Family Medicine
As COVID-19 soars in many communities, schools attempt to find ways through the crisis
20 Nov, 2020 | 08:43h | UTCAs COVID-19 soars in many communities, schools attempt to find ways through the crisis – Science
Systematic review: Routine laboratory tests are not useful for accurately ruling in or ruling out COVID-19 on their own
20 Nov, 2020 | 08:42h | UTCRoutine laboratory testing to determine if a patient has COVID‐19 – Cochrane Library
Summary: Routine laboratory testing to determine if a patient has COVID‐19 – Cochrane Library
Opinion: Improving care for heart failure with reduced ejection fraction—a potential polypill-based strategy
20 Nov, 2020 | 08:37h | UTC
Pfizer and BioNTech to submit Covid-19 vaccine data to FDA as full results show 95% efficacy
19 Nov, 2020 | 09:36h | UTCPfizer and BioNTech to submit Covid-19 vaccine data to FDA as full results show 95% efficacy – STAT
News release: Pfizer and Biontech conclude phase 3 study of Covid-19 vaccine candidate, meeting all primary efficacy endpoints
Commentaries: ‘Incredible milestone for science.’ Pfizer and BioNTech update their promising COVID-19 vaccine result – Science AND Pfizer: COVID-19 shot 95% effective, seeking clearance soon – Associated Press AND Expert reaction to announcement by Pfizer that they have concluded the Phase III study of their COVID-19 vaccine candidate after demonstrating 95% efficacy – Science Media Centre AND Covid vaccine: Pfizer says ‘94% effective in over-65s’ – BBC
More people are getting COVID-19 twice, suggesting immunity wanes quickly in some
19 Nov, 2020 | 09:29h | UTCMore people are getting COVID-19 twice, suggesting immunity wanes quickly in some – Science
Opinion: “Proposed British guidelines reject useless chronic fatigue syndrome treatments”
19 Nov, 2020 | 09:22h | UTCProposed British guidelines reject useless chronic fatigue syndrome treatments – STAT
NICE Draft Guideline: Myalgic encephalomyelitis (or 6 encephalopathy)/chronic fatigue syndrome: diagnosis and management
Lessons from Europe, where cases are rising but schools are open
18 Nov, 2020 | 09:18h | UTCLessons From Europe, Where Cases Are Rising But Schools Are Open – NPR
Estimation of US children’s educational attainment and years of life lost associated with primary school closures during the Covid-19 pandemic
18 Nov, 2020 | 09:15h | UTC
[Preprint] Study suggests immunity to the Coronavirus may last years
18 Nov, 2020 | 09:20h | UTCImmunological memory to SARS-CoV-2 assessed for greater than six months after infection – bioRxiv
Commentaries: Immunity to the Coronavirus May Last Years, New Data Hint – New York Times AND Could coronavirus immunity last YEARS? Study finds even survivors who had mild COVID-19 are protected for at least 8 months and their immune ‘memory’ may last MUCH longer – Daily Mail AND COVID-19: Study Suggests Durable Immune Response After SARS-CoV-2 Infection – NEJM Journal Watch
Commentary from the author on Twitter (thread – click for more)
1/ Our pre-print on immune memory to SARS-CoV-2 is out today. To our knowledge, this is the largest such study for any acute infection.
The upshot is that there is substantial immune memory after COVID-19.
