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Family Medicine

Cohort Study: Sulfonylureas as Second Line Drugs in Type 2 Diabetes and the Risk of Adverse Outcomes

20 Jul, 2018 | 03:24h | UTC

Sulfonylureas as second line drugs in type 2 diabetes and the risk of cardiovascular and hypoglycaemic events: population based cohort study – The BMJ (free)

Editorial: Sulfonylureas as second line treatment for type 2 diabetes – The BMJ (free for a limited period)

Commentaries: Diabetes: Switching to Sulfonylureas from Metformin Linked to Increased Side Effects – MedicalResearch.com (free) AND Switching diabetes patients to sulfonylurea linked with complications – Pulse (free) AND Raised risk of MI and mortality when starting sulfonylurea – OnMedica (free)

 


Cohort Study: Metformin and Risk of Hypertension

20 Jul, 2018 | 03:20h | UTC

Metformin and Risk of Hypertension in Taiwanese Patients With Type 2 Diabetes Mellitus – Journal of the American Heart Association (free)

“A reduced risk of hypertension is observed in metformin users in a dose‐response pattern”.

 


Randomized Trial: E-Counseling for Hypertension

20 Jul, 2018 | 03:07h | UTC

Randomized Controlled Trial of E-Counseling for Hypertension: REACH – Circulation: Cardiovascular Quality and Outcomes (free)

Commentaries: Virtual counseling helps lower blood pressure – AHA News (free) AND E-counseling can lower blood pressure, heart disease risk – Medical News Today (free)

 


Systematic Review: Omega-3 fatty Acids for the Prevention of Cardiovascular Disease

20 Jul, 2018 | 03:18h | UTC

Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease – Cochrane Library (link to abstract – $ for full-text)

Cochrane Summaries: New Cochrane health evidence challenges belief that omega 3 supplements reduce risk of heart disease, stroke or death (free) AND Omega-3 intake for cardiovascular disease (free)

Commentaries: Expert reaction to Cochrane review on omega-3 fatty acids and risk of heart disease, stroke and death – Science Media Centre (free) AND Omega 3 supplements don’t protect against heart disease – new review – The Conversation (free)

Related Meta-Analysis: Omega-3 Fatty Acid Supplements Don’t Reduce Cardiovascular Risk (free article and commentary)

 


Meta-Analysis: Cognitive Behavioral Therapy for Anxiety and Related Disorders

20 Jul, 2018 | 03:00h | UTC

Cognitive behavioral therapy for anxiety and related disorders: A meta-analysis of randomized placebo-controlled trials – Depression and Anxiety (free)

Commentary: CBT for anxiety: new meta-analysis confirms significant improvements to target symptoms – The Mental Elf (free) (via @AllenFrancesMD)

 


Cohort Study: Occult Blood in Feces is Associated with All-cause and Non-colorectal Cancer Mortality

20 Jul, 2018 | 02:46h | UTC

Occult blood in faeces is associated with all-cause and non-colorectal cancer mortality – Gut (free)

Commentaries: FOB associated with rise in all-cause mortality – OnMedica (free) AND 3 key findings from Gut study on all-cause mortality associated with occult blood in stool – GI & Endoscopy (free) AND Fecal Occult Blood Flags Risks Beyond Colon Cancer – MedPage Today (free)

 


Clinical Review: Novel Therapies for Diabetes Mellitus in Pregnancy

20 Jul, 2018 | 02:42h | UTC

Novel therapies for diabetes mellitus in pregnancy – The BMJ (free for a limited period)

 


Richard Lehman’s Journal Review – 16 July 2018

20 Jul, 2018 | 02:28h | UTC

Richard Lehman’s journal review, 16 July 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Position Statement: Reducing Inappropriate Medication Use & Polypharmacy

20 Jul, 2018 | 02:21h | UTC

International Group for Reducing Inappropriate Medication Use & Polypharmacy (IGRIMUP): Position Statement and 10 Recommendations for Action – Drugs & Aging (free)

