Family Medicine
Guideline Synopsis: 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Part 1, Lifestyle and Behavioral Factors
1 Aug, 2019 | 08:51h | UTC2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Part 1, Lifestyle and Behavioral Factors – JAMA Cardiology (free for a limited period)
Original Guideline: 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease (free guideline and related resources)
Related Summaries: The ABCs of Primary Cardiovascular Prevention: 2019 Update – American College of Cardiology (free) AND Key Points From the 2019 ACC/AHA Guidelines on the Primary Prevention of Cardiovascular Disease – American College of Cardiology (free)
Consensus on Non-cardiac Chest Pain
1 Aug, 2019 | 08:52h | UTCThe Mexican consensus on non-cardiac chest pain – Revista de Gastroenterología de México (free)
Related Reviews: Non-Cardiac Chest Pain – Visceral Medicine (free) AND Review article: the current treatment of non‐cardiac chest pain – Alimentary Pharmacology and Therapeutics (free)
[Abstract Only] Randomized Trial: Little Added Benefit of Antidepressants in Youth with Depression Treated with Cognitive Behavioral Therapy
1 Aug, 2019 | 08:50h | UTCThe addition of fluoxetine to cognitive behavioural therapy for youth depression (YoDA-C): a randomised, double-blind, placebo-controlled, multicentre clinical trial – The Lancet Psychiatry (link to abstract – $ for full-text)
Commentaries: Psychotherapy should be first-line treatment for depression in young people, trial finds – by Orygen, the National Centre of Excellence in Youth Mental Health (free) AND Psychotherapy should be first option to treat depression in young people, study says – UPI (free)
Observational Study Suggests Use of Acid-Suppressing Drugs May Increase the Risk of Allergies
1 Aug, 2019 | 07:37h | UTCCommentaries: Stomach-protecting medicines can trigger allergies – Medical University of Vienna (free) AND Acid-Suppressing Drugs Tied to Later Use of Anti-Allergy Drugs – NEJM Journal Watch (free) AND Your heartburn drugs may be giving you allergies, study suggests – CNN (free)
New Protocol for HIV Prevention Drug Reduces The Number Of Pills Required
31 Jul, 2019 | 02:08h | UTCNew Protocol For HIV Prevention Drug Reduces The Number Of Pills Required – Kaiser Health News (free)
Related: British Guidelines on the Use of HIV Pre–exposure Prophylaxis (PrEP) (several guidelines on the subject) AND USPSTF Statement: Preexposure Prophylaxis for the Prevention of HIV Infection (free guideline and commentaries)
“both organizations now endorse a strategy that requires taking just four pills timed to a specific sexual encounter — two within two to 24 hours before sex and one on each of the two following days… The new strategy, called “2-1-1” or “on-demand” PrEP, is becoming popular overseas but has gotten little traction in the United States thus far.”
Meta-Analysis: Association of Early Interventions With Birth Outcomes and Child Linear Growth in Low-Income and Middle-Income Countries
31 Jul, 2019 | 01:56h | UTC
Related Commentary on Twitter
New @JAMANetworkOpen meta-analyses of 169 randomized trials including 302,061 participants concludes it is important to intervene early for child development in LMICs, during pregnancy if possible, & combine interventions from multiple domains https://t.co/YQnIqlz1P1 pic.twitter.com/q48D3SWhqm
— Keith Godfrey, MBE (@KeithMGodfrey) July 28, 2019
Simulation Study: Uniform CT Imaging for Patients with Hematuria May Result in Increased Costs and Harms of Secondary Cancers
30 Jul, 2019 | 01:37h | UTCComparison of the Harms, Advantages, and Costs Associated With Alternative Guidelines for the Evaluation of Hematuria – JAMA Internal Medicine (free for a limited period)
Commentaries: Hematuria Practice Guidelines That Explicitly Consider Harms and Costs – JAMA Internal Medicine (free for a limited period) AND Evaluating Hematuria: Uniform Use of CT Seen as Risky and Expensive – NEJM Journal Watch (free)
Related Commentary on Twitter (Thread – Click for More)
