Family Medicine
What does 95% COVID-19 vaccine efficacy really mean?
19 Feb, 2021 | 02:58h | UTCWhat does 95% COVID-19 vaccine efficacy really mean? – The Lancet Infectious Diseases
Related: Pfizer vaccine: what an ‘efficacy rate above 90%’ really means – The Conversation
Fauci: There’s evidence COVID-19 vaccines don’t just protect you — they may stop you from spreading the virus to others, too
19 Feb, 2021 | 02:46h | UTCRelated: [Preprint] Covid-19 vaccination associated with reduced viral load, may reduce transmission (study and commentary)
How many people get ‘long COVID’ – and who is most at risk?
19 Feb, 2021 | 02:54h | UTCHow many people get ‘long COVID’ – and who is most at risk? – The Conversation
SR: Integrating palliative care in ambulatory care of noncancer serious chronic illness
19 Feb, 2021 | 02:28h | UTCFull report: Integrating Palliative Care in Ambulatory Care of Noncancer Serious Chronic Illness
Evidence summary: Integrating Palliative Care in Ambulatory Care of Noncancer Serious Illness
A food allergy epidemic… or just another case of overdiagnosis?
19 Feb, 2021 | 02:13h | UTCA food allergy epidemic… or just another case of overdiagnosis? – The BMJ Opinion
Original study: Food anaphylaxis in the United Kingdom: analysis of national data, 1998-2018 – The BMJ
M-A: Not enough evidence there are individual differences in response to antidepressants
19 Feb, 2021 | 02:15h | UTCIndividual Differences in Response to Antidepressants: A Meta-analysis of Placebo-Controlled Randomized Clinical Trials – JAMA Psychiatry (free for a limited period)
Editorial: New Directions in Research on Heterogeneity of Treatment Effects for Major Depression (free for a limited period)
Commentary: Antidepressants for MDD: Time to Rethink Personalized Therapy? – Physician’s Weekly
Related studies: What are the chances for personalised treatment with antidepressants? Detection of patient-by-treatment interaction with a variance ratio meta-analysis – BMJ Open AND Individual response to antidepressants for depression in adults-a meta-analysis and simulation study – PLOS One
Commentary on Twitter (thread – click for more)
1/ Treatment effect heterogeneity in antidepressant tx – a retracted paper by Maslej et al. was now re-published, with a complete reversal of the main-findings – no difference in variability in tx outcome bw antidepressant and placebo. https://t.co/ME5qawCQlL https://t.co/IgegV5kZpT
— Pfluft (@PloederlM) February 18, 2021
RCT: Levothyroxine does not reduce the risk of developing depressive symptoms in older adults with subclinical hypothyroidism
18 Feb, 2021 | 02:46h | UTCRelated Studies: Association Between Levothyroxine Treatment and Thyroid-Related Symptoms Among Adults Aged 80 Years and Older With Subclinical Hypothyroidism – JAMA AND Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism – New England Journal of Medicine AND L-Thyroxine Therapy for Older Adults With Subclinical Hypothyroidism and Hypothyroid Symptoms: Secondary Analysis of a Randomized Trial – Annals of Internal Medicine
Guidelines (conflicting viewpoints): BMJ Guideline: Treatment of Subclinical Hypothyroidism AND Society for Endocrinology & British Thyroid Association issue statement against new treatment recommendations for subclinical hypothyroidism
Commentary on Twitter
Ancillary study of the TRUST RCT of levothyroxine therapy finds it does not reduce depression risk among older adults with subclinical hypothyroidism and shouldn't be prescribed for this purpose. #VisualAbstract https://t.co/yu3EChdkm1
— JAMA Network Open (@JAMANetworkOpen) February 10, 2021
AAP: 2021 Recommendations for Preventive Pediatric Health Care
18 Feb, 2021 | 03:01h | UTCRecommendations: Periodicity Schedule
Open schools in Sweden during the SARS-CoV-2 pandemic were associated with low incidence of severe Covid-19 among schoolchildren and children of preschool age
18 Feb, 2021 | 03:19h | UTCOpen Schools, Covid-19, and Child and Teacher Morbidity in Sweden – New England Journal of Medicine
SR: Concomitant use of levothyroxine and proton pump inhibitors causes a significant increase in TSH concentration
18 Feb, 2021 | 02:48h | UTC
M-A: Preventable medication harm across health care settings
18 Feb, 2021 | 02:43h | UTCCommentary: Preventable medication harm across health care settings: a systematic review and meta-analysis – PSNet
USPSTF Draft Recommendation: Screening for gestational diabetes mellitus
17 Feb, 2021 | 01:28h | UTCGestational Diabetes Mellitus: Screening – U.S. Preventive Services Task Force
RCT: Among patients with knee osteoarthritis, high-intensity strength training was not associated with better outcomes compared with low-intensity strength training or an attention control
17 Feb, 2021 | 01:24h | UTCCommentary: No Benefit from High-Intensity Strength Training for Knee Osteoarthritis – NEJM Journal Watch