Related: Polypharmacy Guidance, Realistic Prescribing 3 rd Edition, 2018 – Scottish Government Polypharmacy Model of Care Group (free PDF) AND The Challenge of Polypharmacy: From Rhetoric to Reality – Royal Pharmaceutical Society and Royal College of General Practitioners Partnership (free PDF) AND Common ED Medication Errors: Polypharmacy – emDocs (free) AND Current and future perspectives on the management of polypharmacy – BMC Family Practice (free) AND The other big drug problem: Older people taking too many pills – The Whashington Post (free) AND Routine deprescribing of chronic medications to combat polypharmacy – Therapeutic Advances in Drug Safety (free) AND Polypharmacy—an Upward Trend with Unpredictable Effects – Deutsches Ärzteblatt international (free) AND Clinical Consequences of Polypharmacy in Elderly – Expert Opinion on Drug Safety (free)Too Many Meds? America’s Love Affair With Prescription Medication – Consumer Reports (free) AND CaDeN Deprescribing Guidelines and Algorithms (free) 

 


Meta-Analysis: Effects of Aspirin for CV Disease Prevention According to Bodyweight and Dose

20 Jul, 2018 | 02:20h | UTC

Effects of aspirin on risks of vascular events and cancer according to bodyweight and dose: analysis of individual patient data from randomised trials – The Lancet (free)

Commentaries: Weight-adjusted aspirin for cardiovascular prevention – The Lancet (free) AND One dose of aspirin doesn’t fit all – University of Oxford (free)

Practice Changing Article. “Low doses of aspirin (75–100 mg) were only effective in preventing vascular events in patients weighing less than 70 kg, and had no benefit in the 80% of men and nearly 50% of all women weighing 70 kg or more. By contrast, higher doses of aspirin were only effective in patients weighing 70 kg or more.”

 


Study: Bleeding Risk with Concomitant NSAIDs and Anticoagulants in Atrial Fibrillation

13 Jul, 2018 | 03:04h | UTC

Concomitant Oral Anticoagulant and Nonsteroidal Anti-Inflammatory Drug Therapy in Patients With Atrial Fibrillation – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Bleeding Risk Increased With NSAID Use in Anticoagulated A-fib Patients: RE-LY Analysis – TCTMD (free) AND NSAID, anticoagulant combo ups risk for bleeding events in AFib patients – Cardiovascular Business (free) Concomitant NSAIDs and Anticoagulants in Atrial Fibrillation – American College of Cardiology (free)

 


Infographic: Testing for Non-alcoholic Fatty Liver Disease

13 Jul, 2018 | 03:03h | UTC

Testing for non-alcoholic fatty liver disease -The BMJ (free PDF)

 


Study: Impact of 2017 ACC/AHA Guidelines on Prevalence of Hypertension and Eligibility for Antihypertensive Treatment

13 Jul, 2018 | 02:56h | UTC

Impact of 2017 ACC/AHA guidelines on prevalence of hypertension and eligibility for antihypertensive treatment in United States and China: nationally representative cross sectional study – The BMJ (free)

Commentary: Expert reaction to study looking at American blood pressure guidelines and how many people in the USA and China would be classed as having high blood pressure – Science Media Centre (free)

 


NICE Guideline: Management of Rheumatoid Arthritis in Adults

13 Jul, 2018 | 02:57h | UTC

Rheumatoid arthritis in adults: management – National Institute for Health and Care Excellence (free)

 


FDA Safety Alert: Warnings for Fluoroquinolones on Risks of Mental Health and Low Blood Sugar Adverse Reactions

13 Jul, 2018 | 02:50h | UTC

News Release: FDA updates warnings for fluoroquinolone antibiotics on risks of mental health and low blood sugar adverse reactions – U.S. Food and Drug Administration (free)

Commentaries: FDA Strengthens Warnings for Fluoroquinolone Antibiotics – MPR (free) AND FDA Announces Labeling Changes for Fluoroquinolones Due to Mental Health AEs, Blood Sugar Disturbances – MD Magazine (free)

 


Meta-Analysis: Efficacy of Short-Course Antibiotic Treatments for Community-Acquired Pneumonia

13 Jul, 2018 | 02:54h | UTC

Efficacy of short-course antibiotic treatments for community-acquired pneumonia in adults: A systematic review and meta-analysis – Antimicrobial Agents and Chemotherapy (link to abstract – $ for full-text)

Commentary: Is Short-Course Antibiotic Treatment for CAP Effective? – MPR (free)

 


Study: 75% of African-Americans Have High Blood Pressure Before age 55

13 Jul, 2018 | 02:51h | UTC

Cumulative Incidence of Hypertension by 55 Years of Age in Blacks and Whites: The CARDIA Study – Journal of the American Heart Association (free)

