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Alex Nowbar’s Research Reviews – 12 November 2018

16 Nov, 2018 | 01:39h | UTC

Alex Nowbar’s research reviews, 12 November 2018 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Meta-Analysis: SGLT2 Inhibitors for Prevention of Cardiovascular and Renal Outcomes in Type 2 Diabetes

16 Nov, 2018 | 01:35h | UTC

SGLT2 inhibitors for primary and secondary prevention of cardiovascular and renal outcomes in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials – The Lancet (link to abstract – $ for full-text)

Commentary: SGLT2 Inhibitors and CV and Renal Outcomes in Type 2 Diabetes – American College of Cardiology (free)

 


Study: Less Surveillance Needed for Simple Ovarian Cysts

16 Nov, 2018 | 01:34h | UTC

Risk of Malignant Ovarian Cancer Based on Ultrasonography Findings in a Large Unselected Population – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Most simple ovarian cysts require no treatment, surveillance – UPI (free) AND Less surveillance needed for simple ovarian cysts – University of California, San Francisco (free)

“New study finds that simple cysts should be considered normal and ignored” (from The University of California)

 


Guideline: Use of Risk Assessment Tools to Guide Decision-Making in the Primary Prevention of Atherosclerotic Cardiovascular Disease

16 Nov, 2018 | 01:08h | UTC

Use of Risk Assessment Tools to Guide Decision-Making in the Primary Prevention of Atherosclerotic Cardiovascular Disease – A Special Report From the American Heart Association and American College of Cardiology (free PDF)

Summary: Use of Risk Assessment Tools to Guide Decision-Making in ASCVD Prevention – American College of Cardiology (free)

 


New AHA/ACC Guideline on the Management of Blood Cholesterol

16 Nov, 2018 | 01:09h | UTC

2018 AHA/ACC Guideline on the Management of Blood Cholesterol – Circulation – A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines (free PDF)

Summary: 2018 ACC/AHA Multisociety Guideline on the Management of Blood Cholesterol – American College of Cardiology (free)

See also: Cholesterol Guideline Hub (free resources)

 


Randomized Trial: Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease

16 Nov, 2018 | 01:08h | UTC

Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease – New England Journal of Medicine (free)

Editorial: VITAL Signs for Dietary Supplementation to Prevent Cancer and Heart Disease (free)

Commentaries: Vitamin D And Fish Oil Supplements Mostly Disappoint In Long-Awaited Research Results – NPR (free) AND Fish Oil And Vitamin D Pills No Guard Against Cancer Or Serious Heart Trouble – Kaiser Health News (free)

 


Randomized Trial: Marine n−3 Fatty Acids and Prevention of Cardiovascular Disease and Cancer

16 Nov, 2018 | 01:07h | UTC

Marine n−3 Fatty Acids and Prevention of Cardiovascular Disease and Cancer – New England Journal of Medicine (free)

Commentaries: Vitamin D, omega-3 supplements do not prevent cancer or heart disease, study says – CNN (free) AND Vitamin D and Fish Oils Are Ineffective for Preventing Cancer and Heart Disease – The New York Times (10 articles per month are free)

Related Systematic Review: Omega-3 fatty Acids for the Prevention of Cardiovascular Disease (free review and commentaries)

 


Guideline: Management of Atrial Fibrillation

16 Nov, 2018 | 00:59h | UTC

2018 Focused Update of the Canadian Cardiovascular Society Guidelines for the Management of Atrial Fibrillation – Canadian Journal of Cardiology (free)

 


Systematic Review: Perioperative Alcohol Cessation Intervention for Postoperative Complications

16 Nov, 2018 | 01:01h | UTC

Perioperative alcohol cessation intervention for postoperative complications – Cochrane Library (free)

Summary: Effects of perioperative alcohol cessation interventions on postoperative complications following surgery – Cochrane Library (free)

“Intensive alcohol cessation interventions offered for four to eight weeks to participants undergoing all types of surgical procedures to achieve complete alcohol cessation before surgery probably reduced the number of postoperative complications.”

 


Guideline Synopsis: Incidental Pulmonary Nodules Detected on CT Images

9 Nov, 2018 | 03:00h | UTC

Incidental Pulmonary Nodules Detected on CT Images – JAMA (free)

 


WHO Guideline: Management of Physical Health Conditions in Adults with Severe Mental Disorders

9 Nov, 2018 | 03:02h | UTC

Guideline: Management of physical health conditions in adults with severe mental disorders – World Health Organization (free PDF)

News Release: WHO guidelines: Management of physical health conditions in adults with severe mental disorders (free)

WHO Video: Improving the physical health of people with severe mental disorders (free)

 


Review: Gastroesophageal Reflux Disease, Functional Dyspepsia and Irritable Bowel Syndrome

9 Nov, 2018 | 02:53h | UTC

Gastroesophageal reflux disease, functional dyspepsia and irritable bowel syndrome: common overlapping gastrointestinal disorders – Annals of Gastroenterology (free)

 


Study: Artificial Intelligence may Predict Alzheimer’s Years Before Diagnosis

9 Nov, 2018 | 02:50h | UTC

A Deep Learning Model to Predict a Diagnosis of Alzheimer Disease by Using 18F-FDG PET of the Brain – Radiology (free for a limited period)