Commentary on Twitter
Hot from press: JAMA paper puts question mark on the effectiveness of both low- and high-intensity exercise for knee OA pain. Attention controls had similar improvement. Contextual effects and RTM phenomenon in OA may be powerful! https://t.co/EBrXZcvyXH@OARSInews @JAMA_current pic.twitter.com/880InW1Lag
— Martin Englund (@dr_englund) February 16, 2021
Effect of High-Intensity Strength Training on Knee Pain and Knee Joint Compressive Forces Among Adults With Knee OsteoarthritisThe START Randomized Clinical Trial
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— Physio Meets Science (@PhysioMeScience) February 16, 2021
WHO launches consolidated guidelines for malaria
17 Feb, 2021 | 01:27h | UTCWHO launches consolidated guidelines for malaria – World Health Organization
Online Platform: WHO Guidelines for malaria
Cohort study: Risk factors associated with transition from acute to chronic low back pain
17 Feb, 2021 | 01:21h | UTC
Commentary on Twitter
Risk Factors Associated With Transition From Acute to Chronic Low Back Pain in US Patients Seeking Primary Care
????https://t.co/DzpfvWMzIV pic.twitter.com/qzvoJL2Mxf
— Physio Meets Science (@PhysioMeScience) February 16, 2021
Cohort study: Factors associated with severe SARS-CoV-2 infection in children
17 Feb, 2021 | 01:38h | UTCFactors Associated With Severe SARS-CoV-2 Infection – Pediatrics
Commentary: Large study outlines risk factors for severe COVID-19 in children – 2 Minute Medicine
Review: Diagnosis and treatment of hip and knee osteoarthritis
16 Feb, 2021 | 02:05h | UTCDiagnosis and Treatment of Hip and Knee Osteoarthritis: A Review – JAMA (free or a limited period)
SR: Interventions for improving outcomes in patients with multimorbidity in primary care and community settings
17 Feb, 2021 | 01:11h | UTCSummary: Improving outcomes for people with multiple chronic conditions – Cochrane Library
Effectiveness of telerehabilitation in physical therapy: A rapid overview
16 Feb, 2021 | 01:53h | UTCEffectiveness of telerehabilitation in physical therapy: A rapid overview – Physical Therapy
M-A: Efficacy of a low-FODMAP diet in adult irritable bowel syndrome
16 Feb, 2021 | 02:01h | UTC
Commentary on Twitter
Efficacy of a low-FODMAP diet in adult irritable bowel syndrome: a systematic review and meta-analysis "The low-FODMAP diet reduces GI symptoms and improves quality of life in IBS subjects as compared to control diets"https://t.co/tTeRjKOV1O pic.twitter.com/raLdnlDQCJ
— Lukas Schwingshackl (@LSchwingshackl) February 15, 2021
Covid-19: Are cloth masks still effective? And other questions answered
16 Feb, 2021 | 02:22h | UTCCovid-19: Are cloth masks still effective? And other questions answered – The BMJ
Review: Diagnostics for SARS-CoV-2 infections
16 Feb, 2021 | 02:20h | UTCDiagnostics for SARS-CoV-2 infections – Nature Materials
Recommended childhood and adolescent immunization schedule: United States, 2021
15 Feb, 2021 | 00:58h | UTCRecommended Childhood and Adolescent Immunization Schedule: United States, 2021 – Pediatrics
Commentary: AAP Releases 2021 Child, Adolescent Immunization Schedule – HealthDay
Table 3. Recommended Child and Adolescent Immunization Schedule by Medical Indication, United States, 2021
See also: All CDC Immunization Schedulles
Take whatever COVID vaccine you can get. All of them stop death and hospitalization
15 Feb, 2021 | 01:17h | UTCTake whatever COVID vaccine you can get. All of them stop death and hospitalization – USA Today
“All seven COVID-19 vaccines that have completed large efficacy trials — Pfizer, Moderna, Johnson & Johnson, Novavax, AstraZeneca, Sputnik V and Sinovac — appear to be 100% effective for serious complications. Not one vaccinated person has gotten sick enough to require hospitalization. Not a single vaccinated person has died of COVID-19.”
Small RCT: No effect from Zinc and Vitamin C supplementation among ambulatory patients with SARS-CoV-2 infection
15 Feb, 2021 | 01:20h | UTCCommentaries: Vitamin C, zinc don’t lessen Covid-19 symptoms, study finds – CNN AND Supplements for the Treatment of Mild COVID-19—Challenging Health Beliefs With Science From A to Z – JAMA Network Open AND Zinc, vitamin C show no effect for COVID-19 in small study – CIDRAP AND Expert reaction to a study looking at prophylactic anticoagulants as a treatment for hospitalised patients with COVID-19 – Science Media Centre
Commentary on Twitter
RCT finds high-dose zinc, ascorbic acid (vitamin C), or both, did not significantly decrease the duration of symptoms in ambulatory patients with #COVID19 vs standard of care. @DesaiMilindY @ClevelandClinic @ErinMichos @miguelcainzos23 #VisualAbstract https://t.co/ahcc2awJB8
— JAMA Network Open (@JAMANetworkOpen) February 12, 2021