— Annals of the Rheumatic Diseases (@eular_ARD) April 27, 2022
EAP Recommendations: Adolescents with eating disorders in pediatric practice.
16 May, 2022 | 02:12h | UTC
Mortality in people with schizophrenia: a systematic review and meta-analysis of relative risk and aggravating or attenuating factors.
16 May, 2022 | 01:55h | UTC
RCT: Dorzagliatin add-on therapy to metformin in patients with type 2 diabetes.
16 May, 2022 | 01:51h | UTCCommentary: DAWN: Support for dorzagliatin–metformin combination therapy in type 2 diabetes – medwireNews
Commentary on Twitter
The DAWN study is a #phase3 clinical trial that demonstrates effective #glycemic control of #dorzagliatin as an add-on therapy to #metfomin in patients with type 2 #diabetes. #T2D #NMEDClinicalhttps://t.co/9bHWQNvNTJ
— Nature Medicine (@NatureMedicine) May 12, 2022
Gabapentin and pregabalin in bipolar disorder, anxiety states, and insomnia: Systematic review, meta-analysis, and rationale.
16 May, 2022 | 01:45h | UTC
Commentary on Twitter
SR: there is moderate evidence of the efficacy of gabapentinoids in anxiety states (SMD ranging between -2.25 and -0.25), but minimal evidence in bipolar disorder and insomnia and they should be used for these disorders only with strong justification https://t.co/zrxduX2q6l pic.twitter.com/6mKYwHKKbo
— P𝘧OL (@psychopharmacol) May 12, 2022
Under a http://creativecommons.org/licenses/by/4.0/ license
Effectiveness of pre-anesthetic assessment clinic: a systematic review of randomized and non-randomized prospective controlled studies.
16 May, 2022 | 01:42h | UTC
Oral pre-exposure prophylaxis (PrEP) to prevent HIV: a systematic review and meta-analysis of clinical effectiveness, safety, adherence and risk compensation in all populations.
16 May, 2022 | 01:41h | UTC
Podcast: Pediatric anxiety pearls.
16 May, 2022 | 01:27h | UTC#50: Facing the (Core) Fear! Pediatric Anxiety Pt 1: Live the Exposure Lifestyle – The Cribsiders
RCT: Multicomponent intervention to prevent mobility disability in frail older adults.
13 May, 2022 | 11:41h | UTCEditorial: Preserving community mobility in vulnerable older people – The BMJ
News Release: Regular exercise with dietary advice linked to better mobility in frail older people – BMJ Newsroom
Commentary on Twitter
A programme of regular exercise along with expert dietary advice is linked to a reduction in mobility problems among frail older people living in the community, finds this trial by @Emanuel00962649 and colleagueshttps://t.co/xT44sTwe4k
— The BMJ (@bmj_latest) May 12, 2022
Explaining the unexplained hepatitis in children.
13 May, 2022 | 11:39h | UTCExplaining the unexplained hepatitis in children – The Lancet Infectious Diseases
Related:
Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Cohort Study: Health outcomes in people 2 years after surviving hospitalization with COVID-19.
13 May, 2022 | 11:32h | UTC
Canadian guidelines for peripheral arterial disease.
13 May, 2022 | 11:12h | UTC
AUA Guideline: Diagnosis and treatment interstitial cystitis/bladder pain syndrome.
13 May, 2022 | 11:07h | UTC
M-A: Prevalence of burnout among GPs.
13 May, 2022 | 11:01h | UTCRelated:
Viewpoint | How to Measure Progress in Addressing Physician Well-being: Beyond Burnout.
Physician Well-being 2.0: Where Are We and Where Are We Going?
[Abstract Only] Assessment of Risk Factors for Suicide Among US Health Care Professionals
Beyond Burnout: Docs Decry ‘Moral Injury’ From Financial Pressures of Health Care
Perspective: Hospital Administration Response to Physician Stress and Burnout
Opinion: It’s Time to Talk About Physician Burnout and Moral Injury
Systematic Review: Effect of Organization-Directed Workplace Interventions on Physician Burnout
Perspective: The 3 Causes Of Physician Burnout (And Why There’s No Simple Solution)
Physician Burnout: A Global Crisis (several resources on the subject)
Systematic Review: Antibiotic prophylaxis for preventing bacterial endocarditis following dental procedures.
12 May, 2022 | 10:24h | UTC
Commentary on Twitter
Have a look at the evidence on antibiotics for preventing bacterial endocarditis in people undergoing dental treatment. Summary here: https://t.co/7uxnkbgt8t. Full review here: https://t.co/3Au3EsHZIU pic.twitter.com/RLsF3fHiZa
— Cochrane Oral Health (@CochraneOHG) May 11, 2022
Cohort Study: Impact of modifiable healthy lifestyle adoption on lifetime gain from middle to older age.
12 May, 2022 | 10:14h | UTC
Commentary on Twitter
https://twitter.com/EricTopol/status/1524446562545405952