Lots of stuff in this manuscript.https://t.co/lSAyZp0XiK@SetteLab
— Prof. Shane Crotty (@profshanecrotty) November 17, 2020
ATS Guideline: Home oxygen therapy for adults with chronic lung disease
18 Nov, 2020 | 09:13h | UTC
#AHA20 – RCT: Sotagliflozin improved cardiovascular outcomes in patients with Diabetes and CKD. Diarrhea, genital mycotic infections, volume depletion, and diabetic ketoacidosis were more common with sotagliflozin than with placebo
18 Nov, 2020 | 09:08h | UTCSotagliflozin in Patients with Diabetes and Chronic Kidney Disease – New England Journal of Medicine (link to abstract – $ for full-text)
#AHA20 – RCT: Sotagliflozin improved cardiovascular outcomes in patients with Diabetes and Recent Worsening Heart Failure. Diarrhea and severe hypoglycemia were more common with sotagliflozin than with placebo
18 Nov, 2020 | 09:06h | UTCSotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure – New England Journal of Medicine (link to abstract – $ for full-text)
Opinion: A new important study supports wider use of the polypill
18 Nov, 2020 | 09:01h | UTCRichard Smith: A new important study supports wider use of the polypill – The Lancet
Original study and commentaries: Randomized trial: A polypill comprising statins, multiple blood pressure lowering drugs, and aspirin prevents cardiovascular events among patients at intermediate cardiovascular risk
Commentary on Twitter
"We seem now to have good evidence that the polypill can reduce cardiovascular events and deaths by at least a third and probably by half in those who take the polypill regularly" @Richard56 discusses a new study in @NEJM https://t.co/B2tkN4pkDP
— The BMJ (@bmj_latest) November 17, 2020
Systematic review: Management of primary headaches in pregnancy
18 Nov, 2020 | 09:00h | UTCManagement of Primary Headaches in Pregnancy – Agency for Healthcare Research and Quality
Full report: Management of Primary Headaches in Pregnancy
Evidence Summary: Management of Primary Headaches in Pregnancy
[Press release – not published yet] Moderna’s COVID-19 vaccine candidate shows 94.5% protection in an interim analysis of the phase 3 COVE study
17 Nov, 2020 | 09:55h | UTCPress release: Moderna’s COVID-19 Vaccine Candidate Meets its Primary Efficacy Endpoint in the First Interim Analysis of the Phase 3 COVE Study
See also: Moderna Announces Longer Shelf Life for its COVID-19 Vaccine Candidate at Refrigerated Temperatures
Commentaries: What Moderna’s Covid-19 vaccine results mean for ending the pandemic – Vox AND Moderna follows Pfizer with exciting vaccine news – how to read these dramatic developments – The Conversation AND Moderna’s COVID Vaccine Is 95% Effective – Independent NIH-Appointed Board Assessment – Higher Storage Temperature Make It Even Better News – Health Policy Watch AND Moderna’s Vaccine News “Encouraging” But Won’t Solve Immediate Problem of Virus Surge in Europe & Americas – WHO – Health Policy Watch AND COVID vaccine excitement builds as Moderna reports third positive result – Nature AND Moderna’s Covid-19 vaccine is strongly effective, early look at data show – STAT AND With strong data on two Covid-19 vaccines, we have more answers about the road ahead — and questions too – STAT AND Early data show Moderna’s COVID vaccine 94.5% effective – CIDRAP AND A Note Of Caution On Moderna’s Promising Covid-19 Vaccine News – Forbes AND Promising Interim Results from Clinical Trial of NIH-Moderna COVID-19 Vaccine – NIH News Releases AND Moderna: Covid vaccine shows nearly 95% protection – BBC AND Latest vaccine success is good news but high price may restrict access – The Guardian AND ‘Just beautiful’—Another COVID-19 vaccine, from newcomer Moderna, succeeds in large-scale trial – Science AND Moderna trial success gives world more hope in race to end pandemic – Reuters AND Expert reaction to Moderna announcement of its phase 3 vaccine interim results – Science Media Centre
CDC Report: Mental health-related emergency department visits among children aged under 18 years raised during the COVID-19 Pandemic
17 Nov, 2020 | 09:48h | UTCCommentary: ER Data Indicates the Pandemic Is Harming Children’s Mental Health – U.S. News
Commentary on Twitter
New @CDCMMWR suggests that the #COVID19 pandemic may be negatively impacting children’s mental health. The proportion of emergency room visits for mental health concerns in children & adolescents increased substantially this past Mar.-Oct. Read the report: https://t.co/9FyLoCzrza pic.twitter.com/fIXMIZg7KK
— CDC (@CDCgov) November 12, 2020
CDC Report: 9% readmitted after Covid-19 hospitalization. Risk factors were age ≥65 y, chronic medical conditions, recent hospitalization before Covid-19, and discharge to a skilled nursing facility or with home health care
17 Nov, 2020 | 09:46h | UTCCommentary: 9 percent readmitted after index COVID-19 hospitalization – MedicalXpress AND One in 11 coronavirus patients discharged from a hospital is readmitted within two months, suggesting long-lasting effects of the infection, CDC report warns – Daily Mail