Commentaries: Artificial intelligence predicts Alzheimer’s years before diagnosis – Radiology Society of North America (free) AND Expert reaction to study looking at AI technology, brain imaging and Alzheimer’s disease detection – Science Media Centre (free) AND AI May Detect Alzheimer’s Years Before Diagnosis – Medscape (free registration required)

 


Meta-Analysis: Triple Therapy in the Management of COPD

9 Nov, 2018 | 02:46h | UTC

Triple therapy in the management of chronic obstructive pulmonary disease: systematic review and meta-analysis – The BMJ (free)

Commentary: Triple Therapy for COPD Tied to Fewer Exacerbations, More Pneumonia – NEJM Journal Watch (free)

 


Podcast: Battle of the Heart Societies: Who Is Right–the US or Europe–Regarding How to Manage Hypertension?

9 Nov, 2018 | 02:27h | UTC

Battle of the Heart Societies: Who Is Right–the US or Europe–Regarding How to Manage Hypertension? – JAMA (free)

Related: Impact of the Discordance Between Blood Pressure Guidelines (free perspective and commentaries)

 


2018 ACC/AHA/HRS Guideline on the Evaluation and Management of Patients With Bradycardia and Cardiac Conduction Delay

9 Nov, 2018 | 02:36h | UTC

2018 ACC/AHA/HRS Guideline on the Evaluation and Management of Patients With Bradycardia and Cardiac Conduction Delay (free)

See also: Executive Summary (free) AND Summary form AAC (free) AND Bradycardia Guideline Hub (free resources)

 


Clinical Practice Guidelines for Quality Palliative Care

9 Nov, 2018 | 02:22h | UTC

Clinical Practice Guidelines for Quality Palliative Care, 4th Edition – National Consensus Project’s (free)

News Release: New National Guidelines Seek to Improve Access to Palliative Care for People Living with Serious Illness (free)

Commentaries: Palliative care guidelines updated with increased focus on collaboration, communication – ACP Internist (free) AND New Palliative Care Guidelines Demand ‘Seismic Shift’ in Care – Medscape (free registration required)

 


Systematic Review: Reduced Salt Intake for Heart Failure

9 Nov, 2018 | 02:19h | UTC

Reduced Salt Intake for Heart Failure: A Systematic Review – JAMA Internal Medicine (free for a limited period)

Commentaries: Sodium Restriction in Heart Failure: Too Much Uncertainty—Do the Trials – JAMA Internal Medicine (free for a limited period) AND Review Questions Wisdom of Limiting Salt Intake in Heart Failure – NEJM Journal Watch (free) AND Review: Low-Sodium Diet for HF on Shaky Ground – MedPage Today (free registration required)

 


Meta-Analysis: Diagnostic Value of Symptoms and Signs for Identifying UTI in Older adults

9 Nov, 2018 | 02:05h | UTC

Diagnostic value of symptoms and signs for identifying urinary tract infection in older adult outpatients: Systematic review and meta-analysis – The Journal of Infection (free)

“A number of symptoms and signs typically associated with UTI, such as nocturia, urgency and abnormal vital signs, were of limited use in older adult outpatients.”

 


Perspective: A Profusion of Diagnoses. That’s Good and Bad

9 Nov, 2018 | 02:17h | UTC

A Profusion of Diagnoses. That’s Good and Bad – The New York Times (10 articles per month are free)

“…we may also be medicalizing much of normal human behavior — labeling the healthy as diseased, and exposing them to undue risk of stigma, testing and treatment.”

 


Systematic Review: Supplements for Preventing Cognitive Decline in People with Mild Cognitive Impairment

9 Nov, 2018 | 01:59h | UTC

Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild cognitive impairment – Cochrane Library (free)

Summary: Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild cognitive impairment – Cochrane Library (free)

“The evidence on vitamin and mineral supplements as treatments for MCI is very limited. “

 


Study: Instant Soups and Noodles Responsible for Burning Nearly 10,000 Children Each Year

9 Nov, 2018 | 01:56h | UTC

Instant soups and noodles responsible for burning nearly 10,000 children each year – American Academy of Pediatrics (free)

Commentary: How Instant Soup, Noodle Burns Send Over 9500 Kids To ERs Each Year – Forbes (free)

 


Review: Diagnosis and Treatment of Hypertension in Pregnancy

9 Nov, 2018 | 01:53h | UTC

State-of-the-Art Diagnosis and Treatment of Hypertension in Pregnancy – Mayo Clinic Proceedings (free)

 


Systematic Review: Antibiotics for Exacerbations of Chronic Obstructive Pulmonary Disease

9 Nov, 2018 | 01:38h | UTC

Antibiotics for exacerbations of chronic obstructive pulmonary disease – Cochrane Library (free)

Summary: Are antibiotics beneficial for flare-ups of chronic obstructive pulmonary disease? – Cochrane Library (free)

 


Study: Shorter Treatment May Be Effective for Selected Patients with Tuberculosis

6 Nov, 2018 | 15:52h | UTC

A patient-level pooled analysis of treatment-shortening regimens for drug-susceptible pulmonary tuberculosis – Nature Medicine (link to abstract – $ for full-text)

Commentary: Pulmonary TB can be cured with shorter treatment, study finds – University of California – San Francisco (free)

 


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