Family Medicine
Systematic Review | Outcomes in deprescribing implementation trials and compliance with expert recommendations
20 Jul, 2023 | 10:55h | UTCRelated:
RCT | Opioids not more effective than placebo for acute low back and neck pain
RCT | A deprescribing intervention reduced medication burden among older adults in post-acute care
Deprescribing proton pump inhibitors – Australian Journal of General Practice
Antihypertensive Deprescribing in Older Adults: a Practical Guide – Current Hypertension Reports
Deprescribing in Palliative Cancer Care – Life
Less is More: Deprescribing Medications in Older Adults with Kidney Disease: A Review – Kidney360
Polypharmacy Management in Older Patients – Mayo Clinic Proceedings
Eliminating Medication Overload: A National Action Plan – Lown Institute
Common ED Medication Errors: Polypharmacy – emDocs
Current and future perspectives on the management of polypharmacy – BMC Family Practice
Polypharmacy—an Upward Trend with Unpredictable Effects – Deutsches Ärzteblatt international
Clinical Consequences of Polypharmacy in Elderly – Expert Opinion on Drug Safety
Review | Painful diabetic peripheral neuropathy
20 Jul, 2023 | 10:53h | UTC
Self-measured blood pressure telemonitoring programs: a pragmatic how-to guide
19 Jul, 2023 | 14:33h | UTC
Podcast | Hematuria pearls
19 Jul, 2023 | 14:19h | UTC#404 Hematuria with Dr. Derek Fine – The Curbsiders
IARC, WHO agency, identifies aspartame as potentially carcinogenic but probably safe within established acceptable daily intake
18 Jul, 2023 | 13:58h | UTCNews Release: Aspartame hazard and risk assessment results released – World Health Organization
Commentaries:
Expert reaction to IARC and JEFCA summary on aspartame – Science Media Centre
Aspartame Hazard and Risk Assessment Results Released by IARC and JECFA – The ASCO Post
AHA Scientific Statement | Cardiopulmonary impact of electronic cigarettes and vaping products
18 Jul, 2023 | 13:56h | UTCNews Releases:
Top Things to Know: Cardiopulmonary Impact of Electronic Cigarettes and Vaping Products – American Heart Association
Commentary: Vaping’s Risks to CV Health Not Yet Fully Known: AHA – CIDRAP
RCT | Direct oral challenge noninferior to skin testing followed by direct oral challenge in low-risk penicillin allergy patients
18 Jul, 2023 | 13:54h | UTCEfficacy of a Clinical Decision Rule to Enable Direct Oral Challenge in Patients With Low-Risk Penicillin Allergy: The PALACE Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)
See also: Visual Abstract
News Release: World-first clinical trial to help millions with penicillin allergies – Vanderbilt University Medical Center
Commentary: Trial supports use of direct oral challenge for penicillin allergy – CIDRAP
RCT | Donanemab slows early symptomatic Alzheimer’s progression, but raises serious safety concerns
18 Jul, 2023 | 13:51h | UTCDonanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial – JAMA (free for a limited period)
Editorials:
Donanemab for Alzheimer Disease—Who Benefits and Who Is Harmed? – JAMA (free for a limited period)
Amyloid-Targeting Monoclonal Antibodies for Alzheimer Disease – JAMA (free for a limited period)
Ushering in a New Era of Alzheimer Disease Therapy – JAMA (free for a limited period)
See also: Visual Abstract
Commentary: Expert reaction to results from Eli Lilly on its anti-amyloid drug donanemab – Science Media Centre
Related: RCT | Lecanemab slows cognitive decline in early Alzheimer’s disease but raises safety concerns.