Commentary on Twitter
A new @CDCMMWR finds 9% of the more than 100,000 patients discharged after being hospitalized for #COVID19 were readmitted to the same hospital within 2 months. Learn more: https://t.co/s96NXLxQUE. pic.twitter.com/ugJq9f1gHP
— CDC (@CDCgov) November 9, 2020
Primary care guidance for persons with HIV: 2020 update by the HIV Medicine Association of the Infectious Diseases Society of America
17 Nov, 2020 | 09:36h | UTCNews Release: IDSA and HIVMA Release New Comprehensive Primary Care Guidance for People with HIV – Infectious Diseases Society of America
[Abstract Only] In a Phase 2 randomized trial, Semaglutide at high doses improved Nonalcoholic Steatohepatitis (NASH), but with no significant beneficial effects in liver fibrosis
17 Nov, 2020 | 09:31h | UTCA Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Semaglutide Shows Promise in NASH Phase 2 Study – Medscape (free registration required)
Commentary on Twitter
https://twitter.com/NEJM/status/1327238536001593346
Podcast on Wilderness Medicine: Pearls on altitude sickness, frostbite, animal bites, thermoregulation, and wound care
17 Nov, 2020 | 09:32h | UTC#242 Wilderness Medicine: Prepare for Disaster – The Curbsiders Internal Medicine Podcast
Worldwide measles deaths climb 50% from 2016 to 2019, claiming over 207 500 lives in 2019
17 Nov, 2020 | 09:34h | UTCSee also: Action needed now to prevent further increases in measles and measles deaths in the coming years – The Lancet AND Progress Toward Regional Measles Elimination — Worldwide, 2000–2019 – CDC Morbidity and Mortality Weekly Report
Commentary on Twitter
NEW—Action needed now to prevent further increases in #measles and measles deaths in the coming years
Kim Mulholland, Katrina Kretsinger, Liya Wondwossen & Natasha Crowcroft lay out three pillars of action needed to address this concerning situation https://t.co/m6nD6yupMp pic.twitter.com/njd5PD9K3s
— The Lancet (@TheLancet) November 13, 2020
#AHA20 – Randomized trial: A polypill comprising statins, multiple blood pressure lowering drugs, and aspirin prevents cardiovascular events among patients at intermediate cardiovascular risk
16 Nov, 2020 | 02:03h | UTCPolypill with or without Aspirin in Persons without Cardiovascular Disease – New England Journal of Medicine (link to abstract – $ for full-text)
News release: New study confirms combo pill alone and with aspirin lowers heart disease risk – American Heart Association
Commentaries: Polypill along with aspirin cuts heart attacks and strokes by up to 40%: International study – McMaster University AND Big study supports cheap combo pill to lower heart risks – Associated Press AND TIPS-3: International Study Looks at Benefits of Polypill and Polypill Plus Aspirin in Reducing CVD Risk – American College of Cardiology
Commentary on Twitter
Public health vs precision medicine. Thinking through a one size fits all drug prevention approach. "Combined Rx w/polypill+aspirin led to lower incidence of CV events than placebo among participants w/o CV disease who were at intermediate CV risk.” #AHA20https://t.co/TsbvPtA1Pl pic.twitter.com/Ylq3AKThII
— Harlan Krumholz (@hmkyale) November 14, 2020
Sleep problems in dementia: Despite many drugs being widely prescribed, systematic review finds lack of evidence and no randomized controlled trials to guide decisions about drug treatment
17 Nov, 2020 | 09:29h | UTCPharmacotherapies for sleep disturbances in dementia – Cochrane Library
#AHA20 – In patients who had discontinued statins because of side effects, a N-of-1 trial of a statin, placebo, or no treatment found that side effects often attributed to statins were the same for those taking a placebo
16 Nov, 2020 | 01:57h | UTCCommentary: ‘Nocebo effect’ cause of most statin side-effects, study suggests – The Guardian
Original study: N-of-1 Trial of a Statin, Placebo, or No Treatment to Assess Side Effects – New England Journal of Medicine ($ – no abstract available)
Commentary on Twitter
Patients who had discontinued statins because of side effects received four bottles of a statin, four bottles of placebo, and four empty bottles. Each used for 1 month, in random sequence. The symptom burden with placebo was 90% of the symptom burden with the statin. #AHA20
— NEJM (@NEJM) November 15, 2020
#AHA20 – Randomized trial: High-dose Omega-3 fatty acids did not reduce the risk of cardiac events in patients at high cardiovascular risk
16 Nov, 2020 | 01:51h | UTCEditorial 2: Do Omega-3 Fatty Acids Benefit Health?
Commentary on Twitter
In this RCT, omega-3 fatty acids (EPA/DHA) did not reduce major adverse CV events vs corn oil in statin-treated patients at high CV risk
(Compare w Vascepa in REDUCE-IT) https://t.co/7BIs1Rr8YZ#STRENGTHTrial #AHA20 #SteveNissen@ProfSNicholls @Dmozaffarian @ClevelandClinic— JAMA (@JAMA_current) November 15, 2020