Excited to have our work examining tradeoffs of alternative approaches to hematuria evaluation out in @JAMAInternalMed today. Sharing here origin story, highlights from the paper and related thoughts (THREAD)
1/nhttps://t.co/f47L2BZOW7— Matt Nielsen, MD (@m_e_nielsen) July 29, 2019
Study: A Cardiovascular Risk-based Strategy for the Treatment of Hypertensive Patients Could Prevent More Cardiovascular Disease Events
28 Jul, 2019 | 23:08h | UTCCommentaries: Strategies to identify patients for antihypertensive treatment – The Lancet (free) AND Using cardiovascular risk to identify patients eligible for blood pressure treatment could prevent significantly more heart attacks and strokes – London School of Hygiene & Tropical Medicine (free) AND Expert reaction to paper on identifying those eligible for blood pressure treatment and subsequent burden of cardiovascular disease – Science Media Centre (free)
Related Commentary on Twitter
NEW online: A #cardiovascular risk-based strategy could prevent over a third more cardiovascular disease events than the 2011 #NICE guideline and a fifth more than the 2019 #NICE guideline https://t.co/ZmfLpyN3iN @LSHTM
— The Lancet (@TheLancet) July 26, 2019
NICE Guideline: Generalized Anxiety Disorder and Panic Disorder in Adults
28 Jul, 2019 | 23:12h | UTCRelated Guideline: Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for the treatment of panic disorder, social anxiety disorder and generalised anxiety disorder (free)
Updated CDC Recommendations for Measles in Healthcare Settings
28 Jul, 2019 | 23:04h | UTCCommentary: CDC Updates Measles Prevention Guidelines for Healthcare Workers – NEJM Journal Watch (free)
Alex Nowbar’s journal reviews—25 July 2019
28 Jul, 2019 | 22:50h | UTCAlex Nowbar’s journal reviews, 25 July 2019 – The BMJ Opinion (free)
Alex Nowbar reviews the latest research from the top medical journals.
[Abstract Only] Fluoroquinolones Linked to Serious Arrhythmias and Sudden Death in Large Observational Study
28 Jul, 2019 | 22:47h | UTCFluoroquinolone use and serious arrhythmias: A nationwide case-crossover study – Resuscitation (link to abstract – $ for full-text)
Commentary: Fluoroquinolones and Sudden Death – JournalFeed (free)
Related: Committee Recommends New Restrictions on the use of Fluoroquinolones (free report and commentaries) AND FDA Safety Alert: Warnings for Fluoroquinolones on Risks of Mental Health and Low Blood Sugar Adverse Reactions (free statement and commentaries) AND FDA Warns About Increased Risk of Aortic Dissection and Ruptures of Aortic Aneurism with Fluoroquinolones (free report and commentaries)
Management of Preexisting Diabetes in Pregnancy
27 Jul, 2019 | 20:07h | UTCManagement of preexisting diabetes in pregnancy: A Review – JAMA (free)
Related: Management of Diabetes in Pregnancy: Standards of Medical Care in Diabetes—2019 – American Diabetes Association (free) AND Diabetes and Pregnancy – Diabetes Canada Clinical Practice Guidelines Expert Committee (free) AND Current guidelines on the management of gestational diabetes mellitus: a content analysis and appraisal – BMC Pregnancy and Childbirth (free)
Penile Lesions: Patient Presentation, Differential Diagnosis, and Management
27 Jul, 2019 | 15:19h | UTCRelated Reviews: Penile warts: an update on their evaluation and management – Drugs in Context (free) AND Noninfectious Penile Lesions – American Family Physician (free)
Viewpoint: Realizing Shared Decision-making in Practice
26 Jul, 2019 | 01:01h | UTCRealizing Shared Decision-making in Practice – JAMA (free for a limited period)
Related Viewpoint: Shared Decision Making and the Importance of Time – JAMA (free)
Meta-Analysis: Risk of Recurrent Thromboembolism after Discontinuation of Anticoagulant Treatment for First Unprovoked Venous Thromboembolism Event
26 Jul, 2019 | 01:06h | UTCCommentary: Long-Term Risk for Recurrent VTE Significant After Stopping Anticoagulation – NEJM Journal Watch (free)
“the risk of recurrent VTE was 10% in the first year after treatment, 16% at two years, 25% at five years, and 36% at 10 years, with 4% of recurrent VTE events resulting in death.”
