Family Medicine
SR | Nebulized hypertonic saline solution for acute bronchiolitis in infants
17 Apr, 2023 | 12:37h | UTCNebulised hypertonic saline solution for acute bronchiolitis in infants – Cochrane Library
RCT | Doxycycline postexposure prophylaxis effective in preventing gonorrhea, chlamydia, and syphilis in MSM
12 Apr, 2023 | 13:30h | UTCSummary: In this open-label, randomized study involving 501 men who have sex with men (MSM) and transgender women, researchers investigated the effectiveness of postexposure doxycycline in preventing bacterial sexually transmitted infections (STIs), specifically gonorrhea, chlamydia, and syphilis. Participants with a previous STI in the past year, either taking preexposure prophylaxis (PrEP) against HIV or living with HIV, were randomly assigned to receive 200 mg of doxycycline within 72 hours after condomless sex or standard care without doxycycline. STI testing was performed quarterly, with the primary end point being the incidence of at least one STI per follow-up quarter.
Results demonstrated a significant reduction in STI incidence in both the PrEP and persons living with HIV cohorts who received doxycycline. Overall, the combined incidence of these three STIs was lower by two thirds with doxycycline postexposure prophylaxis compared to standard care. The study also reported five grade 3 adverse events but no serious adverse events attributed to doxycycline. This finding supports the use of doxycycline postexposure prophylaxis among MSM with recent bacterial STIs.
Article: Postexposure Doxycycline to Prevent Bacterial Sexually Transmitted Infections – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Doxycycline after sex found to reduce STI incidence in gay men, transgender women – CIDRAP
Commentary on Twitter
In an open-label, randomized study involving men who have sex with men, doxycycline use after high-risk sexual exposure reduced the incidence of sexually transmitted infections (chlamydia, gonorrhea, and syphilis). https://t.co/tYOj8FLEy2 pic.twitter.com/bzNyvwzYS7
— NEJM (@NEJM) April 5, 2023
M-A | Association of inhaled corticosteroids with all-cause mortality risk in patients with COPD
12 Apr, 2023 | 13:25h | UTCAssociation of Inhaled Corticosteroids With All-Cause Mortality Risk in Patients With COPD: A Meta-analysis of 60 Randomized Controlled Trials – Chest (link to abstract – $ for full-text)
Commentary on Twitter
ICS-based inhaled therapy of longer than 6 months associated with reduction in all-cause mortality risk in patients with #COPD in a meta-analysis of 60 RCTs. Read the full original research in the January issue: https://t.co/p2CwSu8aqb#journalCHEST #MedEd pic.twitter.com/0j24enQmX3
— CHEST® Journal (@journal_CHEST) January 20, 2023
Twenty‐four-hour ambulatory blood pressure profile in patients with reflex syncope vs. matched controls
12 Apr, 2023 | 13:21h | UTC
Cohort Study | Association of the AHA’s new “Life’s Essential 8” with all-cause and cardiovascular disease-specific mortality
12 Apr, 2023 | 13:20h | UTCCommentaries:
Related: Life’s Essential 8: Updating and enhancing the AHA construct of cardiovascular health.
RCTs | Eczema Care Online behavioral interventions may support self-care for children and young people
12 Apr, 2023 | 13:02h | UTCEditorial: How to make Eczema Care Online freely available – The BMJ
News Release: New website helps improve eczema in children and young people – University of Southampton
Pharmacological treatments for low back pain in adults: an overview of Cochrane Reviews
11 Apr, 2023 | 14:39h | UTCRelated:
SR | Nonopioid pharmacological management of acute low back pain
M-A | Limited evidence for analgesic effectiveness in acute low back pain treatment
M-A: Effectiveness of treatments for acute and subacute mechanical non-specific low back pain
Guideline Interventions for the management of acute and chronic low back pain.
M-A: Little benefit from muscle relaxants for adults with non-specific low back pain.