Commentaries: Most black adults have high blood pressure before age 55 – AHA / ASA Newsroom (free) AND New CARDIA Data: 75% of African-Americans Have Hypertension by Age 55 – TCTMD (free)

 


Meta-Analysis: Comparative Benefits and Harms of Basal Insulin Analogues for Type 2 Diabetes

13 Jul, 2018 | 02:46h | UTC

Comparative Benefits and Harms of Basal Insulin Analogues for Type 2 Diabetes: A Systematic Review and Network Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Newer, older insulin formulations may offer similar glucose-lowering effects – ACP Internist (free) AND HbA1c Reduction Similar in Old, New Basal Insulin Analogues – MedPage Today (free registration required)

 


USPSTF Statement: Risk Assessment for Cardiovascular Disease With Nontraditional Risk Factors

13 Jul, 2018 | 02:48h | UTC

Risk Assessment for Cardiovascular Disease With Nontraditional Risk Factors: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Editorial: USPSTF Recommendations for Assessment of Cardiovascular Risk With Nontraditional Risk Factors: Finding the Right Tests for the Right Patients (free)

“The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of adding the ankle-brachial index (ABI), high-sensitivity C-reactive protein (hsCRP) level, or coronary artery calcium (CAC) score to traditional risk assessment for cardiovascular disease (CVD) in asymptomatic adults to prevent CVD events”.

 


Meta-Analysis: Multivitamins Do Not Reduce Cardiovascular Disease and Mortality

13 Jul, 2018 | 02:47h | UTC

Association of Multivitamin and Mineral Supplementation and Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis – Circulation: Cardiovascular Quality and Outcomes (free for a limited period)

Editorial: Multivitamins Do Not Reduce Cardiovascular Disease and Mortality and Should Not Be Taken for This Purpose: How Do We Know That? (free)

Commentaries: Study: Multivitamins Do Not Prevent Strokes, Heart Attacks or Cardiovascular Disease Deaths – University of Alabama at Birmingham, via NewsWise (free) AND Multivitamin-mineral supplements do not reduce heart disease, deaths – Reuters (free)

Related: Supplements Not Effective for CVD Prevention and Treatment (link to abstract and commentaries) AND Multivitamins are probably a waste of money (free commentaries)

 


Study: Association of Early Introduction of Solids with Infant Sleep

13 Jul, 2018 | 02:45h | UTC

Association of Early Introduction of Solids With Infant Sleep: A Secondary Analysis of a Randomized Clinical Trial – JAMA Pediatrics (free)

Author Interview: Effects of Early Solid Food Introduction on Infant Sleep (free audio)

Commentaries: Babies fed solids earlier ‘sleep better’ – NHS Choices (free) AND Feeding your baby solids early may help them sleep, study suggests – The Guardian (free) AND Giving your baby solid food early won’t help them sleep better – The Conversation (free)

 


Review: Public Health Implications of Overscreening for Carotid Artery Stenosis, Prediabetes, and Thyroid Cancer

13 Jul, 2018 | 02:40h | UTC

Public health implications of overscreening for carotid artery stenosis, prediabetes, and thyroid cancer – Public Health Reviews (free)

 


Guideline: Recommendations on Screening for Asymptomatic Bacteriuria in Pregnancy

13 Jul, 2018 | 02:37h | UTC

Recommendations on screening for asymptomatic bacteriuria in pregnancy – Canadian Task Force on Preventive Health Care (free)

See also: Summary of recommendations for clinicians and policy-makers / other resources from CTFPHC (all free)

 


NICE Draft Guidance: Antibiotics Should be Restricted for COPD

13 Jul, 2018 | 02:36h | UTC

Antibiotics should be restricted for COPD – National Institute for Health and Care Excellence (free)

Commentaries: Antibiotics should be restricted for COPD, says NICE – OnMedica (free) AND UK officials recommend limits on antibiotics for COPD – CIDRAP (free)

“The draft antimicrobial guidance recommends that antibiotics should be offered to people who have a severe flare up of symptoms, also known as a severe acute exacerbation”

 


Richard Lehman’s journal review – 9 July 2018

13 Jul, 2018 | 02:34h | UTC

Richard Lehman’s journal review, 9 July 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals

 


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