Related Commentary on Twitter
Excited to share my first study published today in @bmj_latest on recurrence risk after stopping #anticoagulation for unprovoked #VTE. Big thanks to the MARVELOUS collaborators, @CIHR_IRSC for funding/support & @RodgerMarc for continued mentorship https://t.co/jnT86dRzHK#phdlife pic.twitter.com/SSVTYwkXth
— Faizan Khan, PhD (@FaizanK91) July 25, 2019
Randomized Trial: Proton Pump Inhibitor Not Effective for Prevention of Gastroduodenal Events in Patients Receiving Low-dose Anticoagulation and/or Aspirin
26 Jul, 2019 | 00:44h | UTC
Opinion: Antidepressants an Ace in the Hole for Urticaria
25 Jul, 2019 | 01:23h | UTCWhat to D.O. Antidepressants an Ace in the Hole for Urticaria – Emergency Medicine News (free)
USPSTF Statement Reaffirms the Benefits of Screening for Hepatitis B Virus Infection in Pregnant Women
24 Jul, 2019 | 09:08h | UTCScreening for Hepatitis B Virus Infection in Pregnant Women – U.S Preventive Services Task Force (free)
See also: Evidence Report and Systematic Review (free) AND Editorial (free) AND Author Interview (free audio)
Commentary: USPSTF Reaffirms Benefit of Hep B Screening in Pregnant Women – Physician’s Briefing (free)
Randomized Trial: Mediterranean-style Diet in Pregnant Women Reduces Gestational Weight Gain and the Risk of Gestational Diabetes
24 Jul, 2019 | 08:05h | UTCCommentaries: Mediterranean diet during pregnancy reduces gestational diabetes and weight gain – Queen Mary University of London (free) AND Mediterranean Diet in Pregnancy Might Reduce Risk for Gestational Diabetes – NEJM Journal Watch (free)
Review: Dietary and Pharmacological Treatment of Nonalcoholic Fatty Liver Disease
24 Jul, 2019 | 08:16h | UTCDietary and Pharmacological Treatment of Nonalcoholic Fatty Liver Disease – Medicina (free)
Related Guidelines: Non-Alcoholic Fatty Liver Disease: Assessment and Management – National Institute for Health and Care Excellence (NICE) (free) AND The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases (free) AND Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis – Japanese Society of Gastroenterology (free) AND Nonalcoholic Fatty Liver Disease Brazilian Society of Hepatology Consensus (free PDF) AND EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease (free)
[Abstract Only] Prevalence of Obstructive Sleep Apnea in Patients with Major Depressive Disorder
24 Jul, 2019 | 01:16h | UTCPrevalence of obstructive sleep apnea in suicidal patients with major depressive disorder – Journal of Psychiatric Research (link to abstract – $ for full-text)
Commentary: Obstructive sleep apnea may be one reason depression treatment doesn’t work – Medical College of Georgia at Augusta University (free)
[Abstract Only] Study Shows Widespread Use of Aspirin for Primary Prevention of CV Disease Despite Few Benefits
24 Jul, 2019 | 07:49h | UTCPrevalence of Aspirin Use for Primary Prevention of Cardiovascular Disease in the United States: Results From the 2017 National Health Interview Survey – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Widespread aspirin use despite few benefits, high risks – Beth Israel Deaconess Medical Center (free) AND Many Americans mistakenly use aspirin to prevent heart disease – Reuters (free) AND Older Adults Should Reevaluate Daily Aspirin – MedicalResearch.com (free) AND Millions still take aspirin for their heart without a doctor’s recommendation, research suggests – CNN (free)
Related Commentary on Twitter (Thread – Click for More)
New pub out today in @AnnalsofIM. Our main finding: aspirin use for primary prevention is widespread among groups at risk for harm. https://t.co/s9h9BhjYgz
— Colin W. O'Brien (@ColinWOBrien) July 22, 2019
Diagnosing the Onset of Menopause
23 Jul, 2019 | 01:47h | UTCDiagnosing the Onset of Menopause – JAMA (free for a limited period)
Clinical Review Audio: Diagnosing Menopause (free)
[Abstract Only] Effect of Systolic and Diastolic Blood Pressure on Cardiovascular Outcomes
19 Jul, 2019 | 09:48h | UTCEffect of Systolic and Diastolic Blood Pressure on Cardiovascular Outcomes – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Hypertension From Top to Bottom: Don’t Ignore Diastolic BP – TCTMD (free) AND Both Systolic and Diastolic BP Affect CV Outcomes – NEJM Journal Watch (free)