M-A | Timing of allergenic food introduction and risk of immunoglobulin E–mediated food allergy
11 Apr, 2023 | 14:32h | UTCNews Release: Earlier introduction of allergenic foods in children may prevent food allergies – Imperial College London
Commentary: Allergenic Food Introduction Led to Fewer Allergies, Higher Withdrawal Rate from Intervention – HCP Live
Related:
AAP Updated Recommendations for Dietary Interventions to Prevent Atopic Disease
Timing of introduction of allergenic solids for infants at high risk – Canadian Paediatric Society
Commentary on Twitter
In this study, earlier introduction of multiple allergenic foods was associated with a reduced risk of food allergy but with significant rates of withdrawal from the intervention. https://t.co/lZFkQIH9q7
— JAMA Pediatrics (@JAMAPediatrics) March 27, 2023
Brief Review | Hoarding disorder: evidence and best practice in primary care
11 Apr, 2023 | 14:28h | UTCHoarding disorder: evidence and best practice in primary care – British Journal of General Practice
Screening colonoscopy in seniors: common in patients with limited life expectancy and associated with higher complication risks
11 Apr, 2023 | 14:30h | UTCFrequency of Use and Outcomes of Colonoscopy in Individuals Older Than 75 Years – JAMA Internal Medicine (link to abstract – $ for full-text)
Related: Study reveals overuse of surveillance colonoscopy in older adults with limited life expectancy
Commentary:
In older adults >75 years of age, most screening colonoscopies were in patients in patients with limited life expectancy (defined as <10 years) and associated with increased risk of adverse events. https://t.co/XOsy2UKNRx @Jessica_Halabi @MRothbergMD @burkegastrodoc
— JAMA Internal Medicine (@JAMAInternalMed) April 4, 2023
Late mortality in childhood cancer survivors: causes & modifiable risk factors
11 Apr, 2023 | 14:16h | UTCSpecific causes of excess late mortality and association with modifiable risk factors among survivors of childhood cancer: a report from the Childhood Cancer Survivor Study cohort – The Lancet (link to abstract – $ for full-text)
News Release: Healthy lifestyle associated with reduced mortality risk in childhood cancer survivors – St. Jude Children’s Research Hospital
M-A | The risk of long-term cardiometabolic disease in women with premature or early menopause
11 Apr, 2023 | 13:59h | UTC
M-A | Benefits and harms of drug treatment for type 2 diabetes
10 Apr, 2023 | 14:03h | UTC
Umbrella review unveils benefits of cutting free sugars to 6 teaspoons/day
10 Apr, 2023 | 14:00h | UTCDietary sugar consumption and health: umbrella review – The BMJ
News Release: Limit added sugar to six teaspoons a day to improve health, urge experts – BMJ Newsroom
Cohort Study | Antiphospholipid antibodies’ prevalence & link to cardiovascular events
10 Apr, 2023 | 13:59h | UTCNews Release: Antiphospholipid antibodies may increase heart disease risk in healthy people – Michigan Medicine
RCT | Maternal RSVpreF vaccination protects infants from severe RSV illness
10 Apr, 2023 | 13:56h | UTCBivalent Prefusion F Vaccine in Pregnancy to Prevent RSV Illness in Infants – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Vaccination during pregnancy could prevent RSV illness in infants – Charité – Universitätsmedizin Berlin
Commentary on Twitter
In a phase 3 trial, adults (≥60 years of age) received one 120-μg dose of RSVpreF vaccine or placebo. Vaccine efficacy against RSV-associated lower respiratory tract illness was 67 to 86%. https://t.co/R9u77iWjF9 pic.twitter.com/iPU8VAMQ9M
— NEJM (@NEJM) April 5, 2023
RCT | RSVpreF vaccine successfully prevents RSV-associated respiratory illness in seniors
10 Apr, 2023 | 13:54h | UTCEfficacy and Safety of a Bivalent RSV Prefusion F Vaccine in Older Adults – New England Journal of Medicine (link to abstract – $ for full-text)
Swiss recommendations for the treatment of type 2 diabetes mellitus
10 Apr, 2023 | 13:50h | UTCRelated: Guideline | ADA 2023 Standards of Medical Care in Diabetes.
Sodium intake linked to both coronary & carotid atherosclerosis in the Swedish population
10 Apr, 2023 | 13:30h | UTC
Commentary on Twitter
Association between salt intake and both carotid and coronary atherosclerosis in a contemporary community-based cohort ?https://t.co/sHTCEdu4Uw#EHJOpen @ehjopen @SaDeRosa78 #cardiotwitter
— European Society of Cardiology Journals (@ESC_Journals) April 3, 2023
Review | Urinary incontinence and pelvic organ prolapse in women
10 Apr, 2023 | 13:27h | UTC
Consensus Paper | Best management of patients with an acute sore throat
6 Apr, 2023 | 13:32h | UTC
Blood pressure targets in adults with hypertension | A clinical practice guideline from the AAFP
6 Apr, 2023 | 13:30h | UTCCommentary: AAFP Issues New Clinical Practice Guideline on Hypertension – Annals of Family Medicine
Review | Post-COVID syndrome
6 Apr, 2023 | 13:21h | UTCPost-COVID Syndrome – Deutsches Ärzteblatt International
Related:
Long COVID: major findings, mechanisms and recommendations – Nature Reviews Microbiology
Podcast | HIV in primary care
6 Apr, 2023 | 13:13h | UTC#388 HIV in Primary Care with Dr. Jonathan J. “JJ” Nunez MD – The Curbsiders
Podcast | Childhood-Onset SLE
6 Apr, 2023 | 13:12h | UTC#77: Childhood-Onset SLE – Is It Sometimes Lupus? – The Cribsiders