Nationwide Cohort Study | Adolescent hypertension linked with increased stroke risk in young adulthood
18 Jul, 2023 | 13:49h | UTCCommentary: The Relationship Between Adolescent Hypertension and Stroke Risk After Age 40 Years – Neurology Advisor
Guideline | Prevention and management of childhood progressive myopia
18 Jul, 2023 | 13:35h | UTC
RCT | Prostatic artery embolization improves symptoms more than combined medical therapy in BPH patients
18 Jul, 2023 | 13:34h | UTC
Guideline | Antibiotic therapy in patients with suspected antibiotic allergy
17 Jul, 2023 | 13:59h | UTC
Retrospective Analysis | Inconsistencies in pediatric drug dosing found in over half of prehospital emergency drug administrations
17 Jul, 2023 | 13:50h | UTCCommentaries:
Children and Drug Dosing Variations When in Transit to the Hospital – AAP Journals Blog
Variation Seen in Dosing of Meds at Prehospital Pediatric Encounters – HealthDay
M-A | One-year usage of elastic compression stockings comparable to two for post-thrombotic syndrome prevention
17 Jul, 2023 | 13:49h | UTC
Meta-Analysis | Nearly 6% of first-episode psychosis patients exhibit clinically relevant MRI abnormalities
17 Jul, 2023 | 13:32h | UTCNews Release: Routine brain scanning may improve clinical care for people with psychosis – University of Oxford
Cohort Study | Mental disorders linked to increased cardiovascular events in young patients
17 Jul, 2023 | 13:20h | UTCIncreased cardiovascular events in young patients with mental disorders: a nationwide cohort study – European Journal of Preventive Cardiology (free for a limited period)
News Release: Under 40s with mental health problems have elevated risks of heart attack and stroke – European Society of Cardiology
M-A | First-line thiazide diuretics show reduced cardiovascular events, comparable mortality vs. other antihypertensive drugs
14 Jul, 2023 | 12:55h | UTC
Quality Improvement Study | Improved asymptomatic bacteriuria management by reduction of unnecessary urine culture requests
14 Jul, 2023 | 12:54h | UTCRelated:
Study: Hospital Intervention Resulted in a 45% Reduction in the Urine Cultures Ordered
USPSTF Recommendation Statement: Screening for Asymptomatic Bacteriuria in Adults
IDSA Guideline for the Management of Asymptomatic Bacteriuria
Commentary on Twitter
???Powerful message from our new study in @JAMAInternalMed: diagnostic stewardship (better use of diagnostic tests) was responsible for ALL the⬇️in unnecessary antibiotic use for ASB. ➕results??nudge to action. Time to??upstream to improve care! https://t.co/yO4UpA6ZKK pic.twitter.com/hXZGvNmVJP
— Valerie Vaughn (@ValerieVaughnMD) July 11, 2023
Cohort Study | No significant difference in kidney risks between lithium and valproate therapies, but high lithium levels remain a concern
14 Jul, 2023 | 12:46h | UTC
Cohort Study | Long-term cancer survivors face higher risk of noncancer death
14 Jul, 2023 | 12:38h | UTC
Commentary on Twitter
Patients surviving ≥5 years from initial diagnosis of early breast, prostate, or colorectal cancer, the risk of dying from the cancer varied widely vs noncancer causes of death. Patients at low risk at diagnosis had a 3x higher risk of noncancer death. https://t.co/z2ffG9LqPv pic.twitter.com/HcqFkWAzZf
— JAMA Network Open (@JAMANetworkOpen) July 12, 2023
Review | Cushing Syndrome
13 Jul, 2023 | 13:08h | UTCCushing Syndrome: A Review – JAMA (free for a limited period)
Audio clinical review: Diagnosis and Treatment of Cushing Syndrome – JAMA
RCT | Metformin boosts effectiveness of lifestyle interventions for diabetes prevention in individuals with impaired glucose regulation
13 Jul, 2023 | 13:07h | UTCSafety and effectiveness of metformin plus lifestyle intervention compared with lifestyle intervention alone in preventing progression to diabetes in a Chinese population with impaired glucose regulation: a multicentre, open-label, randomised controlled trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Related Study: Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin – New England Journal of Medicine (link to abstract – $ for full-text)
Single Arm Trial | Low-carbohydrate diet improves glycemic control in type 1 diabetes
13 Jul, 2023 | 13:04h | UTCRelated:
Management of Type 1 Diabetes With a Very Low–Carbohydrate Diet – Pediatrics (link to abstract – $ for full-text)
Lower carbohydrate diets for adults with type 2 diabetes – British Journal of Nutrition
Low carbohydrate diet: Insights from a general practice service in patients with type 2 diabetes
RCT| Exercise during hemodialysis improves physical function in chronic kidney failure patients
13 Jul, 2023 | 13:01h | UTCExercise during Hemodialysis in Patients with Chronic Kidney Failure – NEJM Evidence
RCT | Cytisinicline shows significant efficacy in smoking cessation over placebo
13 Jul, 2023 | 12:58h | UTCCytisinicline for Smoking Cessation: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
See also: Visual Abstract