Family Medicine
Perspective: The Cost of Technology
6 May, 2020 | 03:35h | UTC
Obesity Could Shift Severe COVID-19 Disease to Younger Ages
5 May, 2020 | 04:53h | UTCObesity could shift severe COVID-19 disease to younger ages – The Lancet
NEW Correspondence—D Kass et al examined the correlation between BMI & age in 265 #COVID19 patients admitted to ICU at 6 hospitals & found a significant inverse correlation between age & BMI, in which younger individuals were more likely to be obese https://t.co/SrNSp2W7JQ pic.twitter.com/ozpBug5Mv9
— The Lancet (@TheLancet) May 1, 2020
[Abstract Only] Randomized Trial: No Benefit from L-thyroxine Among Elderly Patients with Symptomatic Subclinical Hypothyroidism
5 May, 2020 | 04:11h | UTCL-Thyroxine Therapy for Older Adults With Subclinical Hypothyroidism and Hypothyroid Symptoms: Secondary Analysis of a Randomized Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: L-thyroxine did not improve symptoms or tiredness in older patients with subclinical hypothyroidism – ACP Internist AND More Evidence Against L-Thyroxine for Subclinical Hypothyroidism – NEJM Journal Watch
Related Articles: Association Between Levothyroxine Treatment and Thyroid-Related Symptoms Among Adults Aged 80 Years and Older With Subclinical Hypothyroidism – JAMA AND Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism – New England Journal of Medicine
Recommendations for the Management of Lower Urinary Tract Infections in Pregnant and Non-pregnant Women
5 May, 2020 | 03:57h | UTC
Study: In Utero Antidepressants and Neurodevelopmental Outcomes in Kindergarteners
5 May, 2020 | 03:47h | UTCIn Utero Antidepressants and Neurodevelopmental Outcomes in Kindergarteners – Pediatrics
Commentaries: Providing the Evidence for Managing Depression in Pregnancy – Pediatrics AND Adverse neurodevelopmental outcomes linked to prenatal exposure to antidepressants – 2 Minute Medicine
Systematic Review: Corticosteroids as Standalone or Add‐on Treatment for Sore Throat
5 May, 2020 | 03:36h | UTCCorticosteroids as standalone or add‐on treatment for sore throat – Cochrane Library
Summary: Corticosteroids as standalone or add‐on treatment for sore throat – Cochrane Library
Characteristics of 100 Children with Covid-19
3 May, 2020 | 22:29h | UTCChildren with Covid-19 in Pediatric Emergency Departments in Italy – New England Journal of Medicine
Related Systematic Review: SARS-CoV-2 Infection in Children and Adolescents (study and commentaries)
New NICE Coronavirus Rapid Guidelines
3 May, 2020 | 22:46h | UTC- COVID-19 rapid guideline: antibiotics for pneumonia in adults in hospital – National Institute for Health and Care Excellence
- COVID-19 rapid guideline: gastrointestinal and liver conditions treated with drugs affecting the immune response – National Institute for Health and Care Excellence
- COVID-19 rapid guideline: children and young people who are immunocompromised – National Institute for Health and Care Excellence
See Previous NICE Coronavirus Guidelines: Rapid guidelines and evidence summaries – National Institute for Health and Care Excellence
New Observational Studies Confirm the Safety of Renin–Angiotensin–Aldosterone System Blockers in Patients with Covid-19
3 May, 2020 | 22:32h | UTCStudy 3: Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19 – New England Journal of Medicine
Commentary: Blood Pressure Drugs Don’t Increase Coronavirus Risk, Studies Find – The New York Times
See also: Observational Study: Renin-Angiotensin System Inhibitors are Not Associated with Severity or Mortality in Hospitalized Patients with Coronavirus Disease (2 other studies on the subject)
Short Review: Coagulopathy Associated with COVID-19
3 May, 2020 | 22:09h | UTCCoagulopathy associated with COVID-19 – Canadian Medical Association Journal
Case Series: QT Intervals in Patients with COVID-19 Treated with Hydroxychloroquine Alone or in Combination with Azithromycin
3 May, 2020 | 22:01h | UTCCommentary: Beth Israel Deaconess Medical Center – Beth Israel Deaconess Medical Center
Related Studies: The Effect of Chloroquine, Hydroxychloroquine and Azithromycin on the Corrected QT Interval in Patients with SARS-CoV-2 Infection – Circulation: Arrhythmia and Electrophysiology (link to abstract – $ for full-text) AND [Preprint] QT Interval Prolongation and Torsade De Pointes in Patients with COVID-19 treated with Hydroxychloroquine/Azithromycin – medRxiv
FDA Issues Emergency Use Authorization for the Use of Remdesivir to Treat COVID-19
3 May, 2020 | 22:03h | UTCSee also: Remdesivir: A Non-Antiviral Antiviral Drug? – Forbes
Classification of the Cutaneous Manifestations of COVID‐19 with 375 Illustrative Cases
1 May, 2020 | 03:43h | UTCRelated: Journal articles on coronavirus with relevance for skin diseases and dermatology – Centre of Evidence Based Dermatology, University of Nottingham AND Characterization of acute acro-ischemic lesions in non-hospitalized patients: a case series of 132 patients during the COVID-19 outbreak – Journal of the American Academy of Dermatology
Great atlas with the different cutaneous manifestations of Covid-19.
