Family Medicine
Large-scale study finds genetic causes for 41% of rare pediatric diseases
18 Apr, 2023 | 13:25h | UTCGenomic Diagnosis of Rare Pediatric Disease in the United Kingdom and Ireland – New England Journal of Medicine (free for a limited period)
News Release: 5,500 people diagnosed with rare genetic diseases in major research study – University of Exeter
Commentary on Twitter
The DDD study recruited more than 13,500 families with probands with severe, probably monogenic disorders in the United Kingdom and Ireland and obtained a genetic diagnosis in approximately 41% of probands. https://t.co/W3pfg5HPEZ pic.twitter.com/eGb2yNsGBf
— NEJM (@NEJM) April 12, 2023
Guideline | Intrahepatic cholestasis of pregnancy
18 Apr, 2023 | 13:24h | UTCIntrahepatic cholestasis of pregnancy – BJOG
SR | Association between advanced care planning and emergency department visits
18 Apr, 2023 | 13:21h | UTC
Podcast | Resistant hypertension
18 Apr, 2023 | 13:16h | UTC#390 Resistant Hypertension – The Curbsiders
Podcast | Fungi fun! an in-depth look at tinea infections in children
18 Apr, 2023 | 13:14h | UTCFungi Fun! An In-Depth Look at Tinea Infections – The Cribsiders
M-A | Self-sampling strategies in populations at risk of Chlamydia trachomatis and Neisseria gonorrhoeae
18 Apr, 2023 | 13:09h | UTC
Commentary on Twitter
#OnlineFirst https://t.co/hOPwxJ2SLD
Vialard et al ➡️ diagnostic accuracy of self-sampling followed by CT/GC NAAT was similar to clinician-collected for extragenital sites in high-income countries. Vaginal self-sampling for women in low-income countries had lower accuracy. pic.twitter.com/lIzbQPufJl
— STI_BMJ (@STI_BMJ) April 11, 2023
RCT | Heterogeneity in blood pressure response to 4 antihypertensive drugs
17 Apr, 2023 | 13:14h | UTCHeterogeneity in Blood Pressure Response to 4 Antihypertensive Drugs: A Randomized Clinical Trial – JAMA (free for a limited period)
News Release: Personalized blood pressure treatment more effective – Uppsala University
Cohort Study | Association between hearing aid use and all-cause and cause-specific dementia
17 Apr, 2023 | 13:07h | UTCCommentaries: Preventing dementia through correcting hearing: huge progress but more to do – The Lancet Public Health
News Release: Hearing aids may protect against a higher risk of dementia associated with hearing loss, study suggests – Lancet
Related:
M-A | Association of hearing aids and cochlear implants with cognitive decline and dementia
Dementia and hearing-aid use: a two-way street – Age and Ageing
Association of Hearing Loss With Dementia – JAMA Network Open
Commentary on Twitter
NEW—Hearing aids may protect against a higher risk of #dementia associated with hearing loss, a @TheLancetPH study suggests.https://t.co/Yliq2wT7SR pic.twitter.com/v3iuTuHYVI
— The Lancet (@TheLancet) April 13, 2023
RCT | Exercise and protein intervention may improve resilience and reduce frailty in seniors
17 Apr, 2023 | 13:04h | UTC
SR | Oral direct thrombin inhibitors vs. conventional anticoagulants for the treatment of pulmonary embolism
17 Apr, 2023 | 13:02h | UTC
M-A | Efficacy of postpartum pharmacologic thromboprophylaxis
17 Apr, 2023 | 12:55h | UTC
RCT | Safety of Fezolinetant for vasomotor symptoms associated with menopause
17 Apr, 2023 | 12:54h | UTCRelated:
RCT | Fezolinetant for treatment of moderate-to-severe vasomotor symptoms associated with menopause
RCT | Efficacy of Fezolinetant in moderate-to-severe vasomotor symptoms associated with menopause
The earlier the better: an RCT of treatment timing effects for toddlers on the autism spectrum
17 Apr, 2023 | 12:52h | UTC
SR | Inhaled corticosteroids versus placebo for stable chronic obstructive pulmonary disease
17 Apr, 2023 | 12:40h | UTC
SR | Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD)
17 Apr, 2023 | 12:39h | UTC
SR | Nebulized hypertonic saline solution for acute bronchiolitis in infants
17 Apr, 2023 | 12:37h | UTCNebulised hypertonic saline solution for acute bronchiolitis in infants – Cochrane Library
RCT | Doxycycline postexposure prophylaxis effective in preventing gonorrhea, chlamydia, and syphilis in MSM
12 Apr, 2023 | 13:30h | UTCSummary: In this open-label, randomized study involving 501 men who have sex with men (MSM) and transgender women, researchers investigated the effectiveness of postexposure doxycycline in preventing bacterial sexually transmitted infections (STIs), specifically gonorrhea, chlamydia, and syphilis. Participants with a previous STI in the past year, either taking preexposure prophylaxis (PrEP) against HIV or living with HIV, were randomly assigned to receive 200 mg of doxycycline within 72 hours after condomless sex or standard care without doxycycline. STI testing was performed quarterly, with the primary end point being the incidence of at least one STI per follow-up quarter.