New CDC Guidance: Care for Breastfeeding Women with Covid-19
1 May, 2020 | 03:53h | UTCCare for Breastfeeding Women – Centers for Disease Control and Prevention
Study: Within 19 Days After Symptom Onset, 100% of Patients Test Positive for IGG
1 May, 2020 | 03:33h | UTCAntibody responses to SARS-CoV-2 in patients with COVID-19 – Nature Medicine
Commentary: Expert reaction to antibody response in COVID-19 patients – Science Media Centre
Preprint Study Suggests Children May Be as Infectious as Adults
1 May, 2020 | 03:36h | UTC
Treatment Considerations for COVID-19: A Critical Review of the Evidence
1 May, 2020 | 03:20h | UTC
Perspective: Urging Caution on Remdesivir
1 May, 2020 | 03:07h | UTCUrging Caution On Remdesivir – Forbes
Related: About Remdesivir and About “Game-Changers” – Science Translational Medicine AND Conflicting Remdesivir Trial Results Released; Experts Urge More Research – Health Policy Watch AND Is remdesivir a miracle drug to cure coronavirus? Don’t get your hopes up yet – The Conversation AND PulmCrit- First placebo-controlled RCT on remdesivir for COVID-19 – PulmCrit AND Remdesivir: the antiviral drug is being touted as a possible coronavirus treatment – but will it work? – The Guardian
“While I have enormous respect for the Institutes and their leaders, releasing the preliminary news without sharing the data behind it is highly irresponsible.”
We Need to Flatten the ‘Other’ Coronavirus Curve, Our Looming Mental Health Crisis
1 May, 2020 | 02:45h | UTCRelated: Health Care Workers Seek to Flatten COVID-19’s ‘Second Curve’—Their Rising Mental Anguish
Clinical Determinants for Fatality of 44,672 Patients with COVID-19
1 May, 2020 | 02:48h | UTCClinical determinants for fatality of 44,672 patients with COVID-19 – Critical Care
Systematic Review: No Evidence to Support the Use of Aspirin for the Prevention of Dementia
1 May, 2020 | 02:38h | UTCRelated Randomized Trial: Aspirin Not Beneficial for Reducing the Risk of Dementia, MCI, or Cognitive Decline
Men with COVID-19 Twice More Likely to Die than Women
30 Apr, 2020 | 04:21h | UTCNews Release: COVID-19 study shows that men have over double the death rate of women – Frontiers
Perspective: Covid-19 — A Reminder to Reason
30 Apr, 2020 | 04:15h | UTCCovid-19 — A Reminder to Reason – New England Journal of Medicine
USPSTF Statement: Primary Care Interventions for Prevention and Cessation of Tobacco Use in Children and Adolescents
30 Apr, 2020 | 03:48h | UTCEditorial: Recommendations From the USPSTF for Prevention and Cessation of Tobacco Use in Children and Adolescents (free for a limited period)
Author Interview: USPSTF Recommendation: Tobacco Use Prevention and Cessation in Children and Adolescents
Commentary: USPSTF: Clinicians Should Counsel Kids to Not Start Smoking – NEJM Journal Watch
Perspective: What Policy Makers Need to Know About COVID-19 Protective Immunity
29 Apr, 2020 | 05:19h | UTCWhat policy makers need to know about COVID-19 protective immunity – The Lancet
Related: What Covid-19 antibody tests say — and don’t say — about immunity – Vox AND The False Hope of Antibody Tests – The Atlantic AND What Antibody Studies Can Tell You — and More Importantly, What They Can’t – ProPublica AND What if immunity to covid-19 doesn’t last? – MIT Technology Review AND Beware of Antibody-based COVID-19 “Immunity Passports” – Scientific American AND Coronavirus immunity: Can you catch it twice? – BBC
Related Commentary on Twitter
An especially astute and succinct essay on #COVID19 protective immunity @TheLancet todayhttps://t.co/HFGUGPdson
highlights unknowns on duration, role of T lymphocytes, what constitutes real protection, and herd immunity features pic.twitter.com/oBC48DcGCl— Eric Topol (@EricTopol) April 28, 2020