Results demonstrated a significant reduction in STI incidence in both the PrEP and persons living with HIV cohorts who received doxycycline. Overall, the combined incidence of these three STIs was lower by two thirds with doxycycline postexposure prophylaxis compared to standard care. The study also reported five grade 3 adverse events but no serious adverse events attributed to doxycycline. This finding supports the use of doxycycline postexposure prophylaxis among MSM with recent bacterial STIs.
Article: Postexposure Doxycycline to Prevent Bacterial Sexually Transmitted Infections – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Doxycycline after sex found to reduce STI incidence in gay men, transgender women – CIDRAP
Commentary on Twitter
In an open-label, randomized study involving men who have sex with men, doxycycline use after high-risk sexual exposure reduced the incidence of sexually transmitted infections (chlamydia, gonorrhea, and syphilis). https://t.co/tYOj8FLEy2 pic.twitter.com/bzNyvwzYS7
— NEJM (@NEJM) April 5, 2023
M-A | Association of inhaled corticosteroids with all-cause mortality risk in patients with COPD
12 Apr, 2023 | 13:25h | UTCAssociation of Inhaled Corticosteroids With All-Cause Mortality Risk in Patients With COPD: A Meta-analysis of 60 Randomized Controlled Trials – Chest (link to abstract – $ for full-text)
Commentary on Twitter
ICS-based inhaled therapy of longer than 6 months associated with reduction in all-cause mortality risk in patients with #COPD in a meta-analysis of 60 RCTs. Read the full original research in the January issue: https://t.co/p2CwSu8aqb#journalCHEST #MedEd pic.twitter.com/0j24enQmX3
— CHEST® Journal (@journal_CHEST) January 20, 2023
Twenty‐four-hour ambulatory blood pressure profile in patients with reflex syncope vs. matched controls
12 Apr, 2023 | 13:21h | UTC
Cohort Study | Association of the AHA’s new “Life’s Essential 8” with all-cause and cardiovascular disease-specific mortality
12 Apr, 2023 | 13:20h | UTCCommentaries:
Related: Life’s Essential 8: Updating and enhancing the AHA construct of cardiovascular health.
RCTs | Eczema Care Online behavioral interventions may support self-care for children and young people
12 Apr, 2023 | 13:02h | UTCEditorial: How to make Eczema Care Online freely available – The BMJ
News Release: New website helps improve eczema in children and young people – University of Southampton
Pharmacological treatments for low back pain in adults: an overview of Cochrane Reviews
11 Apr, 2023 | 14:39h | UTCRelated:
SR | Nonopioid pharmacological management of acute low back pain
M-A | Limited evidence for analgesic effectiveness in acute low back pain treatment
M-A: Effectiveness of treatments for acute and subacute mechanical non-specific low back pain
Guideline Interventions for the management of acute and chronic low back pain.
M-A: Little benefit from muscle relaxants for adults with non-specific low back pain.
M-A | Timing of allergenic food introduction and risk of immunoglobulin E–mediated food allergy
11 Apr, 2023 | 14:32h | UTCNews Release: Earlier introduction of allergenic foods in children may prevent food allergies – Imperial College London
Commentary: Allergenic Food Introduction Led to Fewer Allergies, Higher Withdrawal Rate from Intervention – HCP Live
Related:
AAP Updated Recommendations for Dietary Interventions to Prevent Atopic Disease
Timing of introduction of allergenic solids for infants at high risk – Canadian Paediatric Society
Commentary on Twitter
In this study, earlier introduction of multiple allergenic foods was associated with a reduced risk of food allergy but with significant rates of withdrawal from the intervention. https://t.co/lZFkQIH9q7
— JAMA Pediatrics (@JAMAPediatrics) March 27, 2023
Brief Review | Hoarding disorder: evidence and best practice in primary care
11 Apr, 2023 | 14:28h | UTCHoarding disorder: evidence and best practice in primary care – British Journal of General Practice
Screening colonoscopy in seniors: common in patients with limited life expectancy and associated with higher complication risks
11 Apr, 2023 | 14:30h | UTCFrequency of Use and Outcomes of Colonoscopy in Individuals Older Than 75 Years – JAMA Internal Medicine (link to abstract – $ for full-text)
Related: Study reveals overuse of surveillance colonoscopy in older adults with limited life expectancy
Commentary:
In older adults >75 years of age, most screening colonoscopies were in patients in patients with limited life expectancy (defined as <10 years) and associated with increased risk of adverse events. https://t.co/XOsy2UKNRx @Jessica_Halabi @MRothbergMD @burkegastrodoc
— JAMA Internal Medicine (@JAMAInternalMed) April